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Saikosaponin a increases interleukin-10 expression and inhibits scar formation after sciatic nerve injury

Neural Regeneration Research 2018年第9期13卷 1650-1656页

作者： Meng-qiang Huang Xiao-Yu Cao xu-Yi Chen Ying-Fu Liu Shuang-Long Zhu Zhong-Lei Sun Xian-Bin Kong Jing-Rui Huo Sai Zhang yun-qiang xu Graduate School Tianjin Medical University Department of Orthopedics Tianjin Medical University General Hospital Department of Rehabilitation Medicine First Affiliated Hospital of Anhui Medical University Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCenter for Neurology and Neurosurgery of Affiliated HospitalLogistics University of Chinese People's Armed Police Force Science and Technology Experiment Center Cangzhou Medical College Graduate School Jinzhou Medical University Graduate School Tianjin University of Traditional Chinese Medicine

Nerve scarring after peripheral nerve injury can severely hamper nerve regeneration and functional ***,the anti-inflammatory cytokine,interleukin-10,can inhibit nerve scar *** a（SSa） is a monomer molecule extracted from the Chinese medicine,*** can exert anti-inflammatory effects in spinal cord injury and traumatic brain ***,it has not been shown whether SSa can play a role in peripheral nerve *** this study,rats were randomly assigned to three *** the sham group,the left sciatic nerve was directly sutured after *** the sciatic nerve injury（SNI）＋ SSa and SNI groups,the left sciatic nerve was sutured and continuously injected daily with SSa（10 mg/kg） or an equivalent volume of saline for 7 *** linked immunosorbent assay results demonstrated that at 7 days after injury,interleukin-10 level was considerably higher in the SNI ＋ SSa group than in the SNI *** staining and western blot assay demonstrated that at 8 weeks after injury,type I and III collagen content was lower and nerve scar formation was visibly less in the SNI ＋ SSa group compared with the SNI ***,sciatic functional index and nerve conduction velocity were improved in the SNI ＋ SSa group compared with the SNI *** results confirm that SSa can increase the expression of the anti-inflammatory factor,interleukin-10,and reduce nerve scar formation to promote functional recovery of injured sciatic nerve.

关键词： nerve regeneration saikosaponin a anti-inflammatory factor inflammation interleukin-l O nerve scar peripheral nerve injury sciatic nerve injury sciatic functional index nerve conduction velocity neuroelectrophysiological function neural regeneration

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Upregulated Ras/Raf/ERK1/2 signaling pathway:a new hope in the repair of spinal cord injury

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Neural Regeneration Research 2015年第5期10卷 792-796页

作者： Tao Liu Fu-jiang Cao Dong-dong xu yun-qiang xu Shi-qing Feng Department of Orthopedics General Hospital of Tianjin Medical University

An increasing number of studies report that the Ras/Raf/extracellular signal-regulated kinase 1/2 （ERK1/2） signaling pathway has a death-promoting apoptotic function in neural cells. We hypothesized that the Ras/Raf/ERK1/2 signaling pathway may be abnormally regulated in rat injured spinal cord models. The weight drop method was used to establish rat spinal cord injury at T9. Western blot analysis and immunohistochemical staining revealed Ras expression was dramatically elevated, and the phosphorylations of A-Raf, B-Raf and C-Raf were all upregulated in the injured spinal cord. Both mitogen-activated protein kinase kinase 1/2 and ERK1/2, which belong to the Ras/Raf signaling kinases, were upregulated. These results indicate that Ras/Raf/ ERK1/2 signaling may be upregulated in injured spinal cord and are involved in recovery after spinal cord injury.

关键词： nerve regeneration Ras/Raf/Erkl/2 signaling pathway spinal cord injury apoptosis repair regulation inhibition neural regeneration

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-qiang xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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一种基于检测器数据的交叉口交通运行特性研究方法

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交通运输研究 2018年第2期4卷 16-22页

作者：赵远洋薛运强徐佳云刘锐华东交通大学交通运输与物流学院江西南昌330013

为了发现交叉口各进口交通流量变化的细微差异,实现交叉口交通运行特性中潜在属性的挖掘,基于道路检测器数据,结合谱聚类算法和快速独立成分分析(Fast Independent Component Analysis,简称Fast ICA)算法,提出了一种研究不同时间长度(1... 详细信息

为了发现交叉口各进口交通流量变化的细微差异,实现交叉口交通运行特性中潜在属性的挖掘,基于道路检测器数据,结合谱聚类算法和快速独立成分分析(Fast Independent Component Analysis,简称Fast ICA)算法,提出了一种研究不同时间长度(1小时、1天、1周)各进口交通运行特性的方法。以交叉口各进口道路检测器数据为研究对象,利用常规的数据处理方法得到短时交通运行特性,然后通过谱聚类算法挖掘出观测当天对向交通运行特性,采用Fast ICA算法获得较长时间内各进口交通运行特性。最后,依据南昌市某交叉口数据进行了计算。结果表明,该交叉口西进口交通运行情况受不稳定交通流的影响,南、北进口交通流处于相对稳定的状态,东进口交通运行状态是整个交叉口交通运行状态的主要影响因素。基于此,上述方法的可行性得到了验证。

关键词：城市交通道路检测器数据不同时间长度谱聚类 FastICA算法

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng qiang Wei Xiao xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Coupled elasto-plasticity damage constitutive models for concrete

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第4期14卷 256-267页

作者： qiang xu Jian-yun CHEN Jing LI Gang xu State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology School of Civil and Hydraulic Engineering Dalian University of Technology Plan and Design Institute of Daqing Oilfield Communication Company

The paper is to design and construct a coupled elasto-plasticity damage constitutive model for *** on the energy dissipation principle,the Hsieh-Ting-Chen four-parameter yield function is *** model can reflect different strength characteristics of concrete in tension and compression,and reduce the limitation and lacuna of the traditional damage constitutive models for ***,numerical test for concrete stress-strain relation under uniaxial tension and compression is ***,the damage process of concrete gravity dam is calculated and analyzed in seismic *** with other damage constitutive models,the proposed model contains only one unknown parameter and the other parameters can be found in the Hsieh-Ting-Chen four-parameter yield *** same damage evolution law,which is used for tension and compression,is good for determining stress-strain constitutive and damage characteristics in complex stress *** coupled damage constitutive models can be applied in analyzing damage of concrete gravity dam and arch dam.

关键词： Concrete Damage constitutive models Hsieh-Ting-Chen four-parameter yield function Uniaxial tension Uniaxial compression Gravity dam Arch dam

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Improved response surface method for anti-slide reliability analysis of gravity dam based on weighted regression

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 432-439页

作者： Jian-yun CHEN qiang XY Jing LI Shu-li FAN qiang xu State Key Laboratory of Coastal and Offshore Engineering Daliatz University of Technology Dalian 116023 China School of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116023 China

The aim of this study was to design and construct an improved response surface method(RSM) based on weighted regression for the anti-slide reliability analysis of concrete gravity *** limitation and lacuna of the traditional RSM were briefly ***,based on small experimental points,research was devoted to an improved RSM with singular value decomposition ***,the method was used on the basis of weighted regression and deviation coefficient correction to reduce iteration times and experimental points and improve the calculation method of checking ***,a test example was given to verify this *** with other conventional algorithms,this method has some strong advantages:this algorithm not only saves the arithmetic operations but also greatly enhances the calculation efficiency and the storage efficiency.

关键词： Response surface method(RSM) Reliability Gravity dam Singular value decomposition Weighted regression Deviation coefficient

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Study on spline wavelet finite-element method in multi-scale analysis for foundation

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Acta Mechanica Sinica 2013年第5期29卷 699-708页

作者： qiang xu Jian-yun Chen Jing Li Gang xu Hong-Yuan Yue School of Civil and Hydraulic Eng. Dalian University of Technology Plan and Design Institute of Daqing Oilfield Commmunication Company

A new finite element method （FEM） of B-spline wavelet on the interval （BSWI） is proposed. Through analyzing the scaling functions of BSWI in one dimension, the basic formula for 2D FEM of BSWI is deduced. The 2D FEM of 7 nodes and 10 nodes are constructed based on the basic formula. Using these proposed elements, the multiscale numerical model for foundation subjected to harmonic periodic load, the foundation model excited by external and internal dynamic load are studied. The results show the pro- posed finite elements have higher precision than the tradi- tional elements with 4 nodes. The proposed finite elements can describe the propagation of stress waves well whenever the foundation model excited by extemal or intemal dynamic load. The proposed finite elements can be also used to con- nect the multi-scale elements. And the proposed finite elements also have high precision to make multi-scale analysis for structure.

关键词： Finite-element method Dynamic response B-spline wavelet on the interval Multi-scale analysis

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