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Journal of Bionic Engineering 2010年第4期7卷 329-336页

作者： Qingxian Hou,Qingsan Zhu,Yuntao Wu,Ran Li,Dan Li,yunfeng Zhang,Qing ruan First Hospital of Jilin University,Changchun 130021,P.R.China First Hospital of Jilin University Changchun P. R. China

In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and biomechanical *** was conducted by posterolateral approach with titanium cage implantation combined with plate *** with the same length but different diameters were *** implantation of titanium cages,the progress of bone healingwas observed and the bone biomechanical properties were measured,including deformation and displacement in axial compression,flexion,extension,and lateral bending *** factors affecting the in vivo growth of spine supporting body *** results show that the area ratio of titanium cage section to vertebral section should reach 1/2 to ensure the bonehealing,sufficient bone intensity and biomechanical *** bone healing indicators,such as BMP,suggest that there isa relationship between the peak time and the peak value of bone formation and metabolism markers and the bone healing strength.

关键词： lumbar corpectomy titanium cage implantation spinal fusion biomechanics bone metabolism markers

Water sources of plants and groundwater in typical ecosystems in the lower reaches of the Heihe River Basin

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Research in Cold and Arid Regions 2014年第3期6卷 226-235页

作者： yunfeng ruan LiangJu Zhao HongLang Xiao GuoDong Cheng MaoXian Zhou Fang Wang Key Laboratory of Ecohydrology and Integrated River Basin Science of CAS Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Heihe Ecohydrology and Basin Science of Gansu Province

Stable oxygen and hydrogen isotopic compositions （δ18O and δD） of soil water and shallow groundwater of a riparian forest, an artificial shrub forest, and Gobi of the lower reaches of the Heihe River Basin are used to study the recharge water sources of those ecosystems. IsoSource software is used to determine the δ180 values for root water of Populous euphratica and Tamarix ramosissima in the riparian forest ecosystem, Haloxylon ammodendron in the artificial shrub forest, and Reaumuria soongorica in the Gobi, as well as for local soil water and groundwater, and precipitation in the upper reaches of the Heihe River Basin. Our results showed that soil water and shallow groundwater of the riparian forest and the artificial shrub forest were recharged by river water which originated from precipitation in the upper reaches, and strong evaporation occurred in the artificial shrub forest. Soil water of the Gobi was not affected by Heihe River water due to this area being far away from the river channel. The main water sources of Populous euphratica were from 40-60-cm soil water and groundwater, and of Tamarix ramosissima were from 40-80-cm soil water in the riparian forest ecosystem. In the artificial forest, Haloxylon ammodendron used 200-cm saturated-layer soil water and shallow groundwater. The Reaumuria soongorica mainly used soil water from the 175-200-cm depth in the Gobi. Therefore, soil water and groundwater are the main water sources which maintain survival and growth of the plants in the extremely arid regions of the lower reaches of the Heihe River Basin.

关键词： stable hydrogen and oxygen isotope composition (δD and δa80) extremely arid regions lower reaches of theHeihe River Basin plant water sources

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黑河流域地下水同位素年龄及可更新能力研究

冰川冻土 2015年第3期37卷 767-782页

作者：阮云峰赵良菊肖洪浪周茅先程国栋中国科学院寒区旱区环境与工程研究所内陆河流域生态水文重点实验室甘肃兰州730000 中国科学院大学北京100049 中国科学院寒区旱区环境与工程研究所冻土工程国家重点实验室甘肃兰州730000

通过对黑河流域地下水的放射性同位素如氚（T）和14C的测定,对该流域浅层和深层地下水的年龄以及其更新速率进行了估算.结果表明：整体上看,从黑河流域的上游、中游至下游,浅层和深层地下水年龄逐渐增加,地下水更新速率也逐渐增大.其中... 详细信息

通过对黑河流域地下水的放射性同位素如氚（T）和14C的测定,对该流域浅层和深层地下水的年龄以及其更新速率进行了估算.结果表明：整体上看,从黑河流域的上游、中游至下游,浅层和深层地下水年龄逐渐增加,地下水更新速率也逐渐增大.其中,黑河上游浅层和深层地下水平均更新速率分别为1.96%·a^-1和1.76%·a^-1,可更新能力最强;中游浅层和深层地下水平均更新速率为1.25%·a^-1和0.68%·a^-1,可更新能力次之;下游浅层和深层地下水平均更新速率分别为0.74%·a^-1和0.18%·a^-1,可更新能力最差.黑河流域不同地带地下水由于循环条件的不同,浅层和深层地下水年龄存在较大的差异.其中,中游山前平原补给条件较好,浅层和深层地下水年龄较小;中、下游远离河道地区浅层和深层地下水补给条件差,显示了更老的年龄.黑河流域埋深40 m以上的浅层地下水平均更新速率（1.13%·a^-1）高于埋深40-100 m之间的中层地下水（0.65%·a^-1）以及埋深100 m以下深层地下水（0.55%·a^-1）.因此,在黑河流域地下水开发过程中要合理开发浅层地下水,适当缩减开发深层地下水.

关键词：放射性同位素地下水年龄可更新能力黑河流域

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氚同位素在黑河流域水循环研究中的应用

第四纪研究 2014年第5期34卷 959-972页

作者：赵良菊阮云峰肖洪浪周茅先程国栋中国科学院寒区旱区环境与工程研究所中国科学院内陆河流域生态水文重点实验室兰州730000 中国科学院大学北京100049 中国科学院寒区旱区环境与工程研究所冻土工程国家重点实验室兰州730000

通过对黑河流域不同水体如降水、河水、深井(>80m)、浅井(<80m)及泉水的氚(T)含量的测定,结合文献资料和国际原子能机构数据,对流域不同水体氚(T)含量的空间分布特征进行了分析,并对黑河流域浅层和深层地下水的补给来源、年龄及其更新... 详细信息

通过对黑河流域不同水体如降水、河水、深井(>80m)、浅井(<80m)及泉水的氚(T)含量的测定,结合文献资料和国际原子能机构数据,对流域不同水体氚(T)含量的空间分布特征进行了分析,并对黑河流域浅层和深层地下水的补给来源、年龄及其更新时间进行了研究。结果表明:1)黑河上游、中游及下游河水T含量分别为50.0TU,33.3TU及20.9TU,呈逐渐降低趋势;上游和中游降水T含量变化也呈相似的规律,说明黑河流域河水来自黑河源区降水,且河水从上游到下游流动过程中与地下水进行转换。尤其是在临泽到正义峡段,河水的平均T含量为31.9TU,说明张掖和临泽灌溉抽提的地下水对河水有补给作用。2)黑河上游和中游山前平原的深层地下水T含量大于30.0TU,补给年龄小于50a;中游盆地及下游深层地下水T含量低于10.0TU,地下水年龄在50a以上,为次现代水,更新速度慢。3)黑河上游地下水和河道附近区域的浅层地下水的T含量高于30.0TU,补给年龄低于50a;远离河道浅层地下水T含量低于10.0TU,补给年龄大于50a。说明黑河源区降水是上游地下水的补给源,出山径流是黑河干流附近浅层地下水的主要补给源,地下水补给年龄低于50a,更新期短;远离河道区域的浅层地下水T含量低于10.0TU,为次现代水,更新速度慢。本研究结果对合理科学地利用黑河流域水资源具有借鉴意义。

关键词：黑河流域氚同位素地下水补给源地下水年龄

U-Pb Zircon and Re-Os Molybdenite Geochronology of the W-Mo Mineralized Region of South Qinling, China, and their Tectonic Implications

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Acta Geologica Sinica(English Edition) 2021年第2期95卷 500-516页

作者： HAN Ke YANG Xingke CHAO Huixia HE Hujun ruan Shiqi GAO yunfeng ZHANG Weisheng ZHU Wei JIN Gang School of Earth Science and Resources Chang an UniversityXi'an 710054China Key Laboratory of West Mineral Resources and Geology Engineering Ministry of Education Chang'an UniversityXi'an 710054China Shaanxi Mineral Resources and Geological Survey Xi'an 710054China

A W-Mo mineralized region is located along the northern margin of the South Qinling tectonic belt of China. WMo mineralization occurs mainly in Cambrian–Ordovician clastic and carbonate rocks, and the ore bodies are structurally controlled by NW–SE-and NNE–SSW-striking faults. Evidence for magmatism in the area is widespread and is dominated by intermediate–felsic intrusives or apophyses, such as the Dongjiangkou, Yanzhiba, Lanbandeng, and Sihaiping granitic bodies. Quartz-vein-type mineralization and fault-controlled skarn-type mineralization dominate the ore systems, with additional enrichment in residual deposits. At present, there are few or insufficient studies on(1) the age of mineralization,(2) the relationship between intermediate–felsic granite and W-Mo mineralization,(3) the source of ore-forming materials, and(4) the metallogenic and tectonic setting of the mineralized area. In this paper, we present geochronology results for numerous intrusive granitic bodies in the South Qinling tectonic belt. U-Pb zircon geochronology of the Lanbandeng monzogranite and Wangjiaping biotite monzogranite yields ages of 222.7 ± 2.3 and 201.9 ± 1.8 Ma, respectively. In contrast to the Late Triassic age of the Lanbandeng monzogranite, the age of the newly discovered Wangjiaping biotite monzogranite places it at the Triassic–Jurassic boundary. Re-Os molybdenite geochronology on the Qipangou W-Mo deposit yielded a model age of 199.7 ± 3.9 Ma, indicating the deposit formed in the early Yanshanian period of the Early Jurassic. Granitoid intrusions in the mineralized area are characterized by composite granite bodies that crystallized at ca. 240–190 Ma. While there were multiple stages of intrusion, most occurred at 210–220 Ma, with waning magmatic activity at 200–190 Ma. The Re-Os age of molybdenite in the region is ca. 200–190 Ma, which may represent a newly discovered period of W-Mo metallogenesis that occurred during the final stages of magmatism. The heat associated with thi

关键词： U-Pb zircon geochronology Re-Os molybdenite geochronology tungsten-molybdenum mineralized area intracontinental orogeny South Qinling

A novel defined risk signature of endoplasmic reticulum stress-related genes for predicting the prognosis and immune infiltration status of ovarian cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第1期24卷 64-77页

作者： Jiahang MO Shunyi ruan Baicai YANG yunfeng JIN Keyi LIU Xukai LUO Hua JIANG Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China Department of Oncology Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China Department of Gynecology Jiaxing University Affiliated Women and Children HospitalJiaxing 314050China Department of Pathology Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou 310006China

Endoplasmic reticulum(ER)stress,as an emerging hallmark feature of cancer,has a considerable impact on cell proliferation,metastasis,invasion,and chemotherapy *** cancer(OvCa)is one of the leading causes of cancer-related mortality across the world due to the late stage of disease at *** have explored the influence of ER stress on OvCa in recent years,while the predictive role of ER stress-related genes in OvCa prognosis remains ***,we enrolled 552 cases of ER stress-related genes involved in OvCa from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)cohorts for the screening of prognosis-related *** least absolute shrinkage and selection operator(LASSO)regression was applied to establish an ER stress-related risk signature based on the TCGA cohort.A seven-gene signature revealed a favorable predictive efficacy for the TCGA,International Cancer Genome Consortium(ICGC),and another GEO cohort(P<0.001,P<0.001,and P=0.04,respectively).Moreover,functional annotation indicated that this signature was enriched in cellular response and senescence,cytokines interaction,as well as multiple immune-associated *** immune infiltration profiles further delineated an immunologic unresponsive status in the high-risk *** conclusion,ER stress-related genes are vital factors predicting the prognosis of OvCa,and possess great application potential in the clinic.

关键词： Ovarian cancer(OvCa) Endoplasmic reticulum(ER)stress Risk signature Prognosis Immune infiltration

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泡沫浸渍法制备的多孔铌基生物材料及性能

稀有金属材料与工程 2010年第11期39卷 2015-2017页

作者：节云峰邹俭鹏阮建明 Cent S Univ Powder Met Res Inst State Key Lab Powder Met Changsha 410083 Peoples R China

采用新型的泡沫浸渍法,以聚氨酯泡沫为载体制备出具有较高强度和良好生物相容性的多孔铌基材料。并借助分析天平、XRD、CS600碳硫测试仪和SEM对多孔铌的孔隙度、性能和微观结构进行了测试及观察。结果表明:制成的多孔铌,具有三维、连通... 详细信息

采用新型的泡沫浸渍法,以聚氨酯泡沫为载体制备出具有较高强度和良好生物相容性的多孔铌基材料。并借助分析天平、XRD、CS600碳硫测试仪和SEM对多孔铌的孔隙度、性能和微观结构进行了测试及观察。结果表明:制成的多孔铌,具有三维、连通孔隙结构且无任何杂质相,孔隙率为71.4%,孔径尺寸为500μm,平均密度为2.45g/cm3。三维连通多孔铌的平均弹性模量为815MPa,抗压强度为36.62MPa,与人体松质骨的力学性能相匹配。

关键词：聚氨酯泡沫浸渍法制备多孔生物材料力学性能 via 生物相容性载体制备微观结构三维平均密度连通孔隙结构孔径尺寸抗压强度分析天平弹性模量测试仪杂质相松质骨

Integration of nanoscale light emitters:an efficient ultraviolet and blue random lasing from NaYF_4:Yb/Tm hexagonal nanocrystals

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Photonics Research 2018年第10期6卷 943-947页

作者： YA-PEI PENG WEI LU PENGPENG REN YIQUN NI yunfeng WANG LONG ZHANG YU-JIA ZENG WENFEI ZHANG SHUANGCHEN ruan Shenzhen Key Laboratory of Laser Engineering Key Laboratory of Advanced Optical Precision Manufacturing Technology of Guangdong Higher Education Institutes College of Optoelectronic Engineering Shenzhen University University Research Facility in Materials Characterization and Device Fabrication The Hong Kong Polytechnic University Department of Applied Physics The Hong Kong Polytechnic University Key Laboratory of Materials for High Power Laser Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences

Near infrared light-controlled release of payloads from ultraviolet-sensitive(UV-sensitive) polymer hydrogels or nanocarriers is one of the most promising strategies for biotherapy. Here, we propose the concept of light activation of NaYF_4:20%Yb, 2%Tm nanocrystals(NCs). NaYF_4:20%Yb, 2%Tm NCs are synthesized by a solvothermal method. Effective upconversion luminescence from NaYF_4:20%Yb, 2%Tm NCs excited by a continuous wave(CW) 980 nm laser is obtained. The NaYF_4:20%Yb, 2%Tm NCs are then used as a laser gain medium and sandwiched between Al and quartz reflectors to form laser microcavities. UV and blue upconverted random lasing is obtained from the laser microcavities. Hence, we verify explicitly that the NaYF_4:Yb, Tm NCs support UV and blue upconversion random lasing via a 980 nm nanosecond laser excitation. Our work provides what we believe is a new concept for precision and localized cancer therapy by external light excitation.

关键词：紫外线激光通讯技术发展现状

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浸渍法制备多孔镍钛生物材料及性能

稀有金属材料与工程 2013年第5期42卷 1023-1027页

作者：李婧杨海林阮建明节云峰中南大学粉末冶金国家重点实验室湖南长沙410083

选用等原子比NiTi预合金粉末作为原料,以聚氨酯泡沫为模板,采用浸渍法制备了一种具有高孔隙率、孔径可控、孔隙三维连通且生物力学相容性优良的多孔镍钛合金材料。通过X射线衍射仪、体视显微镜、扫描电子显微镜及力学试验机,研究分析了... 详细信息

选用等原子比NiTi预合金粉末作为原料,以聚氨酯泡沫为模板,采用浸渍法制备了一种具有高孔隙率、孔径可控、孔隙三维连通且生物力学相容性优良的多孔镍钛合金材料。通过X射线衍射仪、体视显微镜、扫描电子显微镜及力学试验机,研究分析了两种不同型号有机模板（R2D25和DP91308）制备的多孔镍钛合金的物相组成、微观结构和力学性能。结果表明：有机模板浸渍法可以制备出高孔隙率且具有三维连通孔隙结构的多孔镍钛合金。两种模板对应的孔隙率分别为71.8%和63.8%,孔径分布在250~500μm和150~400μm之间,抗压强度分别为16.37和73.52MPa,弹性模量为0.51和2.45GPa,与人体骨组织的结构与性能相匹配。

关键词：多孔镍钛合金浸渍法三维连通孔隙孔隙率

间充质干细胞源性外泌体在糖尿病性骨质疏松中的研究进展

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中国骨质疏松杂志 2022年第1期28卷 104-108页

作者：阮泽松陈云丰上海交通大学附属第六人民医院骨科上海200233

糖尿病性骨质疏松是糖尿病常见的并发症之一,是在糖尿病基础上继发的以骨量减少、骨脆性增加、骨折风险增加为主要特征的代谢性骨病。常规的抗骨质疏松药物对糖尿病性骨质疏松的疗效有限,存在增加非典型骨折的风险,因此亟待寻找新的积... 详细信息

糖尿病性骨质疏松是糖尿病常见的并发症之一,是在糖尿病基础上继发的以骨量减少、骨脆性增加、骨折风险增加为主要特征的代谢性骨病。常规的抗骨质疏松药物对糖尿病性骨质疏松的疗效有限,存在增加非典型骨折的风险,因此亟待寻找新的积极高效的治疗手段。外泌体是一类包含蛋白质、脂质、核酸等物质的胞外囊泡,介导细胞间通讯发挥对靶细胞的生物学效应。近来发现间充质干细胞旁分泌产生的外泌体能够在糖尿病模型中改善胰岛素抵抗、降低炎症水平、促进微血管损伤修复,具有诱导骨髓间充质干细胞成骨分化、调控成骨细胞和破骨细胞活动促进骨形成等功能,对治疗糖尿病性骨质疏松具有巨大的前景。笔者主要就间充质干细胞源性外泌体的特性与糖尿病性骨质疏松的相关病理生理机制进行简要综述,为后续应用于疾病治疗的研究提供参考与思路。

关键词：外泌体糖尿病性骨质疏松间充质干细胞