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Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu Zou Daichao Xu Hongbing Zhang Junying Yuan yunhong Zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no cure.Receptor-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of ALS.Primidone has been identified as an old drug that can also inhibit RIPK1 kinase.We conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS patients.SOD1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor performance.One-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS patients.Repurposing primidone may provide a promising therapeutic strategy for ALS.The effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

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新时代公共安全体系建设的逻辑转向与实现路径——基于大安全大应急框架的分析

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江海学刊 2024年第2期 131-139页

作者：孙运宏张卫江苏省社会科学院社会学研究所江苏区域现代化研究院中央统战部新的社会阶层江苏研究基地江苏高校区域法治发展协同创新中心

当前,中国经济社会正迈向高质量发展的新阶段,发展的复杂性和不确定性日益增加,传统风险跨界交织叠加,新兴风险不断涌现,人们的安全诉求也趋于多层多元,迫切要求建立具有总体性的大安全大应急框架。大安全大应急框架驱动公共安全风险治... 详细信息

当前,中国经济社会正迈向高质量发展的新阶段,发展的复杂性和不确定性日益增加,传统风险跨界交织叠加,新兴风险不断涌现,人们的安全诉求也趋于多层多元,迫切要求建立具有总体性的大安全大应急框架。大安全大应急框架驱动公共安全风险治理全要素的协同联动,推动形成上下联动、统筹协调、全生命周期的公共安全体系建设新格局,以多重逻辑促推公共安全体系建设实现理念转型、制度创新、结构优化和整体再造。基于大安全大应急框架,加强新时代公共安全体系建设,在公共安全力量体系构建和应急物资储备调度上,应秉持系统思维,处理好统一指令和优化配置的关系;在应急能力建设上,应充分借助新的治理要素,发挥好智慧治理和社会协同的作用。

关键词：风险治理大安全大应急框架公共安全体系应急管理

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Construction of Electrocatalytic and Heat-Resistant Self-Supporting Electrodes for High-Performance Lithium–Sulfur Batteries

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Nano-Micro Letters 2019年第4期11卷 386-402页

作者： Xuemei Zhang yunhong wei Boya Wang Mei Wang Yun Zhang Qian Wang Hao Wu College of Materials Science and Engineering Sichuan UniversityChengdu 610064People’s Republic of China Department of Advanced Energy Materials Sichuan UniversityChengdu 610064People’s Republic of China

Boosting the utilization efficiency of sulfur electrodes and suppressing the“shuttle effect”of intermediate polysulfides remain the critical challenge for high-performance lithium-sulfur batteries(LSBs).However,most of reported sulfur electrodes are not competent to realize the fast conversion of polysulfides into insoluble lithium sulfides when applied with high sulfur loading,as well as to mitigate the more serious shuttle effect of polysulfides,especially when worked at an elevated temperature.Herein,we reported a unique structural engineering strategy of crafting a unique hierarchical multifunctional electrode architecture constructed by rooting MOF-derived CoS2/carbon nanoleaf arrays(CoS2-CNA)into a nitrogen-rich 3D conductive scaffold(CTNF@CoS2-CNA)for LSBs.An accelerated electrocatalytic effect and improved polysulfide redox kinetics arising from CoS2-CNA were investigated.Besides,the strong capillarity effect and chemisorption of CTNF@CoS2-CNA to polysulfides enable high loading and efficient utilization of sulfur,thus leading to high-performance LIBs performed not only at room temperature but also up to an elevated temperature(55°C).Even with the ultrahigh sulfur loading of 7.19 mg cm?2,the CTNF@CoS2-CNA/S cathode still exhibits high rate capacity at 55°C.

关键词： Metal organic framework Lithium-sulfur batteries Cobalt sulfide Heat-resistant N-doped carbon foam

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Bio-Derived Hierarchical Multicore–Shell Fe2N-Nanoparticle-Impregnated N-Doped Carbon Nanofiber Bundles:A Host Material for Lithium-/Potassium-Ion Storage

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Nano-Micro Letters 2019年第4期11卷 18-34页

作者： Hongjun Jiang Ling Huang yunhong wei Boya Wang Hao Wu Yun Zhang Huakun Liu Shixue Dou Department of Advanced Energy Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610064People’s Republic of China Institute for Superconducting and Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW 2500Australia

Despite the significant progress in the fabrication of advanced electrode materials,complex control strategies and tedious processing are often involved for most targeted materials to tailor their compositions,morphologies,and chemistries.Inspired by the unique geometric structures of natural biomacromolecules together with their high affinities for metal species,we propose the use of skin collagen fibers for the template crafting of a novel multicore-shell Fe2N-carbon framework anode configuration,composed of hierarchical N-doped carbon nanofiber bundles firmly embedded with Fe2N nanoparticles(Fe2N@N-CFBs).In the resultant heterostructure,the Fe2N nanoparticles firmly confined inside the carbon shells are spatially isolated but electronically well connected by the long-range carbon nanofiber framework.This not only provides direct and continuous conductive pathways to facilitate electron/ion transport,but also helps cushion the volume expansion of the encapsulated Fe2N to preserve the electrode microstructure.Considering its unique structural characteristics,Fe2N@N-CFBs as an advanced anode material exhibits remarkable electrochemical performances for lithium-and potassium-ion batteries.Moreover,this bio-derived structural strategy can pave the way for novel low-cost and high-efficiency syntheses of metal-nitride/carbon nanofiber heterostructures for potential applications in energy-related fields and beyond.

关键词： Anode material Iron nitride Lithium-ion battery Potassium-ion battery Multicore-shell structure

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混动汽车机电耦合系统效率影响因素分析及优化研究

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重庆理工大学学报（自然科学） 2024年第3期38卷 250-259页

作者：黄操张伟李云虹易鹏广州汽车集团股份有限公司汽车工程研究院广州511434 重庆清研理工汽车检测服务有限公司重庆400054

研究了机电耦合系统传动效率主要影响因素,分析了机电耦合系统机械损耗、电控损耗和电机损耗3部分损耗的组成及影响因子,分析得出机械损耗与摩擦条件密切相关,电控损耗包括IGBT损耗和FWD损耗,二者均受开关频率影响,电机损耗与磁场强度... 详细信息

研究了机电耦合系统传动效率主要影响因素,分析了机电耦合系统机械损耗、电控损耗和电机损耗3部分损耗的组成及影响因子,分析得出机械损耗与摩擦条件密切相关,电控损耗包括IGBT损耗和FWD损耗,二者均受开关频率影响,电机损耗与磁场强度和电流大小有关。提出通过改善摩擦条件和调整IGBT开关频率来优化机电耦合系统综合效率,开发了机电耦合系统传动效率测试台架,依托自主开发的测试台架分别测得了纯电模式下机械损耗、电控损耗和电机损耗在不同工况下的结果,分析了机械损耗、电控损耗和电机损耗随工况条件变化的规律。结果表明:采用低摩擦轴承和低黏度油品改善摩擦条件后可以有效降低机械损耗,最高效率提升了0.9%;IGBT开关频率从10 kHz调整为5 kHz,在低速段传动效率有明显提升。因此,提出了基于传动效率的IGBT开关频率动态调整策略。

关键词：混动汽车机电耦合系统传动效率功率损耗测试

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A Natural Polymer Captor for Immobilizing Polysulfide/Polyselenide in Working Li-SeS_(2) Batteries

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Nano-Micro Letters 2021年第7期13卷 55-73页

作者： Yin Zhang Menglei Wang Yi Guo Lingzhi Huang Boya Wang yunhong wei Peng Jing Yueying Zhang Yun Zhang Qian Wang Jingyu Sun Hao Wu Engineering Research Center of Alternative Energy Materials and Devices of Ministry of Education College of Materials Science and EngineeringSichuan UniversityChengdu 610064People’s Republic of China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province College of EnergySoochow Institute for Energy and Materials Innovations(SIEMIS)Soochow UniversitySuzhou 215006People’s Republic of China

SeS_(2) has become a promising cathode material owing to its enhanced electrical conductivity over sulfur and higher theoretical specific capacity than selenium;however,the working Li-SeS_(2) batteries have to face the practical challenges from the severe shuttling of soluble dual intermediates of polysulfide and polyselenide,especially in high-SeS_(2)-loading cathodes.Herein,a natural organic polymer,Nicandra physaloides pectin(NPP),is proposed to serve as an effective polysulfide/polyselenide captor to address the shuttling issues.Informed by theoretical calculations,NPP is competent to provide a Lewis base-based strong binding interaction with polysulfides/polyselenides via forming lithium bonds,and it can be homogeneously deposited onto a three-dimensional double-carbon conductive scaffold to finally constitute a polysulfide/polyselenide-immobilizing interlayer.Operando spectroscopy analysis validates the enhanced polysulfide/polyselenide trapping and high conversion efficiency on the constructed interlayer,hence bestowing the Li-SeS_(2) cells with ultrahigh rate capability(448 mAh g^(−1)at 10 A g^(−1)),durable cycling lifespan(≈0.037%capacity attenuation rate per cycle),and high areal capacity(>6.5 mAh cm^(−2))at high SeS_(2) loading of 15.4 mg cm^(−2).Importantly,pouch cells assembled with this interlayer exhibit excellent flexibility,decent rate capability with relatively low electrolyte-to-capacity ratio,and stable cycling life even under a low electrolyte condition,promising a low-cost,viable design protocol toward practical Li-SeS_(2) batteries.

关键词： Li-SeS_(2)batteries Nicandra physaloides pectin Interlayer Shuttle effect Pouch cells

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Reflections on Perfecting Teaching Quality Monitoring System in Secondary Medical Vocational Colleges

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Journal of Advances in Medicine Science 2018年第2期1卷 61-63页

作者： yunhong wei Chongqing Medical University QijiangChongqing404100China

Teaching quality is an important component which constitutes secondary and higher medical colleges,at the same time teaching quality monitoring system is the key content of teaching quality.In the current,teaching quality system of many Chinese schools is comparatively inadequate and the construction of quality assessment is comparatively backward and unsystematic.This research made further exploration into the above question with effective scheme found question,among which finding effective scheme is the main method to guarantee the improvement and soundness of teaching quality monitoring system.

关键词： Secondary medical vocational college Teaching quality monitoring system Improvement

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Iron atom-nanoparticles for interactional enhancing the electrocatalytic reaction activity in Li-S batteries

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Chinese Chemical Letters 2023年第11期34卷 311-316页

作者： Gamal H.Al-Shawesh Jiawen Zhu wei Zhang Shuai Xie Junjie Xu Guolei Cai Amar Y.Al-Ansi yunhong wei Song Jin Hengxing Ji Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China Department of Chemistry Faculty of EducationThamar UniversityDhamarYemen School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

The undesirable shuttle effect and sluggish redox kinetics of polysulfides seriously result in low sulfur utilization and poor capacity retention.Here,an integrated strategy is proposed by rational designing multifunctional architecture to manipulate the redox kinetics of polysulfides,specifically,by employing iron atoms(Fe-As)and iron-species nanoparticles(Fe-NPs)co-embedded nitrogen-doped carbon nanotube(Fe-NCNT)as catalyst and host for sulfur.The synergistic cooperation of Fe-As and Fe-NPs provides efficient active sites to facilitate the diffusion,strengthen the affinities,and promote the conversion reactions for polysulfides.Furthermore,the NCNT not only offers practical Li+transport pathways but also immobilize the polysulfides effectively.Benefiting from these merits,the Fe-NCNT/S electrodes exhibit high initial specific capacity of 1502.6 mAh/g at 0.1 C,outstanding rate performance(830 mAh/g at 2 C),and good cycling performance(597.8 mAh/g after 500 cycles with an ultralow capacity fading rate of 0.069%per cycle).This work features the distinct interaction of iron atom-nanoparticles on facilitating immobilization-diffusion-transformation process of polysulfides,and it also expected to pave the way for the application in practical Li-S batteries.

关键词： N-doped carbon nanotubes Iron atoms Iron nanoparticles Electrocatalyst Li-S batteries

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癌症患者安宁疗护需求评估工具的研究进展

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护士进修杂志 2024年第11期39卷 1180-1184,1192页

作者：陈小杰杜云红刘玮张笑王莉山东第二医科大学护理学院山东潍坊261053 青岛市中医医院山东青岛266033

目的全面地收集与综合分析国内外安宁疗护需求评估工具相关文献。方法系统检索PubMed、Embase、Web of science核心集、Cochrane Library、中国知网、万方数据库、中国生物医学数据库7个数据库,检索时限为建库至2023年3月31日。按照... 详细信息

目的全面地收集与综合分析国内外安宁疗护需求评估工具相关文献。方法系统检索PubMed、Embase、Web of science核心集、Cochrane Library、中国知网、万方数据库、中国生物医学数据库7个数据库,检索时限为建库至2023年3月31日。按照纳入与排除标准筛查相关文献,提取文献的基本特征并进行分析,并对纳入工具的信效度进行综合评价。结果最终共纳入28篇文献,综合分析了17个安宁疗护需求评估工具,其中有6个评估工具在不同的国家进行了跨文化的调试与验证。结论现存的安宁疗护需求评估工具种类虽多,但是我国在该领域研究匮乏。建议未来进一步验证与完善现有的评估工具,并根据我国国情,开发适合我国癌症患者的安宁疗护需求评估工具。

关键词：安宁疗护需求癌症评估工具综述

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护理学基础实践教学形成性评价体系的构建与实践

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创新创业理论研究与实践 2024年第10期7卷 1-4页

作者：韦春卢运红黄艳菊李颖娟广西医科大学

目的构建护理学基础实践教学形成性评价体系，并探索其应用效果。方法构建评价体系，将“不违背操作原则”作为学生互评的考核标准，以视频作业的形式开展课后评价。在本科护理学专业学生中随机抽取74名学生为试验组，74名学生为对照... 详细信息

目的构建护理学基础实践教学形成性评价体系，并探索其应用效果。方法构建评价体系，将“不违背操作原则”作为学生互评的考核标准，以视频作业的形式开展课后评价。在本科护理学专业学生中随机抽取74名学生为试验组，74名学生为对照组。试验组采用形成性评价体系评价，对照组采用终结性评价方式评价。比较两组学生期末考试成绩及学生对评价效果的反馈情况。结果试验组学生第四学期、第五学期期末技能考核成绩均比对照组高，两组比较差异有统计学意义（P <0.05）；比较两组学生对评价效果的反馈，差异有统计学意义（P <0.05）。结论该评价体系具有可操作性，能够帮助学生提高实践技能及综合能力。

关键词：护理学基础实践教学形成性评价评价体系技能考核考核标准

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