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Fabrication of Conductive Domain Walls in x-cut Congruent Thin-film Lithium Niobate Using an Electrical-field Poling Technique(Invited)

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激光与光电子学进展 2024年第11期 60-66页

作者： Su Yawen Chen Haiwei Zhao Mengwei niu yunfei Li Chen Zhang Yong Yang Shaoguang Zhu Shining Hu Xiaopeng National Laboratory of Solid State Microstructures School of Physics College of Engineering and Applied Sciences Nanjing University Zhejiang Laboratory

Conductive ferroelectric domain walls have attracted increasing research interest in the field of nanoelectronics, and the fabrication technique for such domain walls is vital. In this study, we investigated in detail the fabrication of conductive domain walls in x-cut congruent thin-film lithium niobate(TFLN) using an electrical-field poling technique. The ferroelectric domain structures can be controlled through the applied electrical field and applied pulse numbers, and the domain inversion process is related to the conduction characteristics of the domain walls. The domain structures in TFLN are revealed using confocal second-harmonic microscopy and piezoresponse force microscopy. The results provide further directions for the development and application of conductive domain walls in TFLN.

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Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing

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Journal of Materials Science & Technology 2023年第2期133卷 195-208页

作者： Fan Wang Mengyao Wang Qingsong He Xuehong Wang Ping Sun Yinjun Ji yunfei niu Fengqian Li Jie Wei Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringKey Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Department of Orthopaedics Shanghai Eighth People’s HospitalShanghai 200235China Department of Orthopaedics Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.

关键词： Black tantalic oxide PEEK fibers Artificial ligament Photothermal antibacterial effects Ligament-bone healing

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

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Science China(Life Sciences) 2018年第11期61卷 1320-1332页

作者： Dongdong Ti yunfei niu Zhiqiang Wu Xiaobing Fu Weidong Han Department of Immunology Institute of Basic Medicine Chinese PLA General Hospital Department of Orthopaedics Changhai Hospital Second Military Medical University

The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed.

关键词： genetic engineering chimeric antigen receptors cancer immunotherapy

Demonstration of epitaxial growth of strain-relaxed GaN films on graphene/SiC substrates for long wavelength light-emitting diodes

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Light(Science & Applications) 2021年第7期10卷 1267-1274页

作者： Ye Yu Tao Wang Xiufang Chen Lidong Zhang Yang Wang yunfei niu Jiaqi Yu Haotian Ma Xiaomeng Li Fang Liu Gaoqiang Deng Zhifeng Shi Baolin Zhang Xinqiang Wang Yuantao Zhang State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityQianjin Street 2699Changchun 130012China Electron Microscopy Laboratory School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes.

关键词： diodes relaxed strain

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高压氧在糖尿病足溃疡治疗中的研究进展

中国糖尿病杂志 2023年第8期31卷 632-635页

作者：张皓琛牛云飞海军军医大学第一附属医院创伤骨科上海200433

糖尿病足溃疡(DFU)是DM患者常见慢性并发症,因高血糖导致肢体远端血管和神经病变难以治愈,且截肢率较高。高压氧疗作为常见辅助治疗,在有效治疗基础上有抗感染、促血管再生和瘢痕重塑等作用,在促进溃疡愈合方面取得良好效果。本文综述... 详细信息

糖尿病足溃疡(DFU)是DM患者常见慢性并发症,因高血糖导致肢体远端血管和神经病变难以治愈,且截肢率较高。高压氧疗作为常见辅助治疗,在有效治疗基础上有抗感染、促血管再生和瘢痕重塑等作用,在促进溃疡愈合方面取得良好效果。本文综述高压氧在糖尿病足溃疡治疗中的研究进展。

关键词：糖尿病足溃疡高压氧辅助治疗

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岩性目标油气检测技术在琼东南盆地的应用

石油地球物理勘探 2024年第2期59卷 320-330页

作者：黄饶王建花叶云飞牛聪凌云中海油研究总院有限责任公司北京100028 海洋油气勘探国家工程研究中心北京100028

琼东南盆地超深水区Y目标储层为受多级断阶控制的高位域三角洲水下分流河道砂体,钻井资料揭示的气层和水层在地震资料上均表现为“亮点”,并具有远道增强的第Ⅲ类AVO特征,常规基于振幅信息的油气检测结果存在多解性。为此,提出一种充分... 详细信息

琼东南盆地超深水区Y目标储层为受多级断阶控制的高位域三角洲水下分流河道砂体,钻井资料揭示的气层和水层在地震资料上均表现为“亮点”,并具有远道增强的第Ⅲ类AVO特征,常规基于振幅信息的油气检测结果存在多解性。为此,提出一种充分利用地震数据的振幅、频率和相位信息的地震全信息烃类检测技术。首先,从地震正演出发综合分析砂岩储层叠后、叠前地震响应特征及其影响因素,指出孔隙度和气层厚度是影响利用振幅信息识别流体的主要原因,明确了基于振幅信息可以识别厚层含气砂岩;其次,通过地震反射频谱分析指出造成气层主频降低、频带变窄的主要原因是含烃引起的地震波衰减;最后,通过数值模拟表明厚层气砂和水层背景下的薄层气砂均表现为明显的吸收和相位异常,可以利用与地震波衰减相关的频率、相位信息开展含油气检测。研究区实际应用表明所提方法能够有效区分气层和水层,检测结果与实钻结果相吻合,为钻井实施提供了可靠依据,有效降低了勘探风险。

关键词：琼东南盆地三角洲岩性目标 AVO 地层吸收子波相位油气检测

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城市集群土地利用碳足迹时空分异及响应特征

环境科学与技术 2022年第4期45卷 227-236页

作者：陈义忠乔友凤姚澜牛云飞杨灵芝河北工业大学经济管理学院天津300401

该文基于土地利用碳足迹模型,对比分析长江中游城市群和成渝城市群碳足迹时空分异特征,并利用回归模型明晰社会经济等因素与碳足迹水平之间的响应关系。结果表明:长江中游城市群2000-2015年的碳吸收由11.18×10^(6)t增至11.21×10^(6)t... 详细信息

该文基于土地利用碳足迹模型,对比分析长江中游城市群和成渝城市群碳足迹时空分异特征,并利用回归模型明晰社会经济等因素与碳足迹水平之间的响应关系。结果表明:长江中游城市群2000-2015年的碳吸收由11.18×10^(6)t增至11.21×10^(6)t,成渝城市群则由2.84×10^(5)t增至2.86×10^(5)t,林地的碳吸收占比最大(大于95%)。长江中游城市群和成渝城市群碳排放量整体呈逐年上升趋势,其峰值分别为2.96×10^(8)t(2011年)和2.41×10^(8)t(2013年);城市群碳排放来源差异较大,长江中游城市群以煤炭(36.7%)和原煤(33.6%)为主,成渝城市群则为原油(31.2%)和原煤(36.35%)。长江中游城市群人均碳足迹由0.27 hm^(2)增至0.60 hm^(2)(年增速21.36%),成渝城市群则由0.23 hm^(2)增至0.38 hm^(2)(年增速11.11%);而长江中游城市群的人均碳承载呈轻微的下降趋势,由0.026 hm^(2)下降至0.021 hm^(2),成渝城市群则呈现先上升后下降的趋势,2003年达到峰值(0.0157 hm^(2))。城市群间碳足迹响应关系存在明显差异,其中,调整产业结构和增加财政科学事业费支出能够降低长江中游城市群碳足迹水平,而城镇人口比重和人均生产总值对碳足迹具有正向影响;严格控制农业化肥使用量和人口密度则能够显著降低成渝城市群碳足迹。通过与京津冀城市群碳足迹对比,结果表明京津冀城市群碳压力(82.94)远大于长江中游城市群(40.45)和成渝城市群(67.13)。

关键词：土地利用碳足迹城市群碳承载响应关系碳压力

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一种高精度航空磁法测量系统

科技资讯 2022年第20期20卷 28-31页

作者：王涛牛云飞高定州北京探创资源科技有限公司北京100071

磁法勘探对于寻找铁磁性矿物相关的金属矿床有着显著效果。目前地面磁法勘探逐渐不能满足当下大面积复杂生产环境和快速勘探生产需求,而国内有人机飞行难度高,危险系数大。近几年,国内无人机低空高分辨率航空磁测系统应运而生。该方式... 详细信息

磁法勘探对于寻找铁磁性矿物相关的金属矿床有着显著效果。目前地面磁法勘探逐渐不能满足当下大面积复杂生产环境和快速勘探生产需求,而国内有人机飞行难度高,危险系数大。近几年,国内无人机低空高分辨率航空磁测系统应运而生。该方式可做到低空自主飞行,做到快速有效地开展大面积磁测,同时相比有人机施工操作简易,安全可靠。

关键词：无人机航空磁测磁通门磁补偿金属矿床

矿井工作面瞬变电磁探测数据三维可视化方法研究

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山西煤炭 2022年第2期42卷 87-94页

作者：牛云飞杜雯莉李长江北京探创资源科技有限公司山东济宁273500

针对回采工作面环境复杂,瞬变电磁探测数据量大且复杂,在资料处理解释以及成果展示方面主要以测线、剖面等二维图像为主,不能直观、全面地展示物探资料包含的地质信息的情况,在对瞬变探测数据结构研究基础上,利用Matlab、Vtk等软件强大... 详细信息

针对回采工作面环境复杂,瞬变电磁探测数据量大且复杂,在资料处理解释以及成果展示方面主要以测线、剖面等二维图像为主,不能直观、全面地展示物探资料包含的地质信息的情况,在对瞬变探测数据结构研究基础上,利用Matlab、Vtk等软件强大的编程和运算能力构建三维数据体,实现了回采工作面瞬变电磁三维可视化,能够更加直观地对异常区空间位置及延展范围作出判断。该研究结果极大方便了物探技术人员进行资料解释,同时也方便了非物探专业技术人员对相关成果的判断理解。

关键词：三维可视化矿井瞬变电磁 Matlab Vtk