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Ecological Barrier Deterioration Driven by Human Activities Poses Fatal Threats to Public Health due to Emerging Infectious Diseases

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Engineering 2022年第3期8卷 155-166页

作者： Dayi Zhang yunfeng Yang Miao Li yun Lu Yi liu Jingkun Jiang Ruiping liu Jianguo liu xia Huang Guanghe Li Jiuhui Qu School of Environment Tsinghua UniversityBeijing 100084China Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

The coronavirus disease 2019(COVID-19)and concerns about several other pandemics in the 21st century have attracted extensive global *** emerging infectious diseases threaten global public health and raise urgent studies on unraveling the underlying mechanisms of their transmission from animals to *** numerous works have intensively discussed the cross-species and endemic barriers to the occurrence and spread of emerging infectious diseases,both types of barriers play synergistic roles in wildlife *** far,there is still a lack of a complete understanding of viral diffusion,migration,and transmission in ecosystems from a macro *** this review,we conceptualize the ecological barrier that represents the combined effects of cross-species and endemic barriers for either the natural or intermediate hosts of *** comprehensively discuss the key influential factors affecting the ecological barrier against viral transmission from virus hosts in their natural habitats into human society,including transmission routes,contact probability,contact frequency,and viral *** the significant impacts of human activities and global industrialization on the strength of the ecological barrier,ecological barrier deterioration driven by human activities is critically analyzed for potential *** climate change can trigger and expand the range of emerging infectious diseases,and human disturbances promote higher contact frequency and greater transmission *** addition,globalization drives more transmission routes and produces new high-risk regions in city *** review aims to provide a new concept for and comprehensive evidence of the ecological barrier blocking the transmission and spread of emerging infectious *** also offers new insights into potential strategies to protect the ecological barrier and reduce the wide-ranging risks of emerging infectious diseases to public health.

关键词： Emerging infectious diseases Virus Ecological barrier

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Two Novel Lanthanide Coordination Polymers with Differently Bridging Pyridine-2,4,6-tricarboxylate Ligand

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Chemical Research in Chinese Universities 2009年第6期25卷 796-800页

作者： CHEN Zi-yun PENG Meng-xia Department of Chemistry Jiaying University Meizhou 514015 P. R. China

Two new lanthanide-pyridinetricarboxylic complexes formulated as [Lu（pyta）（H2O）3]（1） and [La（pyta）· （H2O）2]-***2O（2） were synthesized through hydrothermal reactions of LuC13 or La（NO3）y6H2O with pyridine-2,4,6-tricarboxylic acid（H3pyta）, respectively, and characterized by X-ray crystallography. Complex 1 crystal- lized in the monoclinic system with space group P21/n, a=1.01930（12） nm, b=0.73423（9） nm, c=1.45449（17） Mm, β=94.734（2）° V=1.0848（2） nm3, Z=4. Complex 2 crystallized in the monoclinic system with space group P21/c, a=0.68474（8） nm, b=1.20982（15） nm, c=1.36063（17） nm, β=99.823（2）°, V=l.1106（2） nm3, Z=4. The overall structure of complex 1 consists of 2D binuclear Lu2（pyta）4-based grid coordination layers which are further extended into a 3D supramolecular architecture via hydrogen bonding interactions. With different coordination modes of the pyta ligand, complex 2 is a 3D porous network comprised of La-carboxylate framework.

关键词： Pyridine-2,4,6-tricarboxylic acid Lu(Ⅲ) La(Ⅲ) Hydrothermal method

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Two New Iron Coordination Polymers Based on Fe-pyta Chains Incorporating Pyridine-2,4,6-tricarboxylate

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Chemical Research in Chinese Universities 2008年第4期24卷 392-395页

作者： CHEN Zi-yun PENG Meng-xia Department of Chemistry Jiaying University Meizhou 514015 P. R. China

Reaction of FeCIz＇6H20, pyridine-2,4,6-tricarboxylic acid（H3pyta） and NaOH in the hydrothermal system at 185 ℃ resulted in the formation of 1D coordination polymer[Fe（Hpyta）（H2O）2]（1） based on Fe-Hpyta chains. When the abpt[abpt=-4-amino-3,5-bis（4-pyridyl）-l,2,4-triazole] ligand was employed in the reaction system, a 3D supramolecular porous network （H2bpt）[Fe（pyta）（H2O）2]·4H2O（2） was obtained. The framework was constructed with negative （Fe-pyta） chains and the positive H3bpt^＋ in situ, formed from the abpt reagent, to form 1D channels filled with guest water molecules via hydrogen-bonds. X-Ray diffraction crystal structure analysis shows that complex 1 crystallized in the monoclinic system, space group C2/c, a=1.1490（5） nm, b=0.9008（4） nm, c=1.0058（5） nm, B=107.254（9）°, V=0.9942（8） nm3, Z=4; and complex 2 crystallizes in the triclinic system, space group P1 with a=0.90392（11） nm, b=0.96027（11 ） nm, c=1.55540（18） nm, a=73.558（2）°,B= 86.126（2）°,r= 68.745（2）°, V=1.2059（2） nm^3 and Z=2.

关键词： Iron(Ⅱ) Coordination polymer Pyridine-2,4,6-tricarboxylate 4-Amino-3,5-bis(4-pyridyl)-1,2,4-triazole Hydrothermal

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Design,synthesis and anti-HBV activity of novel bis(trifluoroethyl)phosphonomethyl ether derivatives of acyclovir

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Chinese Chemical Letters 2009年第5期20卷 507-510页

作者： Peng Lu Sai Hong Jiang Jiang xia liu Yu She Yang Ru yun Ji State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institute for Biological Sciences Chinese Academy of Science Shanghai 201203 China Fudan University Shanghai 200032 China

A series of novel bis（trifluoroethyl）phosphonomethyl ether derivatives of acyclovir was synthesized and their in vitro anti-HBV activity was evaluated in HepG2 2.2.15 cells. In contrast to acyclovir, most of the described phosphonates emerged as potent inhibitors of HBV replication. Especially, the most active compound 11 with IC50 value of 2.92 μmol/L was 33 times more potent than acyclovir with ICso value of 100 μmol/L.

关键词： Acyclovir Phosphonate Anti-HBV activity

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Nitrogen-rich metal-organic framework mediated Cu-N-C composite catalysts for the electrochemical reduction of CO_(2)

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Journal of Energy Chemistry 2021年第3期30卷 555-563页

作者： Si-Min Cao Hua-Bo Chen Bao-xia Dong Qiu-Hui Zheng Yan-xia Ding Meng-Jie liu She-Liang Qian yun-Lei Teng Zong-Wei Li Wen-Long liu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002ZhejiangChina

Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon ***,the limited conductivity and stability become the stumbling-block that prevents the development of *** exploring of MOFsderived M-C materials starts a new chapter for the MOFs precursors,which provides a remarkable electronic connection between carbon matrix and metals/metal oxides.N-doped M-N-C with extensive M-N sites scattering into the carbon matrix are more popular because of their impressive contribution to catalytic activity and specific product ***,Cu-N-C system remained undeveloped up to *** lack of ideal precursor,the sensitivity of Cu to be oxidized,and the difficulties in the synthesis of small size Cu nanoparticles are thus known as the main barriers to the development of Cu-N-C ***,a nitrogen-rich Cu-BTT MOF is employed for the derivation of N-doped Cu-N-CT composite electrocatalysts by the pyrolyze ***-temperature pyrolysis product of Cu-N-C1100exhibits the best catalytic activity for productions of CO(-0.6 V ***,jCO=0.4 mA/cm^(2))and HCOOH(-0.9 V ***,jHCOOH=1.4 mA/cm^(2)).

关键词： Carbon mono-oxide Formic acid Metal-organic framework Nitrogen-rich Copper nanoparticle Catalyst

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Feature analysis on US military aircraft engine advanced technology programs

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航空动力学报 2014年第7期29卷 1701-1709页

作者： LIANG Chun-hua SUN Ming-xia liu Hong-xia Shenyang Engine Design and Research Institute Aviation Industry Corporation of China

US military aircraft engine advanced technology programs were overviewed and analyzed from light weight gas generator(LWGG)program initiated in 1960 sthrough integrated high performance turbine engine technology(IHPTET)program started in 1980 s,then to versatile affordable advanced turbine engine(VAATE)*** features and trends were summarized and concluded by literature statistics method,such as teams based on closely corporation among government,industries and academics,goals oriented with national defence strategies and weapon system development requirements,engineering manufacture and development including all relative disciplines and areas,verification measured by technology readiness level,the application extending to military aircraft engine,civilian engine,gas turbine and space vehicle,*** experience and lessons obtained can provide reference and guide for technology research and engineering manufacture and development of military aircraft engines in the world.

关键词： aircraft engine military aircraft engine advanced technology program technology corporation multi-discipline development technology verification

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不同材料种植体修复单颗上前牙缺失的三维有限元分析

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中国组织工程研究 2025年第22期29卷 4687-4693页

作者：夏昭鑫高亦辰邓雨瑶王霞兰小蓉何芸陈俊良西南医科大学附属口腔医院口腔颌面外科四川省泸州市646000 口颌面修复重建和再生泸州市重点实验室四川省泸州市646000

背景:种植修复已成为治疗前牙缺失的重要手段,选取合适的种植修复材料尤为重要,但目前临床应用的种植体材料均存在一定的不足,研究者们一直在探索合适的种植体材料。目的:对比不同材料种植体修复单颗上前牙缺失的生物力学特征。方法:将... 详细信息

背景:种植修复已成为治疗前牙缺失的重要手段,选取合适的种植修复材料尤为重要,但目前临床应用的种植体材料均存在一定的不足,研究者们一直在探索合适的种植体材料。目的:对比不同材料种植体修复单颗上前牙缺失的生物力学特征。方法:将1例单颗上颌中切牙缺失患者的锥形束CT数据导入3-matic软件建立单颗上前牙缺失的三维有限元分析模型,将模型导入Marc Mentat中,根据不同的种植体材料(聚醚醚酮、钛锆合金、钛合金和氧化锆,4种材料的弹性模量依次升高)及松质骨密度(高密度、低密度)共设计8组种植体修复模型,模拟正中咬合时上前牙受力情况,比较分析种植体位移、应力以及骨皮质应力和骨松质应变。结果与结论:(1)随着种植体材料弹性模量的增加,种植体的最大位移逐渐降低,聚醚醚酮组种植体最大位移数值超过了10μm;模型中种植体应力集中于唇侧颈部,随着种植体材料弹性模量的增加,种植体最大应力逐渐增大,其中氧化锆-低密度骨质组模型种植体应力最高,达21.31 MPa;所有模型的皮质骨应力均集中于与种植体交界的唇侧皮质骨,聚醚醚酮-低密度骨质组皮质骨应力最高,为29.90 MPa。(2)从生物力学角度来看,钛锆合金、钛合金、氧化锆均可用作修复单颗上前牙缺失的种植体材料,但单纯聚醚醚酮材料在上前牙区种植修复时可能会引起种植体位移过大,导致种植失败。

关键词：三维有限元分析上前牙缺失种植体钛钛锆合金氧化锆聚醚醚酮

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YWHAZ Binds to TRIM21 but Is Not Involved in TRIM21-stimulated Osteosarcoma Cell Proliferation

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Biomedical and Environmental Sciences 2018年第3期31卷 186-196页

作者： ZENG Qing Zhong liu Wan Ting LU Jun Lei liu xiao Hui ZHANG yun Fang liu Lang xia GAO Xue Juan Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health EngineeringJinan University Center of Kidney Disease Huadu District People's HospitalSouthern Medical University

Objective Osteosarcoma is the most common type of malignant bone tumor in children and adolescents. The role of E3 ligases in tumorigenesis is currently a focus in tumor research. In the present study, we investigated the role of the E3 ligase tripartite motif 21（TRIM21） in osteosarcoma cell *** 3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide（MTT） assays were used to assess osteosarcoma cell viability. U2-OS cells stably carrying a recombinant lentivirus expressing tetracycline-regulated TRIM21 were screened. Co-immunoprecipitation was coupled with LCMS/MS analysis to identify novel interacting partners of TRIM21. Co-immunoprecipitation and bimolecular fluorescence complementation（BIFC） were performed to validate the interactions between TRIM21 and its novel partner YWHAZ. A TRIM21-ΔRING construct was generated to test the effects of TRIM21 ligase activity on *** TRIM21 positively regulated osteosarcoma cell proliferation. Overexpression of TRIM21 enhanced osteosarcoma cell tolerance toward various stresses. YWHAZ protein was identified as a novel interacting partner of TRIM21 and its expression levels were negatively regulated by TRIM21. The RING domain of TRIM21 was required for TRIM21 negative regulation of YWHAZ expression. However,overexpression of YWHAZ did not affect positive regulation of osteosarcoma cell proliferation by *** Our results further clarify the molecular mechanisms underlying the pathogenesis of osteosarcoma.

关键词： TRIM21 YWHAZ Osteosarcoma Proliferation

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Self-enhanced photothermal-chemodynamic antibacterial agents for synergistic anti-infective therapy

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Chinese Chemical Letters 2023年第2期34卷 452-457页

作者： Ning Guo Yu xia Yuxi Duan Quanxin Wu Le xiao Yaxin Shi Bin Yang yun liu Guangdong Key Laboratory for Research and Development of Natural Drugs School of PharmacyGuangdong Medical UniversityZhanjiang 524023China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's HospitalDepartment of Biomedical EngineeringSchool of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511436China The Marine Biomedical Research Institute of Guangdong Zhanjiang 524023China

Cu_(2-x)S nanostructures have been intensively studied as outstanding chemodynamic therapy(CDT)and good photothermal therapy(PTT)antibacterial agents due to their highly efficient Cu(Ⅰ)-initiated Fenton-like catalytic activity and good photothermal conversion ***,they still suffer from shortage of Cu(Ⅰ)supply in the long-term and comparatively low inherent photothermal conversion ***,we constructed a self-enhanced synergistic PTT/CDT nanoplatform(Cu_(1.94)S@MPN)by coating Cu_(1.94)S nanoparticles with Fe(Ⅲ)/tannic acid based metal-polyphenol networks(MPN).Activated by the acidic bacterial infection microenvironment,Cu_(1.94)S@MPN could be decomposed to continuously release Cu(Ⅱ),Fe(Ⅲ)ions and tannic *** the result of tannic acid-involved Cu and Fe redox cycling,Cu(Ⅰ)/Fe(Ⅱ)-rich CDT could be achieved through the highly accelerated catalytic Fenton/Fenton-like *** importantly,experimental results demonstrated that Cu_(1.94)S@MPN exhibited both excellent photothermal antibacterial and photothermal-enhanced CDT properties to eradicate bacteria in vitro and in ***,this novel nanotherapeutics has great potential to become a clinic candidate for anti-infective therapy in future.

关键词： Antibacterial Self-enhanced Photothermal therapy Chemodynamic therapy Anti-infective therapy

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Inhibitory effects of antisense phosphorothioate oligodeoxynucleotides on pancreatic cancer cell Bxpc-3 telomerase activity and cell growth in vitro

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World Journal of Gastroenterology 2006年第25期12卷 4004-4008页

作者： yun-Feng Wang Ke-Jian Guo Bei-Ting Huang Yong liu xiao-yun Tang Jian-Jun Zhang Qiang xia Department of General Surgery The Center Hospital of Shanghai Yangpu District (Branch Hospital of The Affiliated Xinhua Hospital of Shanghai Jiaotong University) Shanghai 200127 China Center of Liver Transplantation of The Affiliated Renji Hospital of Shanghai Jiaotong University Shanghai 200127 China Department of Biliary-Pancreatic Surgery The First Affiliated Hospital of China Medical University Shengyang 110001 Liaoning Province China Department of Clinical Epidemiology Staff Room of the First Affiliated Hospital of China Medical University Shengyang 11001 Liaoning Province China The First Department of The Center of Experiment and Technology The China Medical University Shengyang 11001 Liaoning Province China

AIM： To investigate the effect of telomerase hTERT gene antisense oligonucleotide （hTERT-ASO） on proliferation and telomerase activity of pancreatic cancer cell line Bxpc-3. METHODS： MTT assay was used to detect the effect of different doses of hTERT-ASO on proliferation of Bxpc-3 cell for different times. To study the anti-tumor activity, the cells were divided into there groups： Control group （pancreatic cancer cell Bxpc-3）; antisense oligonucleotide （hTERT-ASO） group; and nosense oligonucleotide group decorated with phosphorothioate. Telomerase activity was detected using TRAP-PCR-ELISA. Cell DNA distribution was examined using flow cytometry assay. Cell apoptosis was observed by transmission electron microscope in each group. RESULTS： After treatment with 6 mmollL hTERT- ASO, cell proliferation was inhibited in dose- and time- dependent manner. The telomerase activity decreased after treatment with hTERT-ASO for 72 h. Flow cytometry showed the cell number of G0/G1 phase increased from 2.7% to 14.7%, the cell number of S phase decreased from 72.7% to 51.0%, and a sub-G1 stage cell apoptosis peak appeared in front of G1 stage. CONCLUSION： Telomerase antisense oligodeoxy- nucleotide can inhibit the proliferation of pancreatic cancer cell line Bxpc-3 and decrease the telomerase activity and increase cell apoptosis rate in vitro.

关键词： Antisense oligodeoxynucleotide hTERT Telomerase Telomerase reverse transcriptase

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