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Neural Regeneration Research 2018年第11期13卷 1937-1944页

作者： Xiao-Ying Zhang Li-ming Zhang Wei-Dong mi yun-Feng Li Anesthesia and Operation Center Chinese PLA General Hospital Beijing China State Key Laboratory of Toxicology and Medical Countermeasures Beijing China

Translocator protein has received attention for its involvement in the pathogenesis of depression. This study assessed the effects of the new translocator protein ligand, YL-IPA08, on alleviating inflammation-induced depression-like behavior in mice and investigated its mechanism of action. mice were intracerebroventricularly injected with 1, 10, 100 or 1000 ng lipopolysaccharide. The tail-suspension test and the forced swimming test confirmed that 100 ng lipopolysaccharide induced depression-like behavior. A mouse model was then established by intraventricular injection of 100 ng lipopolysaccharide. On days 16-24 after model establishment, mice were intragastrically administered 3 mg/kg YL-IPA08 daily. Immunohistochemistry was used to determine BrdU and NeuN expression in the hippocampus. YL-IPA08 effectively reversed the depression-like behavior of lipopolysaccharide-treated mice, restored body mass, increased the number of BrdU-positive cells, and the number and proportion of BrdU and NeuN double-positive cells. These findings indicate that YL-IPA08 can attenuate lipopolysaccharide-induced depression-like behavior in mice by promoting the formation of hippocampal neurons.

关键词： nerve regeneration YL-IPA08 hippocampus dentate gyrus lipopolysaccharide neuroinflammation depression translocator protein neural regeneration

Quantum Solitary Wave Solutions in a Ferromagnetic Chain with Nearest-and Next-Nearest-Neighbor Interaction

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Communications in Theoretical Physics 2008年第11期50卷 1177-1180页

作者： LI De-Jun WANG Xiao-yun mi Xian-Wu KUE Jing Department of Physics Jishou University Jishou 416000 China Department of Physics Xiangtan University Xiangtan 411105 China

The quantum solitary wave solutions in a one-dimensional ferromagnetic chain is investigated by using theHartree-Fock approach and the multiple-scale *** is shown that quantum solitary wave solutions can exist in aferromagnetic system with nearest-and next-nearest-neighbor exchange interaction,and at the certain value of the firstBrillouin zone,the solitary wave solution of the Hartree wave function becomes the intrinsic localized mode.

关键词： Hartree-Fock approach multiple-scale method quantum solitary wave solution

A critical regulation of Th2 cell responses by RORa in allergic asthma

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Science China(Life Sciences) 2021年第8期64卷 1326-1335页

作者： jeong-Eun Lee Garam Cho minkyoung Cho Daehong Kim mi-Ock Lee Yeonseok Chung Laboratory of Immune Regulation Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul 08826Republic of Korea BK21 Plus Program College of PharmacySeoul National UniversitySeoul 08826Republic of Korea

Allergic asthma is a chronic inflammatory disease of the lung and the airway,which is characterized by aberrant type 2 immune responses to otherwise unharmful *** the central role of Th2 cells and type 2 cytokines in the pathogenesis of allergic asthma is well documented,the regulation and plasticity of Th2 cells remain incompletely *** using an animal model of allergic asthma in IL-4-reporter mice,we found that Th2 cells in the lung expressed higher levels of Rora than those in the lymph nodes,and that treatment with an RORa agonist SRI 078 resulted in diminished Th2 cell responses in *** determine the T cell-intrinsic role of RORa in allergic asthma in vivo,we established T cell-specific RORa-deficient^(f/f)fyf(Cd4creRora^(f/f))*** intranasal allergen challenges,Cd4creRora^(f/f)mice exhibited a significantly increased Th2 cells in the lungs and the airway and showed an enhanced eosinophilic inflammation compared to littermate control *** with Foxp3^(YFP-cre)Rora^(f/f)mice and CD^(8+)T cell depletion showed that the increased Th2 cell responses in the Cd4creRora^(f/f)mice were independent of Treg cells and CD^(8+)T *** findings demonstrate a critical regulatory role of RORa in Th2 cells,which suggest that RORa agonists could be effective for the treatment of allergic diseases.

关键词： Th2 allergic critical

滇东北镇雄羊场磷矿区下寒武统梅树村组沉积环境及富集成矿机制

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岩石矿物学杂志 2024年第5期43卷 1099-1118页

作者：米云川杜斌夏建峰王枫周骞黄太平胡清华云南省地质调查院(云南省地质科学研究院) 云南昆明650216 自然资源部三江成矿作用及资源勘查利用重点实验室云南昆明650051 云南省三江成矿作用及资源勘查利用重点实验室云南昆明650051 昆明理工大学国土资源工程学院云南昆明650093

羊场超大型磷矿床是新近勘查发现的大埋深全隐伏浅海相碳酸盐岩型层状磷块岩矿床,赋矿地层为下寒武统梅树村组(?1ms),目前对其沉积环境和富集成矿机制认识薄弱。本文在代表性钻孔岩芯系统观测的基础上,利用沉积(微)相分析、矿物学及矿... 详细信息

羊场超大型磷矿床是新近勘查发现的大埋深全隐伏浅海相碳酸盐岩型层状磷块岩矿床,赋矿地层为下寒武统梅树村组(?1ms),目前对其沉积环境和富集成矿机制认识薄弱。本文在代表性钻孔岩芯系统观测的基础上,利用沉积(微)相分析、矿物学及矿物化学示踪等手段,重点解析梅树村组各岩性段的岩石矿物(组合)特征、沉积(微)相类型及其时空分布规律,查明沉积环境演化,探究磷质来源、迁移及富集机制,建立其成矿模式。对比分析表明,赋矿地层垂向上表现出海侵-海退序列的近岸潮坪相沉积环境,识别出潮上坪、潮间坪和潮下坪3个亚相6种微相,潮上坪分为潮上滩、潮上灰坪,潮间坪分为潮间灰坪、潮间滩、风暴流,潮下坪发育低能潮下坪;潮间坪中的高能潮间滩是最有利的磷块岩形成环境,长期保持的浅水环境下多期次潮汐、波浪反复作用,利于富磷粒屑的簸选富集与再造,从而形成矿区北西侧矿层富厚、南东侧渐趋薄贫的磷块岩矿床。由此,羊场磷矿床的成矿作用可分为3个阶段:初始堆积沉淀成矿阶段(上升洋流携带的磷质来源)、生物化学凝聚沉淀与加积异化成矿阶段(微生物分解、转化及复合作用驱动的迁移与富集成矿)、簸选富集与再富集成矿阶段(多期次波浪、潮汐作用驱动的沉淀再次富集成矿)。这为矿区及外围地区找矿勘查提供了重要依据。

关键词：梅树村组羊场背斜沉积环境演化成矿机制磷块岩矿床羊场磷矿镇雄地区滇东北

SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1638-1639页

作者： Ji yun Noh Hye Won jeong Eui-Cheol Shin Division of Infectious Diseases Department of Internal MedicineKorea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineChungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Epidemic Preparedness KAISTDaejeonRepublic of Korea

In a recent study published in Nature,Wang et al.1 investigated the neutralizing activities of antibodies elicited by COVID-19 mRNA vaccines and natural infection with SARS-CoV-2 against SARS-CoV-2 *** devastating impact of the ongoing COVID-19 pandemic on public health,the economy,and society has made vaccine development a top priority for global ***,vaccine development is progressing at an unprecedented pace as an urgent response to COVID-19.

关键词： immunity vaccines variants

扬子西缘羊场磷矿地球化学特征及其对成磷环境的指示

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岩石矿物学杂志 2024年第5期43卷 1119-1138页

作者：周骞米云川赵勇黄太平王加昇胡清华夏建峰宰西昆明理工大学国土资源工程学院云南昆明650093 云南省地质调查院(云南省地质科学研究院) 云南昆明650216 自然资源部三江成矿作用及资源勘查利用重点实验室云南昆明650051 云南省三江成矿作用及资源勘查利用重点实验室云南昆明650051 云南省地质调查局云南昆明650051

寒武纪生命大爆发与海水氧化还原条件息息相关,上扬子地区下寒武统磷块岩较完整记录了早寒武世古海洋环境信息。扬子西缘羊场磷矿床是赋存于下寒武统梅树村组的超大型磷矿床,可重建该时期古海洋环境。本文采用ICP-MS等手段,分析羊场磷... 详细信息

寒武纪生命大爆发与海水氧化还原条件息息相关,上扬子地区下寒武统磷块岩较完整记录了早寒武世古海洋环境信息。扬子西缘羊场磷矿床是赋存于下寒武统梅树村组的超大型磷矿床,可重建该时期古海洋环境。本文采用ICP-MS等手段,分析羊场磷矿床磷块岩及其围岩的元素地球化学组成特征,探讨其形成时的环境条件。结果表明,羊场磷矿床磷块岩CIA值为46.40~65.60,平均57.43,显示其风化程度较低,稀土元素总量ΣREE相对较低(140.0×10^(-6)~237.4×10^(-6)),但较富集Y(87.0×10^(-6)~183.2×10^(-6));北美页岩标准化的稀土元素配分模式曲线相对平缓,LREE/HREE值为4.22~7.50,显示出轻重稀土元素分异不明显,具有明显的Ce负异常(δCe=0.22~0.42),Eu异常不明显(δEu=0.90~1.21),U/Th值为2.55~27.68,反映了磷块岩成矿过程中受到热水活动的影响;结合δCe、V/Cr、Y/Ho、Sr/Cu等元素分析认为,由底部震旦纪灯影组,到含磷层寒武纪梅树村组,直至上覆牛蹄塘组,古海洋氧化还原环境由底部的相对还原环境,向上变为氧化环境,直至顶部变为相对还原环境。古气候环境表现为寒冷干燥-温暖湿润交替出现的变化规律,古海水盐度表现为由咸水→半咸水→咸水→淡水的演化过程。综合分析后认为,羊场磷矿床磷块岩形成于相对氧化的咸水和较为干旱的古气候环境,并有热水活动参与成矿。

关键词：磷块岩梅树村组沉积环境羊场磷矿床扬子地块西缘

基于CiteSpace知识图谱的造口周围粪水性皮炎研究可视化分析

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医学信息 2024年第16期37卷 12-17页

作者：李英米子硕焦亚云陈昊南京中医药大学附属医院/江苏省中医院护理部南京中医药大学护理学院南京中医药大学针灸推拿学院·养生康复学院

目的对造口周围粪水性皮炎相关文献进行可视化分析，探讨该领域的研究现状及发展趋势。方法分别检索中国知网、万方数据库、维普中文科技期刊全文数据库有关造口周围粪水性皮炎的中文文献，利用Cite Space软件对发表年份、作者、期刊... 详细信息

目的对造口周围粪水性皮炎相关文献进行可视化分析，探讨该领域的研究现状及发展趋势。方法分别检索中国知网、万方数据库、维普中文科技期刊全文数据库有关造口周围粪水性皮炎的中文文献，利用Cite Space软件对发表年份、作者、期刊、关键词进行分析。结果共纳入文献286篇。造口周围粪水性皮炎领域年发文量逐渐升高。对该领域的研究已经形成了3大研究团队，但作者间、团队间的合作较少。载文期刊多集中在护理学类的杂志。研究热点方向集中在结直肠癌、护理干预、生活质量等方向。结论造口周围粪水性皮炎的研究整体呈上升态势，研究者应加强跨领域、跨机构、跨地区的合作与交流，挖掘新热点，拓宽研究广度，提高研究层次；预防是降低造口周围粪水性皮炎发生率的重点，而提升患者自我管理效能、注重患者的生活质量提高是未来该领域的研究热点。

关键词：造口周围粪水性皮炎可视化分析 CiteSpace 知识图谱

Fe_(3)O_(4)@silica nanoparticles for reliable identification and magnetic separation of Listeria monocytogenes based on molecular-scale physiochemical interactions

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Journal of Materials Science & Technology 2021年第25期84卷 116-123页

作者： Huawei Rong Tong Gao yun Zheng Lingwei Li Dake Xu Xuefeng Zhang Yanglong Hou mi Yan Key Laboratory for Anisotropy and Texture of Materials(MOE) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory of Electromagnetic Processing of Materials(ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Institute of Advanced Magnetic Materials College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310012China Beijing Key Laboratory for Magnetoelectric Materials and Device(BKLMMD) Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT)Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Listeria monocytogenes(***)is one of the top five dangerous foodborne pathogens which widely exists in most raw food and has approximately 30%mortality rate in high-risk *** safety caused by foodborne pathogens is still a major problem faced by humans in all *** conventional analytical methods currently used involve complex bacteriological tests and usually take several days for incubation and ***,in order to prevent the spread of disease,the development of a detection method with high speed,high accuracy and sensitivity is urgent and ***,we developed an approach for the identification and magnetic capture of *** by using core@shell Fe_(3)O_(4)@silica nanoparticles terminated with hydroxyl or amine *** results show that both amine-and hydroxyl-terminated Fe_(3)O_(4)@silica core@shell nanoparticles functionalized with specific antibodies,present 95.2%±6.2%and 98.6%±0.3%capture efficacies,***,without conjugating the specific antibodies,the hydroxyl-terminated Fe_(3)O_(4)@silica nanoparticles exhibit 17.6%±1.6%efficacy,while the amine-terminated one remains 93.2%±9.2%capture efficiency ascribed to the high *** study quantitatively uncovers the specific and non-specific recognitions relevant to the molecular-scale physiochemical interactions between the microorganisms and the functionalized particles,and the results from this work can be generalized and extended to other bacterial species by changing antibodies,also have important implications in developing advanced analytic methods.

关键词： Listeria monocytogenes Magnetic capture Fe_(3)O_(4)@silica Functionalized nanoparticles

Coral-Like Yolk–Shell-Structured Nickel Oxide/Carbon Composite microspheres for High-Performance Li-Ion Storage Anodes

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Nano-micro Letters 2019年第1期11卷 46-63页

作者： min Su Jo Subrata Ghosh Sang Mun jeong yun Chan Kang Jung Sang Cho Department of Engineering Chemistry Chungbuk National University Department of Chemical Engineering Chungbuk National University Department of Materials Science and Engineering Korea University

In this study, coral?like yolk–shell?structured NiO/C composite microspheres(denoted as CYS?NiO/C) were prepared using spray pyrolysis. The unique yolk–shell structure was characterized, and the formation mechanism of the structure was proposed. Both the phase separation of the polyvinylpyrrolidone and polystyrene(PS) colloidal solution and the decompo?sition of the size?controlled PS nanobeads in the droplet played crucial roles in the formation of the unique coral?like yolk–shell structure. The CYS?NiO/C microspheres delivered a reversible discharge capacity of 991 mAh g^(-1) after 500 cycles at the current density of 1.0 A g^(-1). The dis?charge capacity of the CYS?NiO/C microspheres after the 1000 th cycle at the current density of 2.0 A g^(-1) was 635 mAh g^(-1), and the capacity retention measured from the second cycle was 91%. The final discharge capacities of the CYS?NiO/C microspheres at the current densities of 0.5, 1.5, 3.0, 5.0, 7.0, and 10.0 A g^(-1) were 753, 648, 560, 490, 440, and 389 mAh g^(-1), respectively. The synergetic e ect of the coral?like yolk–shell structure with well?defined interconnected mesopores and highly conductive carbon resulted in the excellent Li+?ion storage properties of the CYS?NiO/C microspheres.

关键词： Yolk-shell Nickel oxide Carbon composite Anode materials Spray pyrolysis Lithium-ion batteries

Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells

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World Journal of Gastroenterology 2007年第13期13卷 1947-1952页

作者： yun jeong Lim Jong Chul Rhee Young Mee Bae Wan Joo Chun Department of Internal Medicine Dongguk University International Hospital Dongguk University College of Medicine Goyang Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Parasitology Seoul National University College of Medicine Seoul Korea Department of Pharmacology Kangwon National University College of Medicine Chuncheon Korea

AIM： To investigate the combined chemotherapeutic effects of celecoxib when used with 5-FU in vitro. METHODS： Two human colon cancer cell lines （HCT-15 and HT-29） were treated with 5-FU and celecoxib, alone and in combination. The effects of each drug were evaluated using the MTT （3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide） assay, flow cytometry, and western blotting. RESULTS： 5-FU and celecoxib showed a dosedependent cytotoxic effect. When treated with 10-3 mol/L 5-FU （IC50） and celecoxib with its concentration ranging from 10.8 mol/L to 10.4 mol/L of celecoxib, cells showed reduced cytotoxic effect than 5-FU （10.3 mol/L） alone. Flow cytometry showed that celecoxib attenuated 5-FU induced accumulation of cells at subG1 phase. Western blot analyses for caspase-3 and poly （ADP-ribose） polymerase （PARP） cleavage showed that celecoxib attenuated 5-FU induced apoptosis. Western blot analyses for cell cycle molecules showed that G2/M arrest might be possible cause of 5-FU induced apoptosis and celecoxib attenuated 5-FU induced apoptosis via blocking of cell cycle progression to the G2/M phase, causing an accumulation of cells at the GI/S phase. CONCLUSION： We found that celecoxib attenuated cytotoxic effect of 5-FU. Celecoxib might act via inhibition of cell cycle progression, thus preventing apoptosis induced by 5-FU.

关键词： Antagonism Celecoxib Colorectal neoplasms Fluorouracil