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液控式卡瓦互锁装置的研制与应用

石油矿场机械 2020年第1期49卷 78-81页

作者：卢云霄范玉斌中石化胜利石油工程有限公司井下作业公司

为防止承重卡瓦组或防顶卡瓦组同时打开,导致管柱飞出或落井事故,目前国内外普遍采用机械式、电磁阀式等多种卡瓦互锁装置。针对目前机械式卡瓦互锁装置卡顿严重,同时打开卡瓦时需拆卸限位装置引起的操作困难问题,以及电磁式卡瓦互锁装... 详细信息

为防止承重卡瓦组或防顶卡瓦组同时打开,导致管柱飞出或落井事故,目前国内外普遍采用机械式、电磁阀式等多种卡瓦互锁装置。针对目前机械式卡瓦互锁装置卡顿严重,同时打开卡瓦时需拆卸限位装置引起的操作困难问题,以及电磁式卡瓦互锁装置的电磁设备电路复杂、防爆要求高、恶劣环境易损坏引起的短寿命和高成本问题,利用液压先导阀组的逻辑控制功能,并将液路进行集成模块化,研发了一种新型的液控式卡瓦互锁装置,解决了机械式及电磁式卡瓦互锁装置存在的问题。现场应用证实了新型卡瓦互锁装置具有精度高、安装与操作简便、环境适用性好的优点。

关键词：卡瓦组液压系统互锁装置先导阀组

Regulation of flowering time in chrysanthemum by the R2R3 MYB transcription factor CmMYB2 is associated with changes in gibberellin metabolism

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Horticulture Research 2020年第1期7卷 1515-1524页

作者： lu Zhu yunxiao Guan Yanan Liu Zhaohe Zhang Muhammad Abuzar Jaffar Aiping Song Sumei Chen Jiafu Jiang Fadi Chen State Key Laboratory of Crop Genetics and Germplasm Enhancement Key Laboratory of LandscapingMinistry of AgricultureCollege of HorticultureNanjing Agricultural UniversityNanjingChina

The switch from vegetative growth to reproductive growth is a key event in the development of a ***,the product of the chrysanthemum gene CmMYB2,an R2R3 MYB transcription factor that is localized in the nucleus,was shown to be a component of the switching *** engineered to overexpress CmMYB2 flowered earlier than did wild-type plants,while those in which CmMYB2 was suppressed flowered *** both the overexpression and RNAi knockdown plants,a number of genes encoding proteins involved in gibberellin synthesis or signaling,as well as in the response to photoperiod,were transcribed at a level that differed from that in the wild *** yeast two-hybrid and bimolecular fluorescence complementation assays revealed that CmMYB2 interacts with CmBBX24,a zinc-finger transcription factor known to regulate flowering by its influence on gibberellin synthesis.

关键词： mechanism synthesis synthesis

输卵管积水患者介入栓塞术后行体外受精-胚胎移植临床妊娠结局影响因素分析

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中华放射学杂志 2024年第9期58卷 929-934页

作者：张凯程志伟乔洪武职云晓赵鑫管一春陆林刘香婷牛广颖王亚萍郑州大学第三附属医院医学影像科郑州450052 郑州大学第三附属医院病案管理科郑州450052 郑州大学第三附属医院生殖医学科郑州450052 郑州大学第三附属医院产科郑州450052 郑州大学药物研究院郑州450052

目的探讨输卵管积水患者介入栓塞术后行体外受精-胚胎移植(IVF-ET)临床妊娠结局影响因素及残存积水对妊娠结局的影响。方法回顾性收集2021年3月至2022年10月于郑州大学第三附属医院因输卵管积水行介入栓塞术且行IVF-ET的65例患者的临床... 详细信息

目的探讨输卵管积水患者介入栓塞术后行体外受精-胚胎移植(IVF-ET)临床妊娠结局影响因素及残存积水对妊娠结局的影响。方法回顾性收集2021年3月至2022年10月于郑州大学第三附属医院因输卵管积水行介入栓塞术且行IVF-ET的65例患者的临床资料,以术中积水处最宽径与盆腔横径比值量化积水指数,记录患者移植时年龄、体重指数(BMI)、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、抗缪勒管激素(AMH)、移植时子宫内膜厚度、移植胚胎个数、胚胎类型、输卵管积水位置等数据,随访至栓塞术后首次移植临床妊娠结局。采用SPSS 25.0进行数据分析,采用两独立样本t检验、秩和检验和卡方检验分析不同妊娠结局间上述指标的差异。采用受试者操作特征(ROC)曲线和约登指数计算积水指数截断值。结果65例患者中临床妊娠率为63.1%(41/65),其中于栓塞前已行胚胎移植且未成功的45例患者栓塞术后临床妊娠率为62.2%(28/45)。数据分析表明IVF-ET临床妊娠结局与年龄、BMI、FSH、LH、E2、AMH、移植时子宫内膜厚度、移植胚胎个数、胚胎类型以及输卵管积水位置无相关性(P>0.05),与输卵管积水指数存在相关性(P<0.001)。ROC曲线分析表明积水指数可以作为妊娠结局的预测指标,曲线下面积为0.825,约登指数分析结果显示积水指数的最优截断值为12.925%。结论输卵管积水行介入栓塞治疗可提高IVF-ET临床妊娠率,但当患者当积水指数较大时对IVF-ET临床妊娠产生不利影响,在移植之前应对输卵管积水进行进一步抽吸处理。

关键词：妊娠结局输卵管积水介入栓塞影响因素

Lenke5型青少年特发性脊柱侧凸腰椎与骨盆参数的相关性

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中国组织工程研究 2024年第36期28卷 5753-5758页

作者：侯俞彤黄承兰杨云霄李娅郭培武于文强赵宇王赞博曾红马振江鲁德志王金武潍坊医学院康复医学院山东省潍坊市261053 潍坊市人民医院康复科山东省潍坊市261053 浙江大学医学院附属第一医院康复科浙江省杭州市310003 上海交通大学转化医学研究院上海市201100 上海交通大学医学院附属第九人民医院康复科上海市200011 上海交通大学医学院附属第九人民医院骨科上海市200011

背景:目前对于Lenke5型主腰弯脊柱侧凸患者腰椎与骨盆的研究仅局限于冠状面及矢状面,尚未明确侧弯与骨盆间的三维关系。目的:分析Lenke5型主腰弯脊柱侧凸患者腰椎侧弯对骨盆的影响,研究腰椎与骨盆三维空间位置的相关性。方法:回顾性分... 详细信息

背景:目前对于Lenke5型主腰弯脊柱侧凸患者腰椎与骨盆的研究仅局限于冠状面及矢状面,尚未明确侧弯与骨盆间的三维关系。目的:分析Lenke5型主腰弯脊柱侧凸患者腰椎侧弯对骨盆的影响,研究腰椎与骨盆三维空间位置的相关性。方法:回顾性分析上海交通大学医学院附属第九人民医院3D打印接诊中心2019年1月至2023年9月收治的60例Lenke5型主腰弯脊柱侧凸患者的影像学数据,包括Cobb角、冠状骨盆倾斜、腰椎前凸角、左右骨盆髋骨宽度比值、脊柱旋转角度、骨盆倾斜、骶骨斜率、骨盆入射角、冠状畸形角比率、矢状畸形角比率、C7铅垂线与骶骨中垂线的距离、椎体顶点平移、冠状骶骨倾角,将信息汇总为数据库,运用SPSS 22.0软件采用Spearman相关性分析和线性回归分析Lenke5型主腰弯青少年特发性脊柱侧凸患者腰椎与骨盆的相关数据。结果与结论:①Cobb角与冠状畸形角比率、椎体顶点平移距离、脊柱旋转角度呈高度正相关关系(r=0.91,r=0.841,r=0.736);②冠状畸形角比率与椎体顶点平移距离呈高度正相关关系(r=0.737),与C7铅垂线到骶骨中垂线的距离呈中度正相关关系(r=0.514),与矢状畸形角比率呈中度负相关关系(r=-0.595);③腰椎前凸角与矢状畸形角比率呈高度正相关关系(r=0.942),与冠状畸形角比率呈中度负相关关系(r=-0.554);④Cobb角与冠状骨盆倾斜角、冠状骶骨倾角呈中度正相关关系(r=0.522,r=0.534),C7铅垂线到骶骨中垂线的距离与冠状骨盆倾斜角呈中度正相关关系(r=0.507);椎体顶点平移距离与冠状骨盆倾斜角、冠状骶骨倾角呈中度正相关关系(r=0.507,r=0.506),腰椎前凸角与骶骨斜率、骨盆入射角呈中度正相关关系(r=0.512,r=0.538);矢状畸形角比率与骶骨斜率、骨盆入射角呈中度正相关关系(r=0.614,r=0.621);⑤结果发现腰椎与骨盆相对位置在水平面、矢状面、冠状面上息息相关,当腰椎出现侧凸、旋转时,骨盆的相对位置也会变化进行代偿,这表明矫正脊柱侧凸的同时,也不能忽略骨盆的矫正。

关键词：青少年特发性脊柱侧凸 Lenke5型腰椎骨盆三维评估相关性

Region-of-interest micro-focus computed tomography based on an all-optical inverse Compton scattering source

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Matter and Radiation at Extremes 2020年第6期5卷 36-41页

作者： Yue Ma Jianfei Hua Dexiang Liu yunxiao He Tianliang Zhang Jiucheng Chen Fan Yang Xiaonan Ning Zhongshan Yang Jie Zhang Chih-Hao Pai Yuqiu Gu Wei lu Department of Engineering Physics Tsinghua UniversityBeijing 100084China Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyangSichuan 621900China

Micro-focus computed tomography(CT),which allows the hyperfine structure within objects to be reconstructed,is a powerful nondestructive testing tool in many ***,current x-ray sources for micro-focus CT are typically limited by their relatively low photon energy and low *** all-optical inverse Compton scattering source(AOCS)based on laser wakefield acceleration can generate intense quasi-monoenergetic x/gamma-ray pulses in the kilo-to megaelectronvolt range with micrometer-level source size,and its potential application for micro-focus CT has become very attractive in recent years because of the rapid progress made in laser wakefield *** here is a successful experimental demonstration of high-fidelity micro-focus CT using an AOCS(∼70 keV)by imaging and reconstructing a test object with complex inner structures.A region-of-interest CT method is adopted to utilize the relatively small field of view of the AOCS to ensure high spatial *** demonstration of AOCS-based region-of-interest micro-focus CT is a key step toward its application in the field of hyperfine nondestructive testing.

关键词： scattering optical source

Ac Josephson effect in Corbino-geometry Josephson junctions constructed on Bi_(2)Te_(3) surface

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Chinese Physics B 2022年第10期31卷 278-282页

作者： yunxiao Zhang Zhaozheng Lyu Xiang Wang Enna Zhuo Xiaopei Sun Bing Li Jie Shen Guangtong Liu Fanming Qu Li lu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Hefei National Laboratory Hefei 230088China

Recently, a Corbino-geometry type of Josephson junction constructed on the surface of topological insulators has been proposed for hosting and braiding Majorana zero modes. As a first step to test this proposal, we successfully fabricated Corbino-geometry Josephson junctions(JJs) on the surface of Bi_(2)Te_(3) flakes. Ac Josephson effect with fractional Shapiro steps was observed in the Corbino-geometry JJs while the flux in the junction area was quantized. By analyzing the experimental data using the resistively shunted Josephson junction model, we found that the Corbino-geometry JJs exhibit a skewed current-phase relation due to its high transparency. The results suggest that Corbino-geometry JJs constructed on the surface of topological insulators may provide a promising platform for studying Majorana-related physics.

关键词： Corbino-geometry Josephson junction topological insulator ac Josephson effect fractional Shapiro steps

诺如病毒P2结构域的原核表达及其抗血清制备

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中国生物制品学杂志 2024年第8期37卷 957-963,969页

作者：陈健伟李浩明雪薇王斌邓建平陆峙金杜云霄蔡璐唐秋阳李再新张智四川轻化工大学生物工程学院四川宜宾644005 自贡市疾病预防控制中心四川自贡643002

目的应用原核表达系统表达并纯化5种基因型(GⅠ.1、GⅡ.2、GⅡ.3、GⅡ.4、GⅡ.17)诺如病毒(norovirus,NV)的P2结构域,并制备其抗血清。方法利用生物信息学方法分析不同基因型NV P2序列保守性,合成P2 DNA序列,亚克隆至pET24a载体,构建重... 详细信息

目的应用原核表达系统表达并纯化5种基因型(GⅠ.1、GⅡ.2、GⅡ.3、GⅡ.4、GⅡ.17)诺如病毒(norovirus,NV)的P2结构域,并制备其抗血清。方法利用生物信息学方法分析不同基因型NV P2序列保守性,合成P2 DNA序列,亚克隆至pET24a载体,构建重组原核表达质粒,转化大肠埃希菌BL21(DE3)感受态细胞,IPTG诱导表达。表达的重组P2蛋白纯化后免疫30只雌性BALB/c小鼠,制备抗血清。通过ELISA法检测抗血清的滴度和交叉反应,Western blot法检测抗血清的特异性,点杂交法分析抗血清对野生病毒的识别与结合能力。结果表达的重组P2蛋白相对分子质量约15000,纯度均达90%以上,GⅠ.1、GⅡ.2、GⅡ.3、GⅡ.4、GⅡ.17型P2蛋白表达量分别为60、26.4、19.8、16.3和33.3 mg/L。针对5种基因型NV P2抗原的抗血清滴度均达1∶128000以上,均能很好地识别自身相应的P2抗原,但不与不相关P2抗原相互作用,均不与重组人A组轮状病毒VP7抗原和重组幽门螺杆菌尿酶抗原发生交叉反应,且对野生型NV具有较好的识别与结合能力。结论利用原核表达系统成功表达并纯化了我国流行的5种基因型NV P2抗原,制备的抗血清滴度较高,特异性良好,为NV快速、现场诊断技术的建立奠定了基础。

关键词：诺如病毒 P2蛋白原核表达抗血清

Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement

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World Journal of Pediatrics 2020年第3期16卷 223-231页

作者： Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin yunxiao Shang Xiaoxia lu Sainan Shu Yan Bai Jikui Deng Min lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao Global Pediatric Pulmonology Alliance Department of Respiratory Medicine Beijing Children's HospitalCapital Medical UniversityBeijingChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Center of Hematologic Oncology Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatrics Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhanChina Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Medicine Shenzhen Children's HospitalShenzhenChina Hospital Management Institute of Wuhan University Zhongnan Hospital of Wuhan UniversityWuhanChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Department of Respiratory Medicine Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Infectious Disease Shenzhen Children's HospitalShenzhenChina Department of Respiratory Medicine Children's Hospital of ShanghaiShanghaiChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Pediatrics Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyangChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina

Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in *** the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 *** among these cases,a total of 28 children aged from 1 month to 17 years have been reported in *** standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus *** statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus *** present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children.

关键词： prevention diagnosis treatment

Sulfur vs. tellurium: the heteroatom effects on the nonfullerene acceptors

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Science China Chemistry 2019年第7期62卷 897-903页

作者： Lei Yang Linqing Qin yunxiao Xu Huotian Zhang Lei Lv Kepeng Chen Xinyu Sui Yangguang Zhong Yuan Guo Feng Gao Jianzhang Zhao Yuhao Li Xinfeng Liu Yuanping Yi Xinhui lu Aidong Peng Hui Huang College of Materials Science and Optoelectronic Technology Center of Materials Science and Optoelectronics Engineering CAS Center for Excellence in Topological Quantum Computation CAS Key Laboratory of Vacuum Physic University of Chinese Academy of Sciences Beijing 101408 China Department of Chemical Engineering Imperial College London London SW7 24Z United Kingdom Biomolecular and Organic Electronics Department of Physics Chemistry and Biology (IFM) Linkoping University Linkuping SE-58183 Sweden Division of Nanophotonics CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Fine Chemicals School of Chemical Engineering Dalian University of Technology Dalian 116024 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Physics The Chinese University of Hong Kong Shatin NT 999077 Hong Kong China

The effect of chalcogen heteroatom variation on donor materials has been systematically investigated. However, this effect on acceptors has rarely been explored. Herein, nonfullerene acceptors BFPSP and BFPTP were reported by simply changing the chalcogen atoms from S to Te. The differences between BFPSP and BFPTP in light absorption, energy levels, excited-state lifetimes, energy loss, charge mobilities, morphology, and photovoltaic properties were systematically investigated to understand the heteroatom effects. More importantly, the electroluminescence spectra, external quantum efficiency of photovoltaics and TDDFTcalculations revealed that the triplet excited state(T1) in energy of BFPTP equals to the charge transfer(CT) state in PBDBT:BFPTP, which allows T1 excitons, generated by intersystem crossing, to split into free charges to contribute to the *** contribution provides a strategy for tuning the photophysical properties of nonfullerene acceptors and designing high performance triplet materials for OSCs.

关键词： heteroatom effects triplet state tellurophene nonfullerene acceptor organic solar cells