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AN IMPROVED RANDOM WALK SEGMENTATION ON THE LUNG NODULES

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International Journal of Biomathematics 2013年第6期6卷 105-120页

作者： LI GUO yunting zhang ZEWEI zhang DONGYUE Li School of Medical Imaging Tianjin Medical University Tianjin 300203 P. R. China General Hospital Radiology Tianjin Medical University Tianjin 300203 P. R. China

In this paper, we proposed a semi-automatic technique with a marker indicating the target to locate and segment nodules. For the lung nodule detection, we develop a Gabor texture feature by FCM （Fuzzy C Means） segmentation. Given a marker indicating a rough location of the nodules, a decision process is followed by applying an ellipse fitting algorithm. From the ellipse mask, the foreground and background seeds for the random walk segmentation can be automatically obtained. Finally, the edge of the nodules is obtained by the random walk algorithm. The feasibility and effectiveness of the proposed method are evaluated with the various types of the nodules to identify the edges, so that it can be used to locate the nodule edge and its growth rate.

关键词： Lung nodules Gabor FCM ellipse fitting random walk.

Negatively charged insulated boron nitride nanofibers directing subsurface zinc deposition for dendrite-free zinc anodes

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Nano Research 2023年第1期16卷 403-410页

作者： Qianqian Song Jianli Liang Si Liu yunting zhang Jian Zhu Changbao Zhu State Key Laboratory of Optoelectronic Materials and Technologies Department of Materials Science and EngineeringKey Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationGuangzhou Key Laboratory of Flexible Electronic Materials and Wearable DevicesSun Yat-Sen UniversityGuangzhou 510275China Department of Chemistry&Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China

The practical application of aqueous zinc-ion batteries(ZIBs)is limited by the growth of dendrite during *** to rationally design and construct an efficient artificial interface layer by selecting suitable building units to control the dendrite growth is still a ***,a porous boron nitride nanofibers(BNNFs)artificial interface layer was constructed,and its working mechanisms were revealed by both experiments(electrochemical characterization and in-situ optical microscope)and theoretical calculations(density functional theory(DFT)and finite element simulation).The insulated BNNFs layer leads to position-selected electroplating between BNNFs layer and Zn *** unique negatively charged surface and porosity of BNNFs contribute to the self-concentrating and pumping features of Zn ions,thus suppressing the concentration polarization on the Zn ***,densely arranged porous BNNFs have a shunt effect on Zn ions diffusion,resulting in uniform distributions of Zn ions and electric *** introduced BNNFs layer not only makes Zn deposition uniform but also restrains the dendrite growth,therefore the Zn+BNNFs symmetric cells perform ultralong stable cycling for 1,600 h at 1 mA·cm–2 and more than 500 h at 10 mA·cm–***,Zn+BNNFs||CNT/MnO2 battery presents a high initial capacity of 293.6 mAh·g–1 and an excellent retention rate of 97.6%at 1 A·g–1 after 400 cycles,while Zn||CNT/MnO2 battery only maintains 37.1%discharge *** artificial interface layer with negatively charged BNNFs exhibits excellent dendrite-inhibit and may have enormous prospects in other metal batteries.

关键词： boron nitride nanofiber dendrite-free Zn anodes Zn ion battery artificial interface layer negatively charged

Boron nitride nanofibers enhanced composite PEO-based solid-state polymer electrolytes for lithium metal batteries

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Chinese Chemical Letters 2024年第6期35卷 216-221页

作者： Qianqian Song yunting zhang Jianli Liang Si Liu Jian Zhu Xingbin Yan School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China Department of Chemistry&Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology School of Physics and Optoelectronic EngineeringFoshan UniversityFoshan 528225China

Polyethylene oxide(PEO)-based solid-state polymer electrolytes(SPEs)are limited by their poor cyclic stability and inferior ionic conductivity for applicating in high-safety,long-cycling and high-energy-density lithium metal ***,porous boron nitride nanofibers(BNNFs)are filled into PEO-based SPE,which significantly suppresses Li dendrites growth and enhances the electrochemical performance of Li metal *** with high porosity have more active sites to connect with PEO,which can effectively reduce the crystallinity of the PEO matrix and enhance its ionic ***,owing to the hardness and good stability of BNNFs,BNNFs/PEO/Li TFSI electrolyte exhibits a wider electrochemical window,better mechanical property and higher thermal stability compared with PEO/Li TFSI ***,the Li symmetric cell composed of 1%BNNFs/PEO/Li TFSI performs good cyclic stability(>1800 h),and the Li||1%BNNFs/PEO/Li TFSI||LFP full battery shows obviously improved performances in charge-discharge polarization voltage,discharge specific capacity,rate performance and cyclic stability than the Li||PEO/Li TFSI||LFP battery.

关键词： Solid-state polymer electrolyte Boron nitride nanofibers Lithium metal battery Ionic conductivity Li dendrite

Understanding Pseudocapacitance Mechanisms by Synchrotron X-ray Analytical Techniques

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Energy & Environmental Materials 2023年第4期6卷 312-331页

作者： Pei Tang Wuyang Tan Guangyang Deng yunting zhang Shan Xu Qijun Wang Guosheng Li Jian Zhu Qingyun Dou Xingbin Yan Department of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China Center of Industrial Analysis and Testing Guangdong Academy of ScienceGuangzhou 510651China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004China

Pseudocapacitive materials that store charges via reversible surface or near-surface faradaic reactions are capable of overcoming the capacity limitations of electrical double-layer *** the structure–activity relationship between the microstructural features of pseudocapacitive materials and their electrochemical performance on the atomic scale is the key to build high-performance capacitor-type devices containing ideal pseudocapacitance ***,the high brightness(flux),and spectral and coherent nature of synchrotron X-ray analytical techniques make it a powerful tool for probing the structure–property relationship of pseudocapacitive ***,we report a comprehensive and systematic review of four typical characterization techniques(synchrotron X-ray diffraction,pair distribution function[PDF]analysis,soft X-ray absorption spectroscopy,and hard X-ray absorption spectroscopy)for the study of pseudocapacitance *** addition,we offered significant insights for understanding and identifying pseudocapacitance mechanisms(surface redox pseudocapacitance,intercalation pseudocapacitance,and the extrinsic pseudocapacitance phenomenon in battery materials)by combining in situ hard XAS and electrochemical ***,a perspective for further depth of understanding into the pseudocapacitance mechanism using synchrotron X-ray analytical techniques is proposed.

关键词： in situ experiments pseudocapacitive materials structure-property relationship synchrotron X-ray analytical techniques

Foamed microemulsion nanodroplets loaded with chlorin e6 for epidermal-targeted treatment against psoriasis

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Nano Research 2024年第11期17卷 9920-9931页

作者： Xiaolu Ma Qiong Bian Yihua Xu Jingyi Hu Weitong Hu Ruxuan Wang yunting zhang Yuxian Ye Xiaoxia Sheng Tianyuan zhang Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Jiangsu Engineering Research Center for New-type External and Transdermal Preparations Changzhou 213149 China Hangzhou SoliPharma Co. Ltd. Hangzhou 310058 China

Psoriasis is a chronic skin disease characterized by the hyperproliferation of keratinocytes and an overactive autoimmune response. Photodynamic therapy (PDT) has been established as a promising intervention for alleviating psoriasis. However, the current transdermal delivery of photosensitizers is inefficient and imprecise. In this study, we developed a foamed microemulsion nanodroplets system containing chlorin e6 (Ce6 FM), exhibiting precise epidermal targeting and retention, which targeted the aberrantly proliferating epidermal cells at psoriatic skin lesions and avoided the damage to the normal cutaneous cells. Upon application in a psoriatic mouse model, Ce6 FM efficiently induced keratinocyte apoptosis by generating reactive oxygen species under laser. Furthermore, Ce6 FM-based PDT activated the cyclooxygenase-2-induced immunosuppressive pathway in keratinocytes, resulting in the amelioration of the autoimmune microenvironment in psoriatic skin. Additionally, Ce6 FM-based PDT did not induce skin damage or atrophy associated with non-targeted halometasone treatment. Overall, Ce6 FM-based PDT holds promise as an effective, safe and compliant strategy for psoriasis treatment.

关键词： transdermal drug delivery foamed microemulsion nanodroplets psoriasis photodynamic therapy

An antigen self-assembled and dendritic cell-targeted nanovaccine for enhanced immunity against cancer

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3518-3534页

作者： yunting zhang Min Jiangy Guangsheng Du Xiaofang Zhong Chunting He Ming Qin Yingying Hou Rong Liu Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

The rise of nanotechnology has opened new horizons for cancer ***,most nano vaccines fabricated with nanomaterials suffer from carrier-related concerns,including low drug loading capacity,unpredictable metabolism,and potential systemic toxicity,which bring obstacles for their clinical ***,we developed an antigen self-assembled nanovaccine,which was resulted from a simple acryloyl modification of the antigen to induce ***,a dendritic cell targeting head mannose monomer and a mevalonate pathway inhibitor zoledronic acid(Zol)were integrated or absorbed onto the nanoparticles(denoted as MEAO-Z)to intensify the immune *** synthesized nano vaccine with a diameter of around 70 nm showed successful lymph node transportation,high dendritic cell internalization,promoted costimulatory molecule expression,and preferable antigen *** virtue of the above superiorities,MEAO-Z induced remarkably higher titers of serum antibody,stronger cytotoxic T lymphocyte immune responses and IFN-γsecretion than free antigen and *** vivo,MEAO-Z significantly suppressed EG7-OVA tumor groth and prolonged the survival time of tumor-bearing *** results indicated the translation promise of our self-assembled nano vaccine for immune potentiation and cancer immunotherapy.

关键词： Subunit antigen Self-assembled nanovaccine Dendritic cell Mannose receptor Zoledronic acid Antigen cross-presentation Cellular immunity Cancer immunotherapy

A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial

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Virologica Sinica 2020年第6期35卷 725-733页

作者： Ke Hu Mengmei Wang Yang Zhao yunting zhang Tao Wang Zhishui Zheng Xiaochen Li Shaolin Zeng Dong Zhao Honglin Li Ke Xu Ke Lan Department of Respiratory and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Frontier Science Center for Immunology and Metabolism Wuhan UniversityWuhan 430072China

We recently reported that inhibitors against human dihydroorotate dehydrogenase(DHODH)have broad-spectrum antiviral activities including their inhibitory efficacies on SARS-CoV-2 replication in infected ***,there are limited data from clinical studies to prove the application of DHODH inhibitors in Coronavirus disease 2019(COVID-19)*** the present study,we evaluated Leflunomide,an approved DHODH inhibitor widely used as a modest immune regulator to treat autoimmune diseases,in treating COVID-19 disease with a small-scale of *** of 10 laboratory-confirmed COVID-19 patients of moderate type with obvious opacity in the lung were *** of the patients were treated with Leflunomide,and another five were treated as blank controls without a *** the patients accepted standard supportive treatment for *** patients given Leflunomide had a shorter viral shedding time(median of5 days)than the controls(median of 11 days,P=0.046).The patients given Leflunomide also showed a significant reduction in C-reactive protein levels,indicating that immunopathological inflammation was well *** obvious adverse effects were observed in Leflunomide-treated patients,and they all discharged from the hospital faster than *** preliminary study on a small-scale compassionate use of Leflunomide provides clues for further understanding of Leflunomide as a potential antiviral drug against COVID-19.

关键词： DHODH inhibitors Leflunomide Coronavirus disease 2019(COVID-19) Viral shedding time Inflammation

Experimental study on angiogenesis in rabbit VX_2 brain tumor using perfusion CT

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The Chinese-German Journal of Clinical Oncology 2006年第6期5卷 431-435页

作者： Liqing Kang yunting zhang Shimei Sun Department of Radiology Cangzhou Central Hospital Cangzhou 061001 China Department of Radiology General Hospital of Tianjin Medical University Tianjin 300052 China Department of Oncology Cangzhou Central Hospital Cangzhou 061001 China

Objective： To study the perfusion CT features of rabbit VX2 brain tumor with correlation to MVD and VEGF, and to validate perfusion CT for reflection of tumor angiogenesis. Methods： Rabbit VX2 brain tumor model was established by injection of 100 μL viable tumor cells （10qmL） through a 2 mm-hole 5 mm to the right of the sagittal suture and 5 mm posterior to the coronal suture bored by dental drill. MRI was performed every 2 days after seven days of implantation to evaluate the growth of the tumor. Twenty New Zealand White rabbits with tumor size over 3 mm in diameter were randomly divided into 2 groups according to the tumor growth time with those less than 3 weeks as group 1 and those more than 3 weeks as group 2, and perfusion CT were performed accordingly. CT measurements of BV, BF and PS from tumor, peritumor and contralateral normal tissue regions were obtained. After that the animals were sacrificed and 2% Evans blue （2 mL/kg） was given intravenously in 16 of these animals 1 h prior to sacrifice to detect breakdown of the blood brain barrier. VEGF and MVD were evaluated in immunohistochemical examination of the specimens. Results： Tumor had significantly higher BV, BF and PS （P=0.000） than peritumor and normal tissue region. Tumor BV, BF and MVD in group 2 were significantly higher than that in group 1 （P〈0.01）. Significant linear correlation was found between MVD and BV （t=-0.915, P=-0.000）, MVD and BF （t=0.901, P=-0.000）, and MVD and PS （t=-0.459, P=0.042）. We also found a rank correlation between PS and blue stain of tumor （rs=0.861, P=0.000）. Conclusion： Perfusion CT can distinguish tumor from peritumor and normal tissue clearly, reflect tumor angiogenesis accurately, and provide useful information for the evaluation of brain tumor.

关键词： brain neoplasms angiogenesis factor perfusion tomography, X-ray computed

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中国融资投资者是否更为过度交易

系统工程理论与实践 2018年第4期38卷 836-847页

作者：廖理张云亭张伟强清华大学五道口金融学院

融资交易既是一种买空机制,也暗含了杠杆效应.自从引入"两融"交易制度以来,融资交易给我国股票市场带来的不仅仅是多了一种交易手段,买空机制和杠杆效应对个人投资者的心理和行为也产生了深刻影响,并进而影响到整个股票市场.此前的研究... 详细信息

融资交易既是一种买空机制,也暗含了杠杆效应.自从引入"两融"交易制度以来,融资交易给我国股票市场带来的不仅仅是多了一种交易手段,买空机制和杠杆效应对个人投资者的心理和行为也产生了深刻影响,并进而影响到整个股票市场.此前的研究表明,我国股票市场个人投资者存在明显的过度交易;我们所关注的问题则是,融资投资者与普通投资者在过度交易行为上是否存在显著差异.本文使用国内某大型证券公司个人投资者的订单数据,对融资投资者的过度交易行为进行了实证研究.结果表明:1)与普通投资者相比,融资投资者的交易更为频繁,过度交易程度更为突出;2)与普通投资者相比,融资投资者的投资绩效受过度交易的损害程度更大.

关键词：行为金融学投资者行为过度交易融资融券