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具有防撞安全约束的无人机集群智能协同控制

航空学报 2024年第5期45卷 398-408页

作者：蔡云鹏周大鹏丁江川航空工业沈阳飞机设计研究所沈阳110035

针对无人机(UAV)集群协同控制问题,本文提出了一种结合深度强化学习(DRL)与防撞策略的无人机集群智能协同控制方法。首先,对研究的无人机集群控制问题进行了整体描述并建立了无人机的运动模型。其次,在深度强化学习架构下建立了无人机... 详细信息

针对无人机(UAV)集群协同控制问题,本文提出了一种结合深度强化学习(DRL)与防撞策略的无人机集群智能协同控制方法。首先,对研究的无人机集群控制问题进行了整体描述并建立了无人机的运动模型。其次,在深度强化学习架构下建立了无人机集群控制策略的训练机制,通过分析无人机的观测空间与动作空间,设计了无人机集群控制策略的网络结构,并且以无人机集群的安全性与紧密一致性为主要目标设计了奖励函数。为了解决深度强化学习方法缺乏安全保障的问题,同时设计了无人机集群的防撞策略,可根据无人机之间以及无人机与威胁区之间的相对运动状态计算防撞指令,避免无人机发生碰撞。仿真结果表明,提出的结合防撞策略的无人机集群协同控制方法可有效避免无人机之间发生碰撞的风险,保障无人机集群的安全性,并且可使得无人机集群更加紧密。

关键词：无人机集群协同控制深度强化学习防撞策略安全约束

Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang Jia Rongkun Xu Dingren Cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang Fu Weiwei Li Lei Cheng Qiang Yang Shiqing Feng Lianlei Wang yunpeng Zhao Xinyu Liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel

Cardiovascular disease burden in patients with urological cancers:The new discipline of uro-cardio-oncology

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Cancer Innovation 2024年第2期3卷 28-44页

作者： Yi Zheng Ying Liu Ziliang Chen yunpeng Zhang Zuo Qi Ning Wu Zhiqiang Zhao Gary Tse Yong Wang Hailong Hu Yuanjie Niu Tong Liu Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of CardiologySecond Hospital of Tianjin Medical UniversityTianjinChina School of Nursing and Health Studies Hong Kong Metropolitan UniversityHong KongChina

Cancer remains a major cause of mortality worldwide,and urological cancers are the most common cancers among *** therapeutic agents have been used to treat urological cancer,leading to improved survival for ***,this has been accompanied by an increase in the frequency of survivors with cardiovascular complications caused by anticancer medica***,we propose the novel discipline of uro-cardio-oncology,an evolving subspecialty focused on the complex interactions between cardiovascular disease and urological *** this comprehensive review,we discuss the various cardiovascular toxicities induced by different classes of antineoplastic agents used to treat urological cancers,including androgen deprivation therapy,vascular endothelial growth factor receptor tyrosine kinase inhibitors,immune checkpoint inhibitors,and *** addition,we discuss possible mechanisms underlying the cardiovascular toxicity associated with anticancer therapy and outline strategies for the surveillance,diagnosis,and effective management of cardiovascular compli***,we provide an analysis of future perspectives in this emerging specialty,identifying areas in need of further research.

关键词： anticancer therapy cardiovascular toxicity mechanism multidisciplinary management urological cancer

Micro/nano flow chemistry by Beyond Limits Manufacturing

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Chinese Chemical Letters 2024年第5期35卷 3-12页

作者： Peiwen Liu Fang Zhao Jing Zhang yunpeng Bai Jinxing Ye Bo Bao Xinggui Zhou Li Zhang Changlu Zhou Xinhai Yu Peng Zuo Jianye Xia Lian Cen Yangyang Yang Guoyue Shi Lin Xu Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for BiomanufacturingEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of ChemistrySchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200241China

In September 2018,we proposed the cutting-edge concept of“Beyond Limits Manufacturing”(BLM).BLM technology is based on the three-dimensional inner engraving or precise outer engraving of ultra-fast laser,to invent micro/nano scale flow chips or devices,which makes it possible for the microform,integration,economy,safety,high efficiency,green and intelligence of research,development and manufacturing process,so as to realize transformational manufacturing in the era of Industry *** this paper,we reviewed the representative results we made in the field of micro/nano flow chemistry during the implementation of the BLM major project(December 2019 to August 2023.,and discussed its application prospects in micro/nano flow chemistry.

关键词： Beyond Limits Manufacturing Flow chemistry Pharmaceutical manufacturing Microreactor

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再热除湿单元式空调机的设计改进及实验研究

制冷学报 2024年第3期45卷 112-119页

作者：解云鹏时竞竞特灵空调系统(中国)有限公司上海200051 苏州大学电子信息学院苏州215031 上海理工大学能源与动力工程学院上海200093

为了满足在不同空调负荷下能够除湿的同时输送舒适的空气温度和相对湿度,设计并搭建了一种新型的可调节再热除湿系统,优化制冷模式和除湿再热两种模式的制冷剂管理以及改进再热运行开度区间,并对比分析了不同再热盘管方案。实验结果表明... 详细信息

为了满足在不同空调负荷下能够除湿的同时输送舒适的空气温度和相对湿度,设计并搭建了一种新型的可调节再热除湿系统,优化制冷模式和除湿再热两种模式的制冷剂管理以及改进再热运行开度区间,并对比分析了不同再热盘管方案。实验结果表明:新式微通道再热盘管应用于风冷单元式空调机组能够更好地平衡制冷与除湿再热模式对充注量的需求;在除湿再热模式额定工况下的能效EER提高了17%;除湿能力增加了6%;制冷剂通过三通阀流向再热盘管的可调节开度范围从20%~70%提升至15%~85%,增大了空气侧再热温升的调节范围,额定除湿再热工况再热温升从8.3.14.4℃的调节区间增至6.1~19.4℃。既能提升再热可调节运行范围,增大除湿能力又更加节能。

关键词：再热除湿制冷剂管理单元式空调机可调节再热微通道再热盘管

Nanomaterials for refining tumor microenvironment and enhancing therapy in head and neck squamous cell carcinoma: a review

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Oncology and Translational Medicine 2024年第4期10卷 151-161页

作者： Kaifeng Zheng Ruibiao Song Ruifeng Li Mengli Liu yunpeng Ba Wei Jiang Kelong Fan Department of Rhinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Application Center for Precision Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules(CAS)CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Zhongyuan Nanozyme Laboratory ZhengzhouHenanChina

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.

关键词： Nanomaterials Tumor microenvironment Antitumor therapy Tumor diagnosis Head and neck squamous cell carcinoma

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共同富裕:新质生产力的时代召唤和价值旨归

毛泽东研究 2024年第3期 32-40页

作者：王赟鹏北京科技大学马克思主义学院

发展新质生产力是新时代生产力发展的必然趋势,旨在实现社会主义生产目的、贯彻共享发展理念、解决新时代面临的社会主要矛盾,是实现共同富裕目标的时代召唤。发展新质生产力是中国式现代化建设的必然要求,而共同富裕作为中国式现代化... 详细信息

发展新质生产力是新时代生产力发展的必然趋势,旨在实现社会主义生产目的、贯彻共享发展理念、解决新时代面临的社会主要矛盾,是实现共同富裕目标的时代召唤。发展新质生产力是中国式现代化建设的必然要求,而共同富裕作为中国式现代化的重要特征和中国特色社会主义的本质要求,可以为生产要素创新性配置、科技创新和创新人才培养等提供重要支撑。发展新质生产力对于提高人民生活水平、形成新型生产关系、有效处理人与自然关系具有重要意义,内含着深厚的价值意蕴。

关键词：共同富裕新质生产力社会主义生产关系

Chemical constituents and pharmacological effects of Croton crassifolius

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Asian Journal of Traditional Medicines 2024年第2期19卷 99-114页

作者： Luyan Yang Yibo Wang Xinyao Wang Xiaoxia Xu yunpeng Yang Meng Zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Business Liaoning UniversityShenyang 110136China

Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the *** had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s *** study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

关键词： Croton crassifolius chemical compositions pharmacological activities

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基于耐高温环境转速传感器的设计

传感器与微系统 2024年第10期43卷 71-74页

作者：井云鹏吴云鹏夏云阳中国电子科技集团公司第四十九研究所黑龙江哈尔滨150028 东北农业大学黑龙江哈尔滨150030

随着工业的发展,转速传感器已经成为了现代工业自动化发展的重要支撑。它在汽车、机械制造和航空航天中发挥着很大的作用。高温转速传感器通常应用于高温环境下旋转机械运动状态的监测和测量,通过传感器为采集系统提供实时数据,帮助监... 详细信息

随着工业的发展,转速传感器已经成为了现代工业自动化发展的重要支撑。它在汽车、机械制造和航空航天中发挥着很大的作用。高温转速传感器通常应用于高温环境下旋转机械运动状态的监测和测量,通过传感器为采集系统提供实时数据,帮助监测和预防设备故障,延长设备寿命,确保设备安全性能。本文介绍了高温磁电式转速传感器的基本原理、结构设计、材料选择,给出了测试数据,并对测试结果进行了分析,结果表明:能够实现在3.0℃环境下转速测量。

关键词：高温机械运动转速传感器