检索结果-南通市图书馆

Application and efficacy of reconstructing forked corpus spongiosum in distal/midshaft hypospadias repair

Asian Journal of Andrology 2021年第1期23卷 47-51页

作者： bin Zhang yun-li bi Shuang-Sui Ruan Department of Pediatric Urology Children's Hospital of Fudan UniversityShanghai 201102China

We reviewed our experience in reconstructing forked corpus spongiosum(FCS)in distal/midshaft hypospadias repair and analyzed the efficacy of this surgical *** August 2013 to December 2018,137 consecutive cases of distal/midshaft hypospadias operated by the same surgeon in Urology Department,Children’s Hospital of Fudan University(Shanghai,China),were retrospectively ***-four patients who underwent routine tubularized incised plate(TIP)or onlay island flap(ONLAY)surgery were included in the nonreconstructing group,and 73 patients who underwent reconstructing FCS during TIP or ONLAY surgery were included as the reconstructing ***-eight cases underwent TIP,and 26 underwent ONLAY in the nonreconstructing group,with a median follow-up of 44(range:30-70)***-seven cases underwent TIP,and 46 underwent ONLAY in the reconstructing group,with a median follow-up of 15(range:6-27)*** the nonreconstructing/reconstructing groups,the mean age at the time of surgery was 37.55(standard deviation[s.d.]:29.65)/35.23(s.d.:31.27)months,the mean operation duration was 91.95(s.d.:12.17)/93.84(s.d.:14.91)min,the mean neourethral length was 1.88(s.d.:0.53)/1.94(s.d.:0.53)cm,and the mean glans width was 11.83(s.d.:1.32)/11.56(s.d.:1.83)***(18.8%)/5(6.8%)postoperative complications occurred in the nonreconstructing/reconstructing *** included fistula(5/2),glans dehiscence(3/0),diverticulum(1/2),residual chordee(3/0),and meatus stenosis(0/1)in each *** was a significant difference in the overall rate of complications(P=0.035).These results indicate that the technique of reconstructing FCS provides excellent outcomes with fewer complications in distal/midshaft hypospadias repair.

关键词： complications distal/midshaft hypospadias forked corpus spongiosum glans tilt

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cryptorchid testicular torsion in children characteristics and treatment outcomes

引用

Asian Journal of Andrology 2021年第5期23卷 468-471页

作者： Hai-Jun Zhong liang-Feng Tang yun-li bi Department of Pediatric Urology Children's Hospital of Fudan UniversityShanghai 201102China.

This study aimed to review and compare the characteristics and treatment outcomes of cryptorchid testicular torsion in pre-and postpubertal *** reviewed the clinical data of 22 patients with testicular torsion complicated by cryptorchidism who were treated between January 2010 and December *** were categorized into prepubertal(1 month to 9 years;n=12)and postpubertal groups(10-16 years;n=10).The age at presentation,clinical presentations,physical examination,and operation outcomes were *** common clinical presentations in both groups were inguinal pain and a tender inguinal *** in the prepubertal group were significantly more likely to present with restlessness(33.3%)than those in the postpubertal group(0%;P-0.044).After detorsion,testicular blood flow recovered during surgery in 25.0%of the prepubertal and 80.0%of the postpubertal patients(P=0.010).Orchiectomy was required in 50.0%of the prepubertal and 20.0%of the postpubertal patients(P=0.145).Of the 22 patients with follow-up data,the rates of testicular salvage were significantly different,at 16.7%in the prepubertal patients and 60.0%in the postpubertal patients(P=0.035).Cryptorchid testicular torsion has various *** an empty hemiscrotum and a painful groin mass were common in both groups,restlessness was more prevalent in the prepubertal patients during early testicular torsion onset than that in the postpubertal ***,the testicular salvage rate was significantly lower in the prepubertal patients than that in the postpubertal patients.

关键词： children cryptorchidism testicular torsion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Responsible genes in children with primary vesicoureteral reflux: findings from the Chinese Children Genetic Kidney Disease Database

引用

World Journal of Pediatrics 2021年第4期17卷 409-418页

作者： Jia-Lu liu Qian Shen Ming-Yan Wu Guang-Hua Zhu Yu-Feng li Xiao-Wen Wang Xiao-Shan Tang yun-li bi Yi-Nv Gong Jing Chen Xiao-Yan Fang Yi-Hui Zhai bing-bing Wu Guo-Min li Yu Bo Sun Xiao-Jie Gao Cui-Hua liu Xiao-yun Jiang Sheng Hao Yu-lin Kang Ying-liang Gong li-Ping Rong Di li Si Wang Duan Ma Jia Rao Hong Xu Chinese Children Genetic Kidney Disease Database(CCGKDD) “Internet Plus”Nephrology Alliance of the National Center for Children’s Care Department of Nephrology Children’s Hospital of Fudan UniversityNational Children’s Medical Center399 Wan Yuan RoadShanghai201102People’s Republic of China Shanghai Kidney Development and Pediatric Kidney Disease Research Center ShanghaiChina Department of Nephrology Shanghai Children’s HospitalShanghaiChina Department of Pediatric Nephrology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Wuhan Children’s Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Urology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rheumatology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Nephrology Shenzhen Children’s HospitalShenzhenGuangdongChina Department of Nephrology and Rheumatology Children’s Hospital Affiliated to Zhengzhou UniversityZhengzhou Key Laboratory of Pediatric Kidney Disease ResearchZhengzhouChina The First Affiliated Hospital of Zhongshan University GuangzhouChina Key Laboratory of Metabolism and Molecular Medicine Ministry of EducationDepartment of Biochemistry and Molecular BiologyInstitutes of Biomedical SciencesSchool of Basic Medical SciencesFudan UniversityShanghaiChina 不详

Background Primary vesicoureteral reflux(VUR)is a common congenital anomaly of the kidney and urinary tract(CAKUT)in *** present study identified the possible genetic contributions to primary VUR in *** Patients with primary VUR were enrolled and analysed based on a national multi-center registration network(Chinese Children Genetic Kidney Disease Database,CCGKDD)that covered 23 different provinces/regions in China from 2014 to *** causes were sought using whole-exome sequencing(WES)or targeted-exome *** A total of 379 unrelated patients(male:female 219:160)with primary VUR were ***-four(16.9%)children had extrarenal manifestations,and 165(43.5%)patients showed the coexistence of other CAKUT ***-eight patient(23.2%)exhibited impaired renal function at their last visit,and 18 of them(20.5%)developed ESRD at the median age of 7.0(IQR 0.9–11.4)years.A monogenic cause was identified in 28 patients(7.39%).These genes included PAX2(n=4),TNXB(n=3),GATA3(n=3),SliT2(n=3),ROBO2(n=2),TBX18(n=2),and the other 11 genes(one gene for each patient).There was a significant difference in the rate of gene mutations between patients with or without extrarenal complications(14.1%vs.6%,P=0.035).The frequency of genetic abnormality was not statistically significant based on the coexistence of another CAKUT(9.6%vs.5.6%,P=0.139,Chi-square test)and the grade of reflux(9.4%vs.6.7%,P=0.429).Kaplan–Meier survival curve showed that the presence of genetic mutations did affect renal survival(Log-rank test,P=0.01).PAX2 mutation carriers(HR 5.1,95%CI 1.3–20.0;P=0.02)and TNXB mutation carriers(HR 20.3,95%CI 2.4–168.7;P=0.01)were associated with increased risk of progression to *** PAX2,TNXB,GATA3 and SliT2 were the main underlying monogenic causes and accounted for up to 46.4%of monogenic *** complications and renal function were significantly related to the findings of genetic factors in children with p

关键词： Children Congenital anomalies of the kidney and urinary tract Gene mutation Vesicoureteral reflux Whole-exome sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Expression of pea antisense Lhcb2 gene in transgenic tobacco and its spectrum analysis

Expression of pea antisense Lhcb2 gene in transgenic tobacco...

引用

全国植物分子生物学与生物技术学术研讨会

作者： SUN Qin-Miao liN Rong-Cheng KUANG Ting-yun li liang-bi(Laboratory of Photosynthesis Basic Research, Institute of Botany, Chinese Academy of Sciences, Beijing 100093)

Photosynthesis in plants is the unique process that utilize solar energy to convert carbon dioxide and water into carbohydrate with the concomitant evolution of oxygen. light absorption and energy transfer rely mainly on light-harvesting complexes (LHC) located in chloroplast thylakoid membranes. LHCII, the light harvesting system of photosysem Ⅱ (PSⅡ), consists of six proteins encoded by six genome genes (Lhcb1～6). LHCII also plays important roles in maintaining the structure of thylakoid and regulating the distribution of excitation energy between the two photosystems as well as protecting the photosynthetic apparatus against photodamage. Previous researches have mainly focused on Lhcb1 gene with an emphasis on the expression and regulation of Lhcb1 gene and the structure and function of its protein. But little is known about Lhcb2 gene.

关键词： Lhcb2 gene transgenic tobacco antisense inhibition spectrum analysis .

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

知柏地黄丸加减治疗小儿紫癜性肾炎肝肾阴虚证的疗效观察

引用

中国实验方剂学杂志 2020年第17期26卷 89-94页

作者：朱小石张渝邓俊超李运璧李建超四川省医学科学院四川省人民医院成都610072

目的:观察知柏地黄丸加减治疗小儿紫癜性肾炎(HSPN)肝肾阴虚证的疗效及对免疫炎症反应和高凝状态的影响。方法:将120例符合要求的患儿按随机数字表法分为观察组和对照组各60例。对照组采用醋酸泼尼松龙片,1.5~2 mg·kg^-1·d^-1,分2次口... 详细信息

目的:观察知柏地黄丸加减治疗小儿紫癜性肾炎(HSPN)肝肾阴虚证的疗效及对免疫炎症反应和高凝状态的影响。方法:将120例符合要求的患儿按随机数字表法分为观察组和对照组各60例。对照组采用醋酸泼尼松龙片,1.5~2 mg·kg^-1·d^-1,分2次口服,4周后逐渐减量,改为隔日口服;注射用环磷酰胺,8~12 mg·kg^-1·d^-1,连续2 d静脉滴注,停2周,再行下1个疗程,共6个月。对照组口服大补阴丸,3 g/次,3次/d;观察组采用知柏地黄丸加减内服,1剂/d。连续治疗6个月。每月检测1次尿常规,记录血尿和蛋白尿消失时间和消失率,评价治疗前后24 h尿蛋白定量、尿微量白蛋白(mAlb)和尿β2微球蛋白(β2-MG)水平。进行治疗前后肝肾阴虚证评分;检测治疗前后T淋巴细胞亚群(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+),纤维蛋白原(FIB),D-二聚体(D-D),纤维蛋白降解产物(FDP),白细胞介素-2(IL-2),IL-4,IL-10和干扰素-γ(IFN-γ)水平。结果:观察组患儿临床疗效优于对照组(Z=2.078,P<0.05);观察组患儿血尿消失时间和蛋白尿消失时间均短于对照组(P<0.01);观察组蛋白尿消失率为90.48%(38/42),高于对照组的69.77%(30/43)(χ^2=5.694,P<0.05);观察组患儿24 h尿蛋白定量,mAlb和β2-MG均低于对照组(P<0.01);观察组患儿CD3^+,CD4^+水平和CD4^+/CD8^+均高于对照组(P<0.05),CD8^+低于对照组(P<0.05);观察组患儿治疗后FIB,D-D和FDP均低于对照组(P<0.01);观察组患儿IL-2,IFN-γ水平均高于对照组(P<0.05),IL-4,IL-10水平均低于对照组(P<0.05);观察组患儿中医证候疗效好于对照组(Z=2.106,P<0.05)。结论:在西医常规治疗的基础上,采用知柏地黄丸加减内服治疗HSPN肝肾阴虚证患儿,可促进蛋白尿和血尿的消失,缩短了病程,并可改善T淋巴细胞亚群,减轻炎症反应,纠正血液高凝状态,很好地提高临床疗效和中医证候疗效。

关键词：紫癜性肾炎肝肾阴虚证知柏地黄丸 T淋巴细胞亚群炎症因子凝血功能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IRAK4在TLR介导的信号通路中的调节作用

引用

实用医院临床杂志 2016年第3期13卷 150-152页

作者：柯敏李运璧四川省医学科学院.四川省人民医院儿科四川成都610072

白细胞介素-1受体相关激酶4(interleukin-1 receptor-associated kinase 4,IRAK4)是细胞内丝氨酸-苏氨酸激酶IRAK家族的成员之一。IRAK4作为Toll样受体(toll like receptor,TLR)与白介素-1受体(IL-IR)信号传导通路下游的关键因子,不仅可促使白细胞介素-1受体相关激酶-1(IRAK-1)磷酸化,还是IRAK-1募集于TLR/IL-1R复合物上的必要条件,从而成为调控IRAK-1生物活性以及内毒素胞内信号转导的最关键分子,并在全身炎症反应中起着非常重要的作用。本文就IRAK4在TLR介导的信号通路中的作用作一综述。

关键词：白细胞介素-1受体相关激酶4 Toll样受体 TLR信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肿瘤坏死因子受体相关因子在内毒素耐受中的作用及其相关机制

引用

实用医院临床杂志 2015年第6期12卷 157-159页

作者：柯敏李运璧四川医科大学四川泸州646000 四川省医学科学院.四川省人民医院儿科四川成都610072

目前在哺前乳动物中已经发现7个肿瘤坏死因子受体相关因子(TNF receptor associated factors,TRAFs)家族成员,它们是肿瘤坏死因子受体和TOLL样受体信号通路中重要的组成部分。单独激活或者联合其他蛋白激活后,TRAFs参与一些细胞因子的... 详细信息

目前在哺前乳动物中已经发现7个肿瘤坏死因子受体相关因子(TNF receptor associated factors,TRAFs)家族成员,它们是肿瘤坏死因子受体和TOLL样受体信号通路中重要的组成部分。单独激活或者联合其他蛋白激活后,TRAFs参与一些细胞因子的产生和释放及细胞存活,控制着许多生理过程。而肿瘤坏死因子受体相关因子3(TRAF3)是TRAFs家族中功能最为多样化的成员之一,它能够正性调节I型干扰素的产生,负性调节丝裂原激活的蛋白激酶(mitogen-activated protein kinase,MAPK)和非经典NF-κB信号的激活,通过这些途径,参与炎症反应过程,也可能参与了内毒素耐受形成的过程。本文就TRAF3在内毒素耐受中的作用及其相关机制的研究进展作一综述。

关键词：肿瘤坏死因子受体相关因子3 蛋白激酶内毒素耐受

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

双冲击联合低分子肝素治疗激素耐药型肾病综合征效果观察

引用

实用医院临床杂志 2007年第5期4卷 46-47页

作者：朱小石李运璧四川省人民医院儿科四川成都610072

目的探讨甲基强的松龙与环磷酰胺双冲击与肝素联合治疗小儿激素耐药型肾病综合征(SRNS)的临床疗效。方法38例SRNS患儿采用环磷酰胺冲击8～12mg/(kg.d),连续2日为1疗程,间隔2周重复1疗程,共6疗程;甲基强的松龙7～15mg/(kg.d),连用3天后,... 详细信息

目的探讨甲基强的松龙与环磷酰胺双冲击与肝素联合治疗小儿激素耐药型肾病综合征(SRNS)的临床疗效。方法38例SRNS患儿采用环磷酰胺冲击8～12mg/(kg.d),连续2日为1疗程,间隔2周重复1疗程,共6疗程;甲基强的松龙7～15mg/(kg.d),连用3天后,改为隔日1次,疗程总共6次;肝素5000U皮下注射,1次/日,共用4周。结果治疗6个月后完全缓解12例,部分缓解16例,无效10例,总有效率73.7%。结论甲基强的松龙与环磷酰胺双冲击与肝素联合治疗SRNS能迅速生效,三者可起到良好的协同作用,能使部分SRNS患儿完全缓解。

关键词：激素耐药型肾病综合征甲基强的松龙环磷酰胺低分子肝素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

儿童过敏性紫癜早期肾上腺皮质激素治疗中尿微量蛋白的变化及意义

引用

华西医学 2008年第4期23卷 736-737页

作者：朱小石李运璧四川省人民医院儿科四川成都610072

目的:通过对观测尿液微量蛋白的变化,探讨在儿童过敏性紫癜早期使用肾上腺皮质激素治疗的临床意义。方法:对入选的214例HSP患儿随机分为激素治疗组和非激素治疗组。分别在治疗前,治疗第七天采用放射免疫法对尿微量白蛋白(mALb),α1微球... 详细信息

目的:通过对观测尿液微量蛋白的变化,探讨在儿童过敏性紫癜早期使用肾上腺皮质激素治疗的临床意义。方法:对入选的214例HSP患儿随机分为激素治疗组和非激素治疗组。分别在治疗前,治疗第七天采用放射免疫法对尿微量白蛋白(mALb),α1微球蛋白(α1-MG),β2微球蛋白(β2-MG)进行测定,并设定健康儿童为对照组。结果:治疗前HSP患儿mALb,β2-MG及α1-MG较健康儿童对照组明显升高。在治疗第七天后激素治疗组与非激素治疗组相比较mALb,β2-MG及α1-MG均有所下降;激素治疗组与正常对照组相比较mALb,α1-MG明显下降;非激素治疗组与健康儿童对照组相比较mALb,β2-MG及α1-MG均仍是升高。结论:尿微量蛋白的检测可全面、早期、敏感地反映HSP患儿肾脏受损情况。早期使用皮质激素治疗可减轻或减缓肾脏的受损,可能也是临床上阻断紫癜性肾炎(HSPN)的发生的一个途径。

关键词：过敏性紫癜尿液微量蛋白早期肾上腺皮质激素治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

小儿肾病综合征与呼吸道病毒基因表达关系的研究

引用

四川医学 2009年第1期30卷 77-78页

作者：朱小石李运璧四川省人民医院儿科四川成都610072

目的通过研究呼吸道病毒基因在激素敏感型单纯性肾病综合征患儿外周血单个核细胞(PBMC)的表达,探讨呼吸道病毒感染与其发病的关系。方法采用逆转录-聚合酶链反应(RT-PCR)法,检测外周血单个核细胞呼吸道病毒基因的表达。结果32例SRSNS组... 详细信息

目的通过研究呼吸道病毒基因在激素敏感型单纯性肾病综合征患儿外周血单个核细胞(PBMC)的表达,探讨呼吸道病毒感染与其发病的关系。方法采用逆转录-聚合酶链反应(RT-PCR)法,检测外周血单个核细胞呼吸道病毒基因的表达。结果32例SRSNS组患儿PBMC中有23例检测到呼吸道病毒RNA,检出的阳性率(71.9%)高于肾炎性肾病组、紫癜性肾炎及正常对照组,差异有统计学意义(P<0.05)。结论呼吸道病毒确实存在于SRSNS患儿体内,呼吸道病毒感染可能为SRSNS的重要发病机制。

关键词：儿童肾病综合征激素敏感型单纯性单核白细胞呼吸道病毒基因

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：