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基于固液氧化还原靶向反应的能量存储技术:材料、器件及动力学

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化工学报 2024年第4期75卷 1222-1240页

作者：李云璇刘新悦陈熙刘文周明月蓝兴英中国石油大学(北京)碳中和未来技术学院北京102249 北京化工大学化学学院北京100029

随着双碳政策的推进和可再生能源的快速发展,能源存储技术成为解决能源转型和可持续发展的关键支撑。氧化还原液流电池(RFB)是一种用于大规模储能的电化学器件,具有设计灵活、存储容量大、循环寿命长、安全性高等特点。然而受氧化还原... 详细信息

随着双碳政策的推进和可再生能源的快速发展,能源存储技术成为解决能源转型和可持续发展的关键支撑。氧化还原液流电池(RFB)是一种用于大规模储能的电化学器件,具有设计灵活、存储容量大、循环寿命长、安全性高等特点。然而受氧化还原介质分子溶解度的限制,其能量密度相对较低,同时可实用化的体系较少。为解决这一问题,基于固液氧化还原靶向反应的能量存储技术应运而生。氧化还原靶向液流电池(RTFB)在提高能量密度的同时保持良好流动性,克服了传统RFB的限制。综述了近年来该技术在材料、器件及动力学方面的研究进展,包括各种材料的特点、器件的设计及性能以及动力学过程的表征与建模。最后总结当前研究的不足之处并展望未来发展趋势。

关键词：电化学氧化还原靶向反应氧化还原靶向液流电池电解液液流电池化学反应器

基于^(18)F-PSMA-1007 PET/CT影像组学模型在前列腺癌与前列腺增生鉴别诊断中的价值

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中华核医学与分子影像杂志 2024年第2期44卷 80-85页

作者：罗量常儒玺李运轩高俊刚刘翔段小艺西安交通大学第一附属医院PET/CT室西安710061

目的评估前列腺特异膜抗原(PSMA)PET/CT影像组学模型对前列腺癌和前列腺增生(BPH)鉴别诊断的价值。方法回顾性收集2020年5月至2022年9月在西安交通大学第一附属医院行前列腺穿刺活组织检查和^(18)F-PSMA-1007 PET/CT显像的50例前列腺癌... 详细信息

目的评估前列腺特异膜抗原(PSMA)PET/CT影像组学模型对前列腺癌和前列腺增生(BPH)鉴别诊断的价值。方法回顾性收集2020年5月至2022年9月在西安交通大学第一附属医院行前列腺穿刺活组织检查和^(18)F-PSMA-1007 PET/CT显像的50例前列腺癌[年龄(70.0±8.8)岁]和25例BPH患者[年龄(66.9±9.4)岁]的资料,采用随机种子数按7∶3分为训练集(n=53)和测试集(n=22)。基于PET/CT配准图像勾画前列腺ROI,提取PET和CT影像组学特征,使用最大相关最小冗余(mRMR)和最小绝对收缩和选择算子(LASSO)算法进行特征筛选。采用logistic回归分别构建PET和PET/CT影像组学模型。通过ROC曲线评价模型的诊断效能,并与游离前列腺特异抗原(fPSA)/总前列腺特异性抗原(tPSA)比值、PET常规代谢参数以及前列腺癌分子成像标准化评估(PROMISE)等指标和参数进行比较(Delong检验)。结果PET影像组学模型共纳入7个特征,PET/CT影像组学模型分别纳入3个CT特征和4个PET特征。训练集、测试集中PET和PET/CT影像组学模型AUC分别为0.941、0.914和0.965、0.914,均高于fPSA/tPSA(0.719和0.710)、SUV_(max)(0.748和0.800)、SUV峰值(SUV_(peak);0.722和0.771)、肿瘤代谢体积(MTV;0.640和0.595)、病灶总摄取值(TLU;0.525和0.476)以及PROMISE(0.644和0.667)的AUC[训练集z值:-6.26~-3.13,均P0.05(fPSA/tPSA、SUV_(max)、SUV_(peak))或P<0.05(MTV、TLU、PROMISA)]。PET和PET/CT影像组学模型在测试集中鉴别诊断的准确性、灵敏度和特异性分别为86.36%(19/22)、13/15、6/7和90.91%(20/22)、15/15、5/7。结论相较于临床指标和PET常规参数,基于PSMA PET/CT的影像组学模型可进一步提高对前列腺癌和BPH鉴别诊断的效能。

关键词：前列腺肿瘤前列腺增生前列腺特异膜抗原影像组学正电子发射断层显像术体层摄影术,X线计算机

The CST bounce universe model——A parametric study

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Science China(Physics,Mechanics & Astronomy) 2019年第1期62卷 9-15页

作者： Yeuk-Kwan Edna Cheung Xue Song ShuYi li yunxuan li YiQing Zhu Department of Physics Nanjing University Institute of High Energy Physics China Academy of Sciences Department of Physics Princeton University Department of Physics Brown University California Institute of Technology ETH Zürich

A bounce universe model with a scale-invariant and stable spectrum of primordial density perturbations was constructed using a consistent truncation of the D-brane dynamics from Type IIB string theory. A coupling was introduced between the tachyon field and the adjoint Higgs field on the D3-branes to lock the tachyon at the top of its potential hill and to model the bounce process,which is known as the Coupled Scalar and Tachyon Bounce(CSTB) Universe. The CSTB model has been shown to be ghost free,and it fulfils the null energy condition; in addition, it can also solve the Big Bang cosmic singularity problem. In this paper we conduct an extensive follow-up study of the parameter space of the CSTB model. In particular we are interested in the parameter values that can produce a single bounce to arrive at a radiation-dominated universe. We further establish that the CSTB universe is a viable alternative to inflation, as it can naturally produce a sufficient number of e-foldings in the locked inflation epoch and in the post-bounce expansion to overcome the four fundamental limitations of the Big Bang cosmology, which are flatness, horizon,homogeneity and singularity, resulting in a universe of the current size.

关键词： bounce universe Big Bang singularity tachyon inflation flatness and horizon problems

Brand New Exploration and Research on Characteristics of the Development of Each Cultural School in the Macro Development of National Culture

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学术界 2016年第6期 263-267页

作者： li yunxuan Ma Zongbao Hui Institute of Ningxia University Yinchuan Ningxia 750021

According to the overall development trend of the modern social development environment and social cultural atmosphere,it is necessary for the diversified coexistence of the national ***,the cultural psychological school,constructivismschool and the universal evolution school have become the fundamental driving force for the development of the national cultures while their inherent development thoughts have also been provided with corresponding featured views.

关键词：民族文化学校发展特征宏观社会发展发展趋势文化氛围文化心理

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雨天过街行人流自组织行为特性及其仿真建模

交通信息与安全 2024年第2期42卷 136-146页

作者：杨海飞卢素情李昀轩陈娴王柳古乐河海大学土木与交通学院南京210024 北京工业大学城市建设学部北京100124

为改善降雨环境下城市过街设施的交通安全与效率,研究了雨天行人流过街的自组织行为特性并对其进行仿真建模。结合现场采集的晴、雨天行人流过街轨迹数据,对比分析常见中、小雨天气下过街行人流的速度统计分布、避让位移偏量以及空间溢... 详细信息

为改善降雨环境下城市过街设施的交通安全与效率,研究了雨天行人流过街的自组织行为特性并对其进行仿真建模。结合现场采集的晴、雨天行人流过街轨迹数据,对比分析常见中、小雨天气下过街行人流的速度统计分布、避让位移偏量以及空间溢出幅度;在此基础上通过改进社会力模型建立雨天行人流过街运动模型;应用实测数据标定模型参数并进行仿真验证。特性分析结果显示:雨天行人流过街速度在0.5~1.25 m/s区间的占比较晴天增加了58.80%,而在1.25~2.0 m/s区间占比降低了24.37%,表明其分布向低速范围显著偏移(p<0.001),同时由于未撑伞或溢出行人的紧迫心理,仍有8.05%的行人以2.0~2.5 m/s的较高步速过街;雨天对向行人避让的位移偏量较晴天平均增幅达46.80%,其整体趋势显著增大(p<0.001);雨天行人流空间溢出的临界过街等待人数和人流量较晴天分别下降7人与3人/分钟,溢出幅度为5.07%~24.80%。仿真验证结果表明:所建立的行人流过街运动模型,其模拟的雨天行人过街轨迹精度与晴天达到同量级,其中晴天单向前行与对向避让轨迹均方根误差分别为0.245和0.483,而雨天则为0.329和0.702;模拟的过街速度统计分布与实测分布无显著差异(晴天p=0.620,雨天p=0.649),且能够还原未撑伞或溢出行人的高速过街行为;模拟典型场景下雨天行人流溢出幅度与实测值的绝对误差为2.08%,而晴天均未发生溢出现象,与实测结果相符。

关键词：交通安全过街行人流社会力模型仿真降雨

自动化控制在煤矿井下皮带运输系统中的应用实践

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设备监理 2024年第2期 47-50页

作者：张振国李昀轩满乐兖矿能源集团股份有限公司东滩煤矿济宁273500

在皮带运输系统的长期运行中,因为负荷较高,易形成故障问题,影响煤矿安全生产。因此,需要在皮带运输系统中应用自动化控制技术,从而确保皮带运输效率和安全性的提升。本文就煤矿井下皮带运输自动化控制系统的特点进行了分析,并对煤矿井... 详细信息

在皮带运输系统的长期运行中,因为负荷较高,易形成故障问题,影响煤矿安全生产。因此,需要在皮带运输系统中应用自动化控制技术,从而确保皮带运输效率和安全性的提升。本文就煤矿井下皮带运输自动化控制系统的特点进行了分析,并对煤矿井下皮带运输自动化控制系统的功能进行了介绍,着重阐述了煤矿井下皮带运输自动化控制系统的具体应用,为提升煤矿井下皮带运输系统的自动化、智能化水平提供了借鉴和参考。

关键词：自动化控制煤矿皮带运输

抑制PPARγ表达对BMSCs成骨分化的影响

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昆明医科大学学报 2024年第9期45卷 17-23页

作者：蒲龙周旋然江陈榕李云轩袁勇昆明医科大学第二附属医院创伤外科云南昆明650032 蒙自市人民医院关节运动创伤骨科云南蒙自661100

目的探究抑制过氧化物酶增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)表达对BMSCs成骨分化的影响,为原发性骨质疏松症(primary psteoporosis,POP)的治疗提供理论基础。方法将骨密度正常患者提取的BMSCs分为... 详细信息

目的探究抑制过氧化物酶增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)表达对BMSCs成骨分化的影响,为原发性骨质疏松症(primary psteoporosis,POP)的治疗提供理论基础。方法将骨密度正常患者提取的BMSCs分为正常对照组(CON组),POP患者提取的BMSCs分为原发性骨质疏松组(POP组),取POP组细胞加入PPARγ抑制剂,分为抑制剂组(INR组),经成骨诱导分化后,检测各组细胞中骨桥蛋白(osteopontin,OPN)、骨钙素(osteocalcin,OCN)、Osterix、Runt相关转录因子2(runt-related transcription factor 2,Runx2)的表达情况;碱性磷酸酶(alkaline phosphatase,ALP)染色观察各组BMSCs成骨分化情况。结果POP组ALP阳性细胞数低于CON组和INR组(P<0.05);与CON组相比,POP组中OCN、OPN、Osterix、Runx2表达量降低,差异具有统计学意义(P<0.05);与POP组相比,INR组中OCN、OPN、Osterix、Runx2表达量升高,差异具有统计学意义(P<0.05)。结论抑制PPARγ表达后,BMSCs成骨分化特异性基因(ALP、OCN、OPN、Osterix、Runx2)表达增加。

关键词：原发性骨质疏松症 PPARγ BMSCs 成骨分化

The cell cycle inhibitor P21 promotes the development of pulmonary fibrosis by suppressing lung alveolar regeneration

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Acta Pharmaceutica Sinica B 2022年第2期12卷 735-746页

作者： Xiaoxi Lv Chang liu Shanshan liu yunxuan li Wanyu Wang Ke li Fang Hua Bing Cui Xiaowei Zhang Jiaojiao Yu Jinmei Yu ZhuoWei Hu Immunology and Cancer Pharmacology Group State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Drug Clinical Trial Institution Children’s HospitalCapital Institute of PediatricsBeijing 100020China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

The cell cycle inhibitor P21 has been implicated in cell senescence and plays an important role in the injury-repair process following lung *** fibrosis(PF)is a fibrotic lung disorder characterized by cell senescence in lung alveolar epithelial *** this study,we report that P21 expression was increased in alveolar epithelial type 2 cells(AEC2 s)in a time-dependent manner following multiple bleomycin-induced *** injury of AEC2 s resulted in telomere shortening and triggered P21-dependent cell ***2 s with elevated expression of P21 lost their self-renewal and differentiation *** particular,elevated P21 not only induced cell cycle arrest in AEC2 s but also bound to P300 andβ-catenin and inhibited AEC2 differentiation by disturbing the P300-β-catenin ***,senescent AEC2 s triggered myofibroblast activation by releasing profibrotic *** of P21 restored AEC2-mediated lung alveolar regeneration in mice with chronic *** results of our study reveal a mechanism of P21-mediated lung regeneration failure during PF development,which suggests a potential strategy for the treatment of fibrotic lung diseases.

关键词： P21 Cell senescence Alveolar epithelial type 2 cells Pulmonary fibrosis Alveolar regeneration Bleomycin Cell cycle arrest P300-β-catenin complex

TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1631-1647页

作者： Xiaoxi Lv Shanshan liu Chang liu yunxuan li Tingting Zhang Jie Qi Ke li Fang Hua Bing Cui Xiaowei Zhang Yuxin liu Jiaojiao Yu Jinmei Yu li li Xia li Zhigang Yao Bo Huang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes ImmunologyMinistry of EducationAnd Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangsha 410011China Drug Clinical Trial Institution Children's HospitalCapital Institute of PediatricsBeijing 100020China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Shandong University Weihai 264209China Department of Respiratory Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Institute of Basic Medicine Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Pulmonary fibrosis(PF)is the pathological structure of incurable fibroproliferative lung diseases that are attributed to the repeated lung injury-caused failure of lung alveolar regeneration(LAR).Here,we report that repetitive lung damage results in a progressive accumulation of the transcriptional repressor SLUG in alveolar epithelial type II cells(AEC2s).The abnormal increased SLUG inhibits AEC2s from self-renewal and differentiation into alveolar epithelial type I cells(AEC1s).We found that the elevated SLUG represses the expression of the phosphate transporter SLC34A2 in AEC2s,which reduces intracellular phosphate and represses the phosphorylation of JNK and P38 MAPK,two critical kinases supporting LAR,leading to LAR ***3,a stress sensor,interacts with the E3 ligase MDM2 to suppress SLUG degradation in AEC2s by impeding MDM2-catalyzed SLUG *** SLUG degradation by disturbing the TRIB3/MDM2 interaction using a new synthetic staple peptide restores LAR capacity and exhibits potent therapeutic efficacy against experimental *** study reveals a mechanism of the TRIB3—MDM2—SLUG—SLC34A2 axis causing the LAR failure in PF,which confers a potential strategy for treating patients with fibroproliferative lung diseases.

关键词： E3 ligase Lung injury MDM2 Protein—protein interaction Proteolysis Ubiquitination UPS