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Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand Hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen yunxiang mu Kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

multifunctional Nacre-Like Nanocomposite Papers for Electromagnetic Interference Shielding via Heterocyclic Aramid/MXene Template-Assisted In-Situ Polypyrrole Assembly

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Xiong, Jinhua Zhao, Xu Liu, Zonglin Chen, He Yan, Qian Lian, Huanxin Chen, yunxiang Peng, Qingyu He, Xiaodong Harbin Inst Technol Ctr Composite Mat & Struct Natl Key Lab Sci & Technol Adv Composites Special Harbin 150080 Peoples R China

The large-scale, high-strength, super-tough, and multifunctional nacre-like heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite papers were fabricated using the in-situ assembly of PPy onto the HA/MXene hydrogel *** "brick-and-mortar" layered structure and abundant hydrogen-bonding interactions among MXene, PPy, and HA respond cooperatively to external stress and effectively increase the mechanical properties of HMP nanocomposite *** templating effect from HA/MXene was utilized to guide the assembly of conducting polymers, leading to high electrical conductivity and outstanding electromagnetic interference shielding performance. Robust, ultra-flexible, and multifunctional MXene-based electromagnetic interference (EMI) shielding nanocomposite films exhibit enormous potential for applications in artificial intelligence, wireless telecommunication, and portable/wearable electronic equipment. In this work, a nacre-inspired multifunctional heterocyclic aramid (HA)/MXene@polypyrrole (PPy) (HMP) nanocomposite paper with large-scale, high strength, super toughness, and excellent tolerance to complex conditions is fabricated through the strategy of HA/MXene hydrogel template-assisted in-situ assembly of PPy. Benefiting from the "brick-and-mortar" layered structure and the strong hydrogen-bonding interactions among MXene, HA, and PPy, the paper exhibits remarkable mechanical performances, including high tensile strength (309.7 MPa), outstanding toughness (57.6 MJ m-3), exceptional foldability, and structural stability against ultrasonication. By using the template effect of HA/MXene to guide the assembly of conductive polymers, the synthesized paper obtains excellent electronic conductivity. More importantly, the highly continuous conductive path enables the nanocomposite paper to achieve a splendid EMI shielding effectiveness (EMI SE) of 54.1 dB at an ultra-thin thickness (25.4 mu m) and a high specific EMI SE of 17,204.7 dB cm2 g-1. In addit

关键词： MXene Remarkable mechanical properties Heterocyclic aramid Electromagnetic interference shielding Polypyrrole multifunctionality

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基于极小极大博弈的水军识别算法研究

成都信息工程大学学报 2023年第3期38卷 306-313页

作者：穆云翔盛志伟卢嘉中成都信息工程大学网络空间安全学院四川成都610225

随着互联网的发展,用户越来越多地在线上完成购物、订餐,并倾向于先参考线上评论。评论对用户决策的重要导向作用催生了网络水军。网络水军会为了自身利益或其他不良动机,发布与实际体验不相符的评价,且会随时调整自己的策略来逃避平台... 详细信息

随着互联网的发展,用户越来越多地在线上完成购物、订餐,并倾向于先参考线上评论。评论对用户决策的重要导向作用催生了网络水军。网络水军会为了自身利益或其他不良动机,发布与实际体验不相符的评价,且会随时调整自己的策略来逃避平台的识别。现提出一个基于行为特征的水军识别算法(FBS),并将FBS加入到极小极大博弈,在这个博弈中,水军与识别器相互竞争,将博弈转换为两个相互依赖的马尔可夫决策过程,不断优化各自的策略,最终得到一个当前场景下最优的识别器。与当前先进的水军识别算法对比,性能有了明显提升,在公开数据集YelpChi上实际效应可以达到3.69。

关键词：网络水军水军识别极小极大博弈马尔可夫决策过程

Genetic Screening of the Lipoprotein Lipase Gene for mutations in Chinese Subjects with or without Hypertriglyceridemia

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Journal of Genetics and Genomics 2007年第5期34卷 381-391页

作者：杨宇虹穆云祥赵郁刘新宇赵莉莉汪军梅解用虹天津医科大学生化教研室天津300070

Objective： To investigate the association between the mutations in lipoprotein lipase gene and hypertriglyceridemia （HTG）. Methods： The lipoprotein lipase （LPL） gene was screened for mutations in 386 Chinese subjects with （108 cases in the HTG group） or without HTG （278 cases in the control group）, by single-strand conformation polymorphism （SSCP） analysis and DNA sequencing. Results： One novel silent mutation L103L, one missense mutation P207L, three splicing mutations Int3/3＇ -ass/C（-6）→T, and the common S447X polymorphism has been identified in the whole coding region and exon-intron junctions of the LPL gene were examined. Heterozygous P207L found in the HTG group was the first case reported in Asia and subsequently another P207L heterozygote was found in the proband＇s family, all of which suggested that P207L was one of the causes of familial combined hyperlipidemia, but was not so prevalent as that in French Canadian. Int3/3＇-ass/C（-6）→T was found in both groups in the present study although it was regarded as a pathogenic variant to HTG earlier on. Moreover about the beneficial polymorphism S447X, there was also some supportive evidence that the levels of triglycerides （TG） in S447X carriers were significantly lower than noncarders in the subjects without HTG. Conclusions： The association between the LPL variants and HTG is quite complicated and versatile, genotyping of LPL in a larger-scale screening should be necessary and justifiable.

关键词： lipoprotein lipase mutations Chinese hypertriglyceridemia

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脂蛋白脂肪酶基因突变的研究

天津医药 2004年第11期32卷 657-660页

作者：赵郁穆云翔杨宇虹刘新宇葛林解用虹天津医科大学生物化学教研室 300070

目的:筛查国人脂蛋白脂肪酶(LPL)基因的突变,并探讨其与高甘油三酯血症的关系。方法:对高甘油三酯血症组(48例)和正常甘油三酯对照组(121例)的各扩增片段进行分析,电泳图谱异常者进行PCR产物测序。对于频率较高的多态性位点,引入限制性... 详细信息

目的:筛查国人脂蛋白脂肪酶(LPL)基因的突变,并探讨其与高甘油三酯血症的关系。方法:对高甘油三酯血症组(48例)和正常甘油三酯对照组(121例)的各扩增片段进行分析,电泳图谱异常者进行PCR产物测序。对于频率较高的多态性位点,引入限制性核酸内切酶位点利用PCR-RFLP进行鉴定。结果:在高甘油三酯血症人群中,检出2例内含子3受位剪接点上游6bp的C→T转换的突变杂合子,1例外显子5Pro207→Leu突变杂合子,在全部样品中检出1例Ser447→stop突变纯合子,50例Ser447→stop杂合子。结论:天津地区人群中存在着LPL基因突变,除Ser447→stop外,内含子3和外显子5的突变多与高甘油三酯血症相关,可能是高甘油三酯血症的遗传易感因子。

关键词：高甘油三酯血症突变杂合子 LPL 检出人群外显子内含子剪接 PCR产物

一种新的脂蛋白脂肪酶基因突变(C^(562)→T)

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天津医药 2006年第7期34卷 433-435页

作者：赵莉莉汪军梅穆云翔杨宇虹赵郁刘新宇解用虹天津医科大学基础医学院生物化学教研室 300070

目的:筛查国人(天津地区)脂蛋白脂肪酶基因突变情况,并探讨其对血脂水平的影响。方法:利用聚合酶链反应-单链构象多态性分析技术,对386例患者(血脂正常组278例,血脂异常组108例)的脂蛋白脂肪酶基因进行突变筛查,对可疑突变的扩增样品进... 详细信息

目的:筛查国人(天津地区)脂蛋白脂肪酶基因突变情况,并探讨其对血脂水平的影响。方法:利用聚合酶链反应-单链构象多态性分析技术,对386例患者(血脂正常组278例,血脂异常组108例)的脂蛋白脂肪酶基因进行突变筛查,对可疑突变的扩增样品进行DNA序列测定。结果:在386例样本中,检出1例外显子3C562→T(Leu103→Leu)同义突变杂合子。结论:新LPL突变(C562→T)的发现,对进一步阐述LPL结构与功能的关系有重要的参考价值。

关键词：脂蛋白脂酶基因突变聚合酶链反应多态现象,单链构象

脂蛋白脂肪酶Pro^(207)→Leu基因突变致高甘油三酯血症

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医学分子生物学杂志 2005年第2期2卷 83-85页

作者：刘新宇穆云翔杨宇虹赵郁解用虹天津医科大学生物化学教研室天津市300070

目的探讨高甘油三酯血症与脂蛋白脂肪酶基因突变之间的内在联系。方法采用PCR-SSCP和DNA测序技术,对1例随访多年的高甘油三酯血症患者LPL基因第1～9个外显子、部分内含子和5′端调节区进行筛查。结果该患者经检测确定为LPL外显子5Pro^(2... 详细信息

目的探讨高甘油三酯血症与脂蛋白脂肪酶基因突变之间的内在联系。方法采用PCR-SSCP和DNA测序技术,对1例随访多年的高甘油三酯血症患者LPL基因第1～9个外显子、部分内含子和5′端调节区进行筛查。结果该患者经检测确定为LPL外显子5Pro^(207)→Leu错义突变。对先证者全家进行家系分析,证实家系中先证者及其父亲均为高甘油三酯血症患者,且均为LPL外显子5Pro^(207)→Leu错义突变。结论推测此突变影响了LPL分子的活性中心的形成,从而降低了催化活性,导致了高甘油三酯血症的发生。

关键词：高甘油三酯血症 LPL 患者错义突变先证者外显子基因突变脂蛋白脂肪酶内含子活性中心

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue mu Ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness