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Inhibitory Effect of Epigallocatechin-3-gallate on Angiotensin Ⅱ-Induced Expression of Adhesion Molecules in Vascular Endothelial Cells.

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Inhibitory Effect of Epigallocatechin-3-gallate on Angiotens...

Large retroperitoneal atypical spindle cell lipomatous tumor,an extremely rare neoplasm:A case report

第十五届国际药理学大会

作者： Hee-Yul Ahn Yeon Jeong Chae Seok Hee yun Hun sik Kim Hao Jia Chan Hyung Kim Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea Department of Pharmacology College of MedicineChungbuk National University Cheongju South Korea

＜正＞ Attachment of leukocytes to the vascular endothelium and the subsequent migration of cells into the vessel wall are early events in atherogenesis. Expression of endothelial adhesion molecules play an important role in this process. In the present study, we tested the effect of Epigllocatechin-3-gallate （ EGCG） on proatherogenic agent, angiotensin Ⅱ （Ang Ⅱ）-induced expression of adhesion molecules in vascular endothelial cells. We showed that EGCG inhibits Ang Li-stimulated VCAM-1 and ICAM-1 expression in HUVECs. Inhibition of Ang Ⅱ-in-duced adhesion molecules expression was manifested already on the transcriptional level. EGCG pretreatment inhibited Ang Ⅱ-stimulated activation of p38 MAPK and ERK 1/2. while EGCG did not exert any significant changes in activation of c-Jun N-terminal kinase （JNK）. In addition, a specific p38 MAPK inhibitor, SB202190 or ERK 1/2 inhibitor, PD98059, suppressed Ang Ⅱ-stimulated VCAM-1 and ICAM-1 expression. Conclusion: These results suggest that EGCG inhibits Ang Ⅱ-induced adhesion molecules expression, which is regulated by p38 MAPK and ERK 1/2 signaling pathways

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World Journal of Clinical Cases 2022年第8期10卷 2584-2590页

作者： Jung-Min Bae Chang-Yeon Jung Woo-Sung yun Joon Hyuk Choi Department of Surgery Yeungnam University College of MedicineDaegu 42415South Korea Kyungpook National University School of Medicine Jung-guDaegu 41944Korea Department of Pathology Yeungnam University College of Medicine Nam-guDaegu 42415Korea

BACKGROUND Atypical spindle cell lipomatous tumor(ASLT)is a rare soft tissue neoplasm with a low potential for *** frequently occurs in the limb and limb ***,large retroperitoneal ASLTs are extremely *** was no concrete case report of retroperitoneal *** SUMMARY An 18-year-old woman presented with abdominal pain and a palpable *** computed tomography revealed a large fatty mass that was approximately 30 cm in size and filled the entire abdominal *** excision was *** tumor did not invade the adjacent *** pelvic cavity was then too narrow to dissect *** mass was successfully excised without tumor rupture or adjacent organ ***,the neoplasm was a well-differentiated adipocytic *** staining showed that the spindle cells were positive for CD34 and desmin,in addition to multifocal positivity for S100 *** histological features were consistent with an *** patient’s postoperative course was *** the 12-mo followup,no evidence of recurrence or metastasis was *** To the best of our knowledge,our study is the first concrete report of a large retroperitoneal ASLT in the English *** the large retroperitoneal ASLT located in the pelvic cavity,which made it too narrow and tight to dissect,complete excision is difficult but very important because of recurrence *** large retroperitoneal ASLTs are considered extremely rare,their detection is important for accurate evaluation and *** to their significant rarity,retrospective multicenter case studies are required to determine the clinicopathologic characteristics.

关键词： Neoplasms Retroperitoneal space Spindle cell Case report

Effect of Tai Chi Chuan on serotonin and cortisol for monitoring stress and quality of life in post-treatment breast cancer patients

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中华乳腺病杂志（电子版） 2014年第4期8卷 34-40页

作者： William Wai nam Tsang Wings Tjing yung Loo Louis Wing Cheong Chow Elizabeth Lam Yan Ng Adrian yun San Yip Jianping Chen Department of Rehabilitation Sciences Hong Kong Polytechnic University UNIMED Medical Institute and Organisation for Oncology and Translational Research School of Chinese Medicine Li Ka Shing Faculty of MedicineUniversity of Hong Kong

Objective Immediate physical exercise has been recommended for patients in the recovery phase to improve survival and quality of life(QOL)and reduce recurrence of *** new NCCN Guidelines for Survivorship also highlighted the role of exercise in post-cancer health,encouraging patients to perform light physical activity following *** aim of our study is to effect of Tai Chi Chuan(TCC)on serotonin and cortisol for monitoring stress and QOL in post-treatment breast cancer *** Totally85 post-treatment breast cancer patients were enrolled in this study to observe the effects of practicing TCC on recovery,as well as stress and happiness which are indicators of QOL of in *** blood was drawn from study subjects to analyze the levels of serotonin,cortisol and high sensitive C-reactive protein(HSCRP)at baseline,and at 3,6 and 12 months of TCC *** was drawn from healthy subjects only at baseline.A QOL questionnaire was administered to study subjects at three time points throughout the study,and once for healthy *** data were processed by analysis of variance of repeated *** At 3,6 and 12 months time points following regular TCC exercise,WBC,RBC,hemoglobin in blood samples showed a statistically significant difference(F=161.55,172.14,289.73;all P=0.00);the level of serotonin(biomarker for well-being),cortisol(indicator of stress)and HS-CRP(biomarker for inflammation)showed a statistical improvement(F=307.46,182.85,102.23;all P=0.00).After 3,6 and 12 months of regular TCC exercise,according to the results of QOL questionnaire,the indicators including quality of sleep,perceived hunger,fatigue,contentment,stress and social interaction presented a significant difference(F=312.98,222.64,543.90,46.05,28.10,78.92,all P<0.05),while there was no statistical difference in life dissatisfaction(F=56.61,P=0.166)Conclusions TCC physical activity for post-treatment breast cancer patients improved QOL and overall

关键词：乳腺病患者临床分析治疗方法

Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

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Cancer Communications 2018年第1期38卷 344-351页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song namsu Lee Eun Mi nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung Soon Jang Do Hyoung Lim Hyun Woo Lee Seok yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University15 Jinju-daero 816beon-gilJinju 52727Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital CheonanCheonan 31151Republic of Korea Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital SeoulSeoul 04401Republic of Korea Department of Internal Medicine Ewha Womans UniversityCollege of MedicineSeoul 07985Republic of Korea Department of Internal Medicine Dankook University HospitalCheonan 31116Republic of Korea Department of Internal Medicine Chung-Ang UniversityCollege of MedicineSeoul 06973Republic of Korea Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer HospitalSeoul 01812Republic of Korea Department of Hematology-Oncology Ajou University HospitalSuwon 16499Republic of Korea

Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer ***,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested *** investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic ***:A multicenter phase II prospective open-label,single-arm study was conducted at 14 *** with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were *** FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 *** primary endpoint was progression-free survival from the initiation of *** endpoints were the objective response rate,disease control rate,overall survival,safety,and *** estimated overall survival and progression-free survival using the Kaplan-Meier ***:We enrolled 39 patients from 14 *** objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,*** progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),*** 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock ***:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabin

关键词： Attenuated FOLFIRINOX Second-line Pancreatic cancer Gemcitabine

Noninvasive Prenatal Testing for Fetal Chromosomal Abnormalities Using Massively Parallel Sequencing: Clinical Experience from 7910 Korean Pregnancies

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Open Journal of Genetics 2018年第3期8卷 42-53页

作者： Seon Young yun Hyuk Jung Kwon Amit Goyal Katiyar P. Shashank Heesu Im Joungsu Joo Jin-sik Bae Min Seob Lee Sunghoon Lee EONE-DIAGNOMICS Genome Center (EDGC) Incheon South Korea

Objective: The purpose of this study is to review the clinical experience and performance of noninvasive prenatal testing (NIPT) method, using cell-free DNAto detect chromosomes 21, 18, 13, X, and Y abnormalities in over 7910 clinical samples from South Korean population. Method: Pregnant women between 1st of November 2015 to 18th of February 2018, with obstetric clinical findings participated in the study. NIPT was performed based on masivelly parallel sequencing with 0.3× low coverage paired-end sequencing using cell-free DNA in maternal plasma. Further invasive prenatal testing was recommended for pregnant women with positive NIPT results. Results: Of the total 7910 participants, 7890 (99.75%) were tested for NIPT and the remaining 20 (0.25%) were below the Quality Control (QC) standards. T13, T18, XXX, XXY and XYY had 100% of sensitivity, specificity, positive predictive values (PPV) and accuracy. The overall sensitivity was 100% and specificity, PPV and accuracy of all chromosomal abnormalities with further validation were 99.92%, 94.25%, and, 99.92% respectively. Conclusion: Our NIPT results showed high positive predictive value for the detection of autosomal trisomies and sex chromosome aneuploidies in our sample cohort.

关键词： Cell-Free DNA Trisomy Clinical Performance Mosaicism CPM Fetal Abnormality Noninvasive Prenatal Testing NIPT

Foldable three dimensional neural electrode arrays for simultaneous brain interfacing of cortical surface and intracortical multilayers

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npj Flexible Electronics 2022年第1期6卷 840-853页

作者： Ju Young Lee Sang Hoon Park Yujin Kim Young Uk Cho Jaejin Park Jung-Hoon Hong Kyubeen Kim Jongwoon Shin Jeong Eun Ju In sik Min Mingyu Sang Hyogeun Shin Ui-Jin Jeong Yuyan Gao Bowen Li Aizhan Zhumbayeva Kyung Yeun Kim Eun-Bin Hong Min-Ho nam Hojeong Jeon Youngmee Jung Huanyu Cheng Il-Joo Cho Ki Jun Yu School of Electrical and Electronic Engineering Yonsei University50 Yonsei-roSeodaemunguSeoul 03722Republic of Korea Department of Biomedical Sciences College of MedicineKorea UniversitySeoul 02841Republic of Korea Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Biotechnology College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of KHU-KIST Convergence Science and Technology Kyung Hee UniversitySeoul 02447Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea School of Electrical and Electronic Engineering YU-KIST InstituteYonsei UniversitySeoul 03722Republic of Korea Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Anatomy College of MedicineKorea UniversitySeoul 02841Republic of Korea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Korea

Challenges in the understanding of three-dimensional(3D)brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted ***,we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical *** device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated *** demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological *** also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker *** platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface.

关键词： neural electrode simultaneous

Chemical characterization of rainwater over Suwon region during farming and non-farming periods

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Journal of Agricultural Chemistry and Environment 2013年第1期2卷 1-7页

作者： Min-Kyeong Kim Jong-sik Lee Goo-Bok Jung Byong-Gu Ko Soon-Ik Kwon Min-Young Kim Kyu-Ho So Sun-Gang yun Department of Agricultural Environment National Academy of Agricultural Science Rural Development Administration (RDA) Suwon Republic of Korea Dresearch Planning Division Rural Development Administration Suwon Republic of Korea

Recently, special attention has been givento acid rain and its problem to environment such as acid precipitation and air pollution in East *** the present study, rainwater samples werecollected from Apr to Oct (farming period) and from Nov to Mar (non-farming period) in 2009 ~ 2011. The samples were chemically characterized for the assessment of emission sources. Suwon region, a typical agricultural area in Gyeonggi province (South Korea) was chosen as a study site. The content of ionic species and theirtemporal variation were used forfactor analysis, which was used to presume the natural and anthropogenic sources depending upon the farming and non-farming periods. The cationsobserved during farming and non-farming periods were?> Na+> Ca2+> K+> H+> Mg2+and Na+> N?>Ca2+> H+= Mg2+> K+, respectively. The anions during farming and non-farming periods were?>?> Cl- and?>?> Cl-, respectively. While the amounts of sulfate, one of the major dissolved components of rainwater were 113.5 and 177.0 ueq.L-1, the ones of NSS-?(Non-Sea Salt sulfate) were 93.7 and 87.1% during farming and non-farming periods, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rainwater considerably went along during farming and non-farming periods. The highest amountof rainfall throughout the year was310.5 mmin August and its corre sponding nitrogen loading was5.03 kg·ha-1. The major ion contents for crop growth, , Ca2+, K+, Mg2+, were 49.4, 5.5, 18.1,1.4 kg·ha-1from April to October. The major contributions to the existing chemical ions in rainwaters during farming and non-farming periods were from the natural sources (sea and soil) and the anthropogenic sources (human and animal waste, vehicular emission + fossil fuels combustion), respectively.

关键词： Acidity Discharge Nutrient Rainwater

SiO2-Promoted Ni Bulk Catalyst for Single-Stage Water Gas Shift Reaction

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华东理工大学学报（自然科学版） 2010年第5期36卷 661-661页

作者： KIM Sung-Ho KIM yun-tae UM Ji-hyun nam Suk-woo LIM Tae-hoon LEE Ho-in School of Chemical and Biological Engineering and Research Center for Energy Conversion and Storage Seoul National University Seoul 151-744 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

Characterization of Fungal Endophytes:Isolated from Five Halophytes of Buan Salt Marsh,Korea

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Characterization of Fungal Endophytes:Isolated from Five Hal...