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Clinical associations of corneal neuromas with ocular surface diseases

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Neural Regeneration Research 2024年第1期19卷 140-147页

作者： Charmaine Jan Li Toh chang Liu Isabelle Xin Yu Lee Molly Tzu Yu lin Louis Tong Yu-Chi Liu Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore Department of Cornea and External Eye Disease Singapore National Eye CentreSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or *** formation of corneal neuromas results from damage to corneal nerves,such as following corneal pathology or corneal or intraocular surge ***,denervated areas of sensory nerve fibers become invaded by sprouts of intact sensory nerve fibers,and later injured axons regenerate and new sprouts called neuromas *** recent years,analysis of corneal nerve abnormalities including corneal neuromas which can be identified using in vivo confocal microscopy,a non-invasive imaging technique with microscopic resolution,has been used to evaluate corneal neuropathy and ocular surface *** neuromas have been shown to be associated with clinical symptoms of discomfort and dryness of eyes,and are a promising surrogate biomarker for ocular surface diseases,such as neuropathic corneal pain,dry eye disease,diabetic corneal neuropathy,neurotrophic keratopathy,Sjogren's syndrome,bullous keratopathy,post-refra ctive surgery,and *** this review,we have summarized the current literature on the association between these ocular surface diseases and the presentation of corneal microneuromas,as well as elaborated on their pathogenesis,visualization via in vivo confocal microscopy,and utility in monitoring treatment *** current quantitative analysis on neuromas mainly relies on manual annotation and quantification,which is user-dependent and labor-intensive,future direction includes the development of artificial intelligence software to identify and quantify these potential imaging biomarkers in a more automated and sensitive manner,allowing it to be applied in clinical settings more *** imaging and molecular biomarkers may also help elucidate the associations between corneal neuromas and ocular surface diseases.

关键词： cornea corneal diseases corneal nerve corneal neuropathy in vivo confocal microscopy microneuroma neuroma ocular surface diseases

Constructing S-scheme charge separation in cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4) heterojunction with enhanced photothermal-assisted photocatalytic H_(2) evolution

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Rare Metals 2024年第1期43卷 198-211页

作者： Wei-Long Shi Zheng Xu Yu-Xing Shi ling-ling Li Jia-lin Lu Xin-Hai Sun Xin Du Feng Guo chang-Yu Lu School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Water Resource and Environment Hebei Province Key Laboratory of Sustained Utilization and Development of Water RecourseHebei Center for Ecological and Environmental Geology ResearchHebei Geo UniversityShijiazhuang 050031China

Hydrogen acquisition from solar energy is an effective way to address energy crisis,which makes the development of efficient photocatalysts become the main direction of scientific ***,cobalt phthalocyanine/oxygen-doped g-C_(3)N_(4)(CoPc/OCN) S-scheme heterojunction photocatalyst was designed by coupling multi-step calcination with solvothermal method for enhanced photothermal-assisted photocatalytic H_(2) *** multistep calcined g-C_(3)N_(4) is easier for O-doping formation,and the ethanol solvothermal strategy is utilized to enhance the dispersion of CoPc on OCN nano sheet surface and forms sufficient S-scheme heterojunction through *** addition,the active sites and excellent photothermal properties of CoPc itself further improve the integrated photocatalytic activity of CoPc/OCN S-scheme *** optimal photocatalytic hydrogen evolution rate of CoPc/OCN S-scheme heterojunction photocatalyst reached 9.56 mmol·g^(-1)·h^(-1),which is 2.69 and 1.23 times higher than that of CN and OCN,*** work provides a valuable design idea and scheme for enhancing the multi-factor co-assisted photocatalytic H_(2) evolution performance.

关键词： Photothermal Photocatalytic H_(2)evolution Cobalt phthalocyanine Oxygen-doped g-C_(3)N_(4) Sscheme heterojunction

Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu lin Hung Ju Chen Yi Kit Chan Wei Ping Hsia Yu Len Huang Chia Jen chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

Methane adsorption effected by pore structure of overmature continental shale:Lower Cretaceous Shahezi Formation,Xujiaweizi Fault,Songliao Basin

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Frontiers of Earth Science 2024年第1期18卷 172-187页

作者： Pengfei ZHANG Shuangfang LU Nengwu ZHOU Zizhi lin Xiangchun chang Junjian ZHANG Guo CHEN Yumao PANG Junjie WANG Hongsheng HUANG Qi ZHI College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025China School of Geoscience China University of Petroleum(East China)Qingdao 266580China College of Resources and Environment Yangtze UniversityWuhan 430100China

Overmature continental shale is commonly developed,but few studies have given insight into its pore structure and sorption *** techniques,including SEM,helium porosity and permeability,N_(2)/CO_(2)adsorption,MICP,and NMR,were used to detect the pore structure of shale from the Shahezi Formation,Xujiaweizi Fault,Songliao *** excess methane adsorption volumes were measured by the volumetric method and modeled by the Langmuir *** on the findings,the most developed pores are intraparticle pores in clay minerals,followed by the dissolution pores in feldspar,but organic pores are *** selected shales have low helium porosity(mean 1.66%)and ultralow permeability(mean 0.0498×10^(−3)μm^(2)).The pore throats are at the nanoscale,and the pore-throat size distributions are unimodal,with most less than 50 *** studied shales are characterized by the lower specific surface area(SSA)and pore volume(PV)but the larger average pore *** total SSA is contributed by the micro-and mesopores,while the PV is dominated by meso-and *** pore structures are more complex and controlled by multiple factors,such as mineral compositions and diagenesis,but organic matter is not *** maximum absolute adsorption methane volume(VL)is 0.97−3.58 cm^(3)/g(mean 1.90 cm^(3)/g),correlating well with the total SSA,SSA,and pore volume of micropores,which indicates that methane is mainly adsorbed and stored in micropores,followed by mesopores.

关键词： continental shale pore structure methane adsorption Shahezi Formation Songliao Basin

Current assessment and management of measurable residual disease in patients with acute lymphoblastic leukemia in the setting of CAR-T-cell therapy

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Chinese Medical Journal 2024年第2期137卷 140-151页

作者： Minghao lin Xiaosu Zhao Yingjun chang Xiangyu Zhao Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China

Chimeric antigen receptor(CAR)-modified T-cell therapy has achieved remarkable success in the treatment of acute lymphoblastic leukemia(ALL).Measurable/minimal residual disease(MRD)monitoring plays a significant role in the prognostication and management of patients undergoing CAR-T-cell *** MRD detection methods include flow cytometry(FCM),polymerase chain reaction(PCR),and next-generation sequencing(NGS),and each method has advantages and *** has been well documented that MRD positivity predicts a poor prognosis and even disease ***,how to perform prognostic evaluations,stratify risk based on MRD status,and apply MRD monitoring to guide individual therapeutic decisions have important implications in clinical *** review assesses the common and novel MRD assessment *** addition,we emphasize the critical role of MRD as a prognostic biomarker and summarize the latest studies regarding MRD-directed combination therapy with CAR-T-cell therapy and allogeneic hematopoietic stem cell transplantation(allo-HSCT),as well as other therapeutic strategies to improve treatment ***,this review discusses current challenges and strategies for MRD detection in the setting of disease relapse after targeted therapy.

关键词： Measurable/minimal residual disease Acute lymphoblastic leukemia Chimeric antigen receptor-modified T-cell therapy Allogeneic hematopoietic stem cell transplantation Relapse

The Existence of a Meridional Curve in Closed Incompressible Surfaces in Fully Alternating link Complements

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 73-80页

作者： Wei lin School of Mathematical Sciences Dalian University of TechnologyDalian 116024LiaoningChina

Menasco showed that a closed incompressible surface in the complement of a non-split prime alternating link in S^(3) contains a circle isotopic in the link complement to a meridian of the *** on this result,he was able to argue the hyperbolicity of non-split prime alternating links in *** et *** that if F■S×I\L is an essential torus,then F contains a circle which is isotopic in S×I\L to a meridian of *** author generalizes his result as follows:Let S be a closed orientable surface,L be a fully alternating link in S×I\If F ■ S×I\L is a closed essential surface,then F contains a circle which is isotopic in S×I\L to a meridian of L.

关键词： Fully alternating Incompressible surfaces Meridionally incompressible

Quantifying trapping stability of optical tweezers with an external flow

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Photonics Research 2024年第8期12卷 1741-1749页

作者： FENG XU YARONG YU YANG LIU YAO chang WENXIANG JIAO lin WANG HOPUI HO BEI WU FEI XU YANQING LU YUANJIE PANG GUANGHUI WANG College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China Key Laboratory of Intelligent Optical Sensing and Integration of the Ministry of Education Nanjing UniversityNanjing 210093China School of Optical and Electronic Information Wuhan National Laboratory of OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China Department of Biomedical Engineering The Chinese University of Hong KongHong Kong 999077China

Optical tweezers(OTs)can immobilize and manipulate objects with sizes that span between nano-and micrometer *** manipulating ability of OTs is traditionally characterized by stability factor(S),which can only indicate an empirical“hit-or-miss”***,the current quantitative models for trapping stability rarely consider the influence of external *** this paper,a comprehensive analysis to quantify the optical trapping stability in a perturbed asymmetric potential well is presented from the perspective of statistics,especially for weak trapping *** analytical formulation takes experimentally measurable parameters including particle size,optical power,and spot width as inputs and precisely outputs a statistically relevant mean trapping ***,this formulation takes into account general and realistic cases including fluidic flow velocity and other *** verify the model,a back-focal-plane-interferometer-monitored trapping experiment in a flow is set up and the statistical characteristics of trapping time demonstrate good agreement with theoretical *** total,the model quantitatively reveals the effects of external disturbance on trapping time,which will find applications where optical trapping stability is challenged by external perturbations in weak trapping conditions.

关键词： process flow trapping

Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer

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Current Medical Science 2024年第4期44卷 833-840页

作者： Jun-he CHEN Cheng-ming WEI Qian-yu lin Zi WANG Fu-ming ZHANG Mei-na SHI Wen-jian LAN chang-gang SUN Wan-jun lin Wen-zhe MA State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao999078China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China College of Traditional Chinese Medicine Weifang Medical UniversityWeifang261053China

Objective Colorectal cancer(CRC),a prevalent malignancy worldwide,has prompted extensive research into anticancer *** Chinese medicinal materials offer promising avenues for cancer management due to their diverse pharmacological *** study investigated the effects of Notopterygium incisum,a traditional Chinese medicine named Qianghuo(QH),on CRC cells and the underlying *** The sulforhodamine B assay and colony formation assay were employed to assess the effect of QH extract on the proliferation of CRC cell lines HCT116 and *** iodide(PI)staining was utilized to detect cell cycle progression,and PE Annexin V staining to detect *** blotting was conducted to examine the levels of apoptotic proteins,including B-cell lymphoma 2-interacting mediator of cell death(BIM),B-cell lymphoma 2(Bcl-2),Bcl-2-associated X protein(BAX)and cleaved caspase-3,as well as BIM stability after treatment with the protein synthesis inhibitor *** expression of BAX was suppressed using lentivirus-mediated shRNA to validate the involvement of the BIM/BAX axis in QH-induced *** in vivo effects of QH extract on tumor growth were observed using a xenograft ***,APC^(Min+)mice were used to study the effects of QH extract on primary intestinal *** QH extract exhibited significant in vitro anti-CRC activities evidenced by the inhibition of cell proliferation,perturbation of cell cycle progression,and induction of ***,QH extract significantly increased the stability of BIM proteins,which undergo rapid degradation under unstressed *** of BAX,the downstream effector of BIM,significantly rescued QH-induced ***,the in vitro effect of QH extract was recapitulated in *** extract significantly inhibited the tumor growth of HCT116 xenografts in nude mice and decreased the number of intestinal polyps in the APC^(Min+)*** QH extract

关键词： Notopterygium incisum colorectal cancer apoptosis B-cell lymphoma 2-interacting mediator of cell death

Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

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Chinese Journal of Polymer Science 2024年第9期42卷 1341-1352,I0007页

作者： Cheng-Jiang lin Jun-Jun Wang Yuan Jiang Shu-Li Chen Hong-Fei Li Wen-Han Zhao Qing-Rong Huang chang-Ru Rong Xiao-Zheng Duan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole