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The Jidong Eye Cohort Study:objectives,design,and baseline characteristics

Eye and Vision 2020年第1期7卷 571-578页

作者： Kai Yang Lele Cui Guoyun Zhang Xianwei Wang Xiaoxuan Zhu yunfan Xiao Binbin Su Daiyu Song Xinyao Zhang Yang Zheng Fan Lu Jia Qu Ming li Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina National Clinical Research Center for Ocular Diseases WenzhouZhejiangChina Dezhou Center for Disease Control and Prevention DezhouShandongChina

Background:To describe the objective,design and baseline characteristics of the Jidong Eye Cohort Study(JECS),a community-based cohort in China based on etiology,imaging and *** JECS will clarify the pathogenesis of visual impairment and status of ocular indicators in the occurrence and progression of cardiocerebrovascular and neurological ***:Between August 2019 and January 2020,the JECS recruited consecutive participants aged 18 years and older from the Jidong communities in *** demographic and clinical characteristics were collected by trained site personnel via face-to-face *** relevant biological samples were also *** participants underwent comprehensive ophthalmic examination,such as retinal photography and optical coherence tomography(OCT)*** following outcomes were measured annually:ocular vascular abnormality,optic nerve degeneration,cardiovascular diseases(CVD)and neurological *** study will be performed until ***:Among 3377 participants,the average age was 45.0±12.5 years and 1809(53.6%)were *** occurred in 825 individuals(25.0%),diabetes in 258(7.7%),hyperglycemia in 474(14.2%),and a CVD history in 100(3.0%).The mean best-corrected visual acuity was 0.1 logMAR in the recruited *** average OCT signal index was 8.2±***,the mean vessel densities for the entire measured area were 46.4%and 50.8%for the superficial and deep vascular complex,*** area and perimeter of foveal avascular zone was 0.3 mm2 and 2.3 ***:The JECS is a large community-based prospective cohort in North *** data collected from this study will provide the opportunity to identify risk factors,imaging,and biomarkers of visual impairment(either ocular vascular anomalies or optic nerve degeneration)and to evaluate their associations with CVD and neurological diseases.

关键词： Cohort Risk factor Visual impairment Cardiovascular disease Neurological disease Epidemiology

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Theoretical investigation on the fluorescent sensing mechanism for recognizing formaldehyde: TDDFT calculation and excited-state nonadiabatic dynamics

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Chinese Physics B 2023年第5期32卷 674-681页

作者：杨云帆杨璐佳马凤才李永庆邱岳 Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China Department of Physics Liaoning UniversityShenyang 110036China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Grimwade Centre for Cultural Materials Conservation School of Historical and Philosophical StudiesFaculty of Arts University of MelbourneParkvilleVIC 3052Australia

Inspired by the activity-based sensing method, the hydrazine-modified naphthalene derivative(Naph1) was synthesized and used as a fluorescent probe to detect formaldehyde(FA) in living cells. Through the condensation reaction between the probe Naph1 and analyte FA, researchers observed a ~14 folds enhancement of fluorescent signal around 510 nm in an experiment, realizing the high selectivity and sensitivity detection of FA. However, a theoretical understanding of the sensing mechanism was not provided in the experimental work. Given this, the light-up fluorescent detecting mechanism was in-depth unveiled by performing the time-dependent density functional theory(TDDFT) and the complete active space self-consistent field(CASSCF) theoretical calculations on excited-state intramolecular proton transfer(ESIPT)and non-adiabatic excited-state dynamics simulation. The deactivation channel of S_1/T_2 intersystem crossing(ISC) was turned off to successfully recognize FA. Insight into the ESIPT-based fluorescent detecting mechanism indicated that ESIPT was essential to light-up fluorescent probes. This work would provide a new viewpoint to develop ESIPT-based fluorescent probes for detecting reactive carbon species in vivo or vitio.

关键词： proton transfer twisting intramolecular charge transfer intersystem crossing fluorescent probe

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γ Active Measurement of Al Foil Bombarded by 1.2GeV Ar15+

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IMP & HIRFL Annual Report 1996年 67-68页

作者： Sun Youmei li Changlin Wang Jing Jin yunfan and Zhu Zhiyong

γＡｃｔｉｖｅＭｅａｓｕｒｅｍｅｎｔｏｆＡｌＦｏｉｌＢｏｍｂａｒｄｅｄｂｙ１．２ＧｅＶＡｒ１５＋￥ＳｕｎＹｏｕｍｅｉ；ＬｉＣｈａｎｇｌｉｎ；ＷａｎｇＪｉｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＺｈｕＺｈｉｙｏｎｇＡｆｔｅｒ３０...

γＡｃｔｉｖｅＭｅａｓｕｒｅｍｅｎｔｏｆＡｌＦｏｉｌＢｏｍｂａｒｄｅｄｂｙ１．２ＧｅＶＡｒ１５＋￥ＳｕｎＹｏｕｍｅｉ；ＬｉＣｈａｎｇｌｉｎ；ＷａｎｇＪｉｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＺｈｕＺｈｉｙｏｎｇＡｆｔｅｒ３０ＭｅＶ／ｕＡｒ１５＋ｉｒｒａ...

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γ Active Measurement of Al Foil Bombarded by 1.2GeV Ar^(15+)

引用

IMP & HIRFL Annual Report 1996年第1期 67-68页

作者： Sun Youmei li Changlin Wang Jing Jin yunfan and Zhu Zhiyong

γＡｃｔｉｖｅＭｅａｓｕｒｅｍｅｎｔｏｆＡｌＦｏｉｌＢｏｍｂａｒｄｅｄｂｙ１．２ＧｅＶＡｒ^（１５＋）￥ＳｕｎＹｏｕｍｅｉ；ＬｉＣｈａｎｇｌｉｎ；ＷａｎｇＪｉｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＺｈｕＺｈｉｙｏｎｇＡｆｔｅ...

γＡｃｔｉｖｅＭｅａｓｕｒｅｍｅｎｔｏｆＡｌＦｏｉｌＢｏｍｂａｒｄｅｄｂｙ１．２ＧｅＶＡｒ^（１５＋）￥ＳｕｎＹｏｕｍｅｉ；ＬｉＣｈａｎｇｌｉｎ；ＷａｎｇＪｉｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＺｈｕＺｈｉｙｏｎｇＡｆｔｅｒ３０ＭｅＶ／ｕＡｒ~１５＋ｉｒｒａ...

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MOSS:An Open Conversational Large Language Model

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Machine Intelligence Research 2024年第5期21卷 888-905页

作者： Tianxiang Sun Xiaotian Zhang Zhengfu He Peng li Qinyuan Cheng Xiangyang liu Hang Yan yunfan Shao Qiong Tang Shiduo Zhang Xingjian Zhao Ke Chen Yining Zheng Zhejian Zhou Ruixiao li Jun Zhan Yunhua Zhou linyang li Xiaogui Yang lingling Wu Zhangyue Yin Xuanjing Huang Yu-Gang Jiang Xipeng Qiu Fudan University Shanghai200438China

Conversational large language models(LLMs)such as ChatGPT and GPT-4 have recently exhibited remarkable capabilities across various domains,capturing widespread attention from the *** facilitate this line of research,in this paper,we report the development of MOSS,an open-sourced conversational LLM that contains 16 B parameters and can perform a variety of instructions in multi-turn interactions with *** base model of MOSS is pre-trained on large-scale unlabeled English,Chinese,and code *** optimize the model for dialogue,we generate 1.1 M synthetic conversations based on user prompts collected through our earlier versions of the model *** then perform preference-aware training on preference data annotated from AI *** results on real-world use cases and academic benchmarks demonstrate the effectiveness of the proposed *** addition,we present an effective practice to augment MOSS with several external *** the development of MOSS,we have established a complete technical roadmap for large language models from pre-training,supervised fine-tuning to alignment,verifying the feasibility of chatGPT under resource-limited conditions and providing a reference for both the academic and industrial *** weights and code are publicly available at https://***/OpenMOSS/MOSS.

关键词： Large language models natural language processing pre-training alignment chatGPT MOSS

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Grassland degradation in Northern Tibet based on remote sensing data

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Journal of Geographical Sciences 2006年第2期16卷 165-173页

作者： GAO Qingzhu li Yu＇e WAN yunfan liN Erda XIONG Wei JIANGCUN Wangzha WANG Baoshan li Wenfu Institute of Environment and Sustainable Development for Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Naqu Agriculture and Animal Husbandry Bureau Tibet Autonomous RegionNaqu 852100China

This study selected vegetation cover as the main evaluation index, calculated the grassland degradation index （GDI） and established the remote sensing monitoring and evaluation system for grassland degradation in Northern Tibet, according to the National Standard （GB19377-2003）, based on the remote sensing data such as NDVI data derived from NOAA/AVHRR with a spatial resolution of 8 km of 1981-2000, from SPOT/VGT with a spatial resolution of 1 km of 2001 and from MODIS with a spatial resolution of 0.25 km of 2002-2004 respectively in this area, in combination with the actual condition of grassland degradation. The grassland degradation processes and their responses to climate change during 1981-2004 were discussed and analyzed in this paper. The result indicated that grassland degradation in Northern Tibet is very serious, and the mean value of GDI in recent 20 years is 2.54 which belongs to the serious degradation grade. From 1981 to 2004, the GDI fluctuated distinctly with great interannual variations in the proportion of degradation degree and GDI but the general tendency turned to severe-grade during this period with the grassland degradation grade changed from light degraded to serious degraded in Northern Tibet. The extremely serious degraded and serious degraded grassland occupied 1.7% and 8.0% of the study area, the moderate and light degraded grassland accounted for 13.2% and 27.9% respectively, and un-degraded grassland occupied 49.2% of the total grassland area in 2004. The grassland degradation was serious, especially in the conjunctive area of Naqu, Biru and Jiali counties, the headstream of the Yangtze River lying in the Galadandong snow mountain and glaciers, the area along the Qinghai-Tibet highway and railway, and areas around the Tanggula and Nianqingtanggula snow mountains and glaciers. So the snow mountains and glaciers as well as their adjacent areas in Northern Tibet were sensitive to climate change and the areas along the vital communication l

关键词： grassland degradation temporal and spatial distribution remote sensing monitoring

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Electronic Energy Loss Effects of Swift Ar Ions in Polyimide

引用

IMP & HIRFL Annual Report 1996年第1期 64-65页

作者： li Changlin Sun Youmei liu Gang Hou Mingdong Jin yunfan and Ma Feng

ＥｌｅｃｔｒｏｎｉｃＥｎｅｒｇｙＬｏｓｓＥｆｆｅｃｔｓｏｆＳｗｉｆｔＡｒＩｏｎｓｉｎＰｏｌｙｉｍｉｄｅ￥ＬｉＣｈａｎｇｌｉｎ；ＳｕｎＹｏｕｍｅｉ；ＬｉｕＧａｎｇ；ＨｏｕＭｉｎｇｄｏｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＭａＦ... 详细信息

ＥｌｅｃｔｒｏｎｉｃＥｎｅｒｇｙＬｏｓｓＥｆｆｅｃｔｓｏｆＳｗｉｆｔＡｒＩｏｎｓｉｎＰｏｌｙｉｍｉｄｅ￥ＬｉＣｈａｎｇｌｉｎ；ＳｕｎＹｏｕｍｅｉ；ＬｉｕＧａｎｇ；ＨｏｕＭｉｎｇｄｏｎｇ；ＪｉｎＹｕｎｆａｎａｎｄＭａＦｅｎｇＡｒｉｏｎｓｗｅｒｅａｃｃｅ...

关键词： Swift

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Critical Energy loss of Ar Ions in Some Polymers

引用

IMP & HIRFL Annual Report 1995年 64-65页

作者： li Changlin Sun Youmei liu Gang Hou Mingdong Jin yunfan and Ma Feng

Ｃｒｉｔｉｃａｌ　Ｅｎｅｒｇｙ　ｌｏｓｓ　ｏｆ　Ａｒ　Ｉｏｎｓ　ｉｎ　Ｓｏｍｅ　ＰｏｌｙｍｅｒｓＣｒｉｔｉｃａｌＥｎｅｒｇｙｌｏｓｓｏｆＡｒＩｏｎｓｉｎＳｏｍｅＰｏｌｙｍｅｒｓ￥ＬｉＣｈａｎｇｌｉｎ；ＳｕｎＹｏｕｍｅ...

Ｃｒｉｔｉｃａｌ　Ｅｎｅｒｇｙ　ｌｏｓｓ　ｏｆ　Ａｒ　Ｉｏｎｓ　ｉｎ　Ｓｏｍｅ　ＰｏｌｙｍｅｒｓＣｒｉｔｉｃａｌＥｎｅｒｇｙｌｏｓｓｏｆＡｒＩｏｎｓｉｎＳｏｍｅＰｏｌｙｍｅｒｓ￥ＬｉＣｈａｎｇｌｉｎ；ＳｕｎＹｏｕｍｅｉ；ＬｉｕＧａｎｇ；ＨｏｕＭｉｎｇ...

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Lattice Damage of 6H-SiC Implanted with Multiple-energy Xe Ions

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IMP & HIRFL Annual Report 2011年第1期 109-110页

作者： li Jianjian Zhang Chonghong Xu Chaoliang Jia Xiujun Song Yin Jin yunfan

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新型席夫碱Cr3+荧光探针及其细胞成像研究

引用

有机化学 2019年第4期39卷 1023-1028页

作者：常永新李白高云帆徐括喜河南大学化学化工学院功能有机分子研究中心河南省阻燃与功能材料工程实验室开封475004 河南大学民生学院开封475004

Cr^3+离子在脂肪、核酸、糖和蛋白质的代谢中发挥着重要作用,并且Cr^3+离子被认为是一种致癌物质,对人类有极大的危害.因此,通过将8-羟基喹啉醛和硫代碳酰肼反应制备出化合物L.探针L的CH3CN/H2O(V:V=1:2,Tris buffer 50 mmol/L,pH=7.3)... 详细信息

Cr^3+离子在脂肪、核酸、糖和蛋白质的代谢中发挥着重要作用,并且Cr^3+离子被认为是一种致癌物质,对人类有极大的危害.因此,通过将8-羟基喹啉醛和硫代碳酰肼反应制备出化合物L.探针L的CH3CN/H2O(V:V=1:2,Tris buffer 50 mmol/L,pH=7.3)溶液中加入Cr^3+离子,可以通过肉眼观察到其颜色从无色到黄色的变化和明显的荧光增强效应,这些现象表现出探针L对Cr^3+离子具有良好的选择性.根据Job曲线、荧光滴定、质谱和密度泛函理论(DFT)计算确定了探针L与Cr^3+离子形成1:1的络合物.络合常数为1.00×10^5L/mol,检测限为2.85×10^-7mol/L.此外,生物成像实验表明,探针L可以通过荧光增强信号检测活细胞中的Cr^3+离子.

关键词： Cr^3+ 荧光探针 DFT 细胞成像

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