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Pd@Ir-l.D mul.ienzyme util.zing endogenous l.ctate consumption cooperates with photothermal.for tumor therapy

Nano Research 2024年第1期17卷 270-281页

作者： Zichen Ye yun l. Jingchao l. Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide guo Xiaol.n Chen State Key l.boratory for Physical.Chemistry of Sol.d Surfaces Collaborative Innovation Center of Chemistry for Energy Materials and Engineering Research Center for Nano-Preparation Technology of Fujian ProvinceCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key l.boratory of Mol.cul.r Vaccinol.gy and Mol.cul.r Diagnostics&Center for Mol.cul.r Imaging and Transl.tional.Medicine School.of Publ.c Heal.h Xiamen UniversityXiamen 361102China The High Educational.Key l.boratory for Biomedical.Engineering&Key l.boratory of Fire Retardant Material. of Fujian Province Department of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361102China

l.ctic acid(l.)pl.ys a major rol. in the occurrence,devel.pment,and spread of *** by its high accumul.tion in tumor site,a novel.l.ctate oxidase(l.D)conjugated two-dimensional.Pd@Ir nanopl.tform(Pd@Ir-l.D,PIl.was fabricated to combine cascade reaction with photothermal.for tumor *** detail.the overexpressed l. in tumor microenvironment(TME)was a key factor to activate the PIl.based cascade reaction:(1)Pl.nty of H_(2)O_(2)coul. be generated from l. by the catal.sis of l.D with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-l.ke activity of PIl.(3)meantime,PIl.s catal.se(CAT)-l.ke activity coul. decompose part H_(2)O_(2)into O_(2)to achieve the purpose of l. cycl.c ***,the reduced gl.tathione(GSH)scavenging capabil.ty of PIl.might protect the produced reactive oxygen species(ROS)from being cl.ared to further improve the cascade therapeutic *** importantl.,PIl.had excel.ent photothermal.conversion efficiency(37.35%)and manifested a surprising temperature rising effect in *** together,the decreasing l. concentration,accumul.tion of high-toxic ROS,the depl.tion of GSH together with the higher intra-tumoral.temperature potentl. enhanced in vivo antitumor ***,a promising therapeutic tactic based on PIl.integrating endogenous l. consumption,chemodynamic therapy(CDT),and photothermal.therapy(PTT)has been put forward.

关键词： l.ctate oxidase chemodynamic therapy photothermal.therapy cascade reaction tumor microenvironment

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The Mass Assembl. History for Gal.xies with MaNGA

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Research in Astronomy and Astrophysics 2024年第3期24卷 58-69页

作者： Xue Ge Hong-Tao Wang Cheng-l.ng l.i yun-Jun guo Yi-l.ng Jiang Xiao-Xiao Cao School.of Physics and Information Engineering Jiangsu Second Normal University Jiangsu Province Engineering Research Center of Basic Education Big Data Appl.cation Jiangsu Second Normal University Key l.boratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education School.of Science Langfang Normal University

How gal.xies assembl. masses through their own star formation or interaction with the external.environment is stil. an important topic in the fiel. of gal.xy formation and *** use Val.e Added Catal.gs with gal.xy features that are spatial.y and temporal.y resol.ed from Sl.an Digital.Sky Survey Data Rel.ase 17 to investigate the mass growth histories of earl.-type gal.xies(ETGs)and l.te-type gal.xies(l.Gs).We find that the mass growth of ETGs is earl.er than that of l.Gs for massive gal.xies(M_(*)>10^(10)M_⊙),whil. l.w-mass(M_(*)≤10^(10)M_⊙)ETGs have statistical.y simil.r mass assembl. histories as l.w-mass *** stel.ar metal.icity of al. massive gal.xies shows a negative gradient and basical.y does not change with ***,in l.w-mass gal.xies,the stel.ar metal.icity gradient of el.iptical.gal.xies is negative,and the stel.ar metal.icity gradient of l.nticul.r and spiral.gal.xies evol.es from positive to *** are not al. in a high-density environment,but exhibit mass *** the tidal.strength increases,the star formation rate of l.w-mass ETGs rapidl. *** resul.s support a picture where massive gal.xies exhibit inside-out quenching mode,whil. l.w-mass gal.xies show outside-in quenching *** effects pl.y an important rol. in regul.ting the mass assembl. histories of l.w-mass ETGs.

关键词： Gal.xy evol.tion-gal.xies star formation-Gal.xy formation

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Manipul.tion of l.w-refractive-index particl.s using customized dark traps

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Photonics Research 2024年第6期12卷 1334-1343页

作者： MINRU HE YANSHENG l.ANG XUE yun SHAOWEI WANG TIANYU ZHAO l.NQUAN guo XINYU ZHANG SHIQI KUANG JINXIAO CHEN MING l.I MOE Key l.boratory for Non-Equil.brium Synthesis and Modul.tion of Condensed Matter School of PhysicsXi’an Jiaotong UniversityXi’an 710049China State Key l.boratory of El.ctrical.Insul.tion and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China

l.w-refractive-index particl.s pl.y significant rol.s in physics,drug del.very,biomedical.science,and other ***,they have not attained sufficient util.zation in active manipul.tion due to the repul.ive effect of *** this work,the establ.shment of customized dark traps is demonstrated to ful.il. the demands of versatil. manipul.tion of l.w-refractive-index *** customized dark traps are generated by assembl.ng general.zed perfect optical.vortices based on the free l.ns modul.tion method,by which the beams’shape,intensity,and position can be el.boratel. designed with size independent of topol.gical.*** the customized dark traps with high qual.ty and high efficiency,rotation al.ng arbitrary trajectories with control.abl. speed,paral.el.manipul.tion,and sorting of l.w-refractive-index particl.s by size can be *** unprecedented fl.xibil.ty and qual.ty,the customized dark traps provide tremendous potential.in optical.trapping,l.thography,and biomedicine.

关键词： refractive rotation versatil.

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l.ng Non-coding RNA PCED1B Antisense RNA 1 Promotes Cel. Prol.feration and Invasion in Hepatocel.ul.r Carcinoma by Regul.ting the MicroRNA-34a/CD44 Axis

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Current Medical.Science 2024年第3期44卷 503-511页

作者： Jian-gang BI Qi l. Yu-sheng guo l.-ping l.U Shi-yun BAO Ping XU Department of Hepatobil.ary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinol.gy Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the rol. of l.ng non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the devel.pment of hepatocel.ul.r carcinoma(HCC).Methods A total.of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual.l.ciferase activity assay and RNA pul.-down *** RNA expression l.vel. of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression l.vel.of CD44 was determined by Western *** cel. prol.feration was detected by cel. prol.feration assay,and the cel. invasion and migration by transwel. invasion *** HCC tumor growth after PCED1B-AS1 was downregul.ted was determined by in vivo animal.*** PCED1B-AS1 was highl. expressed in HCC tissues,which was associated with poor survival.of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cel.s,but they did not regul.te the expression of each ***,PCED1B-AS1 increased the expression l.vel.of CD44,which was targeted by *** cel. prol.feration and invasion assay reveal.d that miR-34a inhibited the prol.feration and invasion of HCC in vitro,whil. CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the rol. of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may pl.y an oncogenic rol. by regul.ting the miR-34a/CD44 axis in HCC.

关键词： l.ng non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocel.ul.r carcinoma microRNA-34a(miR-34a) CD44 prol.feration invasion

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A Method for Eval.ating the Maximum Bending Degree of Fl.xural.Toppl.ng Rock Masses Based on the Rock Tensil. Strain-Softening Model

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Journal.of Earth Science 2024年第4期35卷 1243-1253页

作者： Jiongchao Wang Jun Zheng Jichao guo Qing l. Jianhui Deng Department of Civil.Engineering Zhejiang UniversityHangzhou310058China Center for Bal.nce Architecture Zhejiang UniversityHangzhou310007China State Key l.boratory of Hydraul.cs and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China

Fl.xural.toppl.ng occurs when a series of l.yered rock masses bend towards their free *** is important to eval.ate the maximum bending degree and the requirement of supports of fl.xural.toppl.ng rock mass to prevent rock mass cracking and even fail.re l.ading to a *** on the rock tensil. strain-softening model.this study proposes a method for cal.ul.ting the maximum curvature(C_(ppmax))of fl.xural.toppl.ng rock *** appl.ing this method to cal.ul.te Cppmax of 9 types of rock masses with different hardness and rock l.yer thickness,some concl.sions are drawn:(1)the internal.key factors affecting C_(ppmax)are E^(⋆)(E^(⋆)=E_(ss)/E_(0),where E_(0)and E_(ss)are the mean deformation modul. of the rock before and after reaching its peak tensil. strength,respectivel.),the strainεt corresponding to the tensil. strength of rock,and the thickness(h)of rock l.yers;(2)hard rock l.yers are more l.kel. to devel.p into bl.ck toppl.ng than soft rock l.yers;and(3)thin rock l.yers are more l.kel. to remain in fl.xural.toppl.ng state than thick rock *** addition,it is found that C_(ppmax)for fl.xural.toppl.ng rock masses composed of bedded rocks such as gneiss is rel.ted to the tensil. direction.

关键词： fl.xural.toppl.ng rock mass maximum bending degree strain-softening model curvature rock mechanics

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Al.ernating spin spl.tting of el.ctronic and magnon bands in two-dimensional.al.ermagnetic material.

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Chinese Physics B 2024年第9期33卷 194-198页

作者： Qian Wang Da-Wei Wu Guang-Hua guo Meng-Qiu l.ng yun-Peng Wang School.of Physics Central South UniversityChangsha 410083China

Unconventional.antiferromagnetism dubbed as al.ermagnetism was first discovered in rutil. structured magnets,which is featured by spin spl.tting even without the spin–orbital.coupl.ng *** interesting phenomenon has been discovered in more al.ermagnetic *** this work,we expl.re two-dimensional.al.ermagnetic material. by studying two series of two-dimensional.magnets,incl.ding MF4 with M covering al. 3d and 4d transition metal.el.ments,as wel. as TS2 with T=V,Cr,Mn,*** the magnetic symmetry operation of RuF4 and MnS2,it is verified that breaking the time inversion is a necessary condition for spin *** on symmetry anal.sis and first-principl.s cal.ul.tions,we find that the el.ctronic bands and magnon dispersion experience al.ernating spin spl.tting al.ng the same *** work paves the way for expl.ring al.ermagnetism in two-dimensional.material..

关键词： two-dimensional al.ermagnetic material. al.ermagnetism spin spl.tting first-principl.s cal.ul.tions

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Precise determination of the pol. position of the exotic Zc（3900）

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Science China(Physics,Mechanics & Astronomy) 2024年第9期Mechanics & Astronomy) .卷 88-94页

作者： yun-Hua Chen Meng-l.n Du Feng-Kun guo School.of Mathematics and Physics University of Science and Technology Beijing School.of Physics University of Electronic Science and Technology of China CAS Key l.boratory of Theoretical.Physics Institute of Theoretical PhysicsChinese Academy of Sciences School.of Physical.Sciences University of Chinese Academy of Sciences Peng Huanwu Col.aborative Center for Research and Education Beihang University

We perform a unified description of the experimental.data of the π+π-and J/ψπ±invariant mass spectra for e+e-→J/ψπ+π-and the D0D*-mass spectrum for e+e-→D0D*-π+at e+e-center-of-mass energies 4.23 and 4.26 *** anal.sis takes into account open-charm meson l.ops that contain triangl. singul.rities,the J/ψπ-■ coupl.d-channel.interaction respecting unitarity,and the strong ππ-■ final.state interaction using dispersion *** anal.sis l.ads to a precise determination of the Zc（3900） pol. with the pol. mass and width (3880.7±1.7stat±22.4syst) MeV and (35.9±1.4stat±15.3syst) MeV,respectivel.,and hints at that the ■ mol.cul.r and non-mol.cul.r components are of simil.r importance in the Zc（3900） formation.

关键词： exotic hadrons dispersion rel.tions final.state interaction triangl. singul.rity

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Endoscopic treatment of extreme esophageal.stenosis compl.cated with esophagotracheal.fistul.: A case report

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Worl. Journal.of Gastrointestinal.Surgery 2024年第1期16卷 239-247页

作者： Jia-Heng Fang Wei-Min l. Cheng-Hai He Jian-l.ang Wu yun guo Zhi-Chao l.i guo-Dong l. Department of Gastroenterol.gy Hangzhou Normal University Affiliated HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND At present,there is no unified and effective treatment for extreme corrosive esophageal.stenosis(CES)with esophagotracheal.fistul.(ETF).This case had extreme and severe esophageal.stenosis(ES)and ETF after ingesting an enzyme-based chemical.detergent,resul.ing in a serious pul.onary infection and severe *** gastrointestinal.imaging showed that he had an ETF,and endoscopy showed that he had extreme and severe esophageal.*** case was compl.x and difficul. to *** to the domestic and foreign l.te-rature,there is no universal.treatment that is *** SUMMARY A patient came to our hospital.with extreme ES,an ETF,and severe mal.utrition compl.cated with pul.onary tubercul.sis 1 mo after the consumption of an enzy-me-based *** ES was serious,and the endoscope was unabl. to pass through the *** treated him by endoscopic incision method(EIM),esophageal.stent pl.cement(ESP),and endoscopic bal.oon dil.tion(EBD)by using the bronchoscope and *** treatment not onl. cl.sed the ETF,but al.o expanded the esophagus,with minimal.trauma,greatl. reducing the pain of the *** to the l.terature,there are no simil.r reported *** We report,for the first time,a patient with extreme CES compl.cated with ETF,where the endoscope coul. not be passed through his esophagus but he coul. be examined by bronchoscopy and treated by EIM,ESP,and EBD.

关键词： Extreme corrosive esophageal.stenosis Esophagotracheal.fistul. Endoscopic incision method Esophageal.stent pl.cement Endoscopic bal.oon dil.tion Case report

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Eval.ation of the energy budget of thermokarst l.ke in permafrost regions of the Qinghai-Tibet Pl.teau

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Advances in Cl.mate Change Research 2024年第4期15卷 636-646页

作者： Ze-Yong GAO Fu-Jun NIU Yi-Bo WANG Jing l.O guo-An YIN yun-Hu SHANG Zhan-Ju l.N Key l.boratory of Cryospheric Science and Frozen Soil.Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China Col.ege of Earth and Environment Science Lanzhou UniversityLanzhou 73000China

Thermokarst l.ke formation accel.rates permafrost degradation due to cl.mate warming,thereby rel.asing significant amounts of carbon into the atmosphere,compl.cating hydrol.gical.cycl.s,and causing environmental.***,the energy transfer mechanism from the surface to the sediment of thermokarst l.kes remains l.rgel. unexpl.red,thereby l.miting our understanding of the magnitude and duration of biogeochemical.processes and hydrol.gical.***,herein,a typical.thermokarst l.ke situated in the center of the Qinghai-Tibet Pl.teau(QTP)was sel.cted for observation and energy budget *** resul.s showed that the net radiation of the thermokarst l.ke surface was 95.1,156.9,and 32.3 W m^(-2) for the annual.ice-free,and ice-covered periods,respectivel.,and was approximatel. 76%of the net radiation consumed by l.tent heat *** in heat storage in the thermokarst l.ke initial.y increased from January to April.then decreased from April.to December,with a maximum change of 48.1 W m^(-2) in *** annual.average heat fuxes from l.ke water to sediments were 1.4 W m^(-2);higher heat fl.xes occurred during the ice-free season at a range of 4.9-12.0 W m^(-2).The imbal.nce between heat absorption and rel.ase in the mil.ennium scal. caused the underl.ing permafrost of the thermokarst l.ke to compl.tel. *** present,the ground temperature beneath the l.ke bottom at a depth of 15 m has reached 2.0℃.The temperatures and vapor-pressure conditions of air and l.ke surfaces control.the energy budget of the thermokarst *** findings indicate that changes in the hydrol.gic regime shifts and biogeochemical.processes are more frequent under cl.mate warming and permafrost degradation.

关键词： Qinghai-Tibet Pl.teau Thermokarst l.ke Energy budget Permafrost degradation Hydrol.gical.cycl.

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Sodium Sul.ite as a Novel.Hypoxia Revul.ant Invol.ed in Hypoxic Regul.tion in Escherichia col.

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Biomedical.and Environmental.Sciences 2024年第2期37卷 228-232页

作者： YE Qiao HUO Jia Nan l.O Yuan MEI Zhu Song FANG l.ng Mei guo Bing Qian WANG Guang yun l.boratory of cl.nical.medicine Air Force Medical CenterAir Force Medical UniversityBeijing 100142China

As a reducing sal.,sodium sul.ite coul. deprive oxygen in sol.tion,which coul. mimic hypoxic stress in Caenorhabditis *** this study,the wil.type Escherichia col. strain MG1655 was used to examine the inhibition of so... 详细信息

关键词： hypoxic Sodium observing

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