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Development of Chinese herbal medicine for sensorineural hearing loss

Acta Pharmaceutica Sinica B 2024年第2期14卷 455-467页

作者： yunhao Wu Jingwen zhang Qiuping Liu Zhuang Miao Renjie Chai Wenyong Chen State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced Institute for Life and HealthJiangsu Province HighTech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology-Head and Neck the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China Department of Otolaryngology-Head and Neck Surgery Affiliated Hospital of Jiangnan UniversityWuxi 214000China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610000China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100085China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

According to the World Health Organization’s world report on hearing,nearly 2.5 billion people worldwide will suffer from hearing loss by 2050,which may contribute to a severe impact on individual life quality and national economies.Sensorineural hearing loss(SNHL)occurs commonly as a result of noise exposure,aging,and ototoxic drugs,and is pathologically characterized by the impairment of mechanosensory hair cells of the inner ear,which is mainly triggered by reactive oxygen species accumulation,inflammation,and mitochondrial dysfunction.Though recent advances have been made in understanding the ability of cochlear repair and regeneration,there are still no effective therapeutic drugs for SNHL.Chinese herbal medicine which is widely distributed and easily accessible in China has demonstrated a unique curative effect against SNHL with higher safety and lower cost compared with Western medicine.Herein we present trends in research for Chinese herbal medicine for the treatment of SNHL,and elucidate their molecular mechanisms of action,to pave the way for further research and development of novel effective drugs in this field.

关键词： Sensorineural hearing loss Chinese herbal medicine Molecular mechanism Active ingredients Prescriptions Ototoxic drugs Noise Hair cells

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Troy: Efficient Service Deployment for Windows Systems

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Chinese Journal of Electronics 2024年第1期33卷 313-322页

作者： Deyu zhang Yu XIE Mucong XU En CHENG Xiaoyan KUI Bangwen HE yunhao LI School of Computer Science and Engineering Central South University

The modern university computer lab and kindergarden through 12th grade classrooms require a centralized solution to efficiently manage a large number of desktops. The existing solutions either bring virtualization overhead in runtime or requires loading a large image over 30 GB leading to an unacceptable network latency. In this work, we propose Troy which takes advantage of the differencing virtual hard disk techniques in Windows systems.As such, Troy only loads the modifications made on one machine to all other machines. Troy consists of two modules that are responsible to generate an initial image and merge a differencing image with its parent image, respectively. Specifically, we identify the key fields in the virtual hard disk image that links the differencing image and the parent image and find the modified blocks in the differencing images that should be used to replace the blocks in the parent image. We further design a lazy copy solution to reduce the I/O burden in image merging. We have implemented Troy on bare metal machines. The evaluation results show that the performance of Troy is comparable to the native implementation in Windows, without requiring the Windows environment.

关键词： Service deployment Virtual hard disk File system merging Windows system

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Pre-locate net for object detection in high-resolution images

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Chinese Journal of Aeronautics 2022年第10期35卷 313-325页

作者： yunhao zhang Tingbing XU Zhenzhong WEI Key Laboratory of Precision Opto-mechatronics Technology Ministry of Educationand the School of Instrumentation and Optoelectronic EngineeringBeihang UniversityBeijing 100083China

Small-object detection has long been a challenge.High-megapixel cameras are used to solve this problem in industries.However,current detectors are inefficient for high-resolution images.In this work,we propose a new module called Pre-Locate Net,which is a plug-and-play structure that can be combined with most popular detectors.We inspire the use of classification ideas to obtain candidate regions in images,greatly reducing the amount of calculation,and thus achieving rapid detection in high-resolution images.Pre-Locate Net mainly includes two parts,candidate region classification and behavior classification.Candidate region classification is used to obtain a candidate region,and behavior classification is used to estimate the scale of an object.Different follow-up processing is adopted according to different scales to balance the variance of the network input.Different from the popular candidate region generation method,we abandon the idea of regression of a bounding box and adopt the concept of classification,so as to realize the prediction of a candidate region in the shallow network.We build a high-resolution dataset of aircraft and landing gears covering complex scenes to verify the effectiveness of our method.Compared to state-of-the-art detectors(e.g.,Guided Anchoring,Libra-RCNN,and FASF),our method achieves the best m AP of 94.5 on 1920×1080 images at 16.7 FPS.

关键词： Aircraft and landing gear detection Candidate region Convolutional neural network High resolution images Small object

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Repairing of rutin to the toxicity of combined F-53B and chromium pollution on the biofilm formed by Pseudomonas aeruginosa

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Journal of Environmental Sciences 2023年第5期127卷 158-168页

作者： yunhao zhang Yi Qian Ming zhang Weichuan Qiao Department of Environmental Engineering College of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China

The wastewater discharge from the process of chrome plating,which contains 6:2 chlorinated polyfluorinated ether sulfonate(F-53B)and chromium(Cr),may be toxic to biofilm.In this study we found that the biofilm formed by Pseudomonas aeruginosa PAO1 was inhibited by exposure to a combination of F-53B and Cr(VI).The combined pollution damaged the cell membranes and the structure of the biofilm,and inhibited the production of the Pseudomonas quinolone-based signal,which affected biofilm formation.Moreover,the secretion of extracellular polymeric substances decreased as a result of this combined exposure.Exposure to F-53B and Cr(VI)individually or in combination could induce the excessive accumulation of intracellular reactive oxygen species(ROS),and the ROS positive rate of the bacteria increased under the treatment with 0.2 mmol/L of Cr(VI)and 250 nmol/L of F-53B,respectively.In addition,the activities of superoxide dismutase(SOD)and catalase(CAT)were enhanced for scavenging ROS in the bacteria that were exposed to Cr(VI)and F-53B.As an antioxidant,rutin was used to repair the toxicity of Cr(VI)and F-53B towards the biofilm formed by the bacteria.When rutin was added to the bacteria medium,with either Cr(VI)or F-53B as pollutant,or with the combined pollutants,the extracellular protein content of the bacteria recovered to 0.84,0.94,and 0.85 times that of the control,respectively.Meanwhile,the accumulation of ROS and the activities of SOD and CAT decreased,which indicated that the addition of rutin can alleviate the oxidative stress and promote the antioxidant stress system.

关键词： F-53B Chromium(Cr) Rutin Biofilm Toxic effect Repair

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Enhancing Photovoltaic Performance of Nonfused-Ring Electron Acceptors via Asymmetric End-Group Engineering and Noncovalently Conformational Locks

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Chinese Journal of Chemistry 2024年第5期42卷 485-490页

作者： Bo Liu Congqi Li Xiaobin Gu Yinghui Han Zhixiang Wei yunhao Cai Xin zhang Hui Huang Yanping Huo School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong510006 China College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physics University of Chinese Academy of SciencesBeijing100049 China College Resources and Environment University of Chinese Academy of SciencesBeijing100049 China Center for Excellence in Nanoscience (CAS) & Key Laboratory of Nanosystem and Hierarchical Fabrication (CAS) National Center for Nanoscience and TechnologyBeijing100190 China

By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and synthesized.Compared with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical results.The organic solar cells based on J52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of J52:NoCA-17(9.50%)and J52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film morphology.These findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs.

关键词： Organic solar cells Nonfused-ring electron acceptors Asymmetric end-group engineering Noncovalently conformational locks Low-cost acceptors

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Boosting Fischer-Tropsch Synthesis via Tuning of N Dopants in TiO_(2)@CN-Supported Ru Catalysts

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Transactions of Tianjin University 2024年第1期30卷 90-102页

作者： Xincheng Li yunhao Liu Dejian Zhao Shuaishuai Lyu Jingwei Ye Xiaoshen Li Peipei Wu Ye Tian Yingtian zhang Tong Ding Song Song Qingpeng Cheng Xingang Li State Key Laboratory of Chemical Engineering Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Haihe Laboratory of Sustainable Chemical TransformationsTianjin Key Laboratory of Applied Catalysis Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Zhejiang Institute of Tianjin University Shaoxing 312300China Sinopec Research Institute of Petroleum Processing Co. LTDBeijing 100083China Physical Sciences and Engineering Division Advanced Membranes and Porous Materials(AMPM)CenterKing Abdullah University of Science and Technology(KAUST)23955-6900 ThuwalSaudi Arabia

Nitrogen(N)-doped carbon materials as metal catalyst supports have attracted signifi cant attention,but the eff ect of N dopants on catalytic performance remains unclear,especially for complex reaction processes such as Fischer-Tropsch synthesis(FTS).Herein,we engineered ruthenium(Ru)FTS catalysts supported on N-doped carbon overlayers on TiO_(2)nanoparticles.By regulating the carbonization temperatures,we successfully controlled the types and contents of N dopants to identify their impacts on metal-support interactions(MSI).Our fi ndings revealed that N dopants establish a favorable surface environment for electron transfer from the support to the Ru species.Moreover,pyridinic N demonstrates the highest electron-donating ability,followed by pyrrolic N and graphitic N.In addition to realizing excellent catalytic stability,strengthening the interaction between Ru sites and N dopants increases the Ru^(0)/Ru^(δ+)ratios to enlarge the active site numbers and surface electron density of Ru species to enhance the strength of adsorbed CO.Consequently,it improves the catalyst’s overall performance,encompassing intrinsic and apparent activities,as well as its ability for carbon chain growth.Accordingly,the as-synthesized Ru/TiO_(2)@CN-700 catalyst with abundant pyridine N dopants exhibits a superhigh C_(5+)time yield of 219.4 mol CO/(mol Ru·h)and C_(5+)selectivity of 85.5%.

关键词： Fischer-Tropsch synthesis N-doped carbon materials Ruthenium catalyst Pyridinic N Metal-N interaction

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Degradation behavior of ZE21C magnesium alloy suture anchors and their effect on ligament-bone junction repair

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Bioactive Materials 2023年第8期26卷 128-141页

作者： Delin Ma Jun Wang Mingran Zheng Yuan zhang Junfei Huang Wenxiang Li Yiwen Ding yunhao zhang Shijie Zhu Liguo Wang Xiaochao Wu Shaokang Guan School of Material Science and Engineering Zhengzhou UniversityZhengzhou450001China Henan Key Laboratory of Advanced Magnesium Alloys Zhengzhou450002China Key Laboratory of Advanced Materials Processing&Mold Ministry of EducationZhengzhou450002China Shimadzu(China)Co. LtdShenzhen BranchShenzhen528042China Zhengzhou Orthopedic Hospital Zhengzhou450053China

Current materials comprising suture anchors used to reconstruct ligament-bone junctions still have limitation in biocompatibility,degradability or mechanical properties.Magnesium alloys are potential bone implant materials,and Mg^(2+) has been shown to promote ligament-bone healing.Here,we used Mg-2 wt.%Zn-0.5 wt.%Y-1 wt.%Nd-0.5 wt.%Zr(ZE21C)alloy and Ti6Al4V(TC4)alloy to prepare suture anchors to reconstruct the patellar ligament-tibia in SD rats.We studied the degradation behavior of the ZE21C suture anchor via in vitro and in vivo experiments and assessed its reparative effect on the ligament-bone junction.In vitro,the ZE21C suture anchor degraded gradually,and calcium and phosphorus products accumulated on its surface during degradation.In vivo,the ZE21C suture anchor could maintain its mechanical integrity within 12 weeks of implantation in rats.The tail of the ZE21C suture anchor in high stress concentration degraded rapidly during the early implantation stage(0-4weeks),while bone healing accelerated the degradation of the anchor head in the late implantation stage(4-12weeks).Radiological,histological,and biomechanical assays indicated that the ZE21C suture anchor promoted bone healing above the suture anchor and fibrocartilaginous interface regeneration in the ligament-bone junction,leading to better biomechanical strength than the TC4 group.Hence,this study provides a basis for further research on the clinical application of degradable magnesium alloy suture anchors.

关键词： ZE21C Suture anchor Degradation behavior Reparative effect Ligament-bone junction

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利用无线电极化特征的跳频网台分选方法

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电子与信息学报 2024年第4期46卷 1286-1295页

作者：齐子森张梓轩许华史蕴豪空军工程大学信息与导航学院西安710077

针对现有方法在跳频通信用户“空时频能”域特征相近、跳频参数捷变等条件下,跳频网台分类识别效果不佳的问题,该文提出一种基于无线电极化特征的跳频用户分选方法。该方法将无线电双极化特征引入到跳频侦察,充分利用各用户的交叉极化... 详细信息

针对现有方法在跳频通信用户“空时频能”域特征相近、跳频参数捷变等条件下,跳频网台分类识别效果不佳的问题,该文提出一种基于无线电极化特征的跳频用户分选方法。该方法将无线电双极化特征引入到跳频侦察,充分利用各用户的交叉极化鉴别度差异,实现了跳频网台精准分选。针对同类用户交叉极化鉴别度参数易受噪声污染的问题,构建了双通道双极化接收系统,抑制了信号噪声,保证了极化特征提取的精度。在此基础上,基于谱聚类思想,完成了极化特征的分类软判决,进一步提升了跳频网台分选效果,实现了跳频信号的精准识别。仿真实验表明,在5 dB信噪比条件下,所提方法可对同步正交和非正交组网方式下的多跳频网台准确识别,识别分类成功率达99%以上,验证了新方法的有效性。

关键词：跳频网台极化特征分选识别

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公共政策过程中的知识运用:理论模型与演进逻辑

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北京行政学院学报 2024年第2期61卷 96-108页

作者：张云昊中国海洋大学国际事务与公共管理学院山东青岛266100

随着现代社会问题的日益复杂与技术化,在公共政策过程中寻求学术研究的知识支持就逐渐成为一个多学科交叉的前沿议题。为此,在梳理西方知识运用理论发展脉络和最新进展的基础上,提出了知识运用理论的相关性模型、政策知识模型、知识中... 详细信息

随着现代社会问题的日益复杂与技术化,在公共政策过程中寻求学术研究的知识支持就逐渐成为一个多学科交叉的前沿议题。为此,在梳理西方知识运用理论发展脉络和最新进展的基础上,提出了知识运用理论的相关性模型、政策知识模型、知识中介模型、知识“共生产”模型以及过程运用模型。通过对五大理论模型的预设、内容、功能、缺陷等方面的分析,探讨了它们之间的演进逻辑:在认知逻辑上,知识运用理论正由客观主义的“为了政策的知识”向建构主义的“政策中的知识”转向;在实践逻辑上,知识运用理论形成了结果主义和过程主义两大范式。知识运用的五大模型和演进逻辑为中国背景下的研究与实践提供了“理论地图”和重要启示。

关键词：公共政策知识运用理论模型演进逻辑

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网络科学理论与方法在旅游领域中的应用:研究进展与展望

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地球信息科学学报 2024年第2期26卷 259-273页

作者：郑允豪张毅牟乃夏蒋琪刘瑜北京大学地球与空间科学学院遥感与地理信息系统研究所北京100871 山东科技大学测绘与空间信息学院青岛266590 中国海洋大学信息科学与工程学部青岛266100

网络科学为全面探索旅游领域中各研究对象间的动态关系结构提供了有力支撑,打破了传统研究缺乏系统性思维的局限,对于进一步理解旅游业的运行规律具有重要意义。近年来随着旅游业的数字化变革,旅游信息变得更具灵活性与可扩展性,大幅提... 详细信息

网络科学为全面探索旅游领域中各研究对象间的动态关系结构提供了有力支撑,打破了传统研究缺乏系统性思维的局限,对于进一步理解旅游业的运行规律具有重要意义。近年来随着旅游业的数字化变革,旅游信息变得更具灵活性与可扩展性,大幅提高了网络科学理论与方法在旅游领域中的应用可行性。本文对与网络科学理论与方法在旅游领域中的应用研究相关的学术论文进行了系统梳理,并通过多尺度的视角归纳该领域的核心研究内容。本文首先概述了相关理论基础和应用现状,之后根据不同观测尺度下的旅游领域网络现象进行研究进展总结,具体为:微观尺度关注于目标旅游行动者的交互属性,介观尺度关注于旅游行动者的聚集现象,宏观尺度关注于旅游行动者网络的全局拓扑结构特征。在此基础上,本文指出了当前研究存在的问题(如数据可靠性、成果可解释性等),并对相关研究在当前的大数据时代与复杂性科学新纪元背景下的未来发展方向(如多尺度研究框架、多层网络等)进行了梳理,从而为后续研究提供思路。

关键词：旅游研究网络科学系统论信息化旅游管理社会网络复杂性

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