检索结果-南通市图书馆

Computational insights into different regioselectivities in the Ir-porphyrin-catalyzed C–H insertion reaction of quinoid carbene

在线全文

学校读者我要写书评

暂无评论

Organic Chemistry Frontiers 2022年第4期9卷 1143-1151页

作者： Xiahe Chen Chaoqin Cao yun-fang yang Yuan-Bin She College of Chemical Engineering Zhejiang University of TechnologyHangzhouZhejiang 310014China

The mechanisms and regioselectivities of the Ir-porphyrin-catalyzed C–H insertion reaction of quinoid carbene(QC)were investigated by density functional theory(DFT)*** competing catalytic cycles were identified as the hydrogen-atom abstraction by quinoid oxygen(HAA-O)and hydrogen-atom abstraction by carbene carbon(HAA-C)catalytic cycles.

关键词： porphyrin insertion catalyzed

Tuning the Excited State of Tetradentate Pd(ll) and Pt(ll) Complexes through Benzannulated N-Heteroaromatic Ring and Central Metal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2022年第2期40卷 223-234页

作者： Guijie Hua Guo Xiaoli fang yun-fang yang Yulu Sun Weiwei Lou Qisheng Zhang Yuanbin She College of Chemical Engineering Zhejiang University of TechnologyHangzhouZhejiang 310014China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhouZhejiang 310027China

A series of tetra de ntate Pd(ll)and Pt(ll)complexes containing fused 5/6/6 metallocycles with phe nyl/V-heteroaromatic ben-zo[d]imidazole(pbiz),benzo[d]oxazole(pboz)or benzo[d]thiazole(pbthz)-containing ligands was *** studies by experiments and theoret:ical calculations reveal that both the central metal and the benzannulated A/-heteroaromatic ring have sig-n ificant in flue nee on the electrochemical,photophysical and excited-state properties of the Pd(ll)and Pt(ll)*** identical condition,compared to pb/z-based Pd(ll)and Pt(ll)complexes,the corresponding metal complexes with pboz and pbthz-containing ligand show significant red-shift emission spectra.

关键词： Semiconductors Luminescence Platinum and Palladium Energy conversion OLED

Genetic Polymorphism in the Second Exon of HLA-DRB1 in Cervical Cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical oncology and cancer researeh 2010年第1期7卷 27-32页

作者： Yan-yun LI Gui-fang yang Yan-ju JIA Jun XING Yan-ni LI Wei-ming ZHANG Department of Biochemistry and MolecularBiology Basic Medical College Tianjin Medical University Tianjin 300070 China.

OBJECTIVE The aim of this investigation was to assess the association between single nucleotide polymorphisms （SNPs） in HLA-DRB1 and the risk of developing cervical cancer. Our study focused on the second exon of the HLA-DRB1 alleles, which have most of the SNP sites on HLA-DRB1. METHODS We examined 30 cervical cancer patients and 66 control patients using the sequence-based typing polymerase chain reaction technique （PCR-SBT） to type 55 single nucleotide polymorphisms （SNPs） and haplotypes in the second exon of HLA-DRB1. The Chi-square test and the Bonferroni correction method were utilized for the statistical analysis of the data. An association between the alleles and cervical cancer was examined by the linkage disequilibrium test and the odds ratio （OR）. RESULTS Compared with the control group, among the 55 SNPs we studied in the second exon of HLA-DRB1, 4 showed an evident association with cervical cancer. Rs17880292 （P = 0.033, OR = 0.322） and rs1059586 （P = 0.029, OR = 2.657） had positive significance for the risk of developing cervical cancer, while rs17879702 （P = 0.016, OR = 0.222） and rs17882525 （P = 0.025, OR = 0.128） were negative. The difference in frequency of the 5582A-5592A-5667T haplotype between cervical cancer patients and the controls was significant （P = 0.043, OR = 2.735）. CONCLUSION The rs17880292 G/A genotype and the rs1059586 A/A genotype could be linked to an increased risk of cervical cancer. Rs17879702 and rs17882525 might be haplotype-tag SNPs （htSNPs） or belong to some other haplotypes, which might exert a protective effect against cervical cancer in combination. The 582A-5592A-5667T haplotype was shown to be a marker for susceptibility to cervical carcinogenesis.

关键词： HLA-DRB1 susceptibility SNPs. cervical cancer genetic

Numerical Modelling of Ore-forming Dynamics of Fractal Dispersive Fluid Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2001年第2期75卷 220-232页

作者： DENG Jun, fang yun, yang Liqiang, yang Junchen, SUN Zhongshi, WANG Jianping , DING Shijiang and WANG QingfeiChina University of Geosciences, Beijing 100081China University of Geosciences, Wuhan 430074 Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101 Jilin University, Changchun 130026 China Univ Geosci Beijing 100081 Peoples R China China Univ Geosci Wuhan 430074 Peoples R China Acad Sinica Inst Geol & Geophys Beijing 100101 Peoples R China Jilin Univ Changchun 130026 Peoples R China

Based on an analysis of the fractal structures and mass transport mechanism of typical shear-fluid-ore formation system, the fractal dispersion theory of the fluid system was used in the dynamic study of the ore formation system. The model of point-source diffusive illuviation of the shear-fluid-ore formation system was constructed, and the numerical simulation of dynamics of the ore formation system was finished. The result shows that: (1) The metallogenic system have nested fractal structure. Different fractal dimension values in different systems show unbalance and inhomogeneity of ore-forming processes in the geohistory. It is an important parameter to symbolize the process of remobilization and accumulation of ore-forming materials. Also it can indicate the dynamics of the metallogenic system quantitatively to some extent. (2) In essence, the fractal dispersive ore-forming dynamics is a combination of multi-processes dominated by fluid dynamics and supplemented by molecule dispersion in fluids and

关键词： fluid system fractal dispersion point-source illuviation model ore-forming dynamics numerical simulation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

医养结合发展热潮的冷思考

卫生经济研究 2017年第8期34卷 22-24页

作者：肖云芳何宇杨小丽重庆医科大学公共卫生与管理学院.医学与社会发展研究中心.健康领域社会风险预测治理协同创新中心重庆400016

老龄化及慢病化的人口形势迫切需要医养结合服务模式。然而,由于我国对医疗护理与养老服务、门诊与住院治疗之间的转接缺乏技术标准和评估机制,医保机构对医养结合服务机构提供的医疗服务合理性难以甄别和监管。为此,相关部门应尽快建... 详细信息

老龄化及慢病化的人口形势迫切需要医养结合服务模式。然而,由于我国对医疗护理与养老服务、门诊与住院治疗之间的转接缺乏技术标准和评估机制,医保机构对医养结合服务机构提供的医疗服务合理性难以甄别和监管。为此,相关部门应尽快建立健全医养服务转接的技术标准和评估机制,完善医养结合服务信息系统,加强对违规行为的监督和处罚力度,为医养结合服务模式的健康有序发展提供良好的制度环境。

关键词：医养结合医疗保险临床路径

邻苯二酚和对苯二酚在金纳米修饰玻碳电极(GNP/GCE)上的同时灵敏检测

在线全文

学校读者我要写书评

暂无评论

化学研究与应用 2018年第3期30卷 432-436页

作者：孟奎奎郭珈玲云阳方白慧云贺艳斌山西省长治医学院药学系山西长治046000

用恒电位沉积法制备了金纳米修饰玻碳电极(GNP/GCE),并利用循环伏安法研究了邻苯二酚和对苯二酚在该修饰电极上的电化学行为。结果表明,在p H=6.5的磷酸盐缓冲液中,邻苯二酚和对苯二酚在该修饰电极上均出现一对准可逆氧化还原峰,峰电位... 详细信息

用恒电位沉积法制备了金纳米修饰玻碳电极(GNP/GCE),并利用循环伏安法研究了邻苯二酚和对苯二酚在该修饰电极上的电化学行为。结果表明,在p H=6.5的磷酸盐缓冲液中,邻苯二酚和对苯二酚在该修饰电极上均出现一对准可逆氧化还原峰,峰电位分别为:Epa=0.250 V、Epc=0.220 V和Epa=0.140 V、Epc=0.100V。在最佳测定条件下,邻苯二酚和对苯二酚在1×10-6~8×10-5mol·L-1的浓度范围内线性良好,检出限分别为3.7×10-7mol·L-1,2.4×10-7mol·L-1。该方法用于模拟水样和茶叶中邻苯二酚和对苯二酚的测定,结果满意。

关键词：金纳米对苯二酚邻苯二酚同时测定恒电位沉积

α-萘酚胁迫对普通小球藻生长及抗氧化酶活性的影响

在线全文

学校读者我要写书评

暂无评论

武汉大学学报（理学版） 2001年第4期47卷 449-452页

作者：彭金良严国安沈国兴常利英王昀杨方星武汉大学资源与环境科学学院湖北武汉430072

研究了 α-萘酚对普通小球藻的生长、光合色素和 MDA含量及抗氧化酶 ( SOD、CAT、POD)活性的影响 .结果表明 ,随着 α-萘酚浓度的升高 ,藻的生长速率、叶绿素 a与类胡萝卜素的含量 ,SOD、CAT、POD活性均先升高后下降 ,除 POD活性在 5 .0... 详细信息

研究了 α-萘酚对普通小球藻的生长、光合色素和 MDA含量及抗氧化酶 ( SOD、CAT、POD)活性的影响 .结果表明 ,随着 α-萘酚浓度的升高 ,藻的生长速率、叶绿素 a与类胡萝卜素的含量 ,SOD、CAT、POD活性均先升高后下降 ,除 POD活性在 5 .0 0 m g· L- 1时达到最大值外 ,其余均在 2 .0 0 mg· L- 1达到最大 .而在 α-萘酚浓度低于 2 .0 0 mg· L- 1时 ,MDA含量变化不大 ,只有当 3种抗氧化酶活性呈不同程度的下降后 ,MDA含量才急剧上升 ,膜脂过氧化加剧 .说明 α-萘酚导致普通小球藻膜脂过氧化是其致毒机制之一 ,而抗氧化酶在一定污染物浓度范围内具有防御保护作用 .

关键词： α-萘酚普通小球藻生长速率抗氧化酶有机污染物酶活性致毒机制

Trudinger–Moser Inequalities on a Closed Riemann Surface with a Symmetric Conical Metric

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第9期40卷 2263-2284页

作者： Yu fang yun Yan yang College of Teacher Education Quzhou UniversityQuzhou 324003P.R.China Department of Mathematics Renmin University of ChinaBeijing 100872P.R.China

This is a continuation of our previous work(*** ***.,20,1295–1324,2020).Let(Σ,g)be a closed Riemann surface,where the metric g has conical singularities at finite *** G is a group whose elements are isometries acting on(Σ,g).Trudinger–Moser inequalities involving G are established via the method of blow-up analysis,and the corresponding extremals are also *** extends previous results of Chen(***.,1990),Iula–Manicini(Nonlinear Anal.,2017),and the authors(2020).

关键词： Trudinger-Moser inequality blow-up analysis conical singularity

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 153-167页

作者： Bo-Fan Chen Li Liu fang-Zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-fang Zhang Cong-Cong Liu Xiang Chen Jie Peng yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le Liu yun Liu Zheng-Zheng Li Xin-Xing Zeng The Second Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second Clinical Medical College Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Rehabilitation Medicine The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Provincial People’s Hospital The First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006Jiangxi ProvinceChina Department of Psychiatry Jiangxi Mental HospitalHospital of Nanchang UniversityNanchang UniversityNanchang 330029Jiangxi ProvinceChina

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood *** drug treatment modalities are crucial for managing *** To analyze the current status and future trends of global research on BD drug treatment over the last *** The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were *** visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration *** University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this *** Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited *** This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future *** study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

关键词： Bipolar disorder Drug treatment Bibliometric analysis Visualization Mental disorder