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Comparison of He/icobacter py/ori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients

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World Journal of Gastroenterology 2005年第7期11卷 976-981页

作者： Chuan Zhang Nobutaka Yamada yun-lin wu Min Wen Takeshi Matsuhisa Norio Matsukura Department of Gastroenterology Baogang HospitalShanghai Second Medical UniversityShanghai 2019O0China Department of Pathology Division of Surgical Pathology.Nippon Medical SchoolTokyo 113-8602Japan Takeshi Matsuhisa Department of Gastrointestinal Endoscopy CenterTamaNagayama HospitalTokyo 206-8512Japan Norio Matsukura Department of First SurgeryNippon Medical SchoolTokyo 113-8602Japa Department of Gastroenterology Ruijin HospitalShanghai Second Medical UniversityShanghai 200025China

AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy ***: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney ***: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P＜0.05). The rate of H pylori colonization of chronic gastritis in ＜30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and ＞70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in ＜30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and ＞70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with gastric ulcer.

关键词： Helicobacter pylori infection Gastric ulcer Glandular atrophy Intestinal metaplasia

Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia

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World Journal of Gastroenterology 2009年第4期15卷 489-495页

作者： Wei wu yun-lin wu Yan-Bo Zhu Qing Wei Yan Guo Zheng-Gang Zhu Yao-Zong Yuan Department of Pathology Shanghai Ruijin Hospital Affiliated to Sh'anghai JiaotongUniversity School of Medicine Shanghai 200025 China Department of Surgery Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200025 China

AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March *** sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations,endoscopic features,biopsy and surgical pathology of all patients were collected and *** data acquired were subjected to univariate and multivariate analysis. RESULTS:Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions,most of which(96.4%)were differentiated *** result of univariate analysis indicatedthat the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer(P<0.05),when high grade intraepithelial neoplasia was diagnosed by biopsy *** results of multivariate analysis revealed the size greater than 1.5 cm[odds ratio(OR)18.400,P<0.001]and the presence of 5-odd mm ulcer plaque or scar(OR 10.000,P=0.044)were associated with gastric ***,the sensitivity,specificity and negative predictive value of multivariate analysis for predicting"true high grade intraepithelial neoplasia" was 87.5%,89.3%and 96.2%,respectively. CONCLUSION:Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric *** may simplify patient work-up and save costs for patients and healthcare system.

关键词： Stomach neoplasm Precancerous conditions Carcinoma in situ Endoscopy Gastrointestinal Path-ology

Suppression of gastric cancer growth by baculovirus vector-mediated transfer of normal epithelial cell specific-1 gene

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World Journal of Gastroenterology 2008年第38期14卷 5810-5815页

作者： Wei Huang Xiang-Long Tian yun-lin wu Jie Zhong Li-Fen Yu Sheng-Ping Hu Biao Li Department of Nuclear Medicine Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China Department of Gastroenterology Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 China

AIM: To study the inhibitory effect of baculovirus- mediated normal epithelial cell specific-1 (NES1) gene therapy on gastric cancer (GC) in vitro and in vivo. METHODS: We first constructed recombinant baculovirus vectors and then transfected them into gastric cancer cells (SGC-7901). Efficiency of the baculovirus for gene transfer into SGC-7901 cells and cell growth curves were detected by fluorescence microscopy, Western blot and 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro, respectively. The therapeutic effect of this gene therapy on GC was confirmed in xenografted nude mice. Tumor growth was determined by tumor volume, and expression of NES1 in tumor was analyzed by immunohistochemistry. RESULTS: Baculovirus vectors were successfully transfected into SGC-7901 cells. SGC-7901 cells transfected with the NES1 gene inhibited cell growth. In the Bac-NES1 treated group, tumor growth was significantly reduced with a high level of NES1 expression CONCLUSION: Baculovirus-mediated NES1 gene can be used in gene therapy for GC.

关键词： Gastric cancer Normal epithelial cellspecific-1 gene Baculovirus Gene therapy

Endoscopic treatment for pancreatic diseases:Needle-knife-guided cannulation via the minor papilla

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World Journal of Gastroenterology 2015年第19期21卷 5950-5960页

作者： Wei Wang Biao Gong Wei-Song Jiang Lei Liu Kouken Bielike Bin Xv yun-lin wu Department of Gastroenterology Ruijin Hospital North Shanghai Jiao Tong University School of Medicine Department of Digestive Endoscopy Center Ruijin Hospital Shanghai Jiao Tong University School of Medicine Department of Emergency Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine

AIM: To determine the efficacy and safety of meticulous cannulation by ***: Three needle-knife procedures were used to facilitate cannulation in cases when standard cannulation techniques failed. A total of 104 cannulationsvia the minor papilla attempted in 74 patients at our center between January 2008 and June 2014 were retrospectively ***: Standard methods were successful in79 cannulations. Of the 25 cannulations that could not be performed by standard methods, 19 were performed by needle-knife, while 17(89.5%) were successful. Needle-knife use improved the success rate of cannulation [76.0%, 79/104 vs 92.3%,(79 +17)/104; P = 0.001]. When the 6 cases not appropriate for needle-knife cannulation were excluded, the success rate was improved further(80.6%, 79/98 vs98.0%, 96/98; P = 0.000). There were no significant differences in the rates of post-endoscopic retrograde cholangiopancreatography adverse events between the group using standard methods alone and the group using needle-knife after failure of standard methods(4.7% vs 10.5%, P = 0.301).CONCLUSION: The needle-knife procedure may be an alternative method for improving the success rate of cannulation via the minor papilla, particularly when standard cannulation has failed.

关键词： Needle-knife Minor papilla Cannulation Meticulous procedure Endoscopic retrograde cholangiopancreatography

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun Li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao Yu Yingjie Zhou Yao lin Ying wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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日本生物类似药注册监管政策绩效评价研究及启示

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中国卫生政策研究 2016年第12期9卷 50-55页

作者：陈永法卞云云伍琳中国药科大学国际医药商学院江苏南京211198

目的:为完善我国生物类似药的注册监管提供参考。方法:以日本生物类似药研发注册审评政策为研究对象,分析其注册审评流程及核心特征,并探讨政策实施效果。结果与结论:日本注册监管政策有助于提高生物类似药的可获得性与可支付性,同时促... 详细信息

目的:为完善我国生物类似药的注册监管提供参考。方法:以日本生物类似药研发注册审评政策为研究对象,分析其注册审评流程及核心特征,并探讨政策实施效果。结果与结论:日本注册监管政策有助于提高生物类似药的可获得性与可支付性,同时促进了生物医药产业的健康发展。启示:我国可以引入适度简化原则,减免部分研发程序和申报资料要求,促进生物类似药的研发上市;沿用新药审评程序,确保生物类似药研发注册的稳定性。

关键词：生物类似药注册监管绩效评价

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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氩离子凝固术治疗疣状胃炎40例

世界华人消化杂志 2000年第12期8卷 1332-1335页

作者：冯莉吴云林钟捷诸琦山西太原钢铁集团公司总医院消化科山西省太原市030003 上海第二医科大学附属瑞金医院消化科上海市200025

目的探讨氩离子凝固(APC)术治疗疣状胃炎的疗效.方法选择上海瑞金医院2000-01/08内镜诊断为成熟型疣状胃炎患者40例,先行内镜检查,同时行幽门螺杆菌(Hp)检测及病理组织学检查,首先给予达克普隆+甲硝唑+丽珠得乐,4 wk 舌复查内镜并使用... 详细信息

目的探讨氩离子凝固(APC)术治疗疣状胃炎的疗效.方法选择上海瑞金医院2000-01/08内镜诊断为成熟型疣状胃炎患者40例,先行内镜检查,同时行幽门螺杆菌(Hp)检测及病理组织学检查,首先给予达克普隆+甲硝唑+丽珠得乐,4 wk 舌复查内镜并使用氩离子凝固术,以1s～3s/次的时间施以氩离子凝固治疗,根据病灶的大小采用不同的次数,以内镜下所有疣状病灶灼除后粘膜平坦或略凹为止.所有病例治疗1mo 后进行临床随访及内镜复查.结果 APC 术治疗40例成熟型疣状胃炎,病灶数共计212枚,平均每枚病灶治疗时间为4.96s(范围2.5s～5s).1mo 后随访,38例(95%)患者临床症状明显改善.内镜复查发现,原病灶处均覆有新生的粘膜上皮及肉芽组织,无明显疤痕形成.2例(5%)患者仍见少许疣状灶及糜烂残留,再次行 APC 术治疗.结论疣状胃炎临床治疗颇为困难,作者经初步研究证实,APC 术操作简便,易于掌握.应用 APC 术为消除成熟型疣状胃炎病灶的一种有效方法.

关键词：氩离子凝固术治疗疣状胃炎