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淡水鱼中16种喹诺酮类抗生素UPLC-MS/MS检测方法的建立及膳食风险评价

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食品与机械 2024年第1期40卷 40-46,54页

作者：高云慨陈春泉陈小妹周凌聿邓英林尹青春海南省食品检验检测中心国家市场监管重点实验室〔热带果蔬质量与安全〕海南海口570100

目的:建立一种UPLC-MS/MS同时检测淡水鱼中16种喹诺酮类抗生素的方法,并分析水煮、清蒸及油炸3种不同烹饪方式对喹诺酮类抗生素残留量的影响。方法:样品经乙腈(含4%甲酸)超声提取,C_(18)固相萃取柱净化,Waters ACQUITY UPLC BEH C_(18)(... 详细信息

目的:建立一种UPLC-MS/MS同时检测淡水鱼中16种喹诺酮类抗生素的方法,并分析水煮、清蒸及油炸3种不同烹饪方式对喹诺酮类抗生素残留量的影响。方法:样品经乙腈(含4%甲酸)超声提取,C_(18)固相萃取柱净化,Waters ACQUITY UPLC BEH C_(18)(1.7μm,2.1 mm×100 mm)色谱柱分离,以0.1%甲酸水—乙腈为流动相梯度洗脱。质谱(ESI+)采用多反应离子监测模式,内标法定量。结果:在2.0~50.0 ng/mL质量浓度范围内,16种喹诺酮类抗生素呈良好线性关系,相关系数>0.99849,检出限和定量限分别为0.3~4.1,0.9~11.0μg/kg;基质中低、中、高3个添加水平下的平均回收率为79.0%~104.7%,相对标准偏差为1.0%~8.1%;与对照相比,3种不同烹饪方式的鱼肉阳性样品中16种喹诺酮类抗生素残留量均无显著性差异。结论:该方法前处理简便快速、灵敏度高,能够满足淡水鱼中多种喹诺酮类抗生素的高通量筛查及膳食风险评价。

关键词： UPLC-MS/MS 淡水鱼喹诺酮检测膳食风险评价

龙眼及其制品中44种真菌毒素高通量检测方法的建立及其膳食暴露风险评估

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现代食品科技 2024年第7期40卷 254-266页

作者：尹青春陈小妹周凌聿陈春泉高云慨李备梁成美邓英林邓浩海南省检验检测研究院食品检验检测中心国家市场监管重点实验室(热带果蔬质量与安全)海南海口570314 海南医学院热带医学院环境科学系海南海口570000 海南省农业科学院农产品加工设计研究所海南省热带果蔬冷链研究重点实验室海南海口571100

建立基于UPLC-MS/MS测定龙眼及其制品中44种真菌毒素的高通量检测方法。样品经80%乙腈水溶液(V/V,含1%乙酸)提取,PSA和C18净化。采用Waters ACQUITY UPLC BEH C18色谱柱分离,以φ=0.2%甲酸(Formic Acid,FA)-乙腈和水-乙腈为流动相进行... 详细信息

建立基于UPLC-MS/MS测定龙眼及其制品中44种真菌毒素的高通量检测方法。样品经80%乙腈水溶液(V/V,含1%乙酸)提取,PSA和C18净化。采用Waters ACQUITY UPLC BEH C18色谱柱分离,以φ=0.2%甲酸(Formic Acid,FA)-乙腈和水-乙腈为流动相进行梯度洗脱,在正负离子多反应监测模式下内标法定量。结果表明,44种真菌毒素线性关系均良好,R2≥0.99041,检出限为0.003~0.7μg/kg,定量限为0.01~2.0μg/kg;方法的精密度RSD(n=6)为0.7%~9.7%,低、中、高3个添加水平的回收率为70.7%~123.6%。通过对市售17批次龙眼及其制品中44种真菌毒素进行检测,阳性率为100%,其中15-ADON、Fus X、PAT、TeA等含量较高,说明在龙眼生长、贮藏及加工过程中,这4类真菌毒素为主要污染毒素。采用风险商(Hazard Quotient,HQ)进行膳食暴露风险评估,评估结果显示,21种真菌毒素的风险商值HQ为0~0.01237,均低于1,说明没有风险,对人体健康威胁性较小。

关键词：超高效液相色谱-串联质谱真菌毒素检测膳食暴露风险评估

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超高效液相色谱-串联质谱法测定水产品中5种卡因类麻醉剂及其代谢物的不确定度

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化学分析计量 2024年第3期33卷 121-128页

作者：肖璇周凌聿陈春泉高云慨万娜尹青春海南省检验检测研究院食品检验检测中心国家市场监管重点实验室海口570314

采用超高效液相色谱-串联质谱法,对水产品中卡因类麻醉剂3-氨基苯甲酸乙酯甲磺酸盐及其代谢物间氨基苯甲酸、苯佐卡因及其代谢物对氨基苯甲酸和对乙酰氨基苯甲酸残留量的不确定度进行评定,根据BJS 202110《水产品及相关用水中12种卡因... 详细信息

采用超高效液相色谱-串联质谱法,对水产品中卡因类麻醉剂3-氨基苯甲酸乙酯甲磺酸盐及其代谢物间氨基苯甲酸、苯佐卡因及其代谢物对氨基苯甲酸和对乙酰氨基苯甲酸残留量的不确定度进行评定,根据BJS 202110《水产品及相关用水中12种卡因类麻醉剂及其代谢物的测定》建立数学模型,分析影响测量不确定度的主要因素。目标水产品中3-氨基苯甲酸乙酯甲磺酸盐、间氨基苯甲酸、苯佐卡因、对氨基苯甲酸、对乙酰氨基苯甲酸质量分数测定结果分别为0.70、5.53、0.67、6.19、7.33μg/kg,扩展不确定度分别为0.07、0.52、0.09、0.59、0.99μg/kg(k=2,置信区间=95%)。结果显示该方法测量不确定度主要来源于标准溶液配制和标准曲线的拟合。该评定方法为卡因类麻醉剂的测定提供技术依据,解决该方法不确定度的溯源问题。

关键词：超高效液相色谱-串联质谱法麻醉剂水产品 3-氨基苯甲酸乙酯甲磺酸盐苯佐卡因不确定度

Development of Calculation Software for Automotive Side Swing Door Closing Energy

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Chinese Journal of Mechanical Engineering 2010年第6期23卷 690-698页

作者： gao yunkai XU Ruiyao YANG Lei MA Jtmjie College of Automotive Engineering Tongji University Shanghai 201804 China Pan Asia Technical Automotive Center Co. Ltd. Shanghai 201201 China

The existing research of the automotive side swing door and the closing angle via tests and simulations. In these tests, the closing energy is mainly conducted by measuring the closing energy door closing velocity and initial door closing angle are usually not taken into consideration, so the accuracy of the test data cannot be ensured, and, meanwhile, simulations require a great deal of manpower and time. Moreover, frequent tests would give rise to the increasing research and development costs. In this paper, in response to the deficiencies of these current methods, the complicated door closing process is decomposed into the closing processes of different subsystems of door, which includes weather strip seal＇, air-binding effect, door weight, hinge, check-link and latch. Mathematical models of those subsystems are established according to their working principles during the door closing process. In addition to the theoretical research, an Excel-based software using Visual Basic Application programming language is developed to realize the mathematical models, which aims to calculate the energy consumption of the subsystems. The energy consumption of different subsystems of a production vehicle door is measured to verify the accuracy of the calculation sottware developed. The proposed research provides not only the theoretical basis for the future door closing energy research, but also an interactive method and system, effectively improving the quality and efficiency of vehicle door design.

关键词： side swing door closing energy mathematical model software

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百香果果酒酿造工艺研究进展

食品安全导刊 2024年第11期 151-153,157页

作者：邓英林陈春泉周凌聿周小钰高云慨尹青春海南省检验检测研究院食品检验检测中心国家市场监管重点实验室(热带果蔬质量与安全)海南海口570314

在百香果果酒的酿造过程中,发酵用的酵母菌株、发酵周期、发酵温度、糖分等对其口感和品质影响极大。本文从适宜的菌种、发酵工艺条件、酸度调整手段及果酒澄清技术等多方面,讨论百香果果酒酿造工艺。同时,本文指出当前百香果果酒酿造... 详细信息

在百香果果酒的酿造过程中,发酵用的酵母菌株、发酵周期、发酵温度、糖分等对其口感和品质影响极大。本文从适宜的菌种、发酵工艺条件、酸度调整手段及果酒澄清技术等多方面,讨论百香果果酒酿造工艺。同时,本文指出当前百香果果酒酿造中存在的主要问题及后续研究方向,旨在为提高百香果果酒的品质提供科学依据。

关键词：百香果果酒发酵工艺

Research on multi-parametric sensors based on multi-mode microfiber

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Optoelectronics Letters 2024年第1期20卷 18-22页

作者： DONG Taiji LIU Xu WANG yunkai gao Bingkun JIANG Chunlei WANG Xiufang College of Electrical and Information Engineering Northeast Petroleum UniversityDaqing 163318China

A multi-parametric sensor based on multi-mode microfiber(MMF)is proposed,utilizing the modal interference between HE11mode and HE12mode in the elongated multi-mode fiber to achieve the temperature and pressure *** this paper,the simulation model of modal interference based on MMF is established and the mechanism of modal interference is *** the different mechanisms of modal response in the fiber at different wavelengths,the temperature was inverted using the offset of wavelengths in the spectrum,and the pressure was measured using the change of light *** independent measurement of temperature and pressure was *** experimental results show that the sensor has a temperature sensitivity of 1.305 nm/℃.In the case of pressure sensing,the sensor shows a sensitivity of-0.163 d Bm/g.

关键词： measurement mode modal

Stress Relaxation and Sensitivity Weight for Bi-Directional Evolutionary Structural Optimization to Improve the Computational Efficiency and Stabilization on Stress-Based Topology Optimization

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Computer Modeling in Engineering & Sciences 2021年第2期126卷 715-738页

作者： Chao Ma yunkai gao Yuexing Duan Zhe Liu School of Automotive Studies Tongji UniversityShanghai201804China

Stress-based topology optimization is one of the most concerns of structural optimization and receives much attention in a wide range of engineering *** solve the inherent issues of stress-based topology optimization,many schemes are added to the conventional bi-directional evolutionary structural optimization(BESO)method in the previous ***,these schemes degrade the generality of BESO and increase the computational *** study proposes an improved topology optimization method for the continuum structures considering stress minimization in the framework of the conventional BESO method.A global stress measure constructed by p-norm function is treated as the objective *** stabilize the optimization process,both qp-relaxation and sensitivity weight scheme are *** variables are updated by the conventional BESO *** 2D and 3D examples are used to demonstrate the validity of the proposed *** results show that the optimization process can be stabilized by *** value of q and p are crucial to reasonable *** proposed sensitivity weight scheme further stabilizes the optimization process and evenly distributes the stress *** computational efficiency of the proposed method is higher than the previous methods because it keeps the generality of BESO and does not need additional schemes.

关键词： Stress-based topology optimization aggregation function stress relaxation sensitivity weight bi-directional evolutionary structural optimization

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考虑疲劳性能的驾驶室拓扑优化设计

汽车工程 2023年第3期45卷 468-476,450页

作者：高云凯张锁袁泽同济大学汽车学院上海201804

针对某重型货车驾驶室台架疲劳试验出现破坏问题,提出了以疲劳寿命最大化为目标的双向渐进结构优化方法(FA-BESO)。首先,进行驾驶室的台架试验,找到驾驶室疲劳薄弱位置。进一步推导单元低周疲劳分析的灵敏度,以此值作为单元删减依据,通... 详细信息

针对某重型货车驾驶室台架疲劳试验出现破坏问题,提出了以疲劳寿命最大化为目标的双向渐进结构优化方法(FA-BESO)。首先,进行驾驶室的台架试验,找到驾驶室疲劳薄弱位置。进一步推导单元低周疲劳分析的灵敏度,以此值作为单元删减依据,通过对有限元软件进行二次开发来实现连续体结构的FA-BESO。接着,通过标准算例验证了此方法的有效性。最后,为提高优化效率,建立驾驶室的梁骨架简化模型,并验证了简化模型对于疲劳破坏位置具有良好预测性,将该算法运用到A柱加强板的考虑疲劳性能的拓扑优化中,优化结果表明,驾驶室的疲劳寿命可比优化前提高2倍,验证了FA-BESO提高驾驶室疲劳寿命的可行性。

关键词：驾驶室疲劳分析拓扑优化双向渐进结构法

The Study on Fatigue Test of Cab with Suspension Based on 4-channel Road Simulation Rig

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The Study on Fatigue Test of Cab with Suspension Based on 4-...