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Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis

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Chinese Chemical Letters 2024年第8期35卷 413-417页

作者： Tian Feng yun-ling gao Di Hu Ke-Yu Yuan Shu-Yi Gu Yao-Hua Gu Si-Yu Yu Jun Xiong Yu-Qi Feng Jie Wang Bi-Feng Yuan School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430071China University of Chinese Academy of Sciences Beijing 101408China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441000China Phase I Clinical Trial Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Sleep deprivation(SD)is a widespread issue that disrupts the lives of millions of *** effects ini-tiate as changes within neurons,specifically at the DNA and RNA level,leading to disruptions in neuronal plasticity and the dysregulation of various cognitive functions,such as learning and *** acid epigenetic modifications that could regulate gene expression have been reported to play crucial roles in this ***,there is a lack of comprehensive research on the correlation of SD with nucleic acid epigenetic *** the current study,we aimed to systematically investigate the landscape of modifications in DNA as well as in small RNA molecules across multiple tissues,including the heart,liver,kidney,lung,hippocampus,and spleen,in response to chronic sleep deprivation(CSD).Using liquid chromatography-tandem mass spectrometry(LC-MS/MS)analysis,we characterized the dynamic changes in DNA and RNA modification profiles in different tissues of mice under CSD ***,we ob-served a significant decrease in the level of 5-methylcytosine(5mC)and a significant increase in the level of 5-hydroxymethylcytosine(5hmC)in the kidney in CSD *** RNA modifications,we observed an overall increased trend for most of these significantly changed modifications across six tis-sues in CSD *** study sheds light on the significance of DNA and RNA modifications as crucial epigenetic markers in the context of CSD-induced stress.

关键词： Sleep deprivation Epigenetics Mass spectrometry DNA modification RNA modification Small RNA

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m Components-Admissible Solutions of Systems of Higher-Order Partial Differential Equations on C^n

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Acta Mathematicae Applicatae Sinica 2008年第2期24卷 211-220页

作者： ling-yun gao Department of Mathematics Jinan University Cuangzhou 510632 China

Using value distribution theory and techniques in several complex variables,we investigate the problem of existence of m components-admissible solutions of a class of systems of higher-order partial differential equations in several complex variables and estimate the number of admissible components of *** related results will also be obtained.

关键词： m components-admissible solutions several complex variables systems of partial differential equa-tions

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Admissible Solutions of Systems of Complex Partial Difference Equations on C^n

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 297-306页

作者： ling-yun gao Ze-mei ZHENG Department of Mathematics Jinan University Guangzhou

In a recent papers,some authors applied Nevanlinna theory to prove some results on complex difference equations reminiscent of the classical Malmquist theorem in complex differential equations. We will mainly investigate Malmquist theorem of a type of systems of complex partial difference equations on Cn,improvements and extensions of such results are presented in this paper.

关键词： Malmquist type meromorphic solution value distribution partial difference equations

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On the Growth of Components of Meromorphic Solutions of Systems of Complex Differential Equations

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Acta Mathematicae Applicatae Sinica 2005年第3期21卷 499-504页

作者： ling-yun gao Department of Mathematics Jinan University Guangzhou Guangdong 510632 China

This paper investigates the problem of the growth of the components of meromorphic solutions of a class of a system of complex algebraic differential equations, and generalized some of N. Toda＇s results concerning the growth of differential equations to the case of systems of differential equations. The paper considers the existence of admissible solutions of the system of differential equations.

关键词： Meromorphic solution characteristic functions systems of differential equations

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Transcendental Meromorphic Solutions of Second-Order Algebraic Differential Equations

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Journal of Mathematical Research and Exposition 2011年第3期31卷 497-502页

作者： Hai Chou LI ling yun gao Department of Mathematics Ji'nan University Guangdong 510632 P. R. China

Using Nevanlinna theory of the value distribution of meromorphic functions,we discuss some properties of the transcendental meromorphic solutions of second-order algebraic differential equations,and generalize some re... 详细信息

关键词： meromorphic functions transcendental meromorphic solutions second-order algebraic differential equations.

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复微分方程组的超越解

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数学学报（中文版） 2015年第1期58卷 41-48页

作者：高凌云暨南大学数学系广州510632

利用最大模原理,讨论了复代数微分方程组的超越亚纯解存在性问题,得到了在一定条件下,该方程组的超越解为代数解的一个结果.例子表明这个结果是精确的.

关键词：代数解超越亚纯函数微分方程最大模原理

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一类复差分方程组的亚纯解

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数学学报（中文版） 2016年第3期59卷 363-368页

作者：高凌云暨南大学数学系广州510632

许多作者研究了复差分方程解的存在性及增长性问题,得到了较多理想的结果.本文利用亚纯函数Nevanlinna值分布理论,研究了一类复高阶非线性差分方程解的表达式问题,将复差分方程的一结果推广至复差分方程组中.

关键词：表达式复差分方程组亚纯函数

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Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-Hua He Jian-Fei gao ling-Bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

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Molecular cloning, characterization and expression of the energy homeostasis-associated gene in piglet

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第6期16卷 524-532页

作者： Sheng-ping WANG yun-ling gao Gang LIU Dun DENG Rong-jun CHEN Yu-zhe ZHANG Li-li LI Qing-qi WEN Yong-qing HOU Ze-meng FENG Zhao-hui GUO Research Center of Healthy Breeding Livestock & Poultry Hunan Engineering & Research Center of Animal & Poultry ScienceKey Lab Agro-ecology Processing Subtropical RegionScientific Observational and Experimental Station of Animal Nutrition and Feed Science in South-CentralMinistry of AgricultureInstitute of Subtropical AgricultureChinese Academy of Sciences Hunan Institute of Microbiology Rice Research Institute of Sichuan Agricultural University Fujian Aonong Biotechnology Corporation Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety Wuhan Polytechnic University

The energy homeostasis-associated（Enho） gene encodes a secreted protein, adropin, which regulates the expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor γ, a major regulator of lipogenesis. In the present study, the porcine（Sus scrofa） homologue of the Enho gene, which was named p Enho, was amplified by reverse transcriptase polymerase chain reaction（RT-PCR） using oligonucleotide primers derived from in silico sequences. The gene sequence was submitted into the Gen Bank of NCBI, and the access number is GQ414763. The p Enho encodes a protein of 76 amino acids which shows 75% similarity to Homo sapiens adropin. The expression profile of p Enho in tissues（liver, muscle, anterior jejunum, posterior jejunum, and ileum） was determined by quantitative real-time RT-PCR. p Enho was localized on porcine chromosome 10 and no introns were found. In conclusion, p Enho was cloned and analysed with the aim of increasing knowledge about glucose and lipid metabolism in piglets and helping to promote the health and growth of piglets through adropin regulation.

关键词： Adropin Energy homeostasis-associated(Enho) gene Gene coloning Piglets RT-PCR

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Atomically Dispersed Catalysts:Precise Synthesis,Structural Regulation,and Structure-Activity Relationship

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CCS Chemistry 2024年第4期6卷 833-855页

作者： yun gao Dingsheng Wang Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084

Atomically dispersed catalysts(ADCs)have been diffusely researched for the development of advanced catalytic processes owing to their welldefined structure,high atomic utilization,and outstanding *** decoding the intrinsic structures and coordination microenvironments of ADCs still confronts significant *** these challenges is important for profound understanding of the structure-activity relationships and directing the future design of ***,this minireview summarizes recent progress and advanced characterization techniques for the engineering of ADCs,including single-atom catalysts,dualatom catalysts,and atomic cluster catalysts with regard to precise synthesis,structural regulation,and the structure-performance *** catalytic merits and regulation strategies of recent breakthroughs in energy conversion,enzyme mimicry,and organic synthesis are thoroughly discussed to disclose the catalytic mechanism-guided ADCs ***,a comprehensive summary of the future challenges and potential prospects is presented to stimulate more design and application possibilities for *** believe that this comprehensive minireview will open up novel pathways for the widespread utilization of ADCs in diverse catalytic processes.

关键词： atomically dispersed catalysts precise synthesis structural regulation structure-activity relationship and catalytic application

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