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Establishment of a chronic biliary disease mouse model with cholecystoduodenal anastomosis for intestinal microbiome preservation

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World Journal of Gastroenterology 2024年第46期30卷 4937-4946页

作者： yunseon jang Jung Yeon Kim Song Yeon Han Arum Park So Jeong Baek Gyurim Lee Jihee Kang Hyewon Ryu Seok-Hwan Kim Translational Immunology Institute Chungnam National University School of MedicineDaejeon 35015South Korea Department of Medical Science Chungnam National University School of MedicineDaejeon 35015South Korea AtoGen Co. Ltd.Techno 1-roDaejeon 35015South Korea Department of Internal Medicine Chungnam National University HospitalDaejeon 35015South Korea Department of Surgery Chungnam National University HospitalDaejeon 35015South Korea Research Institute for Medical Science Chungnam National University School of MedicineDaejeon 35015South Korea

BACKGROUND Chronic biliary disease,including cholangitis and cholecystitis,is attributed to ascending infection by intestinal *** of a mouse model for bile duct inflammation is imperative for the advancement of novel therapeutic *** models fail to replicate the harmful bacterial influx to the biliary tract observed in humans and spread of inflammation to the ***,we aimed to establish an animal model of biliary disease that faithfully replicates the mechanisms of human *** To establish a cholecystoduodenal anastomosis model capable of mimicking the mechanisms of ascending infection and inflammation observed in human biliary *** We established a mouse biliary disease model by directly connecting the gallbladder and duodenum,enabling ascending infection into the biliary tract without traversing the sphincter of *** In the cholecystoduodenal anastomosis mouse model,we observed impaired epithelial structure,wall thickening,and macrophage recruitment in the *** the absence of postoperative antibiotics,we detected no changes in serum proinflammatory cytokine levels,indicating no systemic ***,patency between the gallbladder and duodenum was confirmed via common bile duct *** of patient-derived pathogenic bacteria into bile duct-ligated mice led to ascending infection,which significantly increased proinflammatory cytokine mRNA expression in the liver,duodenum,and *** results indicate that our mouse model exhibited a direct connection between the gallbladder and duodenum,leading to ascending infection and closely mimicking the clinical features of biliary diseases observed in *** The cholecystoduodenal anastomosis mouse model is an effective chronic biliary disease model with significant relevance in the development of microbiome-based therapies for the prevention and treatment of biliary disease.

关键词： Experimental animal model Cholecystoduodenal fistula Anastomosis Biliary Disease Microbiome

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