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Bazi Bushen alleviates reproductive aging in aged male mice

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Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing ZHANG Shaolan ZHANG Yaping jiang yuning JI Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WEI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse models.This study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural aging.Therefore,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive aging.This was achieved by assessing sex hormone production,testicular histomorphology,and spermatogenesis.Relative to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged mice.Notably,spermatogenesis was maintained.Further analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory burden.Corroborating these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular damage.In contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid peroxidation.Collectively,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

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Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping LUAN Jianwei SHEN Rui WU Yinglan XU Qiwen WANG Xinyue ZHU Yao XU Xiangru LIU Zitian jiang yuning ZHONG Yong HE Yun jiang Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese Medicine Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing University Emergency Department Longhua HospitalShanghai University of Traditional Chinese Medicine Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese Medicine

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting YDSH.METHODS: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher than in NYX group(56.9% vs 44.4%, P = 0.004). Com

关键词： blood pressure rhythm blood pressure variability hypertension random forest Yin deficiency syndrome

The Roadmap of 2D Materials and Devices Toward Chips

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Nano-Micro Letters 2024年第6期16卷 343-438页

作者： Anhan Liu Xiaowei Zhang Ziyu Liu yuning Li Xueyang Peng Xin Li Yue Qin Chen Hu Yanqing Qiu Han jiang Yang Wang Yifan Li Jun Tang Jun Liu Hao Guo Tao Deng Songang Peng He Tian Tian‑Ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100049People’s Republic of China School of Microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key Laboratory of Dynamic Measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China IMECAS-HKUST-Joint Laboratory of Microelectronics Beijing 100029People’s Republic of China

Due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of Moore’s law.Two-dimensional(2D)materials have emerged as highly promising candidates for the post-Moore era,offering significant potential in domains such as integrated circuits and next-generation computing.Here,in this review,the progress of 2D semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given first.Then 2D transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are discussed.Moreover,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are introduced.Finally,the challenges for 2D materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials Roadmap Integrated circuits Post-Moore era

Effects of Dietary Changes on the Gut Microbiota of Cynops orientalis

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG yuning XIE Siyu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi SHI Yingying SHI Zhirong HE Chunna ZHANG Yixin jiang Na ZHAO Jiaqi LI Supen WANG College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully clarified.Although this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order Caudata.Here,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRNA amplicon sequencing techniques.First,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive individuals.Second,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various diets.Finally,we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of C.orientalis in a large-scale spatiotemporal map.Our study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16S rRNA Caudata core microbiota diet gut microbiota

Circuit design of RRAM-based neuromorphic hardware systems for classification and modified Hebbian learning

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Science China(Information Sciences) 2019年第6期62卷 141-159页

作者： yuning jiang Peng HUANG Zheng ZHOU Jinfeng KANG Institute of Microelectronics Peking University

This paper proposes a solution to the learning of neuromorphic hardware systems based on metal-oxide resistive random access memory(RRAM) arrays, which are used as binary electronic synapses.A modified Hebbian learning method is developed to update the binary synaptic weights, and mixed-signal circuits are designed to implement the proposed learning method. The circuits are verified by SPICE, and systematic simulations are also conducted to verify the capability of the neuromorphic system to process relatively large databases. The results show that the system presents high processing speed(106 examples per second) for both classification and learning, and a high recognition accuracy(up to 95.6%) on the MNIST database.

关键词： RRAM neuromorphic system neuron circuits Hebbian learning pattern classification

中间热交换器二次侧流量分配及阻力特性试验研究

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核动力工程 2024年第1期45卷 55-59页

作者：宋广懂姜林邱斌斌刘昱宁邢帅中国原子能科学研究院北京102413 中国核动力研究设计院成都610213 西安交通大学西安710049

中间热交换器是液态金属钠冷反应堆堆芯和蒸汽发生器之间进行热交换的重要设备。由于管束众多,理论计算难以得到准确的流量分配情况及阻力特性参数。针对上述问题,以某型中间热交换器为原型,在1∶1模型上开展了流量分配及阻力特性试验,... 详细信息

中间热交换器是液态金属钠冷反应堆堆芯和蒸汽发生器之间进行热交换的重要设备。由于管束众多,理论计算难以得到准确的流量分配情况及阻力特性参数。针对上述问题,以某型中间热交换器为原型,在1∶1模型上开展了流量分配及阻力特性试验,获得了不同流量分配结构的流量分配因子以及二次侧中心下降段、换热管段等局部结构的阻力系数。结果表明,锥形盘和无流量分配结构会导致外层流量明显偏高;而孔板结构会降低外层流量分配因子,使流量分配更均匀。二次侧中心下降段、换热管段的阻力系数随雷诺数(Re)的增加而略微降低。二次侧下封头的阻力系数从大到小依次为锥形盘、孔板2、孔板1、无流量分配结构,总阻力系数的变化也满足这一规律。研究结果为中间热交换器的优化设计提供数据支持。

关键词：液态金属钠冷反应堆中间热交换器流量分配特性流动阻力特性

Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

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Journal of Innovative Optical Health Sciences 2021年第4期4卷 55-63页

作者： yuning jiang Yanzheng Cai Sen Hu Xiaoyu Guo Ye Ying Ying Wen Yiping Wu Haifeng Yang College of Chemistry and Materials Science Shanghai Normal University Shanghai 200234P.R.China

Creatinine level in urine is an important biomarker for renal function diseases,such as renal failure,glomerulonephritis,and chronic nephritis.The Au@MIL-101(Fe)was prepared by in situ growth of Au nanoparticles in MIL-101(Fe)as a selective SERS substrate.The Au@MIL-101(Fe)offers the great local surface plasmon resonance(SPR)effect due to gold nanoparticles aggre-gation inside metal-organic frameworks.The framework structure could enrich trace target samples and drag them into SPR hot spots.The optimal Au@MIL-101(Fe)composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1μmol/L and a linear relationship is ranging from 1μmol/L to 100μmol/L.

关键词： surface enhanced Raman scattering Au@MIL-101(Fe) creatinine

补气活血合剂干预脑缺血再灌注模型大鼠相关因子及自噬蛋白的表达

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中国组织工程研究 2025年第6期29卷 1152-1158页

作者：陈玉宁蒋颖廖翔宇陈琼君熊亮刘悦刘通广州中医药大学第五临床医学院广东省广州市510095 广东省第二中医院针灸康复科广东省广州市510095

背景:补气活血合剂治疗气虚痰瘀型缺血性脑卒中有显著的临床疗效,然而其具体起效机制尚不明确。目的:观察补气活血合剂对脑缺血再灌注模型大鼠血管内皮细胞生长因子、碱性成纤维细胞生长因子、脑源性神经营养因子及自噬蛋白Beclin1、p6... 详细信息

背景:补气活血合剂治疗气虚痰瘀型缺血性脑卒中有显著的临床疗效,然而其具体起效机制尚不明确。目的:观察补气活血合剂对脑缺血再灌注模型大鼠血管内皮细胞生长因子、碱性成纤维细胞生长因子、脑源性神经营养因子及自噬蛋白Beclin1、p62表达的影响。方法:取40只雄性SD大鼠,采用随机数字表法分为假手术组、模型组、补气活血合剂组与自噬抑制剂组,每组10只。模型组、补气活血合剂组与自噬抑制剂组建立大脑缺血再灌注损伤模型,补气活血合剂组大鼠再灌注2 h后灌胃给予补气活血合剂(6.49 g/kg,每天分3次给药),自噬抑制剂组大鼠再灌注2 h后灌胃给予补气活血合剂(6.49 g/kg,每天分3次给药)+腹腔注射自噬抑制剂3-甲基腺嘌呤(灌胃前2 h注射,灌胃第1-3天注射),假手术组、模型组灌胃给予等量生理盐水,连续灌胃给药7 d。末次给药24 h后,进行大鼠神经功能、脑梗死体积、脑组织形态及大脑缺血皮质区血管内皮细胞生长因子、碱性成纤维细胞生长因子、脑源性神经营养因子及自噬蛋白Beclin1、p62表达检测。结果与结论:①Zea-Longa评分结果显示,造模后大鼠神经功能受到严重损伤,补气活血合剂组大鼠神经功能损伤轻于模型组、自噬抑制剂组(P0.05);⑤Western blot检测结果显示,与假手术组相比,模型组Beclin1蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);与模型组相比,补气活血合剂组Beclin1蛋白表达升高(P<0.05),p62蛋白表达降低(P<0.05);与补气活血合剂组相比,自噬抑制剂Beclin1蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);⑥结果表明,补气活血合剂可通过促进自噬来减轻大鼠脑缺血再灌注损伤。

关键词：补气活血合剂缺血再灌注神经功能缺损自噬血管内皮生长因子碱性成纤维细胞生长因子脑源性神经营养因子 Beclin1 p62

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基于紫外光谱研究溶解性黑炭质子化

分析试验室 2024年第4期43卷 469-475页

作者：张竑穆玉宁杨晨宇苏友波蒋明张继来傅开道张乃明陈文华云南农业大学资源与环境学院昆明650500 云南省土壤培肥与污染修复工程实验室昆明650201 云南大学国际河流与生态安全研究院昆明650091 保山学院资源与环境学院保山678000

运用紫外光谱滴定技术结合差分光谱与二维相关光谱分析,对溶解性黑炭(DBC)的质子化过程进行定性和定量研究。结果发现:热解温度为280, 360, 440℃的DBC在消光光谱200~250 nm间有特征吸收峰,但DBC特征峰并未随pH变化出现发色团去质子化... 详细信息

运用紫外光谱滴定技术结合差分光谱与二维相关光谱分析,对溶解性黑炭(DBC)的质子化过程进行定性和定量研究。结果发现:热解温度为280, 360, 440℃的DBC在消光光谱200~250 nm间有特征吸收峰,但DBC特征峰并未随pH变化出现发色团去质子化和结构改变;运用差分光谱分析发现,3个热解温度下DBC均于波长280, 355, 385 nm处形成特征差分吸收峰,且吸收峰强度与H+浓度成正相关(p<0.05);二维紫外相关光谱分析表明,DBC的质子化主要发生于羧基及含酚官能团上。以上结果表明,紫外差分光谱滴定法可以定量分析DBC的质子化,DBC发生质子化的主要位点与腐殖酸类似,均为羧基及酚羟基。

关键词：生物碳溶解性黑炭质子化紫外吸收光谱