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Journal of Thermal Science 2022年第5期31卷 1723-1733页

作者： SHENG Jiaming wu yun ZHANG Haideng WANG Yizhou TANG Mengxiao Science and Technology on Plasma Dynamic Laboratory Air Force Engineering UniversityXi’an710038China Institute of Aero-engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an710049China

To achieve efficient control of supersonic compressor cascade flow,a type of spanwise distributed pulsed arc discharge plasma actuation(PADPA)was *** simulate the influences of PADPA on the flow field,a phenomenological model was ***,the flow control effects of PADPA on supersonic compressor cascade flow were researched *** results show that under low static pressure ratio condition,the compressive wave induced by PADPA reduced the intensity of the passage shock wave,which eventually reduced shock wave *** was also found that PADPA produced an adverse pressure gradient(pre-compression effect)around the actuation location,which reduced the strength of the high adverse pressure gradient induced by the passage shock *** airflow on both sides of the actuation location was accelerated by PADPA owing to the spanwise distributed ***,it improved the ability of the boundary layer to resist the effect of the adverse pressure gradient and reduced the separation ***,the total pressure loss was reduced by 6.8%.Under high pressure ratio condition,the effect of PADPA on the suction side controlling the large separation of the boundary layer was *** total pressure loss also increased slightly.

关键词： plasma flow control supersonic cascade shock wave/boundary layer interaction numerical simulation

Map-based cloning of q LP_(A01.1),a favorable allele from the Gossypium tomentosum chromosome segment line

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Journal of Integrative Agriculture 2024年第10期23卷 3283-3293页

作者： Wenwen Wang Lei Chen Yan wu Xin Guo Jinming Yang Dexin Liu Xueying Liu Kai Guo Dajun Liu Zhonghua Teng Yuehua Xiao Zhengsheng Zhang Engineering Research Center of South Upland Agriculture Ministry of EducationSouthwest UniversityChongqing 400716China

Cotton is an important natural fiber crop worldwide which plays a vital role in our daily *** yield is a constant goal of cotton breeding,and lint percentage(LP)is one of the important components of cotton fiber yield.A stable QTL controlling LP,qLP_(A01.1),was identified on chromosome A01 from Gossypium hirsutum introgressed lines with *** chromosome segments in a previous *** fine-map qLP_(A01.1),an F2 population with 986individuals was established by crossing *** cultivar CCRI35 with the chromosome segment substitution line HT_390.A high-resolution genetic map including 47 loci and spanning 56.98 cM was constructed in the QTL region,and qLP_(A01.1)was ultimately mapped into an interval corresponding to an~80 kb genome region of chromosome A01in the reference genome,which contained six annotated *** data and sequence analysis revealed that S-acyltransferase protein 24(GoPAT24)might be the target gene of qLP_(A01.1).This result provides the basis for cotton fiber yield improvement via marker-assisted selection(MAS)and further studies on the mechanism of cotton fiber development.

关键词： cotton lint percentage fine-mapping qLPA01.1 GoPAT24

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基于无人机多光谱影像的寒地水稻品质估测

植物营养与肥料学报 2024年第1期30卷 12-26页

作者：彭显龙武文宇董强李鹏飞朱美瑞刘东晖刘智蕾于彩莲东北农业大学资源与环境学院黑龙江哈尔滨150030 东北农业大学寒地粮食作物种质创新与生理生态教育部重点实验室黑龙江哈尔滨150030 哈尔滨理工大学化工与环境工程学院黑龙江哈尔滨150040

【目的】在稻谷收获前准确估测稻米品质,为改善水稻养分管理、实现优质优价提供参考。【方法】试验在黑龙江省佳木斯市大兴农场和青龙山农场进行,两个地点土壤肥力具有较大差异。每个农场选择一块稻田,以20 m×20 m间隔采集土壤样品分... 详细信息

【目的】在稻谷收获前准确估测稻米品质,为改善水稻养分管理、实现优质优价提供参考。【方法】试验在黑龙江省佳木斯市大兴农场和青龙山农场进行,两个地点土壤肥力具有较大差异。每个农场选择一块稻田,以20 m×20 m间隔采集土壤样品分析碱解氮含量,通过变量施氮形成产量水平、长势差异明显的水稻群体。利用大疆精灵4四旋翼多光谱无人机获取水稻分蘖期、拔节期、抽穗期和成熟期冠层多光谱数据。成熟期采集长势具有明显差异的水稻样品和对应的土壤样品,测定土壤有机质和速效氮、磷、钾含量,水稻籽粒蛋白质和直链淀粉含量,产量和食味值,随机选择其中67%的数据通过逐步多元线性回归构建不同生育时期的品质估算模型,其余33%的数据用于模型的验证。【结果】大兴农场水稻成熟期土壤有机质、碱解氮、有效磷和速效钾含量的变异系数分别为11.65%、14.44%、37.66%和11.60%,青龙山农场分别为14.45%、14.32%、36.37%和28.51%。成熟期两个地点水稻产量和食味值的变异系数均大于10%,青龙山农场水稻蛋白质含量变异系数也超过10%,而两地稻米直链淀粉含量的变异系数仅为1.11%~1.83%,因此,水稻直链淀粉含量不适合用于后续的品质估测分析。分蘖期至抽穗期,大兴农场和青龙山农场水稻蛋白质多元回归模型的R~2和RMSE分别为0.262~0.794和0.259~0.686,食味值多元回归模型的R~2和RMSE分别为0.240~0.755和4.211~7.588,估测效果不理想。成熟期,大兴农场和青龙山农场水稻蛋白质多元回归模型的R~2和RMSE分别为0.791~0.874和0.166~0.365,食味值多元回归模型的R~2和RMSE分别为0.786~0.852和2.836~4.039。成熟期基于植被指数的蛋白质和食味值估测精确度优于抽穗期。在抽穗期,将土壤pH、有机质、碱解氮、有效磷、速效钾等指标与植被指数一起建立与蛋白质和食味值的多元回归模型,大兴农场水稻蛋白质模型的R~2由0.585提高到0.720,RMSE由0.301降低至0.247;两农场食味值模型的R~2由0.565~0.755提高到0.706~0.787,RMSE由4.318~4.854降低至3.993~4.029,基本可以满足对稻米品质估测的精度,而在成熟期加入上述土壤指标提升精度不明显。【结论】水稻成熟期利用多光谱无人机对稻米品质进行原位估测的精度较高,如果将估测时期提前到抽穗期,除植被指数外,还需配合土壤有机质和速效养分含量数据来提高多光谱无人机预测稻米品质的精度。

关键词：水稻多光谱影像植被指数食味值蛋白质直链淀粉

Pan-immune-inflammation value as a prognostic biomarker for colon cancer and its variation by primary tumor location

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World Journal of Gastroenterology 2024年第33期30卷 3823-3836页

作者： Qian-Yu Wang Wen-Tao Zhong Yi Xiao Guo-Le Lin Jun-Yang Lu Lai Xu Guan-Nan Zhang Jun-Feng Du Bin wu Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Medical Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND A growing body of research indicates significant differences between left-sided colon cancers(LCC)and right-sided colon cancers(RCC).Pan-immune-inflammation value(PIV)is a systemic immune response marker that can predict the prognosis of patients with colon ***,the specific distinction between PIV of LCC and RCC remains *** To investigate the prognostic and clinical significance of PIV in LCC and RCC *** This multicenter retrospective cohort study included 1510 patients with colon cancer,comprising 801 with LCC and 709 with *** used generalized lifting regression analysis to evaluate the relative impact of PIV on disease-free survival(DFS)in these ***-Meier analysis,as well as univariate and multivariate analyses,were used to examine the risk factors for *** correlation between PIV and the clinical characteristics was statistically analyzed in these *** A total of 1510 patients{872 female patients(58%);median age 63 years[interquartile ranges(IQR):54-71];patients with LCC 801(53%);median follow-up 44.17 months(IQR 29.67-62.32)}were *** was significantly higher in patients with RCC[median(IQR):214.34(121.78-386.72)vs 175.87(111.92-286.84),P227.84)was associated with worse DFS in LCC[PIV-high:Adjusted hazard ratio(aHR)=2.39;95%confidence interval:1.70-3.38;P<0.001]but not in RCC(PIV-high:aHR=0.72;95%confidence interval:0.48-1.08;P=0.114).CONCLUSION These findings suggest that PIV may predict recurrence in patients with LCC but not RCC,underscoring the importance of tumor location when using PIV as a colon cancer biomarker.

关键词： Colon cancer Left-sided colon cancer Right-sided colon cancer Pan-immune-inflammation value Systemic inflammatory biomarkers Prognosis

胶东地区玲珑双向变质核杂岩的均衡隆升:运动学涡度的指示

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地质学报 2024年第1期98卷 31-49页

作者：吴晓冬朱光合肥工业大学资源与环境工程学院安徽合肥230009 湖南科技大学地球科学与空间信息工程学院湖南湘潭411201

在胶东半岛西北部,围绕着玲珑岩基所发育的早白垩世伸展构造,属于独特的双向变质核杂岩。这一变质核杂岩的东、西边界上,分别发育了倾斜相背的招平与焦家伸展拆离剪切带。双向变质核杂岩的剥露是否也有均衡隆升的贡献,一直没有明确的认... 详细信息

在胶东半岛西北部,围绕着玲珑岩基所发育的早白垩世伸展构造,属于独特的双向变质核杂岩。这一变质核杂岩的东、西边界上,分别发育了倾斜相背的招平与焦家伸展拆离剪切带。双向变质核杂岩的剥露是否也有均衡隆升的贡献,一直没有明确的认识。本次工作以采自这两条边界拆离剪切带不同部位的糜棱岩样品为分析对象,分别应用刚性残斑长短轴比值法(具体又分别使用了Wallis投图法和刚性颗粒网格法)和石英c轴组构与主应变比值法对同一样品进行了运动学涡度测量。对于招平拆离剪切带,应用刚性残斑长短轴比值法获得的涡度值为0.57~0.73,而应用石英c轴组构与主应变比值法获得的涡度值为0.80~0.93。对于焦家剪切带,应用刚性残斑长短轴比值法获得的涡度值为0.58~0.74,而应用石英c轴组构与主应变比值法获得的涡度值为0.79~0.93。对于剪切带的同一样品,这两种测量方法给出的结果明显不同。应用刚性残斑长短轴比值法数据所获得这两条剪切带的减薄率,也明显高于应用石英c轴组构与主应变比值法数据的计算结果。理论分析与实例表明,刚性残斑长短轴比值法所获得的涡度值代表了剪切带的早期变形,而石英c轴组构与主应变比值法所得结果指示了晚期变形。由此表明,玲珑双向变质核杂岩边界拆离剪切带演化中,伴随着纯剪组分的明显降低,指示了剪切带产状的变陡,为均衡隆升的结果。均衡隆升发生在核杂岩演化的晚阶段,是早白垩世郭家岭期同构造花岗闪长岩侵位的响应。本文结果指示,双向与不对称变质核杂岩具有相似的演化规律,都经历过晚阶段均衡隆升,对中—下地壳的剥露具有重要的贡献。

关键词：伸展拆离剪切带运动学涡度一般剪切均衡隆升玲珑双向变质核杂岩

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长江流域地表水中镉生态风险的区域差异分析

环境科学 2024年第6期45卷 3186-3195页

作者：丁仁廖梓童陆韻巫寅虎陈卓高桦楠徐红卫陆松柳惠二清魏东斌胡洪营清华大学环境学院环境模拟与污染控制国家重点联合实验室国家环境保护环境微生物利用与安全控制重点实验室环境前沿技术北京实验室北京100084 上海勘测设计研究院有限公司上海200093 长江生态环保集团有限公司武汉430014 中国科学院生态环境研究中心北京100085 清华苏州环境创新研究院苏州215163

围绕长江流域地表水中镉(Cd)的水质基准和生态风险的区域差异展开分析.首先,根据我国《淡水水生生物水质基准——镉》推荐的方法,结合长江流域地表水的硬度分布对Cd长期水质基准值进行了校正;在此基础上,考虑长江流域的物种区系特征,进... 详细信息

围绕长江流域地表水中镉(Cd)的水质基准和生态风险的区域差异展开分析.首先,根据我国《淡水水生生物水质基准——镉》推荐的方法,结合长江流域地表水的硬度分布对Cd长期水质基准值进行了校正;在此基础上,考虑长江流域的物种区系特征,进一步修正得到了Cd长期水质风险阈值,并依此阐释了长江流域的Cd长期水质风险阈值分布和风险商分布的区域差异性.结果发现,经硬度校正和物种修正后,长江流域不同城市间Cd长期水质风险阈值的最大值为0.75μg·L^(-1),最小值为0.08μg·L^(-1),二者相差近10倍;不同城市间Cd风险商的最高值为1.12,最低值为0.035,二者相差达32倍.长江流域上中游交界区和洞庭湖水系等重点区域的Cd生态风险高,尚需深入研究.

关键词：长江流域水质基准镉(Cd) 生态风险区域差异物种分布

CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan Haiyan Tan Jing wu Ha Won Lee Andrew D.Huber William C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is a cytochrome P450(CYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether CYP3A5 directly influences cancer *** this report,we demonstrate that CYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that CYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that CYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,CYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of CYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan Liangbin Zhou Chenyu Zhao Kit Hang wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina dongguan Key Laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C19 transcription through the nuclear factor-􀇉B signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

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钢轨热锻压断裂原因分析

南方金属 2024年第5期 12-14,23页

作者：武东东韩志杰李钧正河钢集团邯钢公司河北邯郸056015

对锻压热加工过程中发生断裂钢轨的断口及断口附近纵截面,进行宏观和微观组织形貌、化学成分和非金属夹杂物等检验分析。检验结果表明,钢轨的化学成分和非金属夹杂物满足标准要求;缺陷部位存在异常粗大组织,呈冰糖状断口形貌,缺陷部位... 详细信息

对锻压热加工过程中发生断裂钢轨的断口及断口附近纵截面,进行宏观和微观组织形貌、化学成分和非金属夹杂物等检验分析。检验结果表明,钢轨的化学成分和非金属夹杂物满足标准要求;缺陷部位存在异常粗大组织,呈冰糖状断口形貌,缺陷部位附近存在晶界熔融孔洞,属于过烧的典型特征。综合分析钢轨发生断裂的原因为锻压热加工过烧导致。

关键词：钢轨锻压过烧断裂

Optimal Dividend and Dynamic Reinsurance Strategies with Capital Injections and Proportional Costs

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 505-524页

作者： Yi-dong wu Jun-yi GUO School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China School of Economics Yunnan UniversityKunming 650091China

We consider an optimization problem of an insurance company in the diffusion setting, which controls the dividends payout as well as the capital injections. To maximize the cumulative expected discounted dividends minus the penalized discounted capital injections until the ruin time, there is a possibility of （cheap or non-cheap） proportional reinsurance. We solve the control problems by constructing two categories of suboptimal models, one without capital injections and one with no bankruptcy by capital injection. Then we derive the explicit solutions for the value function and totally characterize the optimal strategies. Particularly, for cheap reinsurance, they axe the same as those in the model of no bankruptcy.

关键词： proportional reinsurance non-cheap optimal dividend capital injections