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WIP1 Phosphatase Plays a Critical Neuroprotective Role in Brain Injury Induced by High-Altitude Hypoxic Inflammation

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Neuroscience Bulletin 2017年第3期33卷 292-298页

作者： Dahu Li Lijun Zhang Xin Huang Lili Liu yunling He Lun Xu Yiyao Zhang Tong Zhao Liying wu Yongqi Zhao Kuiwu wu Yan wu Ming Fan Lingling Zhu Department of Cognitive Science Institute of Basic MedicalSciencesBeijing 100850China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Beijing Institute for Brain Disorders Beijing 100069China Navy General Hospital of the PLA Beijing 100048China Air Force General Hospital of the PLA Beijing 100142China

The hypobaric hypoxic environment in highaltitude areas often aggravates the severity of inflammation and induces brain injury as a consequence. However, the critical genes regulating this process remain largely unknown. The phosphatase wild-type p53-induced phosphatase 1（WIP1） plays important roles in various physiological and pathological processes, including the regulation of inflammation in normoxia, but its functions in hypoxic inflammation-induced brain injury remain ***, we established a mouse model of this type of injury and found that WIP1 deficiency augmented the release of inflammatory cytokines in the peripheral circulation and brain tissue, increased the numbers of activated microglia/macrophages in the brain, aggravated cerebral histological lesions, and exacerbated the impairment of motor and cognitive abilities. Collectively, these results provide the first in vivo evidence that WIP1 is a critical neuroprotector against hypoxic inflammation-induced brain injury.

关键词： Hypobaric hypoxia Inflammation Brain injury WIP1 phosphatase Lipopolysaccharide

A 3D Ni_(8)-cluster-based MOF as a molecular electrocatalyst for alcohol oxidation in alkaline media

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Chinese Journal of Structural Chemistry 2023年第2期42卷 5-8页

作者： Wei-Juan Chen Tian-Yu Zhang Xue-Qian wu Yong-Shuang Li yunling Liu Ya-Pan wu Zhao-Bo He Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang443002China College of Electrical Engineering&New Energy China Three Gorges UniversityYichang443002China Hubei Three Gorges Laboratory Yichang443007China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun130012China

*** DAFCs offer significant promise for compact electric devices through the consumption of liquid fuels as one of the renewable energy sources,with minimal environmental effects and prominent energy density[1-4].Beca... 详细信息

关键词： alcohol alkaline cluster

The Analysis of Human Papillomavirus Type 16 E6/E7 Genetic Variability in Jingjiang, Jiangsu Province, China

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Journal of Biosciences and Medicines 2020年第3期8卷 89-103页

作者： Xiaoyue Dai yunling Zhu Wen Xia Longkun Ding Yue Xi Liang wu Chengxue Yi School of Medicine Jiangsu University Affiliated Hospital of Jiangsu University Zhenjiang China Department of Medical Laboratory Jingjiang People’s Hospital Jingjiang China Zhenjiang Key Laboratory of Functional Chemistry Zhenjiang College Zhenjiang China

Human papillomavirus 16 (HPV-16) is a major high-risk type causing cervical cancer. The E6 and E7 genes in HPV-16 are the major virulent genes in HPV, and we wanted to investigate the polymorphism of E6 and E7 genes of HPV-16 originated from Jingjiang, Jiangsu province. In research, HPV-16 sample was collected, and the E6 and E7 genes fragments were amplified by PCR assay. The sequences of E6 and E7 genes were used for phylogenetic analysis by Mega 5.0 software. By comparison, the major mutations of E6 gene were T178G (41.67%) and G658A (17%), as well as C58G, T61A and G188C (14%), T61C and C656A (11%). The mutation of E7 gene was mainly C491A and T935A (23%);G514C, G937C and G519C (11%). The 68 nucleotide site deficiency (69.4%) of E6 and 535 nucleotide site deficiency (23%) of E7 were dominant. In our study, we did not find the relevance between the E6 and E7 genes mutations and pathologic severity. But we think the E6 and E7 genes mutation of HPV-16 might affect vaccine prevention and treatment effect.

关键词： Human Papillomavirus E6 E7 Gene Mutation Phylogenetic Analysis

Chemical constituents from the seeds of Capparis masaikai

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Journal of Chinese Pharmaceutical Sciences 2021年第11期30卷 924-931页

作者： Caicai Xi yunling Xu Kang Feng Renzhao wu Shihong Luo Zhejiang Academy of Traditional Chinese Medicine Hangzhou 310007China MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Zhejiang Vocational College of Special Education Hangzhou 310023China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China

A total of 21 compounds were isolated from the seeds of Capparis masaikai and identified as oxazolidine-2-thione(1), succinimide(2), catechol(3), octathiocane(4), monoethanolamine(5), 3-hydroxypropanenitrile(6), L-arabinose(7), 1,2,3-propanetriol(8), drummondol(9), spionoside B(10), adenosine(11), corchoionoside C(12), coniferin(13), syringin(14), cis-syringin(15), dihydrosyringin(16), indole-3-carboxylic acid(17), β-D-glucopyranosyl indole-3-carboxylic acid(18), 6-hydroxyindole-3-carboxylic acid β-D-glucopyranosyl ester(19), linoleis monoglyceride(20), and triolein(21). Their structures were identified based on physicochemical property and spectroscopic analysis, including MS, NMR, and single-crystal X-ray crystallographic data. Compounds 2–10 and 12–21 were isolated from C. masaikai for the first time.

关键词： Capparis masaikai Chemical constituents Isolation Identification

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密码累加器研究进展及应用

西安电子科技大学学报 2022年第1期49卷 78-91页

作者：苗美霞武盼汝王贇玲西安邮电大学网络空间安全学院陕西西安710121

密码累加器能够将集合中的所有元素进行累加,并高效地给出任意元素的(非)成员证明,即该元素是否存在于集合中。密码累加器主要分为静态累加器、动态累加器以及通用累加器三种类型。静态累加器针对静态集合中元素的累加;动态累加器进一... 详细信息

密码累加器能够将集合中的所有元素进行累加,并高效地给出任意元素的(非)成员证明,即该元素是否存在于集合中。密码累加器主要分为静态累加器、动态累加器以及通用累加器三种类型。静态累加器针对静态集合中元素的累加;动态累加器进一步允许从累加集合中动态地添加和删除元素;通用累加器能够同时支持成员证明和非成员证明(元素不在集合中)。针对上述不同类型的密码累加器,许多学者基于不同的密码工具给出了具体构造,可分为基于RSA的密码累加器、基于双线性映射的密码累加器和基于Merkle哈希树的密码累加器。密码累加器有广泛的应用场景,如群签名、环签名、匿名凭证、时间戳、外包数据验证等。近年来,密码累加器开始应用于区块链中用来解决存储开销大的问题。文中首先从密码累加器的构造方案和功能应用等方面对现有方案进行了分类、分析、总结,其次介绍了密码累加器的主要应用场景,最后指出了现有方案面临的一些问题,以及未来的发展趋势和研究方向。

关键词：密码累加器 RSA累加器双线性映射累加器基于Merkle哈希树的累加器

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长江经济带制造业集聚的环境效应研究

江西师范大学学报（哲学社会科学版） 2022年第5期55卷 88-98页

作者：吴传清邓海叶云岭武汉大学经济与管理学院湖北武汉430072 武汉大学中国发展战略与规划研究院湖北武汉430072

基于2007—2018年长江经济带108地级及以上城市面板数据,采用区位商方法计算制造业集聚指数,主客观赋权法建立长江经济带环境污染指标体系,主客观赋权法建立长江经济带环境污染指标体系,构建空间最小二乘模型,引入制造业集聚的平方项,... 详细信息

基于2007—2018年长江经济带108地级及以上城市面板数据,采用区位商方法计算制造业集聚指数,主客观赋权法建立长江经济带环境污染指标体系,主客观赋权法建立长江经济带环境污染指标体系,构建空间最小二乘模型,引入制造业集聚的平方项,验证长江经济带制造业集聚与环境污染的非线性关系;基于中介效应模型,探讨区域创新在制造业集聚与环境污染之间中介效应。研究结果显示:2007—2018年间长江经济带环境污染指数呈现先上升、后下降的趋势,下游地区的环境污染指数最高,中游地区次之,上游地区最低;长江经济带环境污染均具有显著的空间溢出效应,制造业集聚水平提高对环境污染呈现出先促进、后抑制的作用,而上游地区制造业集聚水平的提升仍然对环境污染表现为促增作用;长江经济带及中下游地区的制造业集聚不仅可以直接影响环境污染,而且还可以通过区域创新影响环境污染,即区域创新在制造业集聚与环境污染之间存在中介效应。为进一步推动长江经济带制造业绿色转型发展,应推进产业结构生态化转型、提升绿色技术创新水平、加强绿色制造体系建设。

关键词：长江经济带制造业集聚环境效应区域创新

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SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3283-3294页

作者： Yan Zhan Yufang Zhu Shanshan Wang Shijun Jia yunling Gao Yingying Lu Caili Zhou Ran Liang Dingwen Sun Xiaobo Wang Zhibing Hou Qiaoqiao Hu Peng Du Hao Yu Chang Liu Miao Cui Gangling Tong Zhihua Zheng Yunsheng Xu Linyu Zhu Jin Cheng Feng wu Yulan Zheng Peijun Liu Peng Hong Department of Rehabilitation Medicine Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei441021China Department of Laboratory Medicine Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei441021China Department of Radiology and Medical Imaging Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei441021China Department of Research Affairs Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei441021China Department of Nephrology Center of Nephrology and UrologySun Yat-sen University Seventh HospitalShenzhenGuangdong518107China Department of Biomedical Science Shenzhen Research InstituteCity University of Hong KongKowloon TongHong KongChina Department of Rehabilitation Medicine Xiangzhou District People’s HospitalXiangyangHubei441000China Department of Rehabilitation Medicine Gucheng People’s HospitalAffiliated Gucheng Hospital of Hubei University of Arts and ScienceXiangyangHubei441700China Division of Quality Control Xiangyang Central Blood StationXiangyangHubei441000China Department of Respiratory and Critical Care Medicine Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyangHubei441021China Department of Pathology Mount Sinai St.Luke’s Roosevelt Hospital CenterNew YorkNY10025USA Department of Oncology Peking University Shenzhen HospitalShenzhenGuangdong518036China Department of Dermatology Sun Yat-sen University Seventh HospitalShenzhenGuangdong518107China Division of Research and Development US Department of Veterans Affairs New York Harbor Healthcare SystemBrooklynNY11209USA Department of Cell Biology State University of New York Downstate Health Sciences UniversityBrooklynNY11203USA

The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of *** we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang,China at 1-year after *** them,chemiluminescence immunoassay-based screening showed 99%(95%CI,98–100%)seroprevalence 10–12 months after infection,comparing to 0.8%(95%CI,0.7–0.9%)in the general *** anti-receptor-binding domain(RBD)antibodies remained stable since discharge,while anti-RBD IgG and neutralization levels decreased over time.A predictive model estimates 17%(95%CI,11–24%)and 87%(95%CI,80–92%)participants were still 50%protected against detectable and severe re-infection of WT SARS-CoV-2,respectively,while neutralization levels against B.1.1.7 and B.1.351 variants were significantly *** non-severe patients showed normal chest CT and 21%reported COVID-19-related *** contrast,53%severe patients had abnormal chest CT,decreased pulmonary function or cardiac involvement and 79%were still *** findings suggest long-lasting immune protection after SARS-CoV-2 infection,while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors.

关键词： immunity patients infection

基于流体腔方法的海上充气膜结构抗弯承载性能研究

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中国造船 2023年第3期64卷 13-22页

作者：叶云凌甘进郑中毅冉小林吴卫国高性能船舶技术教育部重点实验室(武汉理工大学) 武汉430063 武汉理工大学船海与能源动力工程学院武汉430063 武汉理工大学绿色智能江海直达船舶与邮轮游艇研究中心武汉430063 中国汽车工程研究院股份有限公司重庆401122

应用基于表面定义的流体腔方法建立充气膜结构抗弯承载性能数值分析模型,并将其与模型试验对比,验证了数值方法的可靠性。通过数值仿真和模型试验分析了充气膜结构的变形和失效模式,讨论了内压对其承载性能的影响。研究表明,充气膜结构... 详细信息

应用基于表面定义的流体腔方法建立充气膜结构抗弯承载性能数值分析模型,并将其与模型试验对比,验证了数值方法的可靠性。通过数值仿真和模型试验分析了充气膜结构的变形和失效模式,讨论了内压对其承载性能的影响。研究表明,充气膜结构的承载性能与内压线性正相关,且随着局部褶皱现象出现,承载性能快速下降;变形和应力分布与传统的4点弯曲梁相似,而失效模式则为褶皱诱发的局部失稳。论文建立的数值方法对浮式充气膜结构在海洋工程中的应用具有较好的的工程指导意义。

关键词：充气膜结构流体腔方法模型试验弯曲刚度极限承载力

云南中部区域气温变化特征及其受城市化影响程度分析

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地域研究与开发 2015年第6期34卷 137-142页

作者：吴志杰何云玲云南大学资源环境与地球科学学院昆明650091

利用云南中部区域1961—2010年逐月气温资料,采用趋势系数、气候倾向率、Mann-Kendall突变检验、Morlet小波等方法分析该地区气温的时空变化特征,并采用城郊对比法分析城市化对于气温变化的影响程度。结果表明:(1)该地区年均气温上升趋... 详细信息

利用云南中部区域1961—2010年逐月气温资料,采用趋势系数、气候倾向率、Mann-Kendall突变检验、Morlet小波等方法分析该地区气温的时空变化特征,并采用城郊对比法分析城市化对于气温变化的影响程度。结果表明:(1)该地区年均气温上升趋势明显,年均气温存在着24 a的主周期,并于1997年发生了突变,之后进入了一个显著增暖时期。四季平均气温均呈上升趋势,其中冬季气温增幅最大。(2)除西北部的元谋干热河谷存在降温趋势外,其余地区均呈现增温趋势,升温中心位于城市,其中以昆明的升温趋势最为显著。(3)城市化对气温序列变化趋势的影响显著,城市化引起的增温速率在冬季最大,而城市化对气温变化趋势贡献最高的季节则为春季。(4)昆明的城市化增温速率最大,楚雄次之,玉溪最弱;三市的热岛强度从1985年开始逐年增强,2000年后达到最高值,之后趋于平缓;冬春季节的城市化增温速率要明显高于夏秋季节,城市化增温贡献最高的季节为春季。

关键词：气温变化城市化增温贡献云南中部