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Effect of cerium on microstructure,texture and properties of ultrahigh-purity copper

Journal of Rare Earths 2024年第1期42卷 220-227,I0008页

作者： yunxiao hua Haitao Liu Kexing Song Jiangwei Wang Yin'gang Guo Jing Tian Huiwen Guo Provincial and Ministerial Co-construction of Collaborative Innovation Center for Non-ferrous Metal New Materials and Advanced Processing Technology School of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang471023China Henan Academy of Sciences Zhengzhou450000China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China Henan Zhongyuan Gold Smelter Co. Ltd.Sanmenxia472100China Chinalco Luoyang Copper Processing Co. Ltd.Luoyang471039China

The effects of Ce addition(310 ppm and 1500 ppm)on the microstructure,texture and properties of ultrahigh-purity copper(99.99999%)were systematically studied using scanning electron microscopy(SEM),transmission electron microscopy(TEM)and electron backscattered diffraction(EBSD)analyses,combined with the microhardness and conductivity *** the microstructure of the as-cast and as-extruded samples,the addition of Ce refines the grain size of the ultrahigh-purity copper and the refinement effect of 310Ce alloy is greater than that of 1500Ce *** is due to the stronger compone nt supercooling and the accele rated recrystallization caused by lower Ce co *** addition,Ce can react with Cu to form the Cu-Ce eutectic phases,which are deformable during the hot ***,the added Ce can weaken the texture,showing a variation of brass recrystallization(BR),rotated cube,copper and S texture components,which depends on the recrystallization,the particle stimulated nucleation(PSN)as well as the stacking fault energy(SFE).Most remarkably,the introduction of Ce enhances the hardness of the ultrahigh-purity copper without obviously reducing its *** major{111}orientations and the stress distributions are responsible for such a superior conductivity of the Ce-containing alloys.

关键词： Ce addition Grain refinement Texture Conductivity Ultrahigh-purity copper Rare earths

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Identification of novel genes associated with atherosclerosis in Bama miniature pig

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Animal Models and Experimental Medicine 2024年第3期7卷 377-387页

作者： Dengfeng Ding Yuqiong Zhao yunxiao Jia Miaomiao Niu Xuezhuang Li Xinou Zheng hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingChina

Background:Atherosclerosis is a chronic cardiovascular disease of great ***,it is difficult to establish a direct connection between conventional small animal models and clinical *** pig's genome,physiology,and anatomy reflect human biology better than other laboratory animals,which is crucial for studying the pathogenesis of ***:We used whole-genome sequencing data from nine Bama minipigs to perform a genome-wide linkage analysis,and further used bioinformatic tools to filter and identify underlying candidate *** gene function prediction was performed using the online prediction tool STRING *** and immunofluorescence were used to detect the expression of proteins encoded by candidate ***:We mapped differential single nucleotide polymorphisms(SNPs)to genes and obtained a total of 102 differential genes,then we used GO and KEGG pathway enrichment analysis to identify four candidate genes,including SLA-1,SLA-2,SLA-3,and *** cause changes in the primary and tertiary structures of SLA-I and TAP2 proteins,the primary structures of these two proteins have undergone amino acid changes,and the tertiary structures also show slight *** addition,immunohistochemistry and immunofluorescence results showed that the expression changes of TAP2 protein in coronary arteries showed a trend of increasing from the middle layer to the inner ***:We have identified SLA-I and TAP2 as potential susceptibility genes of atherosclerosis,highlighting the importance of antigen processing and immune response in atherogenesis.

关键词： atherosclerosis candidate genes genome-wide linkage analysis major histocompatibility complex whole genome sequencing

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河北省泥河湾盆地石沟遗址C区发掘简报

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人类学学报 2024年第1期43卷 122-131页

作者：赵云啸仝广涂华赵海龙山西大学考古文博学院太原030006 河北省文物考古研究院石家庄050031 汕头大学海洋科学研究院汕头515063 辽宁大学考古文博学院沈阳110136

石沟遗址是位于泥河湾盆地东端大田洼台地北缘的一处旧石器时代早期遗址,发现于1996年。2013年,河北省文物考古研究院与河北师范大学泥河湾考古研究院在遗址C区进行发掘,出土51件砾石、249件石制品和少量动物化石碎屑。石制品的大小、... 详细信息

石沟遗址是位于泥河湾盆地东端大田洼台地北缘的一处旧石器时代早期遗址,发现于1996年。2013年,河北省文物考古研究院与河北师范大学泥河湾考古研究院在遗址C区进行发掘,出土51件砾石、249件石制品和少量动物化石碎屑。石制品的大小、风化和磨蚀程度表明,遗址曾受到较弱水流的干扰后被迅速埋藏。石制品原料以白云岩、燧石和安山玢岩为主,类型有石核、石片类(完整和不完整石片)、断块、碎屑和石器类(包括刮削器、砍砸器和使用石片)。剥片和修理技术均以锤击法为主;仅发现的1件砸击石片表明可能也存在砸击技术;石器加工较为简单,显示出中国北方石片石器的技术特征。石沟遗址C区的发掘对研究泥河湾盆地早更新世遗址的石器工业,探索旧石器时代早期古人类生存策略等方面具有重要意义。

关键词：泥河湾盆地早更新世旧石器时代早期石沟遗址

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Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs

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动物模型与实验医学(英文) 2023年第4期6卷 283-293页

作者： Miaomiao Niu Yuqiong Zhao yunxiao Jia Lei Xiang Xin Dai hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingPR China Beijing Institute of Orthopaedic Trauma Beijing Jishuitan HospitalBeijingPR China

Background:Hundreds of single-nucleotide polymorphism(SNP)sites have been found to be potential genetic markers of type 2 diabetes mellitus(T2DM).However,SNPs related to T2DM in minipigs have been less *** study aimed to screen the T2DM-susceptible candidate SNP loci in Bama minipigs so as to improve the success rate of the minipig T2DM ***:The genomic DNAs of three Bama minipigs with T2DM,six sibling lowsusceptibility minipigs with T2DM,and three normal control minipigs were compared by whole-genome *** T2DM Bama minipig-specific loci were obtained,and their functions were ***,the Biomart software was used to perform homology alignment with T2DM-related loci obtained from the human genome-wide association study to screen candidate SNP markers for T2DM in Bama miniature ***:Whole-genome resequencing detected 6960 specific loci in the minipigs with T2DM,and 13 loci corresponding to 9 diabetes-related genes were ***,a set of 122 specific loci in 69 orthologous genes of human T2DM candidate genes were obtained in the ***,a batch of T2DM-susceptible candidate SNP markers in Bama minipigs,covering 16 genes and 135 loci,was ***:Whole-genome sequencing and comparative genomics analysis of the orthologous genes in pigs that corresponded to the human T2DM-related variant loci successfully screened out T2DM-susceptible candidate markers in Bama miniature *** these loci to predict the susceptibility of the pigs before constructing an animal model of T2DM may help to establish an ideal animal model.

关键词： Bama miniature pig candidate marker SNP type 2 diabetes whole-genome resequencing

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XIAP、Smac表达与乳腺癌新辅助化疗后腋窝阳性淋巴结病理完全缓解及预后的相关性

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中国实验诊断学 2024年第1期28卷 17-22页

作者：张云霄刘志英冬国友王晓烨程华唐山市妇幼保健院病理科河北唐山063003 唐山市妇幼保健院普通外科河北唐山063003

目的探究抑制X染色体连锁的凋亡抑制蛋白(XIAP)、第二个线粒体衍生的半胱氨酸蛋白酶激活剂(Smac)表达与乳腺癌新辅助化疗(NACT)后腋窝淋巴结(ALN)阳性病理完全缓解(pCR)及预后的相关性。方法选取2019年6月至2021年6月期间唐山市妇幼... 详细信息

目的探究抑制X染色体连锁的凋亡抑制蛋白(XIAP)、第二个线粒体衍生的半胱氨酸蛋白酶激活剂(Smac)表达与乳腺癌新辅助化疗(NACT)后腋窝淋巴结(ALN)阳性病理完全缓解(pCR)及预后的相关性。方法选取2019年6月至2021年6月期间唐山市妇幼保健院收治的195例乳腺癌ALN阳性患者纳入乳腺癌组,所有患者均进行NACT,NACT前所有患者均进行活检穿刺取病灶组织。另同期选取195例经进行乳腺活检穿刺,且病理证实为良性乳腺结节的患者,纳入对照组。采用免疫组化法检测患者XIAP、Smac表达水平。根据乳腺癌患者NACT疗效分为pCR组及非pCR组,收集患者临床资料,采用单因素和多因素Logistic回归模型分析NACT后ALN阳性患者非pCR的影响因素,采用Kaplan Meier法分析不同XIAP、Smac表达情况患者的生存预后情况。结果乳腺癌组病灶组织XIAP低表达占比低于对照组,Smac低表达高于对照组(P3.5 cm、ALN数量≥4个、ALN pN1~pN2期、XIAP高表达及Smac低表达占比均高于pCR组(P1);乳腺癌患者随访时间12~36个月,中位随访时间26个月,Kaplan Meier生存分析显示,XIAP低表达者3年累积生存率为94.9%,高于XIAP高表达者的90.4%(Log rank χ^(2)=4.931,P=0.026);Smac低表达者3年累积生存率为89.8%,低于Smac高表达的94.0%(Log rank χ^(2)=4.534,P=0.033)。结论乳腺癌ALN阳性患者组织中XIAP异常高表达,Smac异常低表达,XIAP高表达及Smac低表达是乳腺癌患者NACT后ALN阳性非pCR的独立危险因素,XIAP低表达、Smac高表达患者生存率更高,预后更好。

关键词：乳腺癌抑制X染色体连锁的凋亡抑制蛋白第二个线粒体衍生的半胱氨酸蛋白酶激活剂新辅助化疗腋窝淋巴结阳性预后

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Evolution of urban black and odorous water:The characteristics of microbial community and driving-factors

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Journal of Environmental Sciences 2022年第2期34卷 94-105页

作者： Dan Zhang Huilan Yang Shuhuan Lan Chen Wang Xudong Li yunxiao Xing hua Yue Qiulin Li Ling Wang Yifei Xie Key Laboratory of Environmental and Applied Microbiology Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China Environmental Microbiology Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy ofSciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Material Science Sichuan Normal UniversityChengdu 620068China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 620059China Southwest Jiaotong University Faculty of Geosciences and Environmental EngineeringChengdu 610031China

Urban black blooms that are primarily caused by organic carbon are deleterious environmental ***,detailed studies on the microbial characteristics that form urban black blooms are *** this study,we observed the composition,diversity,and function of bacterial community in the overlying water and sediments during the occurrence and remediation of urban black blooms using high-throughput 16S rRNA gene amplicon sequencing ***,we found that pivotal consortia in the overlying water increased significantly during the formation of black blooms,including the genera Acidovorax,Brevundimonas,Pusillimonas,and Burkholderiales involved in the degradation of refractory organics,as well as the genera Desulfovibrio,Dechloromonas,and Rhizobium related to the production of black and odorous *** RDA analysis revealed that chemical oxygen demand,dissolved oxygen,and oxidation reduction potential were related to the changes in microbial community ***,aeration was found to accelerate the removal of ammonia nitrogen and enhance the function of microbial community by stimulating the growth of order Planktomycetes during the remediation of black blooms,but aeration substantially damaged the microbial diversity and ***,the health of the aquatic ecosystem should be comprehensively considered when aeration is applied to restore polluted ***,we observed a large number of pathogenic bacteria in urban black blooms,which emphasizes the importance of treating domestic sewage so that it is ***,these findings provide new insights and a basis to prevent and manage urban black blooms.

关键词： Urban black blooms Occurrence Remediation Microbial characteristics Aeration

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16S rRNA gene sequencing analysis of gut microbiome in a mini-pig diabetes model

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Animal Models and Experimental Medicine 2022年第1期5卷 81-88页

作者： Miaomiao Niu Yuqiong Zhao Lei Xiang yunxiao Jia Jifang Yuan Xin Dai hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingPR China

Background:Currently,increasing attention is being paid to the important role of intestinal microbiome in ***,few studies have evaluated the characteristics of gut microbiome in diabetic miniature pigs,despite it being a good model animal for assessing ***:In this study,a mini-pig diabetes model(DM)was established by 9-month high-fat diet(HFD)combined with lowdose streptozotocin,while the animals fed standard chow diet constituted the control group.16S ribosomal RNA(rRNA)gene sequencing was performed to assess the characteristics of the intestinal microbiome in diabetic ***:The results showed that microbial structure in diabetic mini-pigs was altered,reflected by increases in levels of Coprococcus_3 and Clostridium_sensu_stricto_1,which were positively correlated with diabetes,and decreases in levels of the bac-teria Rikenellaceae,Clostridiales_vadinBB60_group,and Bacteroidales_RF16_group,which were inversely correlated with blood glucose and insulin ***,PICRUSt-predicted pathways related to the glycolysis and Entner-Doudoroff superpathway,enterobactin biosynthesis,and the L-tryptophan biosynthesis were significantly elevated in the DM ***:These results reveal the composition and predictive functions of the intestinal microbiome in the mini-pig diabetes model,further verifying the relationship between HFD,gut microbiome,and diabetes,and providing novel insights into the application of the mini-pig diabetes model in gut microbiome research.

关键词： 16S rRNA diabetes gut microbiome mini-pig

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稀土铈与磷相互作用对纯铜晶粒尺寸和导电性能的影响

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材料导报 2021年第S2期35卷 329-332页

作者：宋金涛刘海涛宋克兴安士忠程楚华云筱周延军张凌亮王国杰田安福杨璐瑶河南科技大学材料科学与工程学院洛阳471023 河南省有色金属材料科学与加工技术重点实验室洛阳471023 有色金属共性技术河南省协同创新中心洛阳471023

在纯铜铸锭中添加不同含量的稀土铈和磷元素,借助电导率测试和微观组织结构分析,研究了稀土铈与磷元素相互作用对纯铜晶粒尺寸和导电性能的影响,阐明了铈、磷元素相互作用影响含磷纯铜晶粒尺寸与导电性能的有关机理。结果表明:纯铜中稀... 详细信息

在纯铜铸锭中添加不同含量的稀土铈和磷元素,借助电导率测试和微观组织结构分析,研究了稀土铈与磷元素相互作用对纯铜晶粒尺寸和导电性能的影响,阐明了铈、磷元素相互作用影响含磷纯铜晶粒尺寸与导电性能的有关机理。结果表明:纯铜中稀土铈与磷元素相互作用可显著细化铸锭晶粒尺寸,并提高其电导率。含0.016%磷纯铜中添加稀土铈后,晶粒尺寸可由963.67μm减小至198.75μm,晶粒形态由柱状晶转变为等轴晶;电导率随稀土铈含量的增加呈先提高后降低的趋势,铈含量增加至0.014%时,电导率可由81.16%IACS提高至96.14%IACS。这主要与稀土铈可以和磷相互作用形成铈磷化合物有关;一方面,铈磷化合物的形成可抑制磷元素凝固偏析而导致的柱状晶长大,并起到钉扎阻碍晶粒长大的作用;另一方面,可降低铜中固溶磷含量而提高导电性能,但铈过量时将会导致晶界和第二相数量过多、铜材纯度降低,进而影响电子散射而降低其导电性能。

关键词：纯铜铈磷化合物细化晶粒电导率

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冷拉拔对单晶Cu晶粒取向及断裂机理的影响

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特种铸造及有色合金 2020年第12期40卷 1436-1440页

作者：华云筱宋克兴何季麟皇涛周延军封存利丁雨田刘海涛胡勇曹军张朝民程楚河南科技大学材料科学与工程学院有色金属新材料与先进加工技术省部共建协同创新中心河南省有色金属材料科学与加工技术重点实验室郑州大学材料科学与工程学院河南森格材料科技有限公司兰州理工大学材料科学与工程学院河南理工大学机械与动力工程学院

采用自制的热型水平连铸设备制备出φ16mm的铸态单晶Cu杆坯,并对其进行单道次冷拉拔加工制备出φ12mm的拉拔态杆坯。借助XRD、SEM等分析手段,结合室温拉伸试验,研究了冷拉拔对单晶Cu晶粒取向及断裂机理的影响。结果表明,拉拔前后单晶Cu... 详细信息

采用自制的热型水平连铸设备制备出φ16mm的铸态单晶Cu杆坯,并对其进行单道次冷拉拔加工制备出φ12mm的拉拔态杆坯。借助XRD、SEM等分析手段,结合室温拉伸试验,研究了冷拉拔对单晶Cu晶粒取向及断裂机理的影响。结果表明,拉拔前后单晶Cu横截面晶粒取向明显改变,织构组分增多,纵截面织构组分不变但体积分数发生变化。冷拉拔对单晶Cu断裂机理影响显著,铸态单晶Cu为微孔-韧窝聚集型断裂,拉拔态Cu试样为微孔长大型断裂。

关键词：冷拉拔热型连铸单晶Cu 晶粒取向断裂机理

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Long-term case study of a Wuzhishan miniature pig with diabetes

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Animal Models and Experimental Medicine 2020年第1期3卷 22-31页

作者： Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan yunxiao Jia Xin Dai hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingPR China State Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijingPR China

Background:Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and ***,little is known about the complications of diabetes in ***:In this study,a 28-month observation of a Wuzhishan miniature pig with streptozotocin(STZ)-induced(120 mg/kg)diabetes was conducted,to investigate diabetes-related complications and the possibility of self-recovery in miniature *** glucose,serum and urinary biochemistry was measured,and histopathologic examinations of eyes,kidney and pancreas were ***:During the observation,diabetic complications of eyes and kidney were *** eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th *** complications included glomerular mesangial expansion,focal segmental glomerular sclerosis,and renal tubular epithelial degeneration,but no proteinuria was *** 28 months after the application of STZ,with no treatment given,blood glucose had recovered and the number of pancreatic islet beta-cells had increased ***:We showed that the STZ-induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes,and that pancreatic islet beta-cell regeneration did occur in an adult miniature pig,providing a new means for exploring diabetic complications and pancreatic islet beta-cell regeneration.

关键词： beta-cell regeneration diabetes-related complications pig

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