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Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu yang Shuming Dong Shili Gai Dan yang He Ding Lili Feng Guixin yang Ziaur Rehman Piaoping yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and Technology of Heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

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Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus

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The Innovation 2024年第1期5卷 98-108页

作者： Zongshan Shen Shuhong Kuang Yong Zhang Jiayao Chen Shuting Wang Congfei Xu yunjia Huang Min Zhang Shuheng Huang Jun Wang ChuanJiang Zhao Zhengmei Lin Xuetao Shi Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510060China National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou 510006China School of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510650China The First Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510080China

Cognitive decline has been linked to periodontitis through an undetermined pathophysiological mechanism.This study aimed to explore the mechanism underlying periodontitis-related cognitive decline and identify therapeutic strategies for this condition.Using single-nucleus RNA sequencing we found that changes in astrocyte number,gene expression,and cell‒cell communication were associated with cognitive decline in mice with periodontitis.In addition,activation of the NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome was observed to decrease the phagocytic capability of macrophages and reprogram macrophages to a more proinflammatory state in the gingiva,thus aggravating periodontitis.To further investigate this finding,lipid-based nanoparticles carrying NLRP3 siRNA(NPsiNLRP3)were used to inhibit overactivation of the NLRP3 inflammasome in gingival macrophages,restoring the oral microbiome and reducing periodontal inflammation.Furthermore,gingival injection of NPsiNLRP3 reduced the number of Serpina3nhigh astrocytes in the hippocampus and prevented cognitive decline.This study provides a functional basis for the mechanism by which the destruction of periodontal tissues can worsen cognitive decline and identifies nanoparticle-mediated restoration of gingival macrophage function as a novel treatment for periodontitis-related cognitive decline.

关键词： NLRP3 periodontal number

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Fresh-Keeping Decision and Coordination of Fresh Agricultural Product Supply Chain Considering Carbon Cap-and-Trade under Different Dominance

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 30-51页

作者： yang yang Guanxin Yao China Institute for Agricultural Equipment Industrial Development Jiangsu UniversityZhenjiang212013China Jiangsu Modern Logistics Research Base Yangzhou UniversityYangzhou225009China

In the context of low carbon,this paper discussed the impact of the carbon cap-and-trade policy on the fresh-keeping decision-making of two-echelon fresh agricultural product supply chains under different dominance,and designed cost-sharing contracts to coordinate the supply chain of fresh agricultural products dominated by suppliers and retailers respectively.The results showed that:dominance has no effect on the fresh-keeping decision and total revenue of fresh agricultural product supply chain,but it affects the internal income distribution,and dominance does not always bring more benefits;the implementation of carbon cap-and-trade reduces the fresh-keeping decision-making of fresh agricultural products supply chain and reduces the free-rider income of followers;the role of higher carbon trading price is twofold,which not only brings about the speculation of leading enterprises,but also promotes the application of low-carbon technologies;consumers’high preference for freshness,low-cost and high-efficiency low-carbon technology are all conducive to improving the fresh-keeping efforts and benefits of the supply chain;cost-sharing contracts can coordinate the supply chain of fresh agricultural products.

关键词： Dominant power carbon cap-and-trade policy fresh agricultural product supply chain fresh-keeping decision-making

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Overview of radar detection methods for low altitude targets in marine environments

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Journal of Systems Engineering and Electronics 2024年第1期35卷 1-13页

作者： yang Yong yang Boyu School of Electronic Science National University of Defense TechnologyChangsha 410073China

In this paper,a comprehensive overview of radar detection methods for low-altitude targets in maritime environments is presented,focusing on the challenges posed by sea clutter and multipath scattering.The performance of the radar detection methods under sea clutter,multipath,and combined conditions is categorized and summarized,and future research directions are outlined to enhance radar detection performance for low-altitude targets in maritime environments.

关键词： radar sea clutter multipath scattering detection low altitude target

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超高效液相色谱-串联质谱法同时测定黑巧克力中4种牛奶过敏原蛋白

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卫生研究 2022年第2期51卷 286-292页

作者：刘晋源杨蕴嘉姚凯杨奕邵兵丁晓静首都医科大学公共卫生学院北京100069 北京市疾病预防控制中心北京市预防医学研究中心食物中毒诊断溯源技术北京市重点实验室北京100013

目的建立黑巧克力中4种牛奶过敏原蛋白的超高效液相色谱-串联质谱检测方法。方法从Uniprot数据库筛选牛奶主要过敏原蛋白的特异肽段,用Skyline工具模拟胰酶酶切,确定各肽段的多反应监测(multiple reaction monitoring,MRM)方法。50 mmo... 详细信息

目的建立黑巧克力中4种牛奶过敏原蛋白的超高效液相色谱-串联质谱检测方法。方法从Uniprot数据库筛选牛奶主要过敏原蛋白的特异肽段,用Skyline工具模拟胰酶酶切,确定各肽段的多反应监测(multiple reaction monitoring,MRM)方法。50 mmol/L碳酸氢铵(含2 mol/L尿素)提取巧克力中目标蛋白,14000 r/min、4℃离心除脂,胰酶酶解上清液,固相萃取柱净化,Peptide BEH C_(18)(130?,2.1 mm×100 mm,1.7μm)色谱柱分离,以乙腈和水[均含0.1%(V/V)甲酸]为流动相进行梯度分离,标准加入法定量。结果4条特异肽段FFVAPFPEVFGK、NAVPITPTLNR、AVPYPQR和ALPMHIR可分别作为αS1-酪蛋白、αS2-酪蛋白、β-酪蛋白、β-乳球蛋白的定量肽段。其质量浓度与质谱响应峰面积呈现良好线性关系(R^(2)>0.99),方法的检出限和定量限分别为50~100和160~350μg/kg,加标回收率为60.6%~116.7%,相对标准偏差均小于20%(n=6)。结论该方法灵敏、准确、高效,适于检测黑巧克力中4种牛奶过敏原蛋白。

关键词：巧克力过敏原蛋白超高效液相色谱-串联质谱牛奶蛋白

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牛肉、牛奶中可的松和氢化可的松含量分析

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食品科学 2021年第16期42卷 261-266页

作者：杨奕尹杰杨蕴嘉张晶北京市疾病预防控制中心北京市预防医学研究中心北京100013

采用液相色谱-串联质谱技术分析我国部分地区市售牛肉、牛奶中可的松和氢化可的松的含量水平。均质的牛肉或牛奶样品在乙酸-乙酸钠缓冲液中酶解后用甲醇提取,提取液用石墨化碳黑固相萃取小柱和氨基固相萃取小柱净化,洗脱液氮吹至干并用... 详细信息

采用液相色谱-串联质谱技术分析我国部分地区市售牛肉、牛奶中可的松和氢化可的松的含量水平。均质的牛肉或牛奶样品在乙酸-乙酸钠缓冲液中酶解后用甲醇提取,提取液用石墨化碳黑固相萃取小柱和氨基固相萃取小柱净化,洗脱液氮吹至干并用甲醇溶液定容,液相色谱-串联质谱测定。采用SPSS 21.0软件进行数据分析。对采自我国9省市的346份牛肉和牛奶样品进行检测,分析牛肉和牛奶中可的松和氢化可的松的存在水平。牛肉和牛奶中均检出可的松和氢化可的松,检出率在86.1%~100.0%之间,检出含量范围为0.02~74.88μg/kg。牛肉中可的松和氢化可的松的含量平均值(中位数)分别为1.69(1.14)μg/kg和12.16(8.14)μg/kg,牛奶中可的松和氢化可的松的含量平均值(中位数)分别为0.23(0.23)μg/kg和0.72(0.72)μg/kg。牛肉和牛奶中氢化可的松与可的松的含量均呈显著正相关。

关键词：可的松氢化可的松牛肉牛奶

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广告设计中的哲学问题前沿理论研究

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设计 2022年第24期35卷 130-132页

作者：霍楷杨韫嘉东北大学艺术学院

为研究广告设计中的哲学问题。为此运用文献综述法对广告设计中的哲学问题的发展演变进行阐述;通过查阅相关文献分析广告设计中的哲学问题。在综合分析后对广告设计中哲学问题的发展做出预测;最后对广告设计中哲学问题的前景进行前瞻和... 详细信息

为研究广告设计中的哲学问题。为此运用文献综述法对广告设计中的哲学问题的发展演变进行阐述;通过查阅相关文献分析广告设计中的哲学问题。在综合分析后对广告设计中哲学问题的发展做出预测;最后对广告设计中哲学问题的前景进行前瞻和展望。该研究对广告设计相关前沿理论研究具有参考价值。

关键词：广告设计哲学前沿理论辩证研究

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新文科背景下设计与科技融合改革研究

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设计 2022年第15期35卷 100-102页

作者：霍楷杨韫嘉东北大学艺术学院

为解决如何建设新文科、设计专业如何适应科技发展等新课题。为此运用文献综述法、案例列举法与经验总结法对新文科及设计专业与前沿科技融合的状况进行理论阐释;通过查阅文献概括国内外设计专业与前沿科技融合的状况及问题;把握设计专... 详细信息

为解决如何建设新文科、设计专业如何适应科技发展等新课题。为此运用文献综述法、案例列举法与经验总结法对新文科及设计专业与前沿科技融合的状况进行理论阐释;通过查阅文献概括国内外设计专业与前沿科技融合的状况及问题;把握设计专业与前沿科技融合定位。在综合分析后提出以下举措:更新培养方案、革新教学理念、改革教学方法、更新教学内容。该研究在高校布局教育体系新局面、培养新文科人才等方面具有参考价值。

关键词：新文科设计专业前沿科技融合改革研究

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Deficiency of Trp53 and Rb1 in myeloid cell lineage spontaneously develops acute myeloid leukemia in a mouse model

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Genes & Diseases 2024年第1期11卷 4-6页

作者： yang Li Shu-ting yang Shuying yang Department of Basic&Translational Sciences School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopaedic Surgery School of MedicineJohns Hopkins University BaltimoreMD 21205USA Center for Innovation&Precision Dentistry School of Dental MedicineSchool of Engineering and Applied SciencesUniversity of PennsylvaniaPhiladelphiaPA 19104USA The Penn Center for Musculoskeletal Disorders School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Acute myeloid leukemia(AML)is a rapidly lethal blood cancer characterized by aberrant proliferation and differentiation of myeloid progenitors in the hematopoietic tissue.In recent decades,AML patients are significantly increased.In 2019 alone,21,450 new AML cases were diagnosed in the United States,with an estimated 10,920 deaths due to AML.What’s worse,AML occurs with an increasing incidence with advanced age,and the survival rate remains dismal with a median overall survival of only 5e10 months.Notwithstanding great advances in allogenic transplant and chemotherapy,the therapeutic outcomes are unfavorable due to the disease relapse and mortality rates.More importantly,the development of more specific and effective therapies was hampered in part by the lack of proper animal models for AML.Thus,management and elucidation of the pathological mechanism of AML remain an ongoing challenge,and the development of effective AML mouse models and treatment options are urgently needed.

关键词： myeloid Acute leukemia

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The role of exosomes in adult neurogenesis:implications for neurodegenerative diseases

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Neural Regeneration Research 2024年第2期19卷 282-288页

作者： Zhuoyang Yu Yan Teng Jing yang Lu yang Institute of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Laboratory of Aging Research School of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina

Exosomes are cup-shaped extracellular vesicles with a lipid bilayer that is approximately 30 to 200 nm in thickness.Exosomes are widely distributed in a range of body fluids,including urine,blood,milk,and saliva.Exosomes exert biological function by transporting factors between different cells and by regulating biological pathways in recipient cells.As an important form of intercellular communication,exosomes are increasingly being investigated due to their ability to transfer bioactive molecules such as lipids,proteins,mRNAs,and microRNAs between cells,and because they can regulate physiological and pathological processes in the central nervous system.Adult neurogenesis is a multistage process by which new neurons are generated and migrate to be integrated into existing neuronal circuits.In the adult brain,neurogenesis is mainly localized in two specialized niches:the subventricular zone adjacent to the lateral ventricles and the subgranular zone of the dentate gyrus.An increasing body of evidence indicates that adult neurogenesis is tightly controlled by environmental conditions with the niches.In recent studies,exosomes released from different sources of cells were shown to play an active role in regulating neurogenesis both in vitro and in vivo,thereby participating in the progression of neurodegenerative disorders in patients and in various disease models.Here,we provide a state-of-the-art synopsis of existing research that aimed to identify the diverse components of exosome cargoes and elucidate the therapeutic potential of exosomal contents in the regulation of neurogenesis in several neurodegenerative diseases.We emphasize that exosomal cargoes could serve as a potential biomarker to monitor functional neurogenesis in adults.In addition,exosomes can also be considered as a novel therapeutic approach to treat various neurodegenerative disorders by improving endogenous neurogenesis to mitigate neuronal loss in the central nervous system.

关键词： adult neurogenesis Alzheimer’s disease amyotrophic lateral sclerosis exosome Huntington’s disease neurodegenerative disease neurogenic niches Parkinson’s disease

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