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代谢综合征及其组分对重症肺炎患者病情及预后的影响

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中国呼吸与危重监护杂志 2024年第4期23卷 249-255页

作者：张静王徽徽邓华英赖芳周耿标韩云广州中医药大学第二临床医学院广东广州510405 广州中医药大学第一临床医学院广东广州510010 广州中医药大学第二附属医院广东省中医院广东广州510120 广东省中医院晁恩祥学术经验传承工作室广东广州510120 广东省中医急症研究重点实验室广东广州510120

目的探讨代谢综合征(metabolic syndrome,MS)及其组分对重症肺炎患者病情及预后的影响。方法纳入2020年1月~2023年7月在广东省中医院重症监护病房收治的306例重症肺炎患者作为研究对象。根据是否合并MS将患者分为MS组和非MS组,并根据28... 详细信息

目的探讨代谢综合征(metabolic syndrome,MS)及其组分对重症肺炎患者病情及预后的影响。方法纳入2020年1月~2023年7月在广东省中医院重症监护病房收治的306例重症肺炎患者作为研究对象。根据是否合并MS将患者分为MS组和非MS组,并根据28天预后情况分为生存组和死亡组,对MS组和非MS组的一般资料、实验室指标、病情及预后指标等进行比较;采用多因素Logistic回归分析重症肺炎患者预后的独立危险因素。结果MS组的体重指数(body mass index,BMI)、空腹血糖(fasting blood glucose,FBG)、甘油三酯(triglyceride,TG)、血乳酸(lactate,LAC)、血白细胞计数(white blood cell count,WBC)、血尿素(urea phosphate,Urea)、血肌酐(creatinine,SCr)水平,急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)、休克、多器官功能衰竭综合征(multiple organ dysfunction syndrome,MODS)、气管插管发生率,死亡率,ICU治疗费用、总治疗费均显著高于非MS组(P<0.05);MS组高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、氧合指数(oxygenation index,OI)水平显著低于非MS组(P<0.05)。多因素Logistic回归分析显示,合并MS的重症肺炎死亡风险比没有合并MS的高1.276倍(95%CI:1.013,5.114,P=0.047);亚组分析结果也显示,合并MS的非病毒性重症肺炎死亡风险比没有合并MS的高2.147倍(95%CI:1.175,8.428,P=0.023)。结论合并MS的重症肺炎患者病情可能更重,预后可能更差。

关键词：代谢综合征重症肺炎预后

阿替利珠单抗联合贝伐珠单抗、化疗治疗晚期非小细胞肺癌的研究现状

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中国临床药理学杂志 2024年第17期40卷 2591-2595页

作者：赖厚芸梁燕李凤周进陈燕王怡鑫电子科技大学医学院附属肿瘤医院·四川省肿瘤医院药学部四川成都610041 电子科技大学医学院附属肿瘤医院·四川省肿瘤医院胸部肿瘤内科四川成都610041 电子科技大学医学院四川成都610054

免疫治疗已经彻底改变了晚期非小细胞肺癌患者的治疗,然而,由于其单药的低响应率,很多患者并不能从治疗中获益。将免疫治疗联合抗血管生成药和化疗可能有助于解决这一问题,而阿替利珠单抗与贝伐珠单抗、卡铂和紫杉醇(ABCP)的方案已被批... 详细信息

免疫治疗已经彻底改变了晚期非小细胞肺癌患者的治疗,然而,由于其单药的低响应率,很多患者并不能从治疗中获益。将免疫治疗联合抗血管生成药和化疗可能有助于解决这一问题,而阿替利珠单抗与贝伐珠单抗、卡铂和紫杉醇(ABCP)的方案已被批准作为晚期转移性非小细胞肺癌的一线治疗方法,具有巨大的应用潜力。本综述归纳了ABCP方案的抗肿瘤作用机制,总结了其针对不同亚组、不同治疗顺序的临床应用现状,该方案的安全性、经济性,以及ABCP方案中替换药物选择的可能性和新药的研发,为ABCP方案在非小细胞肺癌患者中的个体化应用提供参考。

关键词：抗血管生成药非小细胞肺癌免疫治疗联合治疗

不同土壤改良措施对大棚菜地高度盐渍化土壤改良效果研究

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中国土壤与肥料 2024年第4期 9-16页

作者：程明琨闵炬巨昇容潘云枫赵冬青杨东平施卫明佛山科学技术学院国际膜生物学与环境研究中心广东佛山528000 中国科学院南京土壤研究所土壤与农业可持续发展国家重点实验室江苏南京210008 宜兴市土肥站江苏宜兴214206

设施菜地土壤次生盐渍化现象普遍,严重制约了设施蔬菜的可持续发展。以高度和超高度大棚次生盐渍化土壤为对象,研究不同土壤改良措施对大棚青菜产量、氮肥利用率及土壤性状的影响。在两种盐渍化程度的大棚土壤上分别开展田间试验,设置... 详细信息

设施菜地土壤次生盐渍化现象普遍,严重制约了设施蔬菜的可持续发展。以高度和超高度大棚次生盐渍化土壤为对象,研究不同土壤改良措施对大棚青菜产量、氮肥利用率及土壤性状的影响。在两种盐渍化程度的大棚土壤上分别开展田间试验,设置相同的6个处理:不施氮肥(0%N)、常规施氮(100%N)、施石灰氮+常规施氮(Lime+100%N)、施石灰氮+减氮20%(Lime+80%N)、施石灰氮+填闲玉米+常规施氮(Lime+corn+100%N)和施石灰氮+填闲玉米+减氮20%(Lime+corn+80%N)。结果表明:与100%N处理相比,Lime+corn+80%N处理的青菜产量在高度、超高度次生盐渍化土壤上分别增产91.8%(11.3 t/hm^(2))和62.2%(5.6 t/hm^(2)),显著提高了氮肥利用率。在高度盐渍化土壤上,与100%N处理相比,施石灰氮可使土壤电导率降低16.0%~19.7%(P<0.05),对土壤pH无显著影响;与施石灰氮处理(Lime+100%N和Lime+80%N)相比,土壤电导率在Lime+corn+100%N和Lime+corn+80%N处理下分别降低了49.4%和55.2%(P<0.05),土壤pH升高3.4%和12.6%。在超高度盐渍化土壤上,与100%N处理相比,施石灰氮处理对土壤电导率无显著影响,可使土壤p H升高14.1%~16.0%(P<0.05);与施石灰氮处理相比,土壤电导率在Lime+corn+100%N和Lime+corn+80%N处理下分别降低了43.7%和49.2%(P<0.05)。不同土壤改良措施在高度盐渍化土壤上显著提高了土壤孔隙度,降低了土壤有效磷和速效钾含量,而在超高度盐渍化土壤上影响不显著。

关键词：设施蔬菜次生盐渍化土壤酸化土壤pH 产量氮肥利用率

FINITE ELEMENT NUMERICAL SIMULATION FOR THE HYDRODYNAMIC FIELD EVOLUTION OF GEOTHERMAL WATER IN THE NANWENQUAN ANTICLINE IN CHONGQING IN CHINA

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Journal of Hydrodynamics 2006年第4期18卷 443-448页

作者： LUO yun.ju LIU Dong-yan LIU Xin-rong College of Civil Engineering Chongqing University Chongqing 400045 China

The Nanwenquan （South Hot Spring） and Xiao quan （Small Hot Spring） in the Nanwenquan anticline are well-known attraction for their geothermal water, but currently, the two natural hot springs have hot flow naturally. In order to protect the geothermal water resource, the evolution of hydrodynamic field must be researched for the causation of the hydrodynamic field destroyed. The finite element numerical simulation was adopted and quantitative study on the geothermal water hydrodynamic field. The finite element model was set up to simulate the research sites, the simulated water level was compared with the actual water level, the feasibility of this model was proved when the simulated water level is approximate to actual one, and an applicable finite element model was obtained. The finite element model was used to simulate the evolution of the hydrodynamic field. This paper supplies a basis to exploit adequately and protect effectively the geothermal water resource, at the same time it is proved feasible in practice to apply finite element numerical simulation to quantitative study of the geothermal water.

关键词： Nanwenquan anticline the geothermal water hydrodynamic field finite element numerical simulation water level

Ore-forming Fluid Characteristics of the Saishitang Cu-polymetallic Deposit in Qinghai Province,China

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Acta Geologica Sinica(English Edition) 2015年第2期89卷 485-504页

作者： lai Jianqing ju Peijiao MAO Yin AN Jianghua WANG Xiongjun Key Laboratory of Metallogenic Prediction of Nonferrous Metals Ministry of EducationCentral South University School of Geosciences and Info-Physics Central South University

Saishitang Cu-polymetallic deposit is located in the southeast section of Late Paleozoic arcfoid in the southeastern margin of Qaidam platform. Accoring to the geological process of the deposit, four mineralization episodes were identified： melt/fluid coexisting period （O）, skarn period （A）, first sulfide period （B） and second sulfide period （C）, and 10 stages were finally subdivided. Three types of inclusions were classified in seven stages, namely crystal bearing inclusions （type I）, aqueous inclusions （type Ⅱ） and pure liquid inclusions （type Ⅲ）. Type I and Ⅱ inclusions were observed in stage O1, having homogenization temperature from 252 to 431℃, and salinities ranging from 24.3% to 48.0%. Type I inclusion was present in stage A1, having homogenization temperature from 506 to 548℃, and salinities ranging from 39.4% to 44.6%. In stage B1, type Ⅱ and Ⅲ inclusions were observed, with homogenization temperature concentrating between 300-400℃, and salinities from 0.4% to 4.3%. Type II inclusions were present in stage B2, with homogenization temperature varying from 403 to 550℃. In stage C1, type I and II inclusion commonly coexisted, and constituted a boiling inclusion group, having homogenization temperatures at 187-463℃, and salinities in a range of 29.4%-46.8% and 2.2%-11.0%. Type II and III inclusions were developed in stage C2, having homogenization temperature at 124-350℃, and salinities ranging between 1.6% and 15.4%. In stage C3, type Ⅱ and Ⅲ inclusions were presented, with a homogenization temperature range of 164-360℃, and salinities varying from 4.0% to 11.0%. The results of micro-thermal analysis show that fluids are characterized by high temperature and high salinity in stage O1 and A1, and experienced slight decrease in temperature and dramatic decrease in salinity in stage B1 and B2. In stage C1, the salinity of fluid increased greatly and a further decrease of temperature and salinity occurred in stage C2 and C3. Fluids boiled in stage C1. With calcul

关键词： fluid inclusions ore-forming fluid Laser Raman Spectroscopy Saishitang Qinghai Province

A new approach of using Lorentz force to study single-asperity friction inside TEM

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Journal of Materials Science & Technology 2021年第25期84卷 43-48页

作者： Huanhuan Lu Zhangjie Wang Di yun.ju Li Zhiwei Shan Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano)and Hysitron Applied Research Center in China(HARCC) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an710049People’s Republic of China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an710049People’s Republic of China Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

Taking advantage of the magnetic field inside transmission electron microscope(TEM),a unique Lorentzforce-actuated method for quantitative friction tests was developed via a commercial electromechanical *** this approach,a submicron-sized silver asperity sliding on a tungsten flat punch was actuated by Lorentz force due to electrical current through the punch,with the normal force imposed by the built-in transducer of the *** friction force was determined by tracking the elastic deflection of the fabricated cantilever from in situ *** correlating the friction behavior with the microstructural evolution near the silver-tungsten interface,we revealed that even when the relative motion commenced with the plastic deformation of the silver asperity,the interface can still sustain the further increasing static friction *** following the arrival of the maximum static friction force,the sliding occurred at the interface,indicating the transition from static to dynamic *** work enriches our understanding of the underlying physics of the dynamic friction process for metallic friction behavior.

关键词： friction deformation silver

黄河源区高寒湿地土壤团聚体有机碳矿化特征及其温度敏感性

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草地学报 2024年第7期32卷 2205-2213页

作者：宋娴柴瑜徐文印益西卓玛于金峰马昀峤李希来青海大学农牧学院青海西宁810016 青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

探索土壤碳固存与全球气候变暖的关系是当前环境科学的研究热点。为厘清黄河源区高寒湿地土壤团聚体有机碳矿化特征,本研究利用碱液吸收法测定不同温度(5℃,15℃,25℃)条件下湿地土壤各粒径(>2 mm,2~0.25 mm和0.25 mm)有机碳矿化速率显... 详细信息

探索土壤碳固存与全球气候变暖的关系是当前环境科学的研究热点。为厘清黄河源区高寒湿地土壤团聚体有机碳矿化特征,本研究利用碱液吸收法测定不同温度(5℃,15℃,25℃)条件下湿地土壤各粒径(>2 mm,2~0.25 mm和0.25 mm)有机碳矿化速率显著高于微团聚体(2 mm,<0.25 mm。综上所述,温度升高降低了黄河源区高寒湿地土壤团聚体的固碳能力。

关键词：黄河源区温度团聚体有机碳矿化 Q_(10) 高寒湿地

Prevalence of bacteria, fungi, and virus coinfections with SARS-CoV-2 Omicron variant among patients with severe COVID-19 in Guangzhou, China, winter 2022

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Biosafety and Health 2024年第2期6卷 92-97页

作者： Qinghong Fan Mengling Jiang jun Zhang Guofang Tang Ming Gao Yingfen Wen Xizi Deng jun Dai Honghao lai Peng Qian Yaqing Lin Ruiying He Liya Li Yueping Li Zhengtu Li Xuesong Liu Yimin Li Na Yu yun Lan Fengyu Hu Feng Li Institute of Infectious Diseases Guangzhou Eighth People's HospitalGuangzhou Medical UniversityGuangzhou 510440China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of GuangzhouMedicalUniversityGuangzhou510120China Guangzhou Laboratory Guangzhou 510700China

The status of coinfection during the national outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron BA.5.2 or BF.7 in China in the winter of 2022,which is suspected to contribute substantially to the overloaded severe cases,needs to be *** analyzed the coinfection status of 385 severe patients infected with the Omicron variant in Guangzhou using metagenomic *** found that 317(82.3%)patients were coinfected with at least one additional pathogen(s),including bacteria(58.7%),fungi(27.1%)and viruses(73.5%).Pseudomonas aeruginosa(***)(24.2%),Staphylococcus aureus(***)(14.0%),andKlebsiella pneumoniae(***)(13.4%)ranked as the top three coinfected *** fumigatus(***)(39.5%),Pneumocystis jirovecii(***)(24.4%)andCanidia albicans(***)(22.1%)were the top three coinfected ***-Barr virus(EBV)(63.1%),Human herpesvirus 7(HHV-7)(34.8%),and Herpes simplex virus 1(HSV-1)(32.6%)were the top three coinfected *** note,the detection of multiple coinfections of potential pathogenic bacteria,fungi,and viruses,despite lacking consistent patterns,highlighted a complicated synergistic contribution to disease *** study presents the most comprehensive spectrum of bacterial,fungal,and viral coinfections in Omicron-associated severe coronavirus disease 2019(COVID-19),implying that the coinfection of conditional pathogens might synergistically deteriorate the Omicron infection outcomes.

关键词： SARS-CoV-2 Omicron BA.5.2 Omicron BF.7 Coinfection Severeinfection

基于机器视觉的煤尘环境下掘进空间煤岩界面感知与精准识别

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煤炭学报 2024年第7期49卷 3276-3290页

作者：张云童亮来兴平曹胜根闫保旭刘永孜孙浩强杨彦斌何伟西安科技大学能源学院陕西西安710054 中国矿业大学煤炭资源与安全开采国家重点实验室江苏徐州221116

巷道掘进过程中煤岩识别技术是掘进机截割头自动调整的核心,同样是制约矿山智能化建设的关键难题之一。针对当前采掘失衡,掘进工作面缺乏成熟有效的煤岩识别方案,现有基于图像的煤岩识别模型存在分割精度差、无法灵活部署等问题,提出一... 详细信息

巷道掘进过程中煤岩识别技术是掘进机截割头自动调整的核心,同样是制约矿山智能化建设的关键难题之一。针对当前采掘失衡,掘进工作面缺乏成熟有效的煤岩识别方案,现有基于图像的煤岩识别模型存在分割精度差、无法灵活部署等问题,提出一种应用在掘进工作面下基于图像分割的煤岩截割界面感知与精准识别方法。该方法结合掘进工作面实际截割情况,采用Mobile-NetV2特征提取网络作为DeepLabV3+的主干网络,使模型更好地兼顾分割精度和模型复杂度;将空洞空间卷积池化金字塔模块输出的高级特征进行通道注意力(SE)操作,分配通道权重以强化对重点特征信息的训练;在主干网络输出的浅层特征引入通道空间注意力(CA)机制,使浅层特征图中的低级表征信息加权,从而设计出融合双注意力机制于DeepLabV3+的煤岩截割界面识别模型。同时搭建煤尘环境下煤岩识别实验平台模拟掘进机截割后形成的煤岩截割面,研发巷道掘进过程中煤岩截割界面采集方法,并以实际矿井的掘进工作面为工程背景,验证该煤岩识别模型的分割精度以及实际应用性。研究结果表明:SE-CA-DeepLabV3+模型的平均交并比和平均像素精度分别为97.15%和98.51%,相较于其他模型具有更优的分割性能。将所建立模型对来自陕北试验矿井掘进工作面的原始煤岩图像进行验证,平均误差为0.7%,每秒传输帧数为43 fps,满足井下现场应用部署条件。

关键词：煤岩截割界面 SE-CA-DeepLabV3+ 巷道掘进煤岩识别平台图像分割