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Anti-inflammation Effects of Sinomenine on Macrophages through Suppressing Activated TLR4/NF-kB Signaling Pathway

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Current Medical Science 2020年第1期40卷 130-137页

作者： Meng-you ZENG qiao-yun TONG Institute of Digestive Disease China Three Gorges UniversityYichang 443000China Department of Gastroenterology Yichang Central People's HospitalYichang 443000China

Sinomenine(SN)has been used in the clinical treatment of systemic lupus erythematosus and rheumatoid arthritis for many *** showed that SN held protective effects such as anti-inflammation,scavenging free radicals and suppressing immune response in many autoimmune *** purpose of the present study is to explore the mechanism of anti-inflammation of SN on lipopolysaccharide(LPS)-induced macrophages activation and investigate whether the TLR4/NF-κB signaling pathway participated *** isolated from mouse peritoneal cavity were stimulated by 1 pg/mL LPS for 24 *** then the cells were treated with various concentrations of SN,TLR4 inhibitor respectively for additional 48 *** toxicity was detected by MTT assay and Transwell experiment was used to assess ***,TLR4 and MyD88 mRNA levels were detected by real-time *** blotting was used to examine TLR4,MyD88 and phosphorylated IκB protein expression in *** assay was applied to observe p65 NF-κB protein expression in macrophage *** extracted macrophages with high purity and activity from the abdominal cavity of *** remarkably inhibited the chemotaxis and secretion function of LPS-stimulated *** also down-regulated both the protein levels of inflammatory cytokines(TNF-α,IL-β and IL-6)and the RNA and protein levels of the key factors(TLR4,MyD88,p-IkB)in TLR4 *** expression of p65 NF-κB protein in nuclei was down-regulated,which was correlated with a similar decrease in p-IκB protein *** conclusion,SN can inhibit the LPS induced immune responses in macrophages by blocking the activated TLR4/NF-κB signaling *** results may provide a therapeutic approach to regulate inflammatory responses.

关键词： sinomenine macrophage TLR4/NF-κB pathway

Smart Gait:A Gait Optimization Framework for Hexapod Robots

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 146-159页

作者： yunpeng yin Feng Gao qiao Sun Yue Zhao Yuguang Xiao State Key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Lenovo Corporation ShanghaiChina AI Institute School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The current gait planning for legged robots is mostly based on human presets,which cannot match the flexible characteristics of natural *** paper proposes a gait optimization framework for hexapod robots called Smart *** Gait contains three modules:swing leg trajectory optimization,gait period&duty optimization,and gait sequence *** full dynamics of a single leg,and the centroid dynamics of the overall robot are considered in the respective *** Smart Gait not only helps the robot to decrease the energy consumption when in locomotion,mostly,it enables the hexapod robot to determine its gait pattern transitions based on its current state,instead of repeating the formalistic clock-set step *** Smart Gait framework allows the hexapod robot to behave nimbly as a living animal when in 3D movements for the first *** Smart Gait framework combines offline and online optimizations without any fussy data-driven training procedures,and it can run efficiently on board in real-time after *** experiments are carried out on the hexapod robot *** results show that the energy consumption is reduced by 15.9%when in *** gait patterns can be generated spontaneously both in regular and challenge environments,and when facing external interferences.

关键词： Gait optimization Swing trajectory optimization Legged robot Hexapod robot

Synthesis and Crystal Structure of an Acetate Radical Bridged Dinuclear Copper(Ⅱ) Complex

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Chinese Journal of Structural Chemistry 2007年第3期26卷 347-351页

作者： DU qiao-yun MA Liang QIN Jian-Hua Department of Chemistry Luoyang Normal University Luoyang 471022 China

A new acetate radical bridged dinuclear copper（ Ⅱ ） complex [（C8H9NO2）2- Cu2（CH3COO）4] has been synthesized by the reaction of Cu（OAc）2 with pyridine-3-ethyl formate and further characterized by X-ray single-crystal diffraction. Crystal data for the title compound： triclinic system, space group Pí, with a = 8.1654（14）, b = 9.7010（16）, c = 9.9005（17） A, α = 83.266（2）, β = 78.887（2）, γ = 72.881（2）°, V= 733.9（2） A^3, Mr = 665.58, Z = 1, Dc = 1.506 g/cm^3, F（000） = 342,μ = 1.510 mm^-1, the final R = 0.0392 and wR = 0.1005. According to the structural determination, each unit of the title compound is composed of two Cu（ Ⅱ ） atoms, two pyridine-3-ethyl formate molecules and four acetate ions. Each Cu（Ⅱ） coordinates to oxygen atoms of acetate and nitrogen atoms of pyridine- 3-ethyl formate ligand to give a six-coordinate distorted octahedral geometry. It is worth mentioning that strong Cu-Cu bond can be observed in the title compound.

关键词： pyridine-3-carboxylic acetate radical bridge Cu( Ⅱ ) crystal structure

A New Sufficient Degree Condition for a Graphic Sequence to Be Forcibly k-Edge-Connected

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Acta Mathematicae Applicatae Sinica 2022年第1期38卷 223-228页

作者： Jian-hua yin Ji-yun GUO School of Science Hainan UniversityHaikou 570228China

A graphic sequence π =(d1, d2,..., dn) is said to be forcibly k-edge-connected if every realization of π is k-edge-connected. In this paper, we obtain a new sufficient degree condition for π to be forcibly k-edgeconnected. We also show that this new sufficient degree condition implies a strongest monotone degree condition for π to be forcibly 2-edge-connected and a conjecture about a strongest monotone degree condition for π to be forcibly 3-edge-connected due to Bauer et al.(Networks, 54(2)(2009) 95-98), and also implies a strongest monotone degree condition for π to be forcibly 4-edge-connected.

关键词： graphic sequence forcibly k-edge-connected graphic sequence a strongest monotone degree condition

Numerical Study on the Stress–Strain Cycle of Thermal Self-Compressing Bonding

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 140-147页

作者： yun-Hua Deng qiao Guan Jun Tao Bing Wu Aeronautical Key Laboratory for Welding and Joining Technologies AVIC Beijing Aeronautical Manufacturing Technology Research Institute School of Mechanical Engineering and Automation Beihang University Science and Technology on Power Beam Process Laboratory AVIC Beijing Aeronautical Manufacturing Technology Research Institute

Thermal self-compressing bonding(TSCB) is a new solid-state bonding method pioneered by the authors. With electron beam as the non-melted heat source, previous experimental study performed on titanium alloys has proved the feasibility of TSCB. However, the thermal stress–strain process during bonding, which is of very important significance in revealing the mechanism of TSCB, was not analysed. In this paper, finite element analysis method is adopted to numerically study the thermal elasto-plastic stress–strain cycle of thermal self-compressing bonding. It is found that due to the localized heating, a non-uniform temperature distribution is formed during bonding, with the highest temperature existed on the bond interface. The expansion of high temperature materials adjacent to the bond interface are restrained by surrounding cool materials and rigid restraints, and thus an internal elasto-plastic stress–strain field is developed by itself which makes the bond interface subjected to thermal compressive action. This thermal self-compressing action combined with the high temperature on the bond interface promotes the atom diffusion across the bond interface to produce solid-state joints. Due to the relatively large plastic deformation, rigid restraint TSCB obtains sound joints in relatively short time compared to diffusion bonding.

关键词： Thermal self-compressing bonding Locally non-melted heating Thermal elasto-plastic stress–strain Atom diffusion Solid-state bonding Finite element analysis

Analysis of a rainwater harvesting system for domestic water supply in Zhoushan,China

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第5期11卷 342-348页

作者： Yong-chao ZHOU Wei-yun SHAO Tu-qiao ZHANG Institute of Municipal Engineering Zhejiang University Hangzhou 310058 China

The domestic rainwater harvesting system (DRHS) is an important freshwater source for Zhoushan,China to meet water demands. A computer model has been generated to analyze the performance of the DRHS with different ratios of D/(AR) (water demand/average annual collected runoff) and S/(AR) (storage capacity/average annual collected runoff). The performance of the DRHS was analyzed by means of the model simulation,which is described by its water shortage rate (WSR) and water loss rate (WLR). Using the data,a set of dimensionless design calculation chart is introduced. When the water demand and requirement of the design are known,the established chart can be used to easily determine the storage capacity and catchment (roof and other surface) area required to achieve a desired performance level.

关键词： Domestic rainwater harvesting system (DRHS) Performance Simulation Zhoushan

APJTM streamlines content coverage and submission process to better support tropical medicine research

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Asian Pacific Journal of Tropical Medicine 2022年第6期15卷 239-240页

作者： Yan Lei qiao Zhang yin Pan Editorial Office of Asian Pacific Journal of Tropical Medicine Hainan Medical UniversityHaikou 571199China

Asian Pacific Journal of Tropical Medicine(APJTM)is a peer-reviewed open access monthly publication focusing on neglected tropical diseases and major diseases that are prevalent in the underdeveloped tropical *** Journal received an updated journal Impact Factor of 3.041 in the newly released 2021 Journal Citation Report,an increase of 148%over the past *** the 24 journals under the category of Tropical Medicine in the Science Citation Index-Expanded(SCIE),the Journal ranks 10/24(Q2).Although journal Impact Factor has several shortcomings and limitations,it is the most widely recognized indicator of journal prestige and impact[1].

关键词： journal shortcomings neglected

Nitrous Oxide Production in a Sequence Batch Reactor Wastewater Treatment System Using Synthetic Wastewater

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Pedosphere 2006年第4期16卷 451-456页

作者： MAO Jian JIANG Xiao-Qin YANG Lin-Zhang ZHANG Jian qiao Qing-yun HE Chen-Da yin Shi-Xue State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of SciencesNanjing 210008 （China） Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 （China） College of Environmental Science and Engineering Yangzhou University Yangzhou 225009 （China）

The rate of nitrous oxide emission from a laboratory sequence batch reactor （SBR） wastewater treatment system using synthetic wastewater was measured under controlled conditions. The SBR was operated in the mode of 4 h for aeration, 3.5 h for stirring without aeration, 0.5 h for settling and drainage, and 4 h of idle. The sludge was acclimated by running the system to achieve a stable running state as chemical oxygen demand, NO2^-, NO3^-, NH4^＋, pH, and N2O. indicated by rhythmic changes of total N, dissolved oxygen, Under the present experimental conditions measured nitrous oxide emitted from the off-gas in the aerobic and anaerobic phases, respectively, accounted for 8.6%-16.1% and 0-0.05% of N removed, indicating that the aerobic phase was the main source of N2O emission from the system. N2O dissolved in discharged water was considerable in term of concentration. Thus, measures to be developed for the purpose of reducing N2O emission from the system should be effective in the aeration phase.

关键词： denitrification nitrification nitrous oxide sequence batch reactor wastewater treatment system

Numerical investigation of the influence of vortex generator on propeller cavitation and hull pressure fluctuation by DDES

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Journal of Hydrodynamics 2022年第3期34卷 444-450页

作者： yun Long Han-qiao Han Bin Ji Xin-ping Long Wuhan Second Ship Design and Research Institute Wuhan430064China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China

In this study,the delayed detached eddy simulation(DDES)is coupled with a homogenous cavitation model to simulate the cavitating turbulent flow around a propeller behind a full body ship with special emphasis on the influence of the vortex generator(VG)on the propeller cavitation and the hull pressure *** small calculation uncertainty as evaluated by the DDES verification and validation(V&V)method indicates that the present simulation can accurately reproduce the propeller performance and cavitation,and the predicted hull pressure fluctuation is in a fairly good agreement with the available experimental *** mechanism is explored through the current numerical results how the VG affects the local velocity distribution,along with the influences of the VG on the propeller cavitation and the hull pressure *** is shown that the streamwise vortex is induced by the VG near the hull boundary *** very low velocity region in the hull wake is reduced due to the effect of the streamwise ***,the propeller cavitation develops more mildly and the hull pressure fluctuation decreases due to the influence of the VG.

关键词： Propeller cavitation delayed detached eddy simulation(DDES) vortex generator(VG) streamwise vortex