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Bazi Bushen alleviates reproductive aging in aged male mice

Chinese Journal of Natural Medicines 2024年第5期22卷 416-425页

作者： MA Kun LI Mengnan SONG Yahui MAO Xinjing zhang Shaolan zhang Yaping JIANG yuning JI Chuanyuan NIU Kunxu LI Hongrong HOU Yunlong WEI Cong Graduate School Hebei University of Chinese MedicineShijiazhuang 050091China State Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang 050035China Key Laboratory of State Administration of TCM(Cardio-Cerebral Vessel Collateral Disease) Shijiazhuang 050035China College of Traditional Chinese Medicine·College of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China Hebei Provincial Key Laboratory of Luobing Shijiazhuang 050035China Key Disciplines of State Administration of TCM for Luobing Shijiazhuang 050035China

Bazi Bushen(BZBS),a traditional Chinese medicine(TCM),has demonstrated therapeutic efficacy in testicular dysfunction within D-galactose and NaNO_(2)mouse models.This study aimed to ascertain if BZBS could also mitigate the decline in testicular function associated with natural aging.Therefore,male aged mice were employed to evaluate the preventive effects of BZBS on male reproductive aging.This was achieved by assessing sex hormone production,testicular histomorphology,and spermatogenesis.Relative to the untreated aged control group,BZBS administration elevated the levels of sex hormones and spermatocyte populations and preserved normal testicular structure in aged mice.Notably,spermatogenesis was maintained.Further analyses,including malondialdehyde(MDA)assays and real-time PCR,indicated that BZBS diminished testicular oxidative stress and the inflammatory burden.Corroborating these findings,mice treated with BZBS exhibited reductions in the populations of senescent and apoptotic cells within the seminiferous tubules,suggesting alleviated cellular damage.In contrast,we observed that rapamycin,a drug known for its longevity benefits,induced excessive testicular apoptosis and did not decrease lipid peroxidation.Collectively,our results highlight BZBS’s promising clinical potential in counteracting male reproductive aging,underlining its mechanisms of action.

关键词： Traditional Chinese medicine Male reproductive aging Spermatogenic cells Cell senescence Apoptosis

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Sodium metals for single emitter strong coupling:Alternative plasmonic candidates beyond noble metals

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Yi zhang Shuying Chen yuning Han Xiulai Xu Lin Zhou National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied Sciences Nanjing University School of Information and Electronic Engineering (Sussex Artificial Intelligence Institute) Zhejiang Gongshang University Department of Physics & Astronomy University College London State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking University

This work provides a theoretical investigation into the strong coupling between a single quantum emitter(QE) and the surface plasmons of sodium metals in two representative plasmonic systems, i.e., the semi-infinite metal-dielectric interface and the metal nanoparticles(NPs) of monomer/dimer configuration. In both configurations, sodium metals exhibit distinctly stronger coupling strength and lower optical loss in the optical region than their noble metal counterparts, demonstrating the ideal candidate characteristics for single-molecule-level strong couplings with distinctly facile operation conditions. Our results provide new insights into extreme light-matter interactions with potential applications in quantum information, optical sensors,quantum chemistry, etc.

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3D printing of fine-grained aluminum alloys through extrusion-based additive manufacturing:Microstructure and property characterization

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Journal of Materials Science & Technology 2023年第8期139卷 126-136页

作者： Fengchao Liu Pingsha Dong Abdul Sayeed Khan yuning zhang Randy Cheng Alan Taub Zongyi Ma Department of Naval Architecture and Marine Engineering University of MichiganAnn ArborMI 48109USA Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA

Additive manufacturing(AM)has the potential to transform manufacturing by enabling previously un-thinkable products,digital inventory and delivery,and distributed manufacturing.Here we presented an extrusion-based metal AM method(refer to“SoftTouch”depositionin thefiledpatent)thatis suitablefor making the metal feedstock flowable prior to the deposition through dynamic recrystallization induced grain refinement at elevated temperatures.The flowable metal was extruded out of the printer head like a paste for building dense metal parts with fine equiaxed grains and wrought mechanical properties.Off-the-shelf metal rods were used as feedstock and the printing process was completed in an open-air environment,avoiding pricy powders and costly inert or vacuum conditions.The resulting multi-layer de-posited 6061 aluminum alloys yield strength and ductility comparable to wrought 6061 aluminum alloys after the same T6 heat treatment.The extrusion-based metal AM method can also be advanced as green manufacturing technologies for fabricating novel alloys and composites,adding novel features to existing parts,repairing damaged metal parts,and welding advanced metals for supporting sustainable manufac-turing,in addition to being developed into a cost-effective manufacturing process for the fabrication of dense metal of complex structural forms.

关键词： Additive friction extrusion deposition Microstructure refinement Solid state additive manufacturing Additive friction stir deposition Friction stir welding

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Effects of Dietary Changes on the Gut Microbiota of Cynops orientalis

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG yuning XIE Siyu WU Wenwen zhang Xiner CHENG Zixuan LI Fangfei HAN Jiayi SHI Yingying SHI Zhirong HE Chunna zhang Yixin JIANG Na ZHAO Jiaqi LI Supen WANG College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully clarified.Although this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order Caudata.Here,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRNA amplicon sequencing techniques.First,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive individuals.Second,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various diets.Finally,we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of C.orientalis in a large-scale spatiotemporal map.Our study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16S rRNA Caudata core microbiota diet gut microbiota

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The Roadmap of 2D Materials and Devices Toward Chips

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Nano-Micro Letters 2024年第6期16卷 343-438页

作者： Anhan Liu Xiaowei zhang Ziyu Liu yuning Li Xueyang Peng Xin Li Yue Qin Chen Hu Yanqing Qiu Han Jiang Yang Wang Yifan Li Jun Tang Jun Liu Hao Guo Tao Deng Songang Peng He Tian Tian‑Ling Ren School of Integrated Circuits and Beijing National Research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100049People’s Republic of China School of Microelectronics Fudan UniversityShanghai 200433People’s Republic of China State Key Laboratory of Dynamic Measurement Technology Shanxi Province Key Laboratory of Quantum Sensing and Precision MeasurementNorth University of ChinaTaiyuan 030051People’s Republic of China High‑Frequency High‑Voltage Device and Integrated Circuits R&D Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029People’s Republic of China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049People’s Republic of China IMECAS-HKUST-Joint Laboratory of Microelectronics Beijing 100029People’s Republic of China

Due to the constraints imposed by physical effects and performance degra certain limitations in sustaining the advancement of Moore’s law.Two-dimensional(2D)materials have emerged as highly promising candidates for the post-Moore era,offering significant potential in domains such as integrated circuits and next-generation computing.Here,in this review,the progress of 2D semiconductors in process engineering and various electronic applications are summarized.A careful introduction of material synthesis,transistor engineering focused on device configuration,dielectric engineering,contact engineering,and material integration are given first.Then 2D transistors for certain electronic applications including digital and analog circuits,heterogeneous integration chips,and sensing circuits are discussed.Moreover,several promising applications(artificial intelligence chips and quantum chips)based on specific mechanism devices are introduced.Finally,the challenges for 2D materials encountered in achieving circuit-level or system-level applications are analyzed,and potential development pathways or roadmaps are further speculated and outlooked.

关键词： Two-dimensional materials Roadmap Integrated circuits Post-Moore era

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A 4H-SiC semi-super-junction shielded trench MOSFET: p-pillar is grounded to optimize the electric field characteristics

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Journal of Semiconductors 2022年第12期43卷 79-87页

作者： Xiaojie Wang Zhanwei Shen Guoliang zhang Yuyang Miao Tiange Li Xiaogang Zhu Jiafa Cai Rongdun Hong Xiaping Chen Dingqu Lin Shaoxiong Wu yuning zhang Deyi Fu Zhengyun Wu Feng zhang College of Physical Science and Technology Xiamen UniversityXiamen 361005China Key Laboratory of Semiconductor Material Sciences Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Shenzhen Research Institute of Xiamen University Shenzhen 518057China Jiujiang Research Institute of Xiamen University Jiujiang 332000China

A 4H-SiC trench gate metal-oxide-semiconductor field-effect transistor(UMOSFET)with semi-super-junction shiel-ded structure(SS-UMOS)is proposed and compared with conventional trench MOSFET(CT-UMOS)in this work.The advantage of the proposed structure is given by comprehensive study of the mechanism of the local semi-super-junction structure at the bottom of the trench MOSFET.In particular,the influence of the bias condition of the p-pillar at the bottom of the trench on the static and dynamic performances of the device is compared and revealed.The on-resistance of SS-UMOS with grounded(G)and ungrounded(NG)p-pillar is reduced by 52%(G)and 71%(NG)compared to CT-UMOS,respectively.Additionally,gate ox-ide in the GSS-UMOS is fully protected by the p-shield layer as well as semi-super-junction structure under the trench and p-base regions.Thus,a reduced electric-field of 2 MV/cm can be achieved at the corner of the p-shield layer.However,the quasi-intrinsic protective layer cannot be formed in NGSS-UMOS due to the charge storage effect in the floating p-pillar,resulting in a large electric field of 2.7 MV/cm at the gate oxide layer.Moreover,the total switching loss of GSS-UMOS is 1.95 mJ/cm2 and is reduced by 18%compared with CT-UMOS.On the contrary,the NGSS-UMOS has the slowest overall switching speed due to the weakened shielding effect of the p-pillar and the largest gate-to-drain capacitance among the three.The proposed GSS-UMOS plays an important role in high-voltage and high-frequency applications,and will provide a valuable idea for device design and circuit applications.

关键词： breakdown voltage specific on-resistance silicon carbide switching energy loss super-junction-shield(SS) trench gate MOSFET grounded(G) ungrounded(NG)

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基于变步长扫描策略的FBG高速解调

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红外与激光工程 2024年第4期53卷 233-242页

作者：梁磊张宇宁杜尚明童晓玲武汉理工大学光纤传感技术国家工程实验室湖北武汉430070 武汉理工大学信息工程学院湖北武汉430070 武汉理工大学三亚科教创新园海南三亚572000

现有的FBG高速解调方法都各有优缺点,其中扫描式光谱分析系统通用性好、成本较低,在速度和精度上的表现较为均衡。针对扫描激光器型光纤布拉格光栅波长解调仪在实际应用中调谐次数多、扫描耗时久等问题,设计了一种变步长扫描策略,使用... 详细信息

现有的FBG高速解调方法都各有优缺点,其中扫描式光谱分析系统通用性好、成本较低,在速度和精度上的表现较为均衡。针对扫描激光器型光纤布拉格光栅波长解调仪在实际应用中调谐次数多、扫描耗时久等问题,设计了一种变步长扫描策略,使用较少的波长调谐次数实现光谱局部峰值的检出。实验表明,在通道内只有单个光栅的情况下,使用变步长扫描策略需要扫描的点数降低了至少90%,扫描耗时减少了90%,解调速度提高至10倍。在上位机对传输的局部光谱数据进行高斯拟合解调,并对变步长扫描策略进行信噪比仿真实验测试,仿真证明变步长扫描策略适用于信噪比高于9.23 dB的情况且对后续解调的精度和平均误差几乎没有影响,具有一定的应用价值。

关键词：光纤光栅高速解调可调谐激光器波长调谐

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全生命周期视域下高校“三融合”实践平台构建机理--以汽车产业链为例

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高等工程教育研究 2024年第1期 48-53页

作者：缪勇钟毓宁张红霞湖北汽车工业学院继续教育学院湖北开放大学湖北科技职业学院湖北汽车工业学院党委

基于全生命周期的高校新工科人才培养和实践平台创新是未来中国汽车产业链现代化人才培养重要保障。新工科人才培养以现代汽车产业需求为导向,重点开展新工科人才培养学科专业建设;创新实践平台以面向未来汽车工程师能力为导向,重点构... 详细信息

基于全生命周期的高校新工科人才培养和实践平台创新是未来中国汽车产业链现代化人才培养重要保障。新工科人才培养以现代汽车产业需求为导向,重点开展新工科人才培养学科专业建设;创新实践平台以面向未来汽车工程师能力为导向,重点构建递进式工程教育实践体系及双师型工程教育师资体系。搭建“三创融合”教育体系和实践平台,高校人才培养创新链、知识链、产业链和服务链得以驱动贯通。

关键词：全生命周期专创融合科创融合产教融合新工科实践平台

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AFF4 regulates osteogenic differentiation of human dental follicle cells

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International Journal of Oral Science 2020年第4期12卷 287-297页

作者： Qingyue Xiao yuning zhang Xingying Qi Yaqian Chen Rui Sheng Ruoshi Xu Quan Yuan Chenchen Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontology West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

As a member of the AFF(AF4/FMR2)family,AFF4 is a transcription elongation factor that is a component of the super elongation complex.AFF4 serves as a scaffolding protein that connects transcription factors and promotes gene transcription through elongation and chromatin remodelling.Here,we investigated the effect of AFF4 on human dental follicle cells(DFCs)in osteogenic differentiation.In this study,we found that small interfering RNA-mediated depletion of AFF4 resulted in decreased alkaline phosphatase(ALP)activity and impaired mineralization.In addition,the expression of osteogenic-related genes(DLX5,SP7,RUNX2 and BGLAP)was significantly downregulated.In contrast,lentivirus-mediated overexpression of AFF4 significantly enhanced the osteogenic potential of human DFCs.Mechanistically,we found that both the mRNA and protein levels of ALKBH1,a critical regulator of epigenetics,changed in accordance with AFF4 expression levels.Overexpression of ALKBH1 in AFF4-depleted DFCs partially rescued the impairment of osteogenic differentiation.Our data indicated that AFF4 promoted the osteogenic differentiation of DFCs by upregulating the transcription of ALKBH1.

关键词： impaired impairment alkaline

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癌症治疗中新型抗体偶联药物的研究进展

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中南大学学报（医学版） 2024年第2期49卷 296-304页

作者：李雨凝苏佳琳谭树华罗永忠张乐蒙湖南省肿瘤医院胸部内一科长沙410013 湖南科技大学生命科学与健康学院湖南湘潭411201

传统抗体偶联药物(antibody drug conjugates,ADC)通过将单克隆抗体与细胞毒性药物相结合,实现对癌细胞的精准打击,但在稳定性、靶向性、疗效及安全性等方面依然存在诸多不足。新型ADC,如双特异性、位点特异性、双有效载荷和前药型ADC,... 详细信息

传统抗体偶联药物(antibody drug conjugates,ADC)通过将单克隆抗体与细胞毒性药物相结合,实现对癌细胞的精准打击,但在稳定性、靶向性、疗效及安全性等方面依然存在诸多不足。新型ADC,如双特异性、位点特异性、双有效载荷和前药型ADC,通过同时结合2个不同抗原或表位、选择更稳定的连接子、与抗体特定氨基酸位点偶联、携带不同药物有效载荷以及采用前药策略等优化方法,在保留传统ADC作用特点的基础上,显著提高药物的稳定性、靶向性、疗效和安全性,能更好地满足临床治疗的需求。新型ADC可能会在未来的癌症治疗中发挥重要的作用。探讨新型ADC在癌症治疗中的进展并分析其优势与挑战,可为开发抗癌策略提供理论支持,为药物研发提供方向。

关键词：抗体偶联药物癌症双特异性位点特异性双有效载荷前药型

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