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Cryogenic and conventional milling of AZ91 magnesium alloy

Journal of Magnesium and Alloys 2024年第6期12卷 2503-2519页

作者： Vikas Marakini Srinivasa pai P Gururaj Bolar Bhaskara P Achar Department of Mechanical Engineering Nitte(Deemed to be University)NMAM Institute of Technology(NMAMIT)Nitte 574110India Department of Mechanical and Industrial Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal 576104India

Use of magnesium is the need of the hour due to its low density as well as its high strength-to-weight and stiffness-to-weight ratio *** study focuses on the effectiveness of liquid nitrogen(LN_(2))assisted cryogenic machining on the surface integrity(SI)characteristics of AZ91 magnesium *** milling using uncoated carbide inserts have been performed under liquid nitrogen(LN_(2))assisted cryogenic condition and compared with conventional(dry)*** are performed using machining parameters in terms of cutting speeds of 325,475,625 m/min,feed rates of 0.05,0.1,0.15 mm/teeth and depth of cuts of 0.5,1,1.5 mm *** significant surface integrity characteristics such as surface roughness,microhardness,microstructure,and residual stresses have been *** of SI characteristics with respect to milling parameters have been identified using statistical technique such as ANOVA and signal-to-noise(S/N)ratio ***,the multi criteria decision making(MCDM)techniques such as additive ratio assessment method(ARAS)and complex proportional assessment(COPRAS)have been utilized to identify the optimal conditions for milling AZ91 magnesium alloy under both dry and cryogenic *** of LN_(2)during machining,resulted in reduction in machining temperature by upto 29%with a temperature drop from 251.2℃under dry condition to 178.5℃in cryogenic *** showed the advantage of performing cryogenic milling in improving the surface integrity to a significant *** machining considerably minimized the roughness by upto 28%and maximised the microhardness by upto 23%,when compared to dry *** speed has caused significant impact on surface roughness(95.33%-dry,92.92%-cryogenic)and surface microhardness(80.33%-dry,82.15%-cryogenic).Due to the reduction in machining temperature,cryogenic condition resulted in compressive residual stresses(maximumσ║=-113 MPa)on the alloy *** indicate no

关键词： Magnesium alloy Cryogenic machining Roughness Microhardness Microstructure Residual stress Multi criteria decision making

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Hybrid-type white LEDs based on inorganic halide perovskite QDs: candidates for wide color gamut display backlights

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Photonics Research 2019年第5期7卷 579-585页

作者： Chih-Hao Lin Akta Verma Chieh-Yu Kang yung-min pai Tzu-Yu Chen Jin-Jia Yang Chin-Wei Sher Ya-Zhu Yang Po-Tsung Lee Chien-Chung Lin Yu-Chuan Wu S. K. Sharma Tingzhu Wu Shu-Ru Chung Hao-Chung Kuo Department of Photonics and Institute of Electro-Optical Engineering College of Electrical and Computer Engineering Taiwan Chiao Tung University Hsinchu 30010 China Department of Applied Physics Indian Institute of Technology (Indian School of Mines) Dhanbad-826004 India Fok Ying Tung Research Institute Hong Kong University of Science and Technology Hong Kong China Department of Materials Science and Engineering Taiwan Formosa University Yunlin 63201 China Institute of Photonic System College of Photonics Taiwan Chiao Tung University Tainan 711 China Department of Materials and mineral Resources Engineering Taiwan Taipei University of Technology Taipei 10608 China Department of Chemical and Materials Engineering Chinese Culture University Taipei 11114 China Department of Electronic Science Fujian Engineering Research Center for Solid-state Lighting Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient Devices Xiamen University Xiamen 361005 China

We demonstrate inorganic halide perovskite quantum-dots-based white light-emitting diodes via three different geometries, including liquid, solid, and hybrid types. Problems of fast anion exchange and aggregation in the cases of liquidand solid-type devices are discussed in detail and push us to move towards the fabrication of a hybrid-type device structure. The experiment results illustrate that a hybrid-type device has the highest luminance efficiency(51 lm/W) and a wide color gamut(122% of NTSC and 91% of Rec. 2020). Therefore, we conclude that a hybrid-type device can provide an outstanding color gamut for high color gamut display applications.

关键词： LEDs QDs wide color gamut display backlights

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Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-min Zhang Ken Kin Lam yung Zhi-Ping Lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong Ji EunJin Bang Hyun Hwangbo min Yeong Kim Da Hye Kim Su Hyun Hong Shin-Hyung Park Chang-Young Kwon Gi-Young Kim You-Jin Jeon Suengmok Cho yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

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基于第一性原理GGA+U方法研究Si掺杂β-Ga_(2)O_(3)电子结构和光电性质

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物理学报 2024年第1期73卷 296-305页

作者：张英楠张敏张派胡文博辽宁师范大学物理与电子技术学院大连116029

采用基于密度泛函理论的GGA+U方法,计算了本征和Si掺杂β-Ga_(2)O_(3)的形成能、能带结构、态密度、差分电荷密度和光电性质.结果表明,Si取代四面体Ga(1)更容易实验合成,得到的β-Ga_(2)O_(3)带隙和Ga-3d态峰值与实验结果吻合较好,且贫... 详细信息

采用基于密度泛函理论的GGA+U方法,计算了本征和Si掺杂β-Ga_(2)O_(3)的形成能、能带结构、态密度、差分电荷密度和光电性质.结果表明,Si取代四面体Ga(1)更容易实验合成,得到的β-Ga_(2)O_(3)带隙和Ga-3d态峰值与实验结果吻合较好,且贫氧条件下更倾向于获得有效掺杂.Si掺杂后,总能带向低能端移动,费米能级进入导带,呈现n型导电性;Si-3s轨道电子占据导带底,电子公有化程度加强,电导率明显改善.随着Si掺杂浓度的增加,介电函数ε_(2)(ω)的结果表明,激发导电电子的能力先增强后减弱,与电导率的量化分析结果一致.光学带隙增大,吸收带边上升速度减慢;吸收光谱结果显示Si掺杂β-Ga_(2)O_(3)具有较强的深紫外光电探测能力.计算结果将为下一步Si掺杂β-Ga_(2)O_(3)实验研究和器件设计的创新及优化提供理论参考.

关键词： GGA+U方法 Si掺杂β-Ga_(2)O_(3) 电子结构光电性质

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双钙钛矿卤化物Cs_(2)AgFeX_(6)(X=Cl, Br, I)电子结构和光学性质的第一性原理研究

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原子与分子物理学报 2024年第1期41卷 145-153页

作者：郝久源张敏刘派李瑞祖宁宁齐齐哈尔大学理学院齐齐哈尔161000

近年来,银卤化物双钙钛矿作为铅基杂化卤化物钙钛矿的潜在环保替代品得到了广泛的研究.最近实验上合成的新型无铅双钙钛矿单晶材料Cs_(2)AgFeCl_(6)是一种立方结构半导体,吸收光谱可拓宽至800 nm.本论文采用密度泛函理论的第一性原理方... 详细信息

近年来,银卤化物双钙钛矿作为铅基杂化卤化物钙钛矿的潜在环保替代品得到了广泛的研究.最近实验上合成的新型无铅双钙钛矿单晶材料Cs_(2)AgFeCl_(6)是一种立方结构半导体,吸收光谱可拓宽至800 nm.本论文采用密度泛函理论的第一性原理方法,对Cs_(2)AgFeX_(6)(X=Cl, Br, I)的电子结构和光学性质进行研究,讨论了二者之间的内在关联,并分析了X位元素的改变对材料性质的影响.电荷密度计算结果显示,由Cl到I,Fe-X键逐渐减弱,即原子对电荷的束缚能力减弱.另一方面,三种材料的带隙宽度是逐渐减小的,Cs_(2)AgFeCl_(6)和Cs_(2)AgFeBr6带隙分别为1.40 eV和0.91 eV,而Cs_(2)AgFeI6则呈现金属性质. Cs_(2)AgFeX_(6)双钙钛矿的光谱特征峰随X位原子序数的增加明显红移,且在可见至红外光波段均有明显的光吸收:Cs_(2)AgFeCl_(6)在534 nm处的吸收系数达到21.28×10^(4)cm^(-1),Cs_(2)AgFeBr6在712 nm处的吸收系数为20.54×10^(4)cm^(-1),而Cs_(2)AgFeI6在1200 nm后的红外波段有一极宽的吸收峰,吸收系数可以达到10×10^(4)cm^(-1).本论文为Cs_(2)AgFeX_(6)(X=Cl, Br, I)在光电子器件领域的广泛应用提供了理论指导.

关键词：光学性质电子结构第一性原理双钙钛矿介电函数

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基于“营卫-络脉-玄府”论治开角型青光眼

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湖南中医药大学学报 2024年第8期44卷 1484-1489页

作者：陈姝好周派艾民彭清华湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

原发性开角型青光眼(primary open-angle glaucoma,POAG)是一种以眼压升高、房角开放、房水流出受阻为特征的眼科常见疾病,其早期病情隐匿,发病时已成为不可逆转的致盲性伤害。POAG的发病与营卫、络脉生理病理功能密切相关,产生“营卫-... 详细信息

原发性开角型青光眼(primary open-angle glaucoma,POAG)是一种以眼压升高、房角开放、房水流出受阻为特征的眼科常见疾病,其早期病情隐匿,发病时已成为不可逆转的致盲性伤害。POAG的发病与营卫、络脉生理病理功能密切相关,产生“营卫-络脉-玄府”病机轴。营卫失和、玄府郁闭、气血升降失常、络脉循环瘀阻共同引起POAG发病,基于此病理发展过程探讨治疗POAG的基本原理,丰富从“营卫-络脉-玄府”理论治疗POAG的科学内涵,并附临床验案一则,以期为POAG的中医诊疗提供参考依据。

关键词：原发性开角型青光眼营卫玄府络脉活血利水法

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Increasing ionic conductivity in Li_(0.33)La_(0.56)TiO_(3)thin-films via optimization of processing atmosphere and temperature

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Rare Metals 2022年第1期41卷 179-188页

作者： Shi-pai Song Cheng Yang Chun-Zhi Jiang Yong-min Wu Rui Guo He Sun Jing-Lei Yang Yong Xiang Xiao-Kun Zhang School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power-SourcesShanghai 200245China Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Advanced Energy Research Institute University of Electronic Science and Technology of ChinaChengdu 611731China Sichuan Provincial Engineering Research Center of Flexible Display Material Genome University of Electronic Science and Technology of ChinaChengdu 611731China

As a promising solid electrolyte for thin-film lithium batteries,the amorphous Li_(0.33)La_(0.56)TiO_(3)(LLTO)thin film has gained great ***,enhancing ionic conductivity remains challenging in the ***,a systematical study was performed to improve the ionic conductivity of sputter-deposited LLTO thin films via the optimization of processing atmosphere and *** combining the optimized oxygen partial pressure(30%),annealing temperature(300℃),and annealing atmosphere(air),an amorphous LLTO thin film with an ionic conductivity of 5.32910^(-5)·S·cm^(-1) at room temperature and activation energy of 0.26 eV was *** results showed that,first,the oxygen partial pressure should be high enough to compensate for the oxygen loss,but low enough to avoid the abusive oxygen scattering effect on lithium precursors that results in a lithium-poor *** oxygen partial pressure needs to achieve a balance between lithium loss and oxygen defects to improve the ionic ***,a proper annealing temperature reduces the oxygen defects of LLTO thin films while maintaining its amorphous state,which improves the ionic ***,the highest ionic conductivity for the LLTO thin films that were annealed in air(a static space without a gas stream)occurs because of the decreased lithium loss and oxygen defects during *** findings show that the lithium-ion concentration and oxygen defects affect the ionic conductivity for amorphous LLTO thin films,which provides insight into the optimization of LLTO thin-film solid electrolytes,and generates new opportunities for their application in thinfilm lithium batteries.

关键词： Li_(0.33)La_(0.56)TiO_(3) Thin film Ionic conductivity Lithium-ion concentration Oxygen defects

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滋阴明目方通过Akt/FoxO1/FasL通路抑制感光细胞凋亡治疗视网膜色素变性的机制研究

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湖南中医药大学学报 2024年第2期44卷 206-212页

作者：艾民李丹阳周派彭俊杨毅敬彭清华湖南中医药大学湖南长沙410208 湖南中医药大学第一附属医院湖南长沙410007

目的观察滋阴明目方对视网膜色素变性(retinitis pigmentosa,RP)小鼠视网膜组织中磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)、叉头框蛋白1(forkhead box transcription factor O1,FoxO1)以及凋亡相关因子配体(Fas ligand,FasL)表达的影响,探讨滋阴明目方抑制感光细胞凋亡的机制。方法将60只rd10小鼠随机分为模型组、滋阴明目方低剂量组[10 g/(kg·d)]、滋阴明目方中剂量组[20 g/(kg·d)]、滋阴明目方高剂量组[40 g/(kg·d)]、维生素A组[5 g/(kg·d)],每组12只;选取12只C57小鼠作为空白对照组(等量生理盐水),每组连续干预28 d。通过眼底照相观察小鼠眼底形态改变;进行视网膜电图检查并记录A波和B波振幅;HE染色观察病理形态学变化并测定外核层厚度;Western blot法检测小鼠视网膜组织p-Akt、FoxO1、FasL、半胱氨酸天冬氨酸特异性蛋白(cysteine aspartate-specific protease,Caspase)-3和Caspase-8蛋白表达。结果与空白对照组比较,模型组小鼠视盘苍白、变形,血管萎缩,视网膜电图的A波与B波振幅均降低(P<0.01),视网膜结构模糊,各层界限不清,感光细胞大量丧失,外核层明显变薄(P<0.01),视网膜组织中p-Akt蛋白表达水平明显降低(P<0.01),FoxO1、FasL、Caspase-3和Caspase-8蛋白表达水平明显升高(P<0.01)。与模型组比较,滋阴明目方中、高剂量组及维生素A组小鼠眼底血管较清晰,无视盘苍白表现;视网膜各层结构清晰,细胞排列相对整齐。与模型组、滋阴明目方低剂量组比较,滋阴明目方中、高剂量组的A波与B波振幅、视网膜外核层厚度均明显升高(P<0.01),维生素A组的B波振幅、视网膜外核层厚度明显升高(P<0.01);与滋阴明目方中剂量组比较,滋阴明目方高剂量组的A波与B波振幅、视网膜外核层厚度均明显升高(P<0.01),维生素A组的A波与B波振幅均明显降低(P<0.01);与滋阴明目方高剂量组比较,维生素A组的A波与B波振幅、视网膜外核层厚度均明显降低(P<0.01)。与模型组比较,滋阴明目方低、中、高剂量组和维生素A组p-Akt蛋白表达水平明显升高(P<0.01),FoxO1、FasL和Caspase-3蛋白表达水平降低(P<0.05,P<0.01),滋阴明目方中、高剂量组Caspase-8蛋白表达水平明显降低(P<0.01)。与滋阴明目方低剂量组比较,滋阴明目方高剂量组和维生素A组p-Akt蛋白表达水平明显升高(P<0.01),滋阴明目方中、高剂量组FoxO1、FasL、Caspase-3和Caspase-8蛋白表达水平明显降低(P<0.01)。与滋阴明目方中剂量组比较,滋阴明目方高剂量组和维生素A组p-Akt蛋白表达水平明显升高(P<0.01),滋阴明目方高剂量组FoxO1、Caspase-3和Caspase-8蛋白表达水平明显降低(P<0.01),维生素A组FoxO1、FasL、Caspase-3和Caspase-8蛋白表达水平明显升高(P<0.01)。与滋阴明目方高剂量组比较,维生素A组p-Akt蛋白表达水平明显降低(P<0.01),FoxO1、FasL、Caspase-3和Caspase-8蛋白表达水平明显升高(P<0.01)。结论滋阴明目方可能通过调控Akt/FoxO1/FasL通路,增强p-Akt表达,抑制FoxO1及下游基因FasL、Caspase-3和Caspase-8的蛋白表达,从而减少rd10小鼠视网膜细胞的凋亡,保护视网膜结构和功能,延缓RP的进展。

关键词：视网膜色素变性滋阴明目方磷酸化蛋白激酶B 叉头框蛋白1 凋亡相关因子配体感光细胞细胞凋亡

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Baculoviral inhibitor of apoptosis protein repeatcontaining protein 3 delays early Wallerian degeneration after sciatic nerve injury

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Neural Regeneration Research 2022年第4期17卷 845-853页

作者： min Cai Jian Shao Bryant yung Yi Wang Nan-Nan Gao Xi Xu Huan-Huan Zhang Yu-Mei Feng Deng-Bing Yao Nantong University Medical School NantongJiangsu ProvinceChina School of Life Sciences Jiangsu Key Laboratory of NeuroregenerationCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Wallerian degeneration is a complex biological process that occurs after nerve injury,and involves nerve degeneration and *** cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nervous ***,Wallerian degeneration regulating nerve injury and repair remains largely unknown,especially the early *** have previously reported some key regulators of Wallerian degeneration after sciatic nerve *** inhibitor of apoptosis protein repeat-containing protein 3(BIRC3)is an important factor that regulates apoptosis-inhibiting *** this study,we established rat models of right sciatic nerve *** vitro Schwann cell models were also established and subjected to gene transfection to inhibit and overexpress *** data indicated that BIRC3 expression was significantly up-regulated after sciatic nerve *** BIRC3 upregulation and downregulation affected the migration,proliferation and apoptosis of Schwan cells and affected the expression of related factors through activating c-fos and ERK signal *** of BIRC3 delayed early Wallerian degeneration through inhibiting the apoptosis of Schwann cells after sciatic nerve *** findings suggest that BIRC3 plays an important role in peripheral nerve injury repair and *** study was approved by the Institutional Animal Care and Use Committee of Nantong University,China(approval No.2019-nsfc004)on March 1,2019.

关键词： apoptosis baculoviral inhibitor of apoptosis protein repeat-containing protein 3 nerve degeneration rat Schwann cell sciatic nerve injury signal pathway Wallerian degeneration

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