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Accelerated design for magnetocaloric performance in Mn-Fe-P-Si compounds using machine learning

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Journal of Materials Science & Technology 2022年第1期96卷 241-247页

作者： Defang Tu Jianqi Yan yunbo xie Jun Li Shuo Feng Mingxu Xia Jianguo Li Alex Po Leung School of Material Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Macao University of Science and Technology MacaoChina Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming Shanghai 200240China School of Engineering University of LeicesterLeicester LE17RHUnited Kingdom

Magnetocaloric performance is of vital importance for Mn-Fe-P-Si ***,when processes and compositions are considered,designing alloys with large magnetic entropy changes(ΔS_(m)),low thermal hysteresis(ΔT_(hys)),and Curie temperatures(T_(C))around room temperature become relatively *** this study,we adopt machine learning methods to predict the magnetocaloric performance of Mn-Fe-P-Si compounds for the first *** achieve this goal,503,465,and 660 data points for datasets with T_(C),ΔT_(hys),andΔS_(m)are collected,*** collected datasets contain parameters of compositions,preparations,heat treatment,and magnetic field *** search for the optimal configuration using various methods and also compare their mean squared errors(MSE)and allowable *** results show that the performance of neural networks(NNs)is better than other ***,we select NN to explore the T_(C),ΔT_(hys),andΔS_(m)values as a function of Mn,Si,metal/non-metal ratios,and B(Boron).We also propose to use the composition window with excellent magnetocaloric *** results not only help us gain deep insights into Mn-Fe-P-Si alloys but also accelerate the design process of alloys suitable for magnetocaloric *** work has the potential to solve the challenges and boost the research of Mn-Fe-P-Si alloys.

关键词： Mn-Fe-P-Si alloy Material design Magnetocaloric performance Machine learning Neural network

Mesenchymal stem cell therapy for severe COVID-19

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Signal Transduction and Targeted Therapy 2021年第10期6卷 2945-2949页

作者： Lei Shi Lifeng Wang Ruonan Xu Chao Zhang yunbo xie Kai Liu Tiantian Li Wei Hu Cheng Zhen Fu-Sheng Wang Department of Infectious Diseases Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious Diseases100039BeijingChina

The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has placed a global public burden on health *** the virological characteristics and pathogenesis of COVID-19 has been largely clarified,there is currently no specific therapeutic *** severe cases,acute SARS-CoV-2 infection leads to immune disorders and damage to both the adaptive and innate immune *** roles in immune regulation and regeneration,mesenchymal stem cells(MSCs)serving as a therapeutic option may regulate the over-activated inflammatory response and promote recovery of lung *** the outbreak of the COVID-19 pandemic,a series of MSC-therapy clinical trials has been *** findings indicate that MSC treatment not only significantly reduces lung damage,but also improves patient recovery with safety and good immune ***,we summarize the recent progress in MSC therapy for COVID-19 and highlight the challenges in the field.

关键词： acute lung clarified

Safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong Liu yunbo xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan Liu Xi Chen Meng-Meng Qu Yang Zhang Wei-Guo Hong Yong-Gang Li Junliang Fu Fu-Sheng Wang Out-patient Department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA Medical School Chinese PLA General HospitalBeijing 100039China Hunyuan County People’s Hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary Surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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多归属、互联网平台型企业合并与社会总福利

管理评论 2018年第8期30卷 115-125页

作者：谢运博陈宏民上海交通大学安泰经济与管理学院上海200030

以双边市场理论为基础,在考虑用户多归属行为的情况下,研究了互联网平台型企业的横向合并以及合并后禁止多归属对社会总福利的影响。多归属用户的存在,对社会总福利的提升是有利的。多归属用户越多,也越有利于企业横向合并后社会总福利... 详细信息

以双边市场理论为基础,在考虑用户多归属行为的情况下,研究了互联网平台型企业的横向合并以及合并后禁止多归属对社会总福利的影响。多归属用户的存在,对社会总福利的提升是有利的。多归属用户越多,也越有利于企业横向合并后社会总福利的提升。如果合并后平台型企业禁止了用户的多归属行为,将有很大的可能性降低社会总福利。反垄断监管机构可以对平台型企业的横向合并行为本身比较宽容,但应该更加关注多归属用户的比例,以及企业禁止用户多归属的行为。

关键词：平台型企业多归属横向合并社会总福利反垄断监管

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对象置信度指引下的高分辨率遥感影像分割

仪器仪表学报 2017年第9期38卷 2282-2290页

作者：王超行鸿彦熊允波石爱业谢亚琴南京信息工程大学电子与信息工程学院南京210044 河海大学计算机与信息学院南京211100

如何减小分割结果与实际地理对象间的差异,是目前高分辨遥感影像分割中面临的一个难点问题。为此,构建了一种新的对象置信度(OC)指标来衡量任意区域与地理对象间的匹配程度,进而提出了一种面向地理对象的多尺度分割算法。该算法主要包... 详细信息

如何减小分割结果与实际地理对象间的差异,是目前高分辨遥感影像分割中面临的一个难点问题。为此,构建了一种新的对象置信度(OC)指标来衡量任意区域与地理对象间的匹配程度,进而提出了一种面向地理对象的多尺度分割算法。该算法主要包括两个步骤:首先,通过对影像进行过分割来构建初始种子区域集合,并确定尺度参数集合;而后,通过跟踪对象置信度指标OC的尺度间变化来指引多尺度区域合并过程,使区域合并结果逐步逼近实际的地理对象。多组实验结果表明,所提出的算法能够显著改善过分割及欠分割问题,准确识别建筑物、道路等地理对象的完整轮廓,在定性分析及定量精度评价中均显著优于商业软件e Congnition及传统多尺度分割算法。

关键词：高分辨率遥感影像多尺度分割对象置信度指标

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Apple Pay的优劣势分析

互联网天地 2016年第10期 30-32页

作者：谢运博上海交通大学安泰经济与管理学院上海200030

首先分析了Apple Pay的优劣势,然后指出了其与支付宝、微信支付的模式差异,最后展望了其在中国的未来发展方向。

关键词： Apple Pay 支付宝微信支付

新型冠状病毒肺炎合并肝损伤的临床特征及其机制研究进展

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中华肝脏病杂志 2020年第6期28卷 523-527页

作者：谢云波王嗣予张超王福生解放军医学院北京100853 解放军总医院第五医学中心感染性疾病诊疗与研究中心北京100039

2019年12月暴发的新型冠状病毒肺炎(COVID-19)传染性强,给人类社会带来巨大威胁和损失,引起各国政府高度重视。目前,针对COVID-19尚无特效药物,多种可能有效的抗病毒药物、疫苗、细胞治疗、中药治疗等方法正在进行临床试验。肝损伤是COV... 详细信息

2019年12月暴发的新型冠状病毒肺炎(COVID-19)传染性强,给人类社会带来巨大威胁和损失,引起各国政府高度重视。目前,针对COVID-19尚无特效药物,多种可能有效的抗病毒药物、疫苗、细胞治疗、中药治疗等方法正在进行临床试验。肝损伤是COVID-19患者治疗过程中常见的并发症,发生率较高,且能够影响疾病转归。当前研究中COVID-19合并肝损伤发生机制尚不明确,临床诊断及治疗缺乏相关指南和专家共识,现将相关进展和问题进行综述。

关键词：新型冠状病毒肺炎新型冠状病毒肝损伤

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肿瘤免疫细胞治疗:前景与挑战

中国肿瘤生物治疗杂志 2024年第1期31卷 1-9页

作者：施明谢云波王福生解放军总医院第五医学中心感染病医学部北京100039 解放军总医院解放军医学院北京100853

免疫细胞治疗通过修复患者机体免疫系统、激发免疫功能成为肿瘤的一种新的治疗方法,已经被证实具有较好的安全性,在部分肿瘤患者中取得了良好的治疗效果。本文聚焦近年来国内外开展的CAR-T细胞、TCR-T细胞、NK细胞、TIL等免疫细胞治疗... 详细信息

免疫细胞治疗通过修复患者机体免疫系统、激发免疫功能成为肿瘤的一种新的治疗方法,已经被证实具有较好的安全性,在部分肿瘤患者中取得了良好的治疗效果。本文聚焦近年来国内外开展的CAR-T细胞、TCR-T细胞、NK细胞、TIL等免疫细胞治疗方法在肿瘤中的临床安全性和有效性,同时从技术、产业化、政策等三个层面,提出中国免疫细胞治疗领域存在的关键问题、挑战及相应的解决策略,包括原创性基础理论研究的加强,新技术的应用和转化,细胞产品制备及临床研究的规范,先进的自动化、工业化细胞生产工艺体系的完善,细胞治疗产业上游产品保障,创新能力强的高水平科研、临床研究队伍的培养和壮大,以及与细胞治疗技术发展相适应的政策法规、科学监管体系的建立和完善等。这些问题的解决,可确保中国免疫细胞治疗的良性发展。

关键词：肿瘤免疫细胞治疗临床试验安全性有效性

Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients

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Cellular & Molecular Immunology 2015年第3期12卷 309-316页

作者： Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang yunbo xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang Beijing Institute of Radiation Medicine Beijing China Research Center for Biological Therapy The Institute of Translational Hepatology Beijing 302Hospital Beijing 100039 China Department of Infectious Diseases 88th Hospital of PLA Taian Shandong China Department of Infectious Diseases Beijing You'an Hospital Affiliated to Capital Medical University Beijing China Department of Infectious Diseases Beijing 302 Hospital Beijing China Department of Non-infectious Diseases Beijing 302 Hospital Beijing China Institute of Basic Medicine Hebei University Baoding China Xiangsheng Xu and Qinghua Shang have contributed equally to this work.

B cells play an important role in the clearance of hepatitis B virus （HBV） and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of peripheral B-cell subsets from CHB patients in different phases： immune tolerance （IT）, immune activation （IA）, immune clearance （IC）, responders with HBsAg seroconversion （resolved patients, RP）, and healthy controls （HC）. IA patients displayed lower percentages of peripheral blood memory B cells compared with the other groups. Overall polyclonal activation of B cells, indicated by higher levels of activation markers and secretion of IgG and IgM, was observed in IA patients. This B-cell hyperactivation could be induced by increased IFN-a and soluble CD40 ligands in IA patients. Notably, the expression of the co-stimulator molecule CD80 and serum HBsAb and the frequency of HBsAg-specific B cells were significantly decreased in IT, IA, and IC patients compared with HC subjects. More importantly, the B-cell hyperactivation, co-stimulatory molecule downregulation and HBsAg-specific B-cell impairment were reversed in RP patients. The reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients.

关键词：乙型肝炎慢性乙型肝炎表面抗原乙型肝炎病毒感染记忆抗原抗体复合物免疫球蛋白M 胰岛素