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Toxicity and Carcinogenicity of Ozone in Combination with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and Dibutyl Phthalate in B6C3F1 Mice for 16 and 32 Weeks

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Biomedical and Environmental Sciences 2009年第3期22卷 216-222页

作者： MIN YOUNG KIM M yung cho Laboratory of Toxicology College of Veterinary MedicineSeoul National University Biological Engineering Department Massachusetts Institute of Technology

Objective To evaluate the toxic and carcinogenic potential of ozone alone or in combination with 4-（N-methyl-N-nitrosamino）-1-（3-pyridyl）-1-butanone （NNK） and/or dibutyl phthalate （DBP）. Methods Male and female B6C3F1 mice were exposed, through inhalation, intravenous administration and diet, to 0.5 ppm of ozone, 1.0 mg/kg of NNK and 5000 ppm of DBP, individually and in combination for 16 and 32 weeks. Results No treatment-related death was seen, but significant differences in body and organ weights between control and treated mice were observed during the study. No incidence of lung tumor incidence was recorded in mice exposed to either ozone alone or combined treatment. Oviductal carcinomas were observed in female mice exposed to ozone or DBP alone for 16 weeks and ozone in combination with NNK and DBP for 32 weeks. Conclusion Although ozone alone and in conjunction with NNK and/or DBP does not induce lung cancer under our experimental conditions, they induce oviductal carcinomas in B6C3F1 mice.

关键词： Ozone NNK DBP Combined treatment Toxicity Carcinogenicity

LiNbO_3 Self-Aligned Ridge Waveguide with Dielectric Side Buffers

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光学学报 2003年第S1期23卷 211-212页

作者： Young-Bo cho Hyung-Gi Jung Sang-yung Shin Dept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of KoreaDept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of KoreaDept. EECS Korea Advanced Institute of Science and Technology 373-1 Kusong-dong Yusong-gu Dae jeon. Republic of Korea

A simple fabrication method of self-aligned ridge waveguides with dielectric side buffers is demonstrated on +Z-cut LiNbO3. The ridge waveguide is fabricated by a combination of the annealed proton exchange process an... 详细信息

关键词： with of it In is LiNbO3 Self-Aligned Ridge Waveguide with Dielectric Side Buffers have Cr for been APE length

Thermal Dechlorination Kinetics of Rare Earth Oxychlorides

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Journal of Rare Earths 2007年第S1期25卷 8-12页

作者： Hee-Chul Yang Yong-zun cho Hee-Chul Eun Eung-Ho Kim In-Tae Kim Advanced Fuel Cycle Process Development Group Korea Atomic Energy ResearchInstituteDaejeon 305-353 Korea

The kinetics of a thermal dechlorination and oxidation of NdOCl and GdOCl were investigated by using a non-isothermal thermogravimetric analysis under various oxygen partial pressures. The conversions of NdOCl and GdOCl into each of their stable oxides (Nd2O3 and Gd2O3) appeared to be an oxygen-dependent endothermic and one-step reaction. The observed activation energy for the conversions of NdOCl and GdOCl were determined as 228.3±6.1 kJ·mole-1 and 137.7±4.1 kJ·mole-1, respectively. The conversions of NdOCl and GdOCl into each of their stable oxides (Nd2O3 and Gd2O3) could be described by a power law (g(α)=α3/2) and a linear-contracting boundary reaction (g(α)=α), respectively.

关键词： oxychloride dechlorination oxidation high temperature rare earths

Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen speciesmediated DNA damage and apoptosis in PC12 cells

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Neural Regeneration Research 2016年第5期11卷 795-800页

作者： Yi Wang Xiao-ting Fu Da-wei Li Kun Wang Xin-zhi Wang Yuan Li Bao-liang Sun Xiao-yi Yang zun-cheng Zheng Nam Chun cho Department of Ophthalmology Chonbuk National University Medical College Key Lab of Cerebral Microcirculation in Universities of Shandong Taishan Medical University Department of Rehabilitation Taian Central Hospital

Amyloid beta（Aβ）-induced oxidative stress is a major pathologic hallmark of Alzheimer＇s disease. Cyanidin, a natural flavonoid compound, is neuroprotective against oxidative damage-mediated degeneration. However, its molecular mechanism remains unclear. Here, we investigated the effects of cyanidin pretreatment against Aβ-induced neurotoxicity in PC12 cells, and explored the underlying mechanisms. Cyanidin pretreatment significantly attenuated Aβ-induced cell mortality and morphological changes in PC12 cells. Mechanistically, cyanidin effectively blocked apoptosis induced by Aβ, by restoring the mitochondrial membrane potential via upregulation of Bcl-2 protein expression. Moreover, cyanidin markedly protected PC12 cells from Aβ-induced DNA damage by blocking reactive oxide species and superoxide accumulation. These results provide evidence that cyanidin suppresses Aβ-induced cytotoxicity, by preventing oxidative damage mediated by reactive oxide species, which in turn inhibits mitochondrial apoptosis. Our study demonstrates the therapeutic potential of cyanidin in the prevention of oxidative stress-mediated Aβ neurotoxicity.

关键词： nerve regeneration cyanidin amyloid-beta oxidative damage reactive oxide species apoptosis neural regeneration

Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease

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Journal of Traditional Chinese Medicine 2019年第6期39卷 800-808页

作者： Liu Quanfeng Sang Heon Kim yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan Jang Kyoung Sang cho Songhee Jeon Byung-Soo Koo Department of Oriental Medicine Dongguk UniversityGyeogju38066Republic of Korea Department of Oriental Neuropsychiatry Graduate School of Oriental MedicineDongguk UniversityGyeonggi-do 10326Republic of Korea College of Pharmacy Kyung Hee UniversitySeoul 02447Republic of Korea School of Biomedical Sciences Charles Sturt UniversityBathurstNew South Wales2795Australia Department of Biological Sciences Konkuk UniversitySeoul 05029Republic of Korea Department of Biomedical Sciences Center for Creative Biomedical Scientists at Chonnam National UniversityGwangju 61469Korea

OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)***:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 *** that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were *** different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 ***:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced ***1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control *** with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these *** mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control ***,mice receiving three different doses of KSOP1009 performed better than MPTP-treated ***-treated mice were more hesitant and took longer to traverse the balance beam than the control *** contrast,KSOP1009-treated mice performed significantly better than MPTPtreated ***,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated *** treatment strongly induced Jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK *** addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated ***1009 also restored the decrease in dopaminergic

关键词： Parkinson disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mitochondria Reactive oxygen species Suhexiang Wan

Total Ginsenoside Extract from Panax ginseng Enhances Neural Stem Cell Proliferation and Neuronal Differentiation by Inactivating GSK-3β

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Chinese Journal of Integrative Medicine 2022年第3期28卷 229-235页

作者： LIN Kai-li ZHANG Ji CHUNG Hau-lam WU Xin-yi LIU Bin ZHAO Bo-xin SZE Stephen cho-wing ZHOU Ping-zheng yung Ken Kin-lam ZHANG Shi-qing School of Public Health Guangzhou Medical UniversityGuangzhou(511436)China Department of Biology Hong Kong Baptist University(HKBU)Hong Kong Special Administrative Region(999077)China HKBU Shenzhen Research Institute and Continuing Education ShenzhenGuangdong Provinee(518057)China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou(510515)China Guangzhou Institute of Cardiovascular Disease the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou(510260)China Department of Pharmacy Nan fang HospitalSouther n Medical Un iversityGuan gzhou(510515)China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou(510515)China

Objective:To study the effects of total ginsenosides(TG)extract from Panax ginseng on neural stem cell(NSC)proliferation and differentiation and their underlying ***:The migration of NSCs after treatment with various concentrations of TG extract(50,100,or 200μg/mL)were *** proliferation of NSCs was examined by a combination of cell counting kit-8 and neurosphere *** differentiation mediated by TG extract was evaluated by Western blotting and immunofluorescence staining to monitor the expression of nestin and microtubule associated protein 2(MAP2).The GSK-3β/β-catenin pathway in TG-treated NSCs was examined by Western blot *** NSCs with constitutively active GSK-3βmutant were made by adenovirus-mediated gene transfection,then the proliferation and differentiation of NSCs mediated by TG were further ***:TG treatment significantly enhanced NSC migration(P<0.01 or P<0.05)and increased the proliferation of NSCs(P<0.01 or P<0.05).TG mediation also significantly upregulated MAP2 expression but downregulated nestin expression(P<0.01 or P<0.05).TG extract also significantly induced GSK-3βphosphorylation at Ser9,leading to GSK-3βinactivation and,consequently,the activation of the GSK-3β/β-catenin pathway(P<0.01 or P<0.05).In addition,constitutive activation of GSK-3βin NSCs by the transfection of GSK-3βS9 A mutant was found to significantly suppress TG-mediated NSC proliferation and differentiation(P<0.01 or P<0.05).Conclusion:TG promoted NSC proliferation and neuronal differentiation by inactivating GSK-3β.

关键词： ginsenoside neural stem cell proliferation neuronal differentiation GSK-3β

Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong Ji EunJin Bang Hyun Hwangbo Min Yeong Kim Da Hye Kim Su Hyun Hong Shin-Hyung Park Chang-Young Kwon Gi-Young Kim You-Jin Jeon Suengmok cho yung Hyun choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

Synthesis and Electrochemical Studies on LiCoVO_4 Surface Modified with La_2O_3 for Lithium-ion Cells

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复旦学报（自然科学版） 2007年第5期46卷 649-页

作者： George Ting-Kuo FEY P.Muralidharan yung-da cho Department of Chemical and Materials Engineering National Central University

1 Results An inverse spinel LiCoVO4 cathode material was synthesized by a citric acid-urea polymeric method, calcined at 773 K for 5 h. The synthesized LiCoVO4 sample was surface modified with various wt.% of La2O3 by a polymeric process, calcined at 873 K for 2 h. The samples were characterized by XRD, FTIR, SEM, and TEM techniques. XRD patterns exposed that single-phase crystallinity occurred when they were heated at 773 K for 5 h in air. For the La2O3 coated samples, there was no evident signal corre...

关键词： citric acid-urea La2O3 LiCoVO4 lithium-ion cells surface modification

The Usefulness of Beneficiaries Follow - Up Who Are Applicable the ACR -BIRADS Category 3 Among Health Screenings

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The Usefulness of Beneficiaries Follow - Up Who Are Applicab...