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Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at%Rare Earth alloys(Zn-RE:Sc,Y,La-Nd,Sm-Lu)

Bioactive Materials 2023年第6期24卷 507-523页

作者： Shaokang Du yunong shen Yufeng Zheng Yan Cheng Xiaoxue Xu Dafu Chen Dandan Xia Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China School of Materials Science and Engineering Peking UniversityBeijing100871China School of Biomedical Engineering Faculty of Engineering and Information TechnologyUniversity of Technology SydneyNSW2007Australia Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalBeijing100035China Department of Dental Materials Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical Devices&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijing 100081China

Biomedical implants and devices for tissue engineering in clinics,mainly made of polymers and stiff metallic materials,require possibly secondary surgery or life-long medicine.Biodegradable metals for biomedical implants and devices exhibit huge potential to improve the prognosis of patients.In this work,we developed a new type of biodegradable binary zinc(Zn)alloys with 16 rare earth elements(REEs)including Sc,Y,La to Nd,and Sm to Lu,respectively.The effects of REEs on the alloy microstructure,mechanical properties,corrosion behavior and in vitro and in vivo biocompatibility of Zn were systematically investigated using pure Zn as control.All Zn-RE alloys generally exhibited improved mechanical properties,and biocompatibilities compared to pure Zn,especially the tensile strength and ductility of Zn-RE alloys were dramatically enhanced.Among the Zn-RE alloys,different REEs presented enhancement effects at varied extent.Y,Ho and Lu were the three elements displaying greatest improvements in majority of alloys properties,while Eu,Gd and Dy exhibited least improvement.Furthermore,the Zn-RE alloys were comparable with other Zn alloys and also exhibited superior properties to Mg-RE alloys.The in vivo experiment using Zn-La,Zn-Ce,and Zn-Nd alloys as tibia bone implants in rabbit demonstrated the excellent tissue biocompatibility and much more obvious osseointegration than the pure Zn control group.This work presented the significant potential of the developed Zn-RE binary alloys as novel degradable metal for biomedical implants and devices.

关键词： Biodegradable metals Zn-Rare Earth alloys Mechanical property Biodegradation behavior Biocompatibility

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In vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing

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Nano Materials Science 2020年第1期2卷 96-108页

作者： Wenting Li yunong shen Jie shen Danni shen Xiao Liu Yufeng Zheng Kelvin W.K.Yeung Shaokang Guan Olga B.Kulyasova R.Z.Valiev Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China College of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Department of Orthopaedics and Traumatology The University of Hong KongPokfulamHong KongChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Ufa State Aviation Technical University 12 Karl Marx StreetUfa450008Russia

In the present work,the biomedical as-cast pure Mg,Mg–1 Ca and Mg–2 Sr alloys were processed with equal channel angular pressing(ECAP)technique to develop ultrafine microstructure within the materials,and their microstructures,mechanical properties,degradation behavior,cytocompatibility in vitro and biocompatibility in vivo were studied comprehensively.Finer-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast counterparts.Moreover,after ECAP the degradation rate of pure Mg was increased while that of Mg–1 Ca or Mg–2 Sr alloys decreased compared to the ascast counterparts.Additionally,good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3 T3-E1 and human mesenchymal stem cells(h MSC)and in vivo animal tests at the lateral epicondyle of SD-rats’femur.This study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals.It might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.

关键词： Magnesium alloys Equal channel angular pressing Mechanical property Degradation behavior Biocompatibility

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Tislelizumab in previously treated, locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-276页

作者： Jian Li Ye Xu Aimin Zang yunong Gao Quanli Gao Yanqiao Zhang Dong Wang Jianming Xu Ying Yuan Haiping Jiang Jieer Ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi Huang Xiaoping Qian Yueyin Pan Ying Cheng sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin shen Department of Medical Oncology the First Affiliated Hospital Zhejiang University School of Medicine Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences Department of Medical Oncology Fujian Medical University Union Hospital Department of Oncology the Sixth Affiliated Hospital Sun Yat-sen University Department of Medical Oncology Hunan Cancer Hospital Department of Medical Oncology Zhongshan HospitalFudan University Department of Immunotherapy Hubei Cancer Hospital Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical School Department of Medical Oncology Anhui Provincial Hospital Department of Medical Oncology Jilin Cancer Hospital State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational Research Department of Gastrointestinal Oncology Peking University Cancer Hospital&Institute Department of Medical Oncology Hubei Cancer Hospital Clinical Development BeiGene(Shanghai)Co. Ltd. Biostatistics BeiGene(Beijing)Co. Ltd. Department of Oncology Fudan University Shanghai Cancer Center Department of Medical Oncology Affiliated Hospital of Hebei University Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gynecology Peking University Cancer Hospital&Institute Department of Immunotherapy Henan Cancer Hospital Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical University Department of Gastrointestinal Oncology Chongqing University Cancer Hospital Department of Gastrointestinal Oncology the Fifth Medical Center Chinese PLA General Hospital Department of Medical Oncology the Second Affiliated Hospital Zhejiang University School of Medicine

Objective: The open-label, phase Ⅱ RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody) as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR) tumors.Methods: Adults with previously treated, locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were enrolled. Patients received tislelizumab 200 mg intravenously every 3 weeks. Objective response rate(ORR; primary endpoint), duration of response(DoR), and progression-free survival(PFS) were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results: Eighty patients were enrolled and treated; 75(93.8%) patients had measurable disease at baseline. Most had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79; 98.8%). At primary analysis(data cutoff July 8, 2021; median follow-up 15.2 months), overall ORR [46.7%; 95% confidence interval(95% CI), 35.1-58.6; one-sided P<0.0001] and ORR across tumor-specific subgroups [colorectal(n=46):39.1%(95% CI, 25.1–54.6); gastric/gastroesophageal junction(n=9): 55.6%(95% CI, 21.2-86.3); others(n=20):60.0%(95% CI, 36.1-80.9)] were significantly greater with tislelizumab vs. a prespecified historical control ORR of 10%; five(6.7%) patients had complete responses. Median DoR, PFS, and overall survival were not reached with long-term follow-up(data cutoff December 5, 2022; median follow-up 28.9 months). Tislelizumab was well tolerated with no unexpected safety signals. Treatment-related adverse events(TRAEs) of grade ≥3 occurred in 53.8% of patients; 7.5% of patients discontinued treatment due to TRAEs.Conclusions: Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor

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Collaborative force and shape control for large composite fuselage panels assembly

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Chinese Journal of Aeronautics 2023年第7期36卷 213-225页

作者： Zhanghao WANG Dongsheng LI Liheng shen Yi SUI yunong ZHAI School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Ningbo Institute of Technology Beihang UniversityNingbo 315832China COMAC Shanghai Aircraft Manufacturing Co. LtdShanghai 201324China

This study proposed a force and shape collaborative control method that combined method of influence coefficients(MIC)and the elitist nondominated sorting genetic algorithm(NSGA-II)to reduce the shape deviation caused by manufacturing errors,gravity deformation,and fixturing errors and improve the shape accuracy of the assembled large composite fuselage panel.This study used a multi-point flexible assembly system driven by hexapod parallel robots.The proposed method simultaneously considers the shape deviation and assembly load of the panel.First,a multi-point flexible assembly system driven by hexapod parallel robots was introduced,with the relevant variables defined in the control process.In addition,the corresponding mathematical model was constructed.Subsequently,MIC was used to establish the prediction models between the displacements of actuators and displacements of panel shape control points,deformation loads applied by the actuators.Following the modeling,the shape deviation of the panel and the assembly load were used as the optimization objectives,and the displacements of actuators were optimized using NSGA-II.Finally,a typical composite fuselage panel case study was considered to demonstrate the effectiveness of the proposed method.

关键词： Assembly Collaborative force and shape control Composite panel Hexapod parallel robots Method of influence coefficients

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增材制造可降解金属医用植入物

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金属学报 2021年第11期57卷 1499-1520页

作者：郑玉峰夏丹丹谌雨农刘云松徐钰倩温鹏田耘赖毓霄北京大学材料科学与工程学院北京100871 北京大学口腔医(学)院修复科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室口腔材料国家药监局重点实验室卫生部口腔医学计算机应用工程技术研究中心北京100081 清华大学机械工程系摩擦学国家重点实验室北京100084 北京大学第三医院骨科北京100191 中国科学院深圳先进技术研究院生物医学与健康工程研究所深圳518055

增材制造技术由于其高精度、高自由度等特点,可赋予医用金属植入物定制化的宏观与微观结构,使植入物与患者待修复缺损部位实现更好的生物力学适配,满足临床治疗个性化方案的需求,并为医用金属植入物的制造提供新途径。可降解金属目前是... 详细信息

增材制造技术由于其高精度、高自由度等特点,可赋予医用金属植入物定制化的宏观与微观结构,使植入物与患者待修复缺损部位实现更好的生物力学适配,满足临床治疗个性化方案的需求,并为医用金属植入物的制造提供新途径。可降解金属目前是医用金属的研究热点,增材制造可降解金属医用植入物是个新方向,本文重点对增材制造镁基、锌基、铁基可降解金属的工艺流程及影响因素、力学性能、降解行为、生物相容性相关结果进行分析与总结,并展望了增材制造技术在医用可降解金属植入物领域的未来发展方向。

关键词：增材制造可降解金属力学性能降解行为生物相容性

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PtSi肖脱基势垒红外焦平面光腔结构的研究

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红外研究 1989年第3期8卷 231-236页

作者：冯志华董建民凌裕农吴作良沈重辉中国科学院上海技术物理研究所

重点介绍PtSi肖脱基势垒红外焦平面光腔的介质生长技术及介质的折射率和介质层厚度对PtSi肖脱基势垒探测器性能的影响,发现适当的合金条件和减薄PtSi层厚度有利于提高探测器的量子效率,背面增加抗反射层能减少红外辐射在入射界面的能量... 详细信息

重点介绍PtSi肖脱基势垒红外焦平面光腔的介质生长技术及介质的折射率和介质层厚度对PtSi肖脱基势垒探测器性能的影响,发现适当的合金条件和减薄PtSi层厚度有利于提高探测器的量子效率,背面增加抗反射层能减少红外辐射在入射界面的能量损失.

关键词：红外控测器铂焦平机光腔结构硅

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现代高层建筑电力负荷分析与配电方案选择

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南京师范大学学报（工程技术版） 2007年第3期7卷 1-5页

作者：沈聿农赵彩虹王恩荣陈燕萍南京师范大学电气与自动化工程学院电气工程研究所江苏南京210042

现代高层建筑电力负荷计算时所要考虑的因素与传统情况相比有很大不同,楼宇自动化系统BAS的应用,使电力负荷特点发生了很大的变化,导致高层建筑电力负荷的计算越来越复杂.电力部门开展的需求侧管理DSM也会对高层建筑电力设备的运行产生... 详细信息

现代高层建筑电力负荷计算时所要考虑的因素与传统情况相比有很大不同,楼宇自动化系统BAS的应用,使电力负荷特点发生了很大的变化,导致高层建筑电力负荷的计算越来越复杂.电力部门开展的需求侧管理DSM也会对高层建筑电力设备的运行产生影响,这些特点若不加考虑,将对高层建筑电力负荷计算带来较大的误差.针对上述情况分析了现代高层建筑电力负荷的特点,对传统的的电力负荷的计算方法作了比较分析.基于层次分析法AHP对不同的高层建筑供配电设计方案进行技术经济比较,给出各备选方案的综合评价结果,此方法为合理选择供配电设计方案提供依据.

关键词：高层建筑负荷计算 AHP 方案选择

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风光互补发电实验教学平台的搭建和研究

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南京师范大学学报（工程技术版） 2015年第1期15卷 15-20页

作者：张媛媛沈聿农王永平蒋有斌黄佳星史依茗南京师范大学电气与自动化工程学院江苏南京210042 南通醋酸纤维有限公司江苏南通226000

介绍了一种用于教学的风光互补发电实验平台.在该实验教学平台中,太阳能和风能互补发电,通过控制器将电能储存在蓄电池中,再向负载提供电能,还可通过风光互补发电监测系统对实验平台进行访问和控制,实现能量控制和远程监控.该风光互补... 详细信息

介绍了一种用于教学的风光互补发电实验平台.在该实验教学平台中,太阳能和风能互补发电,通过控制器将电能储存在蓄电池中,再向负载提供电能,还可通过风光互补发电监测系统对实验平台进行访问和控制,实现能量控制和远程监控.该风光互补发电实验平台是一种小型微电网,可从教学投入到实际使用,具有实用价值.

关键词：太阳能风能发电监测

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空间探索用梯度密度气凝胶的合成与应用进展

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航空学报 2011年第6期32卷 961-970页

作者：杜艾周斌钟艳红李宇农归佳寅沈洋沈军吴广明同济大学上海市人工微结构材料与技术重点实验室上海200092

气凝胶是空间探索领域的关键功能材料。系统介绍了单一密度气凝胶和梯度密度气凝胶材料的分类、合成方法、复合工艺、特殊性能及其在空间探索领域的应用。其中,梯度密度气凝胶材料的合成是国际上的技术难点,笔者结合自身研究将其复合方... 详细信息

气凝胶是空间探索领域的关键功能材料。系统介绍了单一密度气凝胶和梯度密度气凝胶材料的分类、合成方法、复合工艺、特殊性能及其在空间探索领域的应用。其中,梯度密度气凝胶材料的合成是国际上的技术难点,笔者结合自身研究将其复合方式分为早期方法、分层粘贴法、逐层凝胶法和梯度溶胶共凝胶法,揭示了梯度气凝胶应遵循由单位深度的低差异到高差异、由分层梯度到连续梯度(界面消除)、由低控制精度向高控制精度、由均匀梯度向任意设计梯度的发展规律;并基于梯度密度气凝胶在高速粒子捕获、高效保温隔热与切伦科夫探测等方面的特殊应用,对梯度气凝胶成分和特性(密度、折射率和热导率等)的梯度分布提供了功能化设计。

关键词：梯度密度气凝胶空间探索功能材料合成应用

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M701F4联合循环机组脱硝系统改造及实践

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河南科技 2023年第14期42卷 46-50页

作者：王晗杜建太董云龙沈应强潘刚江苏华电扬州发电有限公司江苏扬州225007 重庆赛迪热工环保工程技术有限公司重庆401120

【目的】随着新能源发电技术的发展,燃气蒸汽联合循环机组已成为主要调峰电站机组之一,安全环保运行越来越重要,要对SCR脱硝技术还原剂液氨的安全问题进行研究。【方法】以江苏华电扬州发电有限公司M701F4联合循环机组为研究对象,开展... 详细信息

【目的】随着新能源发电技术的发展,燃气蒸汽联合循环机组已成为主要调峰电站机组之一,安全环保运行越来越重要,要对SCR脱硝技术还原剂液氨的安全问题进行研究。【方法】以江苏华电扬州发电有限公司M701F4联合循环机组为研究对象,开展脱硝还原剂液氨改尿素水解制氨改造工程。【结果】阐述燃机NOx产生过程、影响因素和控制策略,并阐明SCR脱硝系统、尿素水解制氨系统和工程设计及运行中的注意事项。【结论】在机组完成脱硝还原剂系统改造后,从机组启机过程和实际运行过程的数据得出,尿素制氨技术稳定可靠,能在燃机烟气治理中广泛运用,且脱硝还原剂氨量和脱硝效率有所保障。

关键词： M701F4 SCR脱硝还原剂尿素水解制氨

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