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Mitochondria targeting drugs for neurodegenerative diseases——Design, mechanism and application

Acta Pharmaceutica Sinica B 2022年第6期12卷 2778-2789页

作者： Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211816China Department of Anatomy Shanxi Medical UniversityTaiyuan 030001China Lee Kang Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030001China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Neurodegenerative diseases(NDDs) such as Alzheimer’s disease(AD) and Parkinson ’s disease(PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons.NDDs threaten the lives of millions of people worldwide and regretfully remain incurable.It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs.Dysfunction of mitochondria results in energy depletion,oxidative stress,calcium overloading,caspases activation,which dominates the neuronal death of NDDs.Therefore,mitochondria are the preferred target for intervention of NDDs.So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome,though there are still some obstacles such as targeting specificity,delivery capacity hindering the drugs development.In present review,we will elaborately address 1) the strategy to design mitochondria targeting drugs,2) the rescue mechanism of respective mitochondria targeting drugs,3) how to evaluate the therapeutic effect.Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs.

关键词： Neurodegenerative diseases Mitochondria Targeting drug Apoptosis Reactive oxygen species Adenosine triphosphate Mitochondrial membrane potential Evaluation

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Ultraviolet‑Irradiated All‑Organic Nanocomposites with Polymer Dots for High‑Temperature Capacitive Energy Storage

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Nano-Micro Letters 2024年第3期16卷 398-406页

作者： Jiale Ding Yao Zhou Wenhan Xu Fan Yang Danying zhao yunhe Zhang Zhenhua Jiang Qing Wang College of Chemistry Jilin UniversityChangchun 130012People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USAs Deutsches Elektronen-Synchrotron DESY Notkestr.8522607 HamburgGermany

Polymer dielectrics capable of operating efficiently at high electric fields and elevated temperatures are urgently demanded by next-generation electronics and electrical power systems.While inorganic fillers have been extensively utilized to improved high-temperature capacitive performance of dielectric polymers,the presence of thermodynamically incompatible organic and inorganic components may lead to concern about the long-term stability and also complicate film processing.Herein,zero-dimensional polymer dots with high electron affinity are introduced into photoactive allyl-containing poly(aryl ether sulfone)to form the all-organic polymer composites for hightemperature capacitive energy storage.Upon ultraviolet irradiation,the crosslinked polymer composites with polymer dots are efficient in suppressing electrical conduction at high electric fields and elevated temperatures,which significantly reduces the high-field energy loss of the composites at 200℃.Accordingly,the ultraviolet-irradiated composite film exhibits a discharged energy density of 4.2 J cm^(−3)at 200℃.Along with outstanding cyclic stability of capacitive performance at 200℃,this work provides a promising class of dielectric materials for robust high-performance all-organic dielectric nanocomposites.

关键词： High-temperature energy storage Polymer dots Ultraviolet irradiation All-organic composite dielectrics

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Visual recognition of cardiac pathology based on 3D parametric model reconstruction

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Frontiers of Information Technology & Electronic Engineering 2022年第9期23卷 1324-1337页

作者： Jinxiao XIAO Yansong LI Yun TIAN Dongrong Xu Penghui LI Shifeng zhao yunhe PAN School of Artificial Intelligence Beijing Normal UniversityBeijing100875China Department of Psychiatry Columbia University&New York State Psychiatric InstituteNew York10032USA College of Computer Science and Technology Zhejiang UniversityHangzhou310027China

Visual recognition of cardiac images is important for cardiac pathology diagnosis and treatment.Due to the limited availability of annotated datasets,traditional methods usually extract features directly from twodimensional slices of three-dimensional(3D)heart images,followed by pathological classification.This process may not ensure the overall anatomical consistency in 3D heart.A new method for classification of cardiac pathology is therefore proposed based on 3D parametric model reconstruction.First,3D heart models are reconstructed based on multiple 3D volumes of cardiac imaging data at the end-systole(ES)and end-diastole(ED)phases.Next,based on these reconstructed 3D hearts,3D parametric models are constructed through the statistical shape model(SSM),and then the heart data are augmented via the variation in shape parameters of one 3D parametric model with visual knowledge constraints.Finally,shape and motion features of 3D heart models across two phases are extracted to classify cardiac pathology.Comprehensive experiments on the automated cardiac diagnosis challenge(ACDC)dataset of the Statistical Atlases and Computational Modelling of the Heart(STACOM)workshop confirm the superior performance and efficiency of this proposed approach.

关键词： 3D visual knowledge 3D parametric model Cardiac pathology diagnosis Data augmentation

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The evolution of China’s regulation of agricultural biotechnology

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aBIOTECH 2022年第4期3卷 237-249页

作者： Jingang Liang Xiaowei Yang Yue Jiao Danxia Wang Qiang zhao Yu Sun yunhe Li Kongming Wu Development Center of Science and Technology Ministry of Agriculture and Rural AffairsBeijing100176China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing100193China Croplife Asia Beijing Office Beijing100125China

To ensure safe use of genetically modified organisms(GMOs),since 1993,China has made great efforts to establish and improve the safety regulatory system for GMOs.Here,we summarize and analyze the regulatory framework of agricultural GMOs,and the progress in regulatory approval of GM crops in China.In general,the development of GMO safety regulations underwent four stages:exploration(1993–2000),development(2001–2010),improvement(2011–2020)and current(2021-present)stage.The first formal regulation was promulgated in 1993,which provided a basis for further development of the regulations,during the exploration stage,when insect-resistant GM cotton,expressing genes from Bacillus thuringiensis(Bt),was approved for cultivation.During the development stage,the Chinese government issued a series of administrative measures,which covered almost all the fields relative to GMO safety when the basic regulatory system was established.Along with the controversy over GMO safety,the regulations have been further,and greatly improved,during improvement stage.From 2021,a few additional revisions have been made,and meanwhile,the new regulation on gene-edited crops was introduced with the development of biotechnology,forming a relative complete regulation and law system for China.The well-developed GMO regulations establishes a firm basis for safe use of GM crops in China.Currently,GM cotton and GM papaya have been widely grown on a large scale in China that have brought great economic and ecological benefits.In addition,12 corn events,3 soybean events,and 2 rice events have also obtained biosafety certification,but presently,these lines have yet to enter commercial production.However,several GM soybean and corn events have entered pilot industrialization,and can soon be expected to be commercially grown in China.In addition to planting,six GM crops,including soybean,corn,cotton,canola,papaya and sugar beet,with a total of 64 events,have been approved for import as processing material in China.

关键词： Genetically modified organisms Biosafety certificate Regulatory approval Gene editing Pilot phase

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Enterogenic Stenotrophomonas maltophilia migrates to the mammary gland to induce mastitis by activating the calcium-ROS-AMPK-mTOR-autophagy pathway

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Journal of Animal Science and Biotechnology 2024年第1期15卷 236-252页

作者： zhaoqi He Caijun zhao Yuhong He Zhuoyu Liu Guyue Fan Kun Zhu Yiqi Wang Naisheng Zhang yunhe Fu Xiaoyu Hu Department of Clinical Veterinary Medicine College of Veterinary MedicineJilin UniversityChangchun 130062Jilin ProvinceChina

Background Mastitis is an inflammatory disease of the mammary gland that has serious economic impacts on the dairy industry and endangers food safety.Our previous study found that the body has a gut/rumen-mammary gland axis and that disturbance of the gut/rumen microbiota could result in‘gastroenterogenic mastitis'.However,the mechanism has not been fully clarified.Recently,we found that long-term feeding of a high-concentrate diet induced mastitis in dairy cows,and the abundance of Stenotrophomonas maltophilia(S.maltophilia)was significantly increased in both the rumen and milk microbiota.Accordingly,we hypothesized that‘gastroenterogenic mastitis'can be induced by the migration of endogenous gut bacteria to the mammary gland.Therefore,this study investigated the mechanism by which enterogenic S.maltophilia induces mastitis.Results First,S.maltophilia was labelled with superfolder GFP and administered to mice via gavage.The results showed that treatment with S.maltophilia promoted the occurrence of mastitis and increased the permeability of the blood-milk barrier,leading to intestinal inflammation and intestinal leakage.Furthermore,tracking of ingested S.maltophilia revealed that S.maltophilia could migrate from the gut to the mammary gland and induce mastitis.Subsequently,mammary gland transcriptome analysis showed that the calcium and AMPK signalling pathways were significantly upregulated in mice treated with S.maltophilia.Then,using mouse mammary epithelial cells(MMECs),we verified that S.maltophilia induces mastitis through activation of the calcium-ROS-AMPK-mTOR-autophagy pathway.Conclusions In conclusion,the results showed that enterogenic S.maltophilia could migrate from the gut to the mammary gland via the gut-mammary axis and activate the calcium-ROS-AMPK-mTOR-autophagy pathway to induce mastitis.Targeting the gut-mammary gland axis may also be an effective method to treat mastitis.

关键词： Calcium-ROS-AMPK-mTOR-autophagy pathway Gut-mammary axis Mastitis S.maltophilia

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Eco-geographical Regionalization of China:An Approach Using the Rough Set Method

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Chinese Geographical Science 2022年第1期32卷 93-109页

作者： DENG Haoyu WU Shaohong YIN yunhe GAO Jiangbo zhao Dongsheng Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Eco-geographical regionalization involves dividing land into regions by considering both intra-regional consistency and interregional disparity and is based on the pattern of differentiation of eco-geographical elements.Owing to the complexity of the land surface,and the limitation of data and appropriate methods,regions in China have hitherto been mapped manually,meaning that the process of mapping was non-repeatable.To make the regionalization technique repeatable,this study aimed to extract and quantify the expert knowledge of regionalization using an automated method.The rough set method was adopted to extract rules of regionalization based on the existing eco-geographical regionalization map of China,as well as its corresponding meteorological and geological datasets.Then,the rules for regionalization were obtained hierarchically for each natural domain,each temperature zone,and each humidity region.Owing to differences in zonal differentiation,the rule extraction sequence for the eastern monsoon zone and Tibetan Alpine zone was temperature zone first followed by humidity region,with the reverse order being applied for the northwest arid/semi-arid zone.Results show that the extracted indicators were similar to those of the existing(expert-produced)regionalization scheme but more comprehensive.The primary indicator for defining temperature zones was the≥10℃ growing season,and the secondary indicators were the January and July mean temperatures.The primary and secondary indicators for identifying humid regions were aridity index and precipitation,respectively.Eco-geographical regions were mapped over China using these rules and the gridded indicators.Both the temperature zones and humidity regions mapped by the rules show≥85%consistency with the existing regionalization,which is higher than values for mapping by the commonly used simplified method that uses the classification of one indicator.This study demonstrates that the proposed rough set method can establish eco-geographical regionalization that is quant

关键词： Eco-geographical regionalization boundary rough set China

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基于深度学习的权函数法应力强度因子求解

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航空学报 2023年第19期44卷 187-198页

作者：赵鋆赫王生楠西北工业大学航空学院西安710129

针对传统多参考载荷条件权函数法在复杂几何构型下存在的问题,提出了一种基于深度学习的多参考载荷条件权函数法,应用该方法得到的有限矩形板单边穿透裂纹权函数解与Wu-Carlsson的解析权函数解在相应各点处的格林函数偏差在0.4%以内,验... 详细信息

针对传统多参考载荷条件权函数法在复杂几何构型下存在的问题,提出了一种基于深度学习的多参考载荷条件权函数法,应用该方法得到的有限矩形板单边穿透裂纹权函数解与Wu-Carlsson的解析权函数解在相应各点处的格林函数偏差在0.4%以内,验证了该方法获得的权函数的精度,证明了该方法的可行性。针对航空航天领域常见的偏心孔边裂纹情况,使用该方法得到了部分几何尺寸下的偏心孔边裂纹权函数解,与有限元法得到的格林函数值对比,绝大部分偏差小于1.5%,最大偏差为4.8%,进一步验证了该方法获得权函数解的准确性。该方法具有应用于复杂几何裂纹体的潜力。

关键词：权函数法应力强度因子深度学习偏心孔边穿透裂纹格林函数

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关于煤矿综采工作面提高回采效率的探析

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山西化工 2023年第10期43卷 133-135页

作者：赵云鹤西山煤电马兰矿综采三队山西太原030200

在我国煤矿行业的现代化建设和发展中,提高矿井生产质量、生产效率,需要从煤矿综采工作面着手,加强对回采工作质量、工作效率的优化,利用综放技术,降低发生在综采工作面中的煤炭损耗,加强对影响矿井开采回收率的各项因素的研究和有效的... 详细信息

在我国煤矿行业的现代化建设和发展中,提高矿井生产质量、生产效率,需要从煤矿综采工作面着手,加强对回采工作质量、工作效率的优化,利用综放技术,降低发生在综采工作面中的煤炭损耗,加强对影响矿井开采回收率的各项因素的研究和有效的治理,提高综采工作面的回采工作质量和效率。本文对影响综采工作面回采效率的因素进行了探讨,分析了提高综采工作面回采效率的有效手段。

关键词：煤矿综采工作面回采效率

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高职院校“三全育人”实施成效检视--以滁州市城高职院校为例

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滁州职业技术学院学报 2022年第1期21卷 26-30页

作者：赵云鹤滁州城市职业学院安徽滁州239000

通过对滁州地区2所高职院校部分学生和教师的访谈和问卷调查发现:“三全育人”教育活动已经在该地区的高职院校中全面展开,并已经取得了初步成效,但仍然存在发展不充分的问题。对调查所得出的结论进行认真的分析,找到根源,针对性提出解... 详细信息

通过对滁州地区2所高职院校部分学生和教师的访谈和问卷调查发现:“三全育人”教育活动已经在该地区的高职院校中全面展开,并已经取得了初步成效,但仍然存在发展不充分的问题。对调查所得出的结论进行认真的分析,找到根源,针对性提出解决的措施,将有益于“三全育人”工作在高职院校的贯彻落实。

关键词：高职院校三全育人思想政治教育

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Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand

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Journal of Rare Earths 2018年第4期36卷 418-423页

作者： Linyan Yang Yanping Zhang Liwei Hu yunhe Zong Ruili zhao Tianming Jin Wen Gu College of Animal Science and Veterinary Medicine Tianjin Agricultural UniversityTianjin 300384China Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004China College of Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300071China Key Laboratory of Advanced Energy Materials Chemistry(KLAEMC) Nankai UniversityTianjin 300071China

Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis（TGA） and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells＇ proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.

关键词： Rare earth Fluorescence Cell imaging

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