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Quantitative detection of citrate for early stage diagnosing of prostate cancer:Discriminating normal to cancer in prostate tissues

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Chinese Chemical Letters 2024年第2期35卷 501-506页

作者： Selvaraj Muthusamy Kanagaraj Rajalakshmi Palanisamy Kannan yun-sik nam Dongwei Zhu Yeonggil Seo Jong-Won Song Dong Nyoung Heo Il Keun Kwon Yuanguo Xu School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Advanced Analysis Center Korea Institute of Science & TechnologySeongbuk-guSeoul02792Republic of Korea School of Medicine Jiangsu UniversityZhenjiang 212013China Department of Chemistry Education Daegu UniversityGyeongsan-siGyeongsangbuk-do 38453Republic of Korea Department of Dental Materials School of DentistryKyung Hee UniversitySeoulRepublic of Korea

Prostate cancer(PC)biomarker-citrate detection is clinically important to diagnose PC in early *** iodide(Q)conjugated indole-phenylboronic acid(IB)was designed as a red-emissive QIB probe for the detection of citrate through Lewis acid-base reaction and intramolecular charge transfer(ICT)sensing *** acid acts as Lewis acid as well as citrate(Lewis base)recognition *** probe reacted with citrate,showing enhanced red *** the probe has excellent water solubility and great biocompatibility,practical application in biological systems is *** was monitored precisely in the mitochondria organelle(in vitro)of living cells with a positive charge on ***,endogenous(in situ)citrate was detected quantitatively to discriminate non-cancerous and PC mice,observed strong and lower(negligible)emission intensity on non-cancerous and cancerous prostate tissues,***,the concentration of citrate is higher in healthy prostate compared with PC ***,the analysis of sliced prostate tissues can give PC-related information for clinical diagnosis to prevent and treat PC in the initial ***,we believe that the present probe is a promising biochemical reagent in diagnosing PC.

关键词： Prostate cancer Biomarker-citrate Boronic acid Lewis acid/base-ICT Red-emissive Mitochondria targeting Prostate tissue

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun yun Su-Hyeon Cho Kil-nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Soil compression influences the avoidance behavior of Allonychiurus kimi(Collembola)to cadmium and copper

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Pedosphere 2022年第3期32卷 487-494页

作者： Jino SON yun-sik LEE Yongeun KIM Kijong CHO OJeong Eco-Resilience Institute Korea UniversitySeoul 02841(Republic of Korea) Department of Environmental Science and Ecological Engineering Korea UniversitySeoul 02841(Republic of Korea) Institute of Environment and Ecology Korea UniversitySeoul 02841(Republic of Korea)

The behavior of soil organisms inhabiting soil pore spaces can be influenced by soil compression,which can affect their avoidance behavior to *** this study,we aimed to evaluate the effect of soil compression on the avoidance behavior of Allonychiurus kimi(Collembola)to heavy metals cadmium and ***,to assess the applicability of the avoidance test guideline of the International Organization for Standardization(ISO)developed for Folsomia candida,we investigated the avoidance behavior of *** to cadmium and copper in an artificial soil with a loose structure(bulk density of 0.25 g cm^(-3)),the porous texture of which was sufficiently loose to enable *** to move between pore *** effect of soil compression on the avoidance behavior of *** to both metals was evaluated in compressed soil(bulk density of 0.64 g cm^(-3))with a uniformly compressed soil surface,and avoidance behavior was investigated at 24-h intervals over a 120-h *** that *** is unable to burrow into compressed soil,the compressed soil test can minimize the effects of differences in soil factors,such as soil porosity and bulk density,on the behavior of this *** the artificial soil,a statistically significant avoidance behavior of *** was observed at cadmium and copper concentrations greater than 50 and 200 mg kg^(-1),respectively,thereby indicating the applicability of the ISO avoidance test guidelines for *** compared at the same exposure time point,the avoidance response to both metals in compressed soil was less sensitive than that in uncompressed *** addition,we observed differences in the effects of metals on avoidance response in the compressed soil over time,with the effect of cadmium increasing with time and the effect of copper showing the opposite ***,we found that soil compression can affect the avoidance behavior of *** to cadmium and copper,and we discussed the advantages and limitations of using compressed

关键词： behavioral endpoint ecotoxicity test habitat function heavy metal pollutant springtail

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Efficient Network Selection Using Multi-Depot Routing Problem for Smart Cities

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Intelligent Automation & Soft Computing 2023年第5期36卷 1991-2005页

作者： R.Shanthakumari yun-Cheol nam yunyoung nam Mohamed Abouhawwash Department of Information Technology Kongu Engineering CollegePerundurai638060India Department of Architecture Joongbu UniversityGoyang10279Korea Department of ICT Convergence Soonchunhyang UniversityKorea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Smart cities make use of a variety of smart technology to improve societies in better *** intelligent technologies,on the other hand,pose sig-niﬁcant concerns in terms of power usage and emission of *** suggested study is focused on technological networks for big data-driven *** the support of software-deﬁned technologies,a transportation-aided multicast routing system is *** using public transportation as another communication platform in a smart city,network communication is *** primary objec-tive is to use as little energy as possible while delivering as much data as *** Attribute Decision Making with Capacitated Vehicle(CV)Routing Problem(RP)and Half Open Multi-Depot Heterogeneous Vehicle Routing Problem is used in the proposed *** the optimum network selection,a Multi-Attribute Decision Making(MADM)method is *** the sake of reducing energy usage,the Capacitated Vehicle Routing Problem(CVRP)is *** reduce the transportation cost and risk,Half Open Multi-Depot Heterogeneous Vehicle Routing Problem is ***,a mixed-integer programming approach is used to deal with the *** produce Pareto optimal solutions,an intelligent algorithm based on the epsilon constraint approach and genetic algorithm is cre-ated.A scenario of Auckland Transport is being used to validate the concept of ofﬂoading the information onto the buses for energy-efﬁcient and delay-tolerant data *** the experiments have demonstrated that the buses may be used effectively to carry out the data by customer requests while using 30%of less energy than the other systems.

关键词： Smart cities data ofﬂoading energy consumption bi-objective capacitated vehicle routing problem public transportation big data

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Extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) for understanding local structure-stability relation in perovskite solar cells

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Journal of Energy Chemistry 2022年第4期31卷 549-554页

作者： Dong-Ho Kang Yong-Jun Park yun-Sung Jeon nam-Gyu Park School of Chemical Engineering and Center for Antibonding Regulated Crystals Sungkyunkwan UniversitySuwon 16419Korea

Perovskite solar cells (PSCs) employing formamidinium lead iodide (FAPbI_(3)) have shown high ***,operational stability has been issued due to phase instability of α phase FAPbI_(3) at ambient *** precursors in the perovskite precursor solution has been proposed to improve not only power conversion efficiency (PCE) but also device ***,there is a controversial issue on the beneficial effect on PCE and/or stability between excess FAI and excess PbI_(2).We report here extended X-ray absorption fine structure (EXAFS) of FAPbI_(3) to study local structural change and explain the effect of excess precursors on photovoltaic performance and *** films prepared from the precursor solution with excess PbI_(2)shows better stability than those from the one with excess FAI,despite similar PCE.A rapid phase transition from α phase to non-perovskite δ phase is observed from the perovskite film formed by excess ***,the (Pb-I) bond distance evaluated by the Pb L_(III)-edge EXAFS study is increased by excess FAI,which is responsible for the phase transition and poor device *** work can provide important insight into local structure-stability relation in the FAPbI_(3)-based PSCs.

关键词： Extended X-ray absorption fine structure EXAFS Excess precursor Local structure Stability Perovskite solar cells

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Improved Shark Smell Optimization Algorithm for Human Action Recognition

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Computers, Materials & Continua 2023年第9期76卷 2667-2684页

作者： Inzamam Mashood Nasir Mudassar Raza Jamal Hussain Shah Muhammad Attique Khan yun-Cheol nam yunyoung nam Department of Computer Science COMSATS University IslamabadWah CampusWah Cantt47040Pakistan Department of Computer Science HITEC UniversityTaxilaPakistan Department of Architecture Joongbu UniversityGoyang10279South Korea Department of ICT Convergence Soonchunhyang UniversityAsan31538Korea

Human Action Recognition(HAR)in uncontrolled environments targets to recognition of different actions froma *** effective HAR model can be employed for an application like human-computer interaction,health care,person tracking,and video *** Learning(ML)approaches,specifically,Convolutional Neural Network(CNN)models had beenwidely used and achieved impressive results through feature *** accuracy and effectiveness of these models continue to be the biggest challenge in this *** this article,a novel feature optimization algorithm,called improved Shark Smell Optimization(iSSO)is proposed to reduce the redundancy of extracted *** proposed technique is inspired by the behavior ofwhite sharks,and howthey find the best prey in thewhole search *** proposed iSSOalgorithmdivides the FeatureVector(FV)into subparts,where a search is conducted to find optimal local features fromeach subpart of *** local optimal features are selected,a global search is conducted to further optimize these *** proposed iSSO algorithm is employed on nine(9)selected CNN *** CNN models are selected based on their top-1 and top-5 accuracy in ImageNet *** evaluate the model,two publicly available datasets UCF-Sports and Hollywood2 are selected.

关键词： Action recognition improved shark smell optimization convolutional neural networks machine learning

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Medical Image Compression Method Using Lightweight Multi-Layer Perceptron for Mobile Healthcare Applications

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Computers, Materials & Continua 2022年第1期70卷 2013-2029页

作者： Taesik Lee Dongsan Jun Sang-hyo Park Byung-Gyu Kim Jungil yun Kugjin yun Won-sik Cheong Kyungnam University Changwon51767Korea Kyungpook National University Daegu41566Korea Sookmyung Women’s University Seoul04310Korea Electronics and Telecommunications Research Institute Daejeon34129Korea

As video compression is one of the core technologies required to enable seamless medical data streaming in mobile healthcare applications,there is a need to develop powerful media codecs that can achieve minimum bitrates while maintaining high perceptual *** Video Coding(VVC)is the latest video coding standard that can provide powerful coding performance with a similar visual quality compared to the previously developed method that is High Efficiency Video Coding(HEVC).In order to achieve this improved coding performance,VVC adopted various advanced coding tools,such as flexible Multi-type Tree(MTT)block structure which uses Binary Tree(BT)split and Ternary Tree(TT)***,VVC encoder requires heavy computational complexity due to the excessive Ratedistortion Optimization(RDO)processes used to determine the optimalMTT block *** this paper,we propose a fast MTT decision method with two Lightweight Neural Networks(LNNs)using Multi-layer Perceptron(MLP),which are applied to determine the early termination of the TT split within the encoding *** results show that the proposed method significantly reduced the encoding complexity up to 26%with unnoticeable coding loss compared to the VVC TestModel(VTM).

关键词： Mobile healthcare video coding complexity reduction multilayer perceptron VVC intra prediction multi-type tree ternary tree neural network

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Usefulness of transcatheter arterial embolization for eighty-three patients with secondary postpartum hemorrhage:Focusing on difference in angiographic findings

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World Journal of Clinical Cases 2023年第15期11卷 3471-3480页

作者： Bong Man Kim Gyeong sik Jeon Min Jeong Choi nam-Soo Hong Department of Radiology Dankook University HospitalDankook University College of MedicineCheonan-si 31116Chungcheongnam-doSouth Korea Department of Radiology CHA Bundang Medical CenterCollege of MedicineCHA UniversitySeongnam-si 13496Gyeonggi-doSouth Korea Department of Preventive Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Transcatheter arterial embolization(TAE)has been widely used as an effective and a safe treatment method and was often used as an alternative to the surgical management,but there are limited studies on the efficacy and the safety for patients undergoing their secondary postpartum hemorrhage(PPH).AIM To evaluate the usefulness of TAE for secondary PPH focusing on the angiographic *** We conducted a research from January 2008 to July 2022 on all 83 patients(mean:32 years,range:24-43 years)presented with secondary PPH and they were treated with TAE in two university *** medical records and angiography were retrospective reviewed in order to evaluate the patients’characteristics,delivery details,clinical status and peri-embolization management,angiography and embolization details,technical/clinical success and *** group with active bleeding sign and the group without it were also compared and *** On angiography,46(55.4%)patients showed active bleeding signs such as contrast extravasation(n=37)or pseudoaneurysm(n=8)or both(n=1),and 37(44.6%)patients showed non-active bleeding signs such as only spastic uterine artery(n=2)or hyperemia(n=35).In the active bleeding sign group there were more multiparous patients,low platelet count,prothrombin time prolongation,and high transfusion *** technical success rates were 97.8%(45/46)in active bleeding sign group and 91.9%(34/37)in non-active bleeding sign group,and the overall clinical success rates were 95.7%(44/46)and 97.3%(36/37).An uterine rupture with peritonitis and abscess formation occurred to one patient after the embolization,therefore hysterostomy and retained placenta removal were performed which was a major *** TAE is an effective and a safe treatment method for controlling secondary PPH regardless of angiographic findings.

关键词： Postpartum hemorrhage Angiography Transcatheter arterial embolization Pseudoaneurysm Nbutylcyanoacrylate

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Reaction to the COVID-19 pandemic in Seoul with biostatistics

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Infectious Disease Modelling 2022年第3期7卷 419-429页

作者： Seungpil Jung Seung-sik Hwang Kyoung-nam Kim Woojoo Lee Department of Public Health Sciences Graduate School of Public HealthSeoul National University08826Republic of Korea Department of Preventive Medicine and Public Health Ajou University School of MedicineSuwon16499Republic of Korea

This paper discusses our collaboration work with government officers in the health department of Seoul during the COVID-19 ***,we focus on short-term forecasting for the number of new confirmed cases and severe ***,we focus on understanding how much of the current infections has been affected by external influx from neighborhood areas or internal transmission within the *** understanding may be important because it is linked to the government policy determining nonpharmaceutical *** obtain the decomposition of the effect,districts of Seoul should be considered simultaneously,and multivariate time series models are ***,we focus on predicting the number of new weekly confirmed cases for each district in *** detailed prediction may be important to the government policy on resource *** consider an ensemble method to overcome poor prediction performance of simple *** paper presents the methodological details and analysis results of the study.

关键词： Count time series model COVID-19 Endemic-epidemic model

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High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

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Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong Kim Beom sik Youn Hyoung-Joon Jin Hyung-Kyu Lim Young Soo yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage *** is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage ***,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic ***-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

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