检索结果-南通市图书馆

Surface charge-convertible quaternary ammonium salt-based micelles for in vivo infection therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第5期32卷 1743-1746页

作者： Dengfeng He Yifeng Tan Pengfei Li Yadong luo Yuhong Zhu yunlong Yu Jiali Chen Ning Ning Shiyong Zhang National Engineering Research Center for Biomaterials and College of Chemistry Sichuan UniversityChengdu 610064China West China Hospital Sichuan UniversityChengdu 610041China

Quaternary ammonium salts(QASs) are excellent candidates for treating stubborn bacterial infections caused by biofilms due to their high sterilization efficiency and potential inhibition of the development of drug ***,the inherent toxicity of QASs,including cytotoxicity,protein absorption and hemolysis,severely limits their applications in ***,a charge-co nvertible quaternary ammonium salt-based micelle(QAS-SL@CM) was constructed by co-assembly of two amphiphiles with opposite charges and shell cross-linking *** toxicity of the QAS-SL@CM could be greatly reduced towa rds human cells contrast to the corresponding *** response to the acidic environment at infection sites,the surface charge of QAS-SL@CM could be immediately changed to positive and then target to negatively charged *** re,β-thiopropionate bonds on QAS-SL@CM could also be disintegrated under acid environment to release QASs to kill ***,the QAS-SL@CM showed significant therapeutic effect in mice subcutaneous abscesses models without interference with normal ***,a surface adaptive micelle constructed by charge-convertible strategy has been developed to ove rcome the cytotoxicity of QAS s,and could intelligently respond to the microenvironment of infected wound for in vivo infection therapy,which shows promising application in clinic.

关键词： Quaternary ammonium salt Co-assembled micelle Biofilm Biological safety In vivo infection

Porcine enteric alphacoronavirus infection increases lipid droplet accumulation to facilitate the virus replication

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第3期23卷 988-1005页

作者： Qi Gao Yongzhi Feng Ting Gong Dongdong Wu Xiaoyu Zheng Yizhuo luo yunlong Yang Zebu Song Lang Gong Guihong Zhang Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China Maoming Branch Guangdong Laboratory for Lingnan Modern AgricultureMaoming 525000China Key Laboratory of Animal Vaccine Development Ministry of Agriculture and Rural AffairsGuangzhou 510000China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Coronaviruses are widely transmissible between humans and animals, causing diseases of varying severity. Porcine enteric alphacoronavirus(PEAV) is a newly-discovered pathogenic porcine enteric coronavirus in recent years, which causes watery diarrhea in newborn piglets. The host inflammatory responses to PEAV and its metabolic regulation mechanisms remain unclear, and no antiviral studies have been reported. Therefore, we investigated the pathogenic mechanism and antiviral drugs of PEAV. The transcriptomic analysis of PEAV-infected host cells revealed that PEAV could upregulate lipid metabolism pathways. In lipid metabolism, steady-state energy processes, which can be mediated by lipid droplets(LDs), are the main functions of organelles. LDs are also important in viral infection and inflammation. In infected cells, PEAV increased LD accumulation, upregulated NF-κB signaling, promoted the production of the inflammatory cytokines IL-1β and IL-8, and induced cell death. Inhibiting LD accumulation with a DGAT-1 inhibitor significantly inhibited PEAV replication, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. The NF-κB signaling pathway inhibitor BAY11-7082 significantly inhibited LD accumulation and PEAV replication. Metformin hydrochloride also exerted anti-PEAV effects and significantly inhibited LD accumulation, downregulated the NF-κB signaling pathway, reduced the production of IL-1β and IL-8, and inhibited cell death. LD accumulation in the lipid metabolism pathway therefore plays an important role in the replication and pathogenesis of PEAV, and metformin hydrochloride inhibits LD accumulation and the inflammatory response to exert anti-PEAV activity and reducing pathological injury. These findings contribute new targets for developing treatments for PEAV infections.

关键词： porcine enteric alphacoronavirus NF-κB inflammatory pathway lipid droplet metformin hydrochloride

First Report of Fusarium striatum Causing Root Rot Disease of Panax notoginseng in Yunnan,China

在线全文

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2022年第1期91卷 13-20页

作者： Xuan Zhou Chongyu luo Kuixiu Li Dan Zhu Lihui Jiang Lixia Wu Youchun Li Xiahong He yunlong Du College of Plant Protection Yunnan Agricultural UniversityKunming650201China Key Laboratory of Agro-Biodiversity and Pest Management of Education Ministry of China Yunnan Agricultural UniversityKunming650201China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming650201China

Panax notoginseng is a traditional Chinese medicinal *** rot of *** is one of the most serious diseases affecting *** growth and causes wilted leaves,fewer lateral roots and rotten *** rot is a soil-borne disease,and mainly occurs from June to August in Yunnan Province when the temperatures are high and the air is *** this study,the endophytic fungal genus Fusarium isolate E-2018.1.22-#3.2 was obtained from a *** *** isolate E-2018.1.22-#3.2 was identified as Fusarium striatum based on morphological characteristics and molecular *** fungus was found to have conidiophores and macroconidia,and its ITS,LSU and TEF-1αgenes shared 100%,99.2%and 99%identities with the homologous genes of Fusarium striatum,*** *** E-2018.1.22-#3.2 can cause root rot symptoms,including black,soft roots,fewer lateral roots and leaf wilt,in 93%of the experimental *** plants,and could be re-isolated,fulfilling Koch’s *** the *** plants were treated with the fungicide pyraclostrobin,isolate *** E-2018.1.22-#3.2 was unable to cause root *** have therefore demonstrated that *** E-2018.1.22-#3.2 is able to cause root rot disease in *** is the first report of root rot disease caused by *** on *** in China.

关键词： Panax notoginseng Fusarium striatum root rot disease endophytic fungus

Effect of head model on Monte Carlo modeling of spatial sensitivity distribution for functional near-infrared spectroscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2015年第5期8卷 77-85页

作者： Ting Li Yan Li yunlong Sun Meixue Duan Liyuan Peng State Key Lab Elect Thin Film&Integrated Device and Department of Biomedical Engineering University of Electronic Science&Technology of ChinaChengdu 610054P.R.China Design Department No.2 Avic Beijing Keeven Aviation Instrument Co.LtdBeijing 100086P.R.China

Modeling Light propagation within human head to deduce spatial sensitivity distribution(SSD)is important for Near-infrared spectroscopy(NIRS)/imaging(NIRI)and diffuse correlation *** of head models have been used on this issue,including layered head model,artificial simplified head model,MRI slices described head model,and visible human head ***,visible Chinese human(VCH)head model is considered to be a most faithful presentation of anatomical structure,and has been highlighted to be employed in modeling light ***,it is not practical for all researchers to use VCH head models and actually increasing number of people are using magnet resonance imaging(MRI)head ***,all the above head models were simulated and compared,and we focused on the effect of using di®erent head models on predictions of *** results were in line with the previous reports on the effect of cerebral cortex folding ***,the in fluence on SSD increases with thefidelity of head *** surprisingly,the SSD percentages in scalp and gray matter(region of interest)in MRI head model were found to be 80%and 125%higher than in VCH head *** head models induced nonignorable discrepancy in SSD estimation when compared with VCH head *** study,as we believe,is the first to focus on comparison among full serials of head model on estimating SSD,and provided quantitative evidence for MRI head model users to calibrate their SSD estimation.

关键词： Visible chinese human functional near-infrared spectroscopy Monte Carlo simulation head model spatial sensitivity distribution

Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2022年第4期96卷 1451-1470页

作者： TIAN Xingwang LIU Guangdi luo Bing YANG Yu WEN Long ZHANG Benjian CHEN Xiao SU Guiping SONG Zezhang PENG Hanlin ZHOU Gang YAN Wei YANG Dailin WANG yunlong SUN Yiting DOU Shuang State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China College of Geosciences China University of PetroleumBeijing 102249China Research Institute of Exploration and Development Southwest Oil and Gas Field CompanyPetroChinaChengdu 610041China

Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate *** results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate ***,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study ***,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic *** NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic *** profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type *** plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal *** them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weak

关键词： northern slope of paleo-uplift unconformity structural characteristics hydrocarbon accumulation Central Sichuan paleo-uplift Sichuan Basin

Preparation of nano-PANI@MnO_2 by surface initiated polymerization method using as a nano-tubular electrode material:The amount effect of aniline on the microstructure and electrochemical performance

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2015年第4期24卷 388-393页

作者： Fen Ran yunlong Yang Lei Zhao Xiaoqin Niu Dingjun Zhang Lingbin Kong Yongchun luo Long Kang State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology Department of Chemistry and Biochemistry University of California

In this study,nano-polyanline and manganese oxide nanometer tubular composites（nano-PANI@MnO2）were prepared by a surface initiated polymerization method and used as electrochemical capacitor electrode materials; and the effect of aniline amount on the microstructure and electrochemical performance was investigated. The microstructures and surface morphologies of nano-PANI@MnO2 were characterized by X-ray diffraction,scanning electron microscopy and fourier transformation infrared spectroscope. The electrochemical performance of these composite materials was performed with cyclic voltammetry,charge–discharge test and electrochemical impedance spectroscopy,respectively. The results demonstrate that the feed ratio of aniline to MnO2 played a very important role in constructing the hierarchically nano-structure,which would,hence,determine the electrochemical performance of the materials. Using the templateassisted strategy and controlling the feed ratio of aniline to MnO2,the nanometer tubular structure of nanoPANI@MnO2 was obtained. A maximum specific capacitance of 386 F/g was achieved in aqueous 1 mol/L Na NO3 electrolyte with the potential range from 0 to 0.6 V（vs. SCE）.

关键词： Electrochemical capacitors Nano-PANI@MnO2 Electrode materials

Time interval measurement with linear optical sampling at the femtosecond level

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2023年第12期11卷 2222-2230页

作者： DONGRUI YU ZIYANG CHEN XUAN YANG yunlong XU ZIYI JIN PANXUE MA YUFEI ZHANG SONG YU BIN luo HONG GUO State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronicsand Center for Quantum InformationTechnologyPeking UniversityBeijing 100871China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

High-precision time interval measurement is a fundamental technique in many advanced applications,including time and distance metrology,particle physics,and ultra-precision ***,many of these applications are confined by the imprecise time interval measurement of electrical signals,restricting the performance of the ultimate system to a few picoseconds,which limits ultrahigh precision ***,we demonstrate an optical means for the time interval measurement of electrical signals that can successfully achieve femtosecond(fs)level *** setup is established using the optical frequency comb(OFC)based linear optical sampling(LOS)technique to realize timescale-stretched *** achieve a measurement precision of 82 fs for a single LOS scan measurement and 3.05 fs for the 100-times average with post-processing,which is three orders of magnitude higher than the results of older electrical *** high-precision time interval measurement of electrical signals can substantially improve precision measurement technologies.

关键词： optical electrical linear

在线全文

学校读者我要写书评

暂无评论

基于亚像素圆心检测法的变形监测技术

岩石力学与工程学报 2011年第11期30卷 2303-2311页

作者：刘学增桑运龙罗仁立同济大学土木信息技术教育部工程研究中心上海200092 同济大学土木工程学院上海200092 中国中铁二院工程集团有限责任公司四川成都610031

通过分析当前应用于变形监测的图像处理技术,基于传统的灰度重心法和圆边缘检测法,提出改进的有标点中心定位法——亚像素圆心检测法。为验证其精度,设计对比试验,从标点尺寸、拍摄距离、光源强弱和标点运动状态4个方面,对比分析改进算... 详细信息

通过分析当前应用于变形监测的图像处理技术,基于传统的灰度重心法和圆边缘检测法,提出改进的有标点中心定位法——亚像素圆心检测法。为验证其精度,设计对比试验,从标点尺寸、拍摄距离、光源强弱和标点运动状态4个方面,对比分析改进算法相对于传统算法的优越性,并得到改进算法的理论精度。同时,通过研究标点位移的特点,建立基于亚像素圆心检测法的变形监测技术,并设计试验,从拍摄距离、光源强弱、标点运动状态3个方面分析该技术的理论可行性。试验结果表明:有标点亚像素圆心检测法精度较高,在50 m拍摄距离内精度达1 mm(15 cm直径圆);基于该算法的变形监测技术对标点坐标变化敏感,在40 m拍摄距离内,识别误差控制在1.0 mm范围内,在25 m拍摄距离内,误差严格控制在0.5 mm内,可行性强。依托江西省石城—吉安(石吉)线B8标李家寨高边坡,进行现场试验,监测结果显示,监测误差与理论研究结果相符,表明新型监测技术具有较好的工程适用性。经理论研究与实践证明,该算法监测精度高、可行性强、工程适用性强、成本较低、可实时反馈监测信息。

关键词：边坡工程变形监测图像处理圆心检测精度试验监测技术

Research on the Real-Time Dynamic Evaluation of Public Transport Passenger Service Satisfaction Based on the Internet

在线全文

学校读者我要写书评

暂无评论

Journal of Shanghai Jiaotong university(Science) 2023年第1期28卷 39-51页

作者：罗京周岱谭云龙夏甘霖赵国华 School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Guangzhou Transport Research Institute Guangzhou 510627China Shanghai University of Political Science and Law Shanghai 201701China Design&Research Institute Shanghai Jiao Tong UniversityShanghai 200030China Consulting Department of PPP Research Center Shanghai Jiao Tong UniversityShanghai 200030China

The current method of evaluating passenger satisfaction primarily adopts the traditional static evaluation mode,which can hardly satisfy the dynamic regulatory requirements of highway passenger transport service quality set by industry management *** this paper,we summarize the characteristics of real-time dynamic evaluation under the requirements of hierarchical and classified evaluation and analyze the entire process of the one-time travel service of highway passenger *** focus on station waiting and in-vehicle services,extract the elements most concerned by passengers as evaluation indexes,and construct a three-level index ***,a multi-indicator comprehensive evaluation method based on the analytic hierarchy process and fuzzy comprehensive evaluation is selected to construct a comprehensive evaluation *** combining with the development level of electronic ticket purchasing and the requirements of satisfaction evaluation,we propose three data collection methods and compare and analyze their strengths and ***,based on actual survey data,the effectiveness of the model is *** verification results show that the real-time dynamic evaluation index system based on the Internet can better satisfy evaluation requirements.

关键词： traffic planning highway passenger transport service satisfaction dynamic evaluation