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A“T.E.S.T.”hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair

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Bioactive Materials 2023年第7期25卷 333-346页

作者： Meiyan Li Ruoyan Wei Chang Liu Haowei Fang Weiming Yang yunzhe wang Yiyong Xian Kunxi Zhang Yong He Xingtao Zhou Department of Ophthalmology EYE&ENT Hospital of Fudan University ShanghaiChina NHC Key Laboratory of Myopia(Fudan University) ShanghaiChina State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhouChina Shanghai Research Center of Ophthalmology and Optometry ShanghaiChina Department of Ophthalmology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Polymer Materials School of Materials Science and EngineeringShanghai UniversityShanghaiChina

Corneal transplantation is an effective clinical treatment for corneal diseases,which,however,is limited by donor corneas.It is of great clinical value to develop bioadhesive corneal patches with functions of“Transparency”and“Epithelium&Stroma generation”,as well as“Suturelessness”and“Toughness”.To simultaneously meet the“T.E.S.T.”requirements,a light-curable hydrogel is designed based on methacryloylated gelatin(GelMA),Pluronic F127 diacrylate(F127DA)&Aldehyded Pluronic F127(AF127)co-assembled bi-functional micelles and collagen type I(COL I),combined with clinically applied corneal cross-linking(CXL)technology for repairing damaged cornea.The patch formed after 5 min of ultraviolet irradiation possesses transparent,highly tough,and strongly bio-adhesive performance.Multiple cross-linking makes the patch withstand deformation near 600%and exhibit a burst pressure larger than 400 mmHg,significantly higher than normal intraocular pressure(10-21 mmHg).Besides,the slower degradation than GelMA-F127DA&AF127 hydrogel without COL I makes hydrogel patch stable on stromal beds in vivo,supporting the regrowth of corneal epithelium and stroma.The hydrogel patch can replace deep corneal stromal defects and well bio-integrate into the corneal tissue in rabbit models within 4 weeks,showing great potential in surgeries for keratoconus and other corneal diseases by combining with CXL.

关键词： Tough hydrogel Bioadhesives Corneal patch CXL Sutureless repair

Recent advances in small incision lenticule extraction(SMILE)-derived refractive lenticule preservation and clinical reuse

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再生工程(英文)

再生工程(英文) 2023年第2期4卷 103-121页

作者： Xiaojun Hu Ruoyan Wei Chang Liu yunzhe wang Danjuan Yang Ling Sun Fei Xia Shengtao Liu Meiyan Li Xingtao Zhou Eye Institute and Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghai 200031China Key Laboratory of Myopia NHC Key Laboratory of Myopia(Fudan University)Chinese Academy of Medical SciencesShanghai 200031China Shanghai Research Center of Ophthalmology and Optometry China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care China

Small incision lenticule extraction(SMILE)has become one of the mainstream refractive surgeries in recent years,with satisfactory efficacy,safety,and predictability.SMILE-derived refractive lenticule,the byproduct of the surgery,holds great potential in clinical practice given its easy access and good biocompatibility.Numerous studies have been published to describe its applications in refractive correction,corneal ectasia diseases,and corneal defects.The feasibility and safety were validated in both animal models and clinical studies.Moreover,the preservation method is also crucial for its further promotion and application.Novel techniques are also evaluated and applied in lenticule preservation.We covered the recent advances in the preservation of corneal stromal lenticules and their clinical reuse in this review.

关键词： Small incision lenticule extraction Refractive lenticule Preservation Clinical reuse

Assessment of tree-ring mercury radial translocation and age effect in Masson pine:Implications for historical atmospheric mercury reconstruction

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Journal of Environmental Sciences 2024年第4期138卷 266-276页

作者： Xu Liu Xun wang Dingyong wang College of Resources and Environment Southwest UniversityChongqing 400715China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

The tree ring has been regarded as an emerging archive to reconstruct historical atmospheric mercury(Hg)trends,but with the large knowledge gaps in the reliability.In this study,we comprehensively evaluated the Hg source,radial translocation and age effect of Masson pine(Pinus massoniana)tree ring at Mt.Jinyun in Chongqing,to assess the suitability of such tree ring as the archive of atmospheric Hg.Results showed that distinct variabilities among Masson pine tree-ring Hg concentration profiles.The Hg concentration significantly increased along with stem height(P<0.05),indicating the Hg in tree rings mainly derived from foliage uptake atmospheric Hg.We found a distinct age effect that the tree ring of young trees had the higher Hg concentration.Besides,we used the advection-diffusion model to demonstrate how Hg concentration shifted by the advection or/and diffusion in tree rings.The modeling results showed that the advection induced radial translocation during the young growth period of tree was a plausible mechanism to result in the tree-ring Hg record largely different from the trend of anthropogenic Hg emissions in Chongqing.We finally suggest that in further Hg dendrochemistry,better discarding the tree-ring Hg profile of the young growth period to reduce impacts of the radial translocation and age effect.

关键词： Masson pine Tree-ring mercury Radial translocation Tree age effect

Pushing the boundaries: an interview with Dae-Hyun Kim on terahertz devices

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National Science Review 2024年第3期11卷 42-45页

作者： Defu wang the Center for Carbon-based Electronics School of Electronics Peking University

Ⅲ–Ⅴ compound semiconductors, such as InGaAs/InAlAs, exhibit exceptional carrier transport properties, establishing them as fundamental elements in terahertz(THz) applications crucial for the development of 6G netwo...

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Enrichment of anammox biomass during mainstream wastewater treatment driven by achievement of partial denitrification through the addition of bio-carriers

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Journal of Environmental Sciences 2024年第3期137卷 181-194页

作者： Yuqing Ma Bo wang Xiaodi Li Shuo wang Wen wang Yongzhen Peng National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology Engineering Research Center of BeijingBeijing University of TechnologyBeijing 100124China

Anammox is widely considered as the most cost-effective and sustainable process for nitrogen removal.However,how to achieve the enrichment of anammox biomass remains a challenge for its large-scale application,especially in mainstream wastewater treatment.In this study,the feasibility of enrichment of anammox biomass was explored through the realization of partial denitrification and the addition of bio-carriers.By using ordinary activated sludge,a sequencing batch reactor(SBR)followed by an up-fow anaerobic sludge bed(UASB)was operated at 25±2℃ for 214 days.The long-term operation was divided into five phases,in which SBR and UASB were started-up in Phases I and II,respectively.By eliminating oxygen and adjusting the infow ratios in Phases III-V,advanced nitrogen removal was achieved with the effuent total nitrogen being 4.7 mg/L and the nitrogen removal efficiency being 90.5%in Phase V.Both in-situ and ex-situ activity tests demonstrated the occurrence of partial denitrification and anammox.Moreover,16S rRNA high-throughput sequencing analysis revealed that Candidatus Brocadia was enriched from below the detection limit to in biofilms(0.4%in SBR,2.2%in UASB)and the foc sludge(0.2%in SBR,1.3%in UASB),while Thauera was mainly detected in the foc sludge(8.1%in SBR,8.8%in UASB),which might play a key role in partial denitrification.Overall,this study provides a novel strategy to enrich anammox biomass driven by rapid achievement of partial denitrification through the addition of bio-carriers,which will improve large-scale application of anammox processes in mainstream wastewater treatment.

关键词： Enrichment Anammox biomass Bio-carriers Partial denitrification Mainstream wastewater

Performance and mechanism of La-Fe metal-organic framework as a highly efficient adsorbent for fluoride removal from mine water

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Journal of Environmental Sciences 2024年第5期139卷 245-257页

作者： Chaomin Jia Jianbing wang Huijiao wang Sichao Zhu Xiaohui Zhang Yuxiang wang School of Chemical&Environmental Engineering China University of Mining&Technology-BeijingBeijing 100083China Beijing Polytechnic Beijing 100176China Chinese Society for Urban Studies Beijing 100835China

Water fluoride pollution has caused non-negligible harm to the environment and humans,and thus it is crucial to find a suitable treatment technology.In this study,La-Fe@PTA adsorbent was synthesized for the defluoridation of mine water.The results showed that the optimum conditions for defluoridation by La-Fe@PTA were p H close to 7.0,the initial F-concentration of 10 mg/L,the dosage of 0.5 g/L and the adsorption time of 240 min.Compared with SO_4^(2-),Cl^(-),NO_(3)^(-),Ca^(2+)and Mg^(2+),CO_(3)^(2-)and HCO_(3)^(-)presented severer inhibition on fluoride uptake by La-Fe@PTA.The adsorption process fits well with the pseudo-second-order kinetic model and Freundlich model,and the maximum adsorption capacity of Langmuir model was 95 mg/g.Fixed-bed adsorption results indicated that fluoride in practical fluorinated mine water could be effectively removed from 3.6 mg/L to less than 1.5 mg/L within130 bed volume(BV)by using 1.5 g La-Fe@PTA.Furthermore,the adsorbent still had good adsorption capacity after regeneration,which confirms the great application potential of La-Fe@PTA as a fluoride ion adsorbent.The mechanism analysis showed that La-Fe@PTA adsorption of fluorine ions is a physicochemical reaction driven by electrostatic attraction and ion exchange.

关键词： Adsorption La-Fe@PTA Fluoride ion Mine water Mechanism

Analysis of Hot Topics Regarding Global Smart Elderly Care Research—1997-2021

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China CDC weekly 2024年第9期6卷 157-161页

作者： Hongman wang Hong Chen Yuqi wang School of Health Humanities Peking UniversityBeijingChina Center for Global Public Health Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?With the assistance of the internet,big data,cloud computing,and other technologies,the concept of smart elderly care has emerged.What is added by this report?This study presents information on the countries or regions that have conducted research on smart elderly care,as well as identifies global hotspots and development trends in this field.

关键词： Smart internet smart

从地方祠祀到宗族信仰:新见张鷟佚文《方仙翁庙碑》考释

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中国典籍与文化 2024年第2期 129-137页

作者：罗韫哲南京大学文学院

清康熙十九年《富阳方氏宗谱》中收录了一长一短两篇署名张鷟的《方仙翁庙碑》。通过史料记载及碑刻文体、内容等证据,可确定短文为唐人张鷟所作,是一篇珍贵的佚文;而长文则是元代方氏族裔据张鷟所撰碑文大幅增篡而成的伪作。真伪两方... 详细信息

清康熙十九年《富阳方氏宗谱》中收录了一长一短两篇署名张鷟的《方仙翁庙碑》。通过史料记载及碑刻文体、内容等证据,可确定短文为唐人张鷟所作,是一篇珍贵的佚文;而长文则是元代方氏族裔据张鷟所撰碑文大幅增篡而成的伪作。真伪两方碑文背后,是一个民间神祇由唐宋地方祠祀转变为元明清宗族信仰的历史缩影,同时也展现出族谱中既可能保存珍贵的前代文献,也可能基于宗族构建的需求而伪造文献。此外据碑文题衔,可证实张鷟曾实际得任左台监察御史。

关键词：张鷟佚文方仙翁族谱伪碑

Continuous-wave operation of 1550 nm low-threshold triple-lattice photonic-crystal surface-emitting lasers

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Light(Science & Applications) 2024年第3期13卷 446-453页

作者： Ziye wang Xia Liu Pinyao wang Huanyu Lu Bo Meng Wei Zhang Lijie wang Yanjing wang Cunzhu Tong State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Central Research Institute Planning Dept 2012 LabsHuawei Technologies Company Ltd.Shenzhen 518129China

Benefitting from narrow beam divergence,photonic crystal surface-emitting lasers are expected to play an essential role in the ever-growing fields of optical communication and light detection and ranging.Lasers operating with 1.55μm wavelengths have attracted particular attention due to their minimum fiber loss and high eye-safe threshold.However,high interband absorption significantly decreases their performance at this 1.55μm wavelength.Therefore,stronger optical feedback is needed to reduce their threshold and thus improve the output power.Toward this goal,photonic-crystal resonators with deep holes and high dielectric contrast are often used.Nevertheless,the relevant techniques for high-contrast photonic crystals inevitably complicate fabrication and reduce the final yield.In this paper,we demonstrate the first continuous-wave operation of 1.55μm photonic-crystal surface-emitting lasers by using a‘triple-lattice photonic-crystal resonator’,which superimposes three lattice point groups to increase the strength of in-plane optical feedback.Using this geometry,the in-plane 180°coupling can be enhanced threefold compared to the normal single-lattice structure.Detailed theoretical and experimental investigations demonstrate the much lower threshold current density of this structure compared to‘single-lattice’and‘double-lattice’photonic-crystal resonators,verifying our design principles.Our findings provide a new strategy for photonic crystal laser miniaturization,which is crucial for realizing their use in future high-speed applications.

关键词： resonator crystal lattice