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Clinical Features and Microvascular Complications Risk Factors of Early-onset Type 2 Diabetes Mellitus

Current Medical Science 2019年第5期39卷 754-758页

作者： Jia-xin HUANG yun-fei liao Yu-ming LI Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The aim of this research was to study the clinical features and microvascular complications risk factors of early-onset type 2 diabetes mellitus(T2DM).We analyzed the clinical data from 1421 T2DM inpatients at Wuhan Union *** were divided into early-onset T2DM group(diagnostic age40 years).All subjects underwent a standardized assessment of microvascular *** were compared with independent-samples t test or Chi-square *** logistic regression was used to determine the risk factors of microvascular *** with early-onset T2DM were more inclined to have a lower systolic blood pressure(SBP),a longer duration of diabetes and higher levels of body mass index(BM1),uric acid(UA),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG)and glycosylated hemoglobin(HbAlc)than those with lateonset T2DM(P<0.05).The prevalence of diabetic retinopathy(DR)was significantly higher and that of diabetic peripheral neuropathy(DPN)was significantly lower in early-onset group than in late-onset group(P<0.05).For DN,UA was an independent risk factor in early-onset *** and TG were independent risk factors in late-onset *** DR,duration of diabetes and SBP were independent risk factors in early-onset *** of diabetes,SBP and HbAlc were independent risk factors in late-onset *** study demonstrated that the clinical characteristics of early-onset T2DM were metabolic disorders,including glucose metabolism,lipid metabolism and amino acid ***-onset T2DM was more likely to be associated with *** potential pathogenesis of early and late-onset T2DM might be *** management of metabolic risk factors especially HbA1c,SBP,TG and UA is advised to be performed in the early stage of diabetes.

关键词： early-onset type 2 diabetes mellitus diabetic microvascular complication diabetic nephropathy diabetic retinopathy diabetic peripheral neuropathy

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Association of Plasma Connective Tissue Growth Factor Levels with Hyperthyroid Heart Disease

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Current Medical Science 2021年第2期41卷 348-355页

作者： Huan LI Ren-li ZENG yun-fei liao Meng-fei FU Huan ZHANG Lin-fang WANG Yu-ming LI Deparment of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Clinical Research Center for Diabees and Metabolic Disorders Wuhan 430022China Deparment of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Hyperthyroid heart disease(HHD)is one of the most severe complications of overt hyperthyroidism and increases the risk of mortality in affected *** identification of patients at a higher risk of developing HHD can improve clinical outcomes through active surveillance and *** tissue growth factor(CTGF),a secreted extracellular protein,plays a significant role in cardiac remodeling and *** aimed to investigate the association between plasma CTGF level and the risk of HHD in this study.A total of 142 overt hyperthyroid patients without HHD and 99 patients with HHD were *** plasma CTGF levels were measured using ELISA *** clinical medical data and echocardiography parameters were recorded for *** plasma CTGF level was significantly higher in patients with HHD than in those without HHD(P=0.002).The plasma CTGF level was positively correlated with free triiodothyronin,tryrotropin receptor antibody,troponin I and lactate dehydrogenase levels and the left atrium diameters,right atrium diameters,and right ventricular end-diastolic diameters(all P<0.05).Logistic regression analysis showed that quartiles 3 and 4 of plasma CTGF levels were significantly associated with the increased risk of HHD(crude OR:2.529;95%CI:1.188-5.387).However,after adjustment for the potentially confounding variables,quartile 4 alone was significantly associated with the higher risk of HHD relative to quartile *** patients with HHD display higher plasma CTGF ***,CTGF is an independent risk factor for ***,the plasma CTGF level may be a potential biomarker for the risk of HHD.

关键词： connective tissue growth factor hyperthyroid heart thyroid hormone

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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基于耦合界面键合效应的石墨烯磨损研究

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原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

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Spectrofluorometry of Ions and Small Molecules Based on Conformational Changes of Specific Oligonucleotides with o-Phthalaldehyde-β-mercaptoethanol

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Chemical Research in Chinese Universities 2010年第3期26卷 360-365页

作者： liao Qie-gen WANG Jian LONG yun-fei LI Yuan-fang Key Laboratory of Lumineseence and Real-Time Analysis Ministry of Education College of Chemistry and Chemical Engineering Southwest University Chongqing 400715 P. R. China Key Laboratory of Quality and Safety of Agricultural Products Jiangxi Academy of Agricultural Sciences Nanchang 330200 R R. China

Specific oligonucleotides such as telomere DNA and aptamer often undergo conformational changes upon ligand binding. Composite reagent composed of o-phthalaldehyde and β-mercaptoethanol（OPAME） has been extensively applied to fluorescent detection of amino compounds based on the reaction of primary amino-group, herein we proposed a general spectrofluorometry for ions and small molecules due to conformational changes upon ligand binding taking K^＋ and ATP as examples. In a borate controlled buffer medium, telomere DNA could react with OPAME, giving a thio-subtituted isoindole compound with strong fluorescence emission at 455 nm when excited at 340 nm. It was found that however, the fluorescence emission was greatly reduced in the presence of K^＋ since the formation of the quadruplex structure inhibits the reaction activity of amino-groups of telomere DNA. In order to testify the general application of OPAME reagent based on the conformational change of oligonucleotides, we further proposed a sensitive method of ATP based on its highly selective interaction with ATP-aptamer. The above mentioned applications show that the spectrofluorometry with the aid of OPAME reagent is simple, label free that is expected to be potentially general for DNA conformational change-based target detection.

关键词： Aptamer o-Phthalaldehyde β-Mercaptoethanol K^+ Adenosine-5′-triphosphoric acid

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Guidance Laws Based on H_∞ Observer Considering Measurement Noises

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Journal of Systems Science & Complexity 2016年第3期29卷 642-656页

作者： liao fei JI Haibo Department of Automation University of Science and Technology of China

Since in practice the line-of-sight(LOS)rate is difficult for a pursuer to measure accurately,the robust nonlinear H∞observer is applied to estimate it using LOS azimuths without any priori information of target maneuvers or its estimate in the presence of measurement noise.A threedimensional guidance law is implemented by replacing the LOS rate with their estimates using only relative range,speed,and LOS *** stability analyses and performed simulations results show that the presented approach is effective.

关键词： Guidance law H∞ observer measurement noise.

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High-dose vs low-dose proton pump inhibitors for upper gastrointestinal bleeding:A meta-analysis

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World Journal of Gastroenterology 2010年第20期16卷 2558-2565页

作者： Wu, Liu-Cheng Cao, yun-fei Huang, Jia-Hao liao, Cun Gao, Feng Guangxi Med Univ Dept Colorectal & Anal Surg Affiliated Hosp 1 Nanning 530021 Guangxi Zhuang Peoples R China

AIM:To evaluate the efficacy of high-dose proton pump inhibitors(PPIs)vs low-dose PPIs for patients with upper gastrointestinal ***:PubMed,Embase,the Cochrane Library,and Web of Science were searched to identify relevant randomized controlled trials(RCTs).Eligible trials were RCTs that compared high-dose PPI with low-dose PPI following endoscopic *** primary endpoint was rebleeding;secondary endpoints were patient numbers that needed surgery,and *** meta-analysis was performed with a fixed effects model or random effects ***:Nine eligible RCTs including 1342 patients were *** results showed that high-dose intravenous PPI was not superior to low-dose intra-venous PPI in reducing rebleeding[odds ratio(OR)= 1.091,95%confidential interval(CI):0.777-1.532],need for surgery(OR=1.522,95%CI:0.643-3.605) and mortality(OR=1.022,95%CI:0.476-2.196).Subgroup analysis according to different region revealed no difference in rebleeding rate between Asian patients(OR=0.831,95%CI,0.467-1.480)and European patients(OR=1.263,95%CI:0.827-1.929).CONCLUSION:Low-dose intravenous PPI can achieve the same efficacy as high-dose PPI following endoscopic hemostasis.

关键词： Meta-analysis High-dose Low-dose Proton pump inhibitors Gastrointestinal bleeding

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Qualitative analysis of the CCEBC/EEAC method

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Science China(Technological Sciences) 2004年第1期47卷 61-76页

作者： liao Haohui TANG yun Department of Mathematical Sciences Tsinghua University Beijing 100084 China Department of Mathematical Sciences Tsinghua University Beijing 100084 China

The CCEBC/EEAC method is an effective method in the quantitative analysis of power system transient stability. This paper provides a qualitative analysis of the CCEBC/EEAC method and shows that from a geometrical point of view, the CCCOl-RM transformation used in the CCEBC/EEAC method can be regarded as a projection of the variables of the system model on a weighted vector space, from which a generalized $\bar P - \bar \delta $ trajectory is obtained. Since a transient process of power systems can be approximately regarded as a time-piecewise simple Hamiltonian system, in order to qualitatively analyse the CCEBC/EEAC method, this paper compares the potential energy of a two-machine infinite bus system with its CCEBC/EEAC energy. Numerical result indicates their similarity. Clarifying the qualitative relation between these two kinds of energies is significant in verifying mathematically the CCEBC/EEAC method for judging the criterion of power system transient stability. Moreover, the qualitative analysis of the CCEBC/EEAC method enables us to better understand some important phenomena revealed by quantitative analysis, such as multi-swing loss of stability and isolated stable domain.

关键词： CCEBC/EEAC, time-piecewise simple Hamiltonian system, transient stability.

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Modified disordered carbon prepared from 3,4,9,10-perylenetetracarboxylic dianhydride as an anode material for Li-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2015年第2期22卷 203-209页

作者： fei-biao Chen Bo-rong Wu yun-kui Xiong Wei-lin liao Dao-Bin Mu Feng Wu Beijing Key Laboratory of Environmental Science and Engineering School of Chemical Engineering and Environment Beijing Institute of Technology Jiangxi Fine Chemical Key Laboratory Jiangxi Normal University

To prepare an anode material for Li-ion batteries with high discharge capacity and good cycling stability, disordered carbon （DC） formed by calcinations of 3,4,9,10-perylenetetracarboxylic dianhydride was modified via an acid treatment using a mixture of HNO3 and H2SO4. The modified disordered carbon （MDC） was characterized by Fourier-transform infrared （FTIR） spectroscopy, X-ray diffraction （XRD） analysis, Brtmaner-Emmett-Teller （BET） analysis, and scanning electron microscopy （SEM）. FTIR spectra confirm the successful introduction of carbonyl groups onto the DC surface. Some pores appear in the columnar structure of MDC, as observed in SEM micro- graphs. Li＋ ions intercalation/deintercalation is facilitated by the modified morphology. Electrochemical tests show that the MDC exhibits a significant improvement in discharge capacity and cycling stability. These results indicate that the MDC has strong potential for use as an anode material in Li-ion batteries.

关键词： carbon perylenetetracarboxylic dianhydride anode materials lithium-ion batteries

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Investigations on methane hydrate formation,dissociation,and viscosity in gas-water-sand system

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Petroleum Science 2022年第5期19卷 2420-2430页

作者： Shang-fei Song Shun-Kang Fu Qing-yun liao Bo-Hui Shi Hong-Ju Chen Jing Gong State Key Laboratory of Natural Gas Hydrates/National Engineering Laboratory for Pipeline Safety China University of PetroleumBeijing102249China PipeChina West East Pipeline Company Shanghai200122China Key Lab of Deepwater Engineering CNOOC Research InstituteBeijing100028China

Understanding the kinetics and viscosity of hydrate slurry in gas-water-sand system is of great significance for the high-efficiency and high-safety development of natural gas *** effect of micronsized sands with various concentrations and particle sizes on the hydrate formation,dissociation,and viscosity in gas-water-sand system are investigated in this *** experimental results show that the hydrate induction time in the sandy system is slightly prolonged compared to the pure gas-water system,and the inhibition effect first strengthens and then weakens as the sand concentration increases from0 wt%to 5 wt%.Besides,the difference of hydrate formation amount in various cases is not *** concentration and particle size of sand have little effect on the kinetics of hydrate *** promoting and inhibiting effects on hydrate formation have been found in the sandy multiphase *** the viscosity characteristics,there are three variations of hydrate slurry viscosity during the formation process:Steep drop type,S-type and Fluctuation ***,appropriate sand size is helpful to reduce the randomness of slurry viscosity ***,even at the same hydrate volume fraction,the slurry viscosity in the formation process is significantly higher than that in dissociation process,which needs further *** work provides further insights of hydrate formation,dissociation,and viscosity in gas-water-sand system,which is of great significance for safe and economic development of natural gas hydrates.

关键词： Hydrate slurry Micron-sized sands Hydrate formation Hydrate dissociation Viscosity characteristics

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