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Effect of NF-κB Inhibitor PDTC on a Herpetic Stromal Keratitis Mouse Model

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Eye Science 2012年第4期27卷 188-192页

作者： Yiqun Geng yunliang shao Yu Zhang Zeyi Li Shantou University.the Chinese University of Hong Kong Joint Shantou International Eye Center Guangdong Lab Animal Monitoring Institute

Purpose:To investigate the effect of NF-κB inhibitor PDTC on inflammation response in mice with herpetic stromal keratitis (HSK). Methods:A total of 120 female BALB/c mice,aged 4 -6 weeks, were treated by scuffing the epithelium of the right cornea with the tip of a 30G syringe needle, and approximately 1×106 PFU of HSV-1virus was seeded onto the corneal surface. The eye was then exposed to 170 mJ/cm2 of UV light 7 weeks later, in order to induce the relapse of HSK. PDTC eye drops were adjusted to various concentrations (0.1,1.0, and 10 mg/ml) with PBS; PBS only was used on control *** animals received PDTC or PBS eye drops 6 times/day,1 drop/time, for 7 consecutive days. Mice were sacrificed at 8h, and 1, 3, and 7d after administration. Corneal tissues were prepared for the detection of IL-1β, IL-4, IL-6, and IL-12 by ELISA and histological study. Results: Neutrophilic leukocytes and lymphocytes were found in the corneas of HSK mice. ELISA results showed fluctuating expressions of IL-1β, IL-4, IL-6, and IL-12. The IL-1β and IL-4 expressions were significantly lower in the high dose group than in the control group (P<0.05), while IL-6 and IL-12 expressions were significantly higher in the high dose group than in the control group (P<0.05). Conclusion:A high concentration of PDTC can suppress the expression of certain inflammatory factors in HSK mice while improving the expression of others.

关键词：小鼠模型眼角膜抑制剂 NF-KB 基质疱疹 IL-12 ELISA法

大视杯人群视盘面积和视网膜神经纤维厚度的关联性分析

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眼科研究 2005年第3期23卷 311-313页

作者：邵运良阎亦农汕头大学医学院眼科中心 515041

目的研究大视杯人群视盘面积和视网膜神经纤维厚度的关系。方法选择39例大视杯受试者(60眼),杯盘面积比介于0.36～0.75之间。用光学相干断层成像术(OCT)对患者的视盘参数和视网膜神经纤维平均厚度进行测量。根据视盘面积的大小,把患者... 详细信息

目的研究大视杯人群视盘面积和视网膜神经纤维厚度的关系。方法选择39例大视杯受试者(60眼),杯盘面积比介于0.36～0.75之间。用光学相干断层成像术(OCT)对患者的视盘参数和视网膜神经纤维平均厚度进行测量。根据视盘面积的大小,把患者分为大视盘组(视盘面积≥2.8mm2)和小视盘组(视盘面积<2.8mm2)。结果小视盘组视盘面积为:2.38mm2±0.29mm2,杯盘面积比:0.50±0.13,神经纤维厚度为:87.73μm±18.59μm。大视盘组视盘面积为:3.26mm2±0.36mm2,杯盘面积比:0.58±0.10,神经纤维厚度为:100.67μm±18.56μm。大视盘组神经纤维厚度显著大于小视盘组神经纤维厚度(P<0.01)。结论大视杯人群中,视盘面积是反映视网膜神经纤维厚度的重要因素之一。视盘越大,神经纤维厚度越大。

关键词：视盘大视杯视网膜神经纤维 OCT

The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

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Neural Regeneration Research 2025年第5期20卷 1513-1520页

作者： Xueyun shao Longfei He Yangyang Liu Physical Education School Shenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Institute of Neuroscience ShenzhenGuangdong ProvinceChina

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67,

关键词： adolescents brain-derived neurotrophic factor children exercise meta-analysis randomized controlled trials

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系泊链海水疲劳性能初步研究

海洋工程 2019年第5期37卷 127-132页

作者：邵云亮李剑张卫新陶兴陶良凤江苏亚星锚链股份有限公司江苏靖江214533 江苏省系泊链设计与应用技术重点实验室江苏靖江214533

通过试验研究了直径最大到187 mm的R4和R4S级系泊链在人工海水中的疲劳性能。根据疲劳试验得到了相应载荷振幅下的疲劳循环次数,并将结果和DNVGL OS-E301及API RP 2SK中的设计曲线进行了比较和分析。通过链环有限元计算,结合实际试验结... 详细信息

通过试验研究了直径最大到187 mm的R4和R4S级系泊链在人工海水中的疲劳性能。根据疲劳试验得到了相应载荷振幅下的疲劳循环次数,并将结果和DNVGL OS-E301及API RP 2SK中的设计曲线进行了比较和分析。通过链环有限元计算,结合实际试验结果,验证了链环在拉伸载荷下的应力分布和断裂热点,为进一步分析系泊链疲劳失效机理和海洋平台系泊系统设计提供了有效的试验数据。

关键词：海洋系泊链腐蚀疲劳循环次数应力分布疲劳曲线断裂分析

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Collaborative Trajectory Planning for Stereoscopic Agricultural Multi-UAVs Driven by the Aquila Optimizer

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Computers, Materials & Continua 2025年第1期82卷 1349-1376页

作者： Xinyu Liu Longfei Wang Yuxin Ma Peng shao School of Computer and Information Engineering Jiangxi Agricultural UniversityNanchang330045China

Stereoscopic agriculture,as an advanced method of agricultural production,poses new challenges for multi-task trajectory planning of unmanned aerial vehicles(UAVs).To address the need for UAVs to perform multi-task trajectory planning in stereoscopic agriculture,a multi-task trajectory planning model and algorithm(IEP-AO)that synthesizes flight safety and flight efficiency is *** on the requirements of stereoscopic agricultural geomorphological features and operational characteristics,the multi-task trajectory planning model is ensured by constructing targeted constraints at five aspects,including the path,slope,altitude,corner,energy and obstacle threat,to improve the effectiveness of the trajectory planning *** combined with the path optimization algorithm,an Aquila optimizer(IEP-AO)based on the interference-enhanced combination model is proposed,which can help UAVs to improve the trajectory search capability in complex operation space and large-scale operation tasks,and jump out of the locally optimal trajectory path region timely,to generate the optimal trajectory planning plan that can adapt to the diversity of the tasks and the flight ***,four simulated flights with different operation scales and different scene constraints were conducted under the constructed real 3Dimension scene,and the experimental results can show that the proposedmulti-task trajectory planning method canmeet themulti-task requirements in stereoscopic agriculture and improve the mission execution efficiency and agricultural production effect of UAV.

关键词： Stereoscopic agriculture unmanned aerial vehicle multi-task interference model Aquila optimizer

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飞秒激光诱导石墨表面周期性纳米结构

激光与光电子学进展 2009年第7期46卷 41-44页

作者：邵云亮周明张伟李健李保家高传玉蔡兰江苏大学光子制造科学与技术中心江苏镇江212013

介绍了使用近阈值飞秒激光(脉宽130fs,中心波长800nm)烧蚀高定向热解石墨(HOPG)的实验,研究了激光强度与烧蚀深度、激光强度与烧蚀面积之间的关系,计算得到石墨的烧蚀阈值为0.44J/cm2。使用SEM观察样品表面的烧蚀凹坑,发现两种不同的周... 详细信息

介绍了使用近阈值飞秒激光(脉宽130fs,中心波长800nm)烧蚀高定向热解石墨(HOPG)的实验,研究了激光强度与烧蚀深度、激光强度与烧蚀面积之间的关系,计算得到石墨的烧蚀阈值为0.44J/cm2。使用SEM观察样品表面的烧蚀凹坑,发现两种不同的周期性纳米结构,其周期分别为400nm和100nm左右。通过改变脉冲数量、激光能量等参数,分析了各种结构的形成条件。

关键词：飞秒激光烧蚀石墨周期性表面结构

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低温环境下的锚链性能和选用标准

船舶标准化工程师 2020年第3期53卷 18-20,51页

作者：张卫新邵云亮杨龙霞江苏亚星锚链股份有限公司江苏靖江214533 江苏省系泊链设计与应用技术重点实验室江苏靖江214533 上海船舶设备研究所上海200031

随着极地航道和油气资源的开发,造船和海工行业开始更多地关注现有装备在极地低温条件下的使用性能。锚链是船舶和平台定位用的重要组件,在使用过程中不可避免会暴露在冰冷海水和极地寒冷的空气中,有时甚至会受到浮冰冲击。钢铁材料的... 详细信息

随着极地航道和油气资源的开发,造船和海工行业开始更多地关注现有装备在极地低温条件下的使用性能。锚链是船舶和平台定位用的重要组件,在使用过程中不可避免会暴露在冰冷海水和极地寒冷的空气中,有时甚至会受到浮冰冲击。钢铁材料的性能会受到低温的影响,从而产生脆化并降低可靠性。文章研究了不同等级的锚链(包括系泊链)材料在低温下的拉伸和冲击性能,并结合现有船级社规范中关于低温环境使用的材料和锚链的要求,对此类条件下锚链的设计和选用提出了参考。

关键词：锚链低温性能设计标准

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-Man shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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