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全球在线政务服务模式创新及对中国的启示——《2018年联合国电子政务调查报告》解读之四

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行政管理改革 2019年第4期 54-59页

作者：翟云中共中央党校(国家行政学院)电子政务研究中心

在线政务服务模式创新已成为政府治理的核心议题。联合国经济和社会事务部自2001年以来在全球范围内启动该项调查工作。最新数据显示,全球各国在信息化基础支撑、网上服务整合、共享开放与公众参与、法律环境优化等方面积累了丰富经验... 详细信息

在线政务服务模式创新已成为政府治理的核心议题。联合国经济和社会事务部自2001年以来在全球范围内启动该项调查工作。最新数据显示,全球各国在信息化基础支撑、网上服务整合、共享开放与公众参与、法律环境优化等方面积累了丰富经验。鉴于此,构建具有中国特色的"互联网+政务服务"体系既须对标中央政策部署,也要积极借鉴国际成功实践,始终坚持以人民为中心,着眼于"互联网+政务服务"与政府改革深度融合,倡导创新引领发展,构建"互联网+政务服务"一体化发展格局,推动"互联网+政务服务"高质量发展。

关键词：政务服务模式创新数字政府一体化

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非饱和膨胀土非稳态渗流方程的参数探讨

冰川冻土 2009年第3期31卷 582-585页

作者：翟聚云河南城建学院河南平顶山467044

在利用有限元方程进行计算非饱和膨胀土地基水分场变化的非稳态渗流问题时,参数渗透系数kw和水体积变化系数m2w取值至关重要.根据膨胀土地基基质吸力与含水量的变化过程,得到了水体积变化系数m2w并非常数,理论与计算说明与干密度的变化... 详细信息

在利用有限元方程进行计算非饱和膨胀土地基水分场变化的非稳态渗流问题时,参数渗透系数kw和水体积变化系数m2w取值至关重要.根据膨胀土地基基质吸力与含水量的变化过程,得到了水体积变化系数m2w并非常数,理论与计算说明与干密度的变化存在相关性.通过拟和探讨了渗透系数kw、水体积变化系数m2w与干密度的相关关系,并对比说明不考虑与考虑干密度影响情况下m2w和kw的数值的差别,干密度对这两个参数的影响规律是在吸力大时影响程度小,在吸力小时影响程度大.

关键词：膨胀土干密度体积变化系数渗透系数

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干密度对非饱和膨胀土水分迁移参数的影响

岩土力学 2009年第11期30卷 3337-3341页

作者：翟聚云卫国祥河南城建学院土木工程系河南平顶山467000

研究了非饱和膨胀土的两个水分迁移参数——水体积变化系数m2w和渗透系数kw,得出非饱和膨胀土的水分迁移参数m2w和kw并非恒值,是基质吸力的函数,而基质吸力与含水率密切相关。因此,其参数大小随含水率变化而变化。此外,还明显受到干密... 详细信息

研究了非饱和膨胀土的两个水分迁移参数——水体积变化系数m2w和渗透系数kw,得出非饱和膨胀土的水分迁移参数m2w和kw并非恒值,是基质吸力的函数,而基质吸力与含水率密切相关。因此,其参数大小随含水率变化而变化。此外,还明显受到干密度的影响,随干密度的不同而变化。取得了考虑干密度和含水率的水体积变化系数m2w、渗透系数kw和基质吸力之间的非线性关系,为进一步研究非饱和膨胀土地基水分场变化提供基础资料。

关键词：非饱和膨胀土干密度基质吸力渗透系数含水率

政务服务“好差评”制度：政策意蕴、理论阐释与路径建构

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行政管理改革 2020年第3期 66-72页

作者：翟云中共中央党校(国家行政学院)电子政务研究中心

党的十八大以来,政务服务已成为建设服务型政府的新引擎。政务服务质量高不高、企业群众满意度如何衡量,长期以来缺乏制度化保障。公共管理学界已经认识到,构建科学合理的政务服务“好差评”制度已提上日程。基于政务服务助力推进政府... 详细信息

党的十八大以来,政务服务已成为建设服务型政府的新引擎。政务服务质量高不高、企业群众满意度如何衡量,长期以来缺乏制度化保障。公共管理学界已经认识到,构建科学合理的政务服务“好差评”制度已提上日程。基于政务服务助力推进政府治理现代化的宏大视角,本文探讨了现阶段我国政务服务“好差评”制度的政策意蕴,基于公共受托责任理论和新公共管理理论阐释了政务服务“好差评”与服务型政府的理念映射,并从价值取向、评价机制、评价内容、评价方法四个维度勾勒出了其建构路径。本文研究既丰富和发展了新公共管理运动的理论体系,亦有助于在实践中为加快我国服务型政府建设提供方法论借鉴。

关键词：政务服务 “好差评”制度政策意蕴治理现代化

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从南北官话的历史层次看副词“满”

四川师范大学学报（社会科学版） 2016年第5期43卷 99-104页

作者：翟赟东北财经大学新闻传播学院辽宁大连116025

关于副词"满"的语义,一直众说纷纭。从南北官话的历史层次着眼,利用新发掘的语料,尤其是域外汉语教科书、旗人作品,考察副词"满"的官话性质,结合"满"的义项分析其在北京官话与现代汉语普通话中的差异,发现副词"满"可以看作北京官话的一... 详细信息

关于副词"满"的语义,一直众说纷纭。从南北官话的历史层次着眼,利用新发掘的语料,尤其是域外汉语教科书、旗人作品,考察副词"满"的官话性质,结合"满"的义项分析其在北京官话与现代汉语普通话中的差异,发现副词"满"可以看作北京官话的一个特征词。

关键词：南北官话 “满” 特征词

Study on Colorimetric Method and Content Determination of Total Phenol in Homemade Plum Wine

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Medicinal Plant 2017年第1期8卷 22-26页

作者： yun TENG Pei QUN Xue zhai Yuan LIU College of Pharmacy Southwest University for Nationalities Ethnic Medicine Institute Southwest University for Nationalities

[Objectives] To study on colorimetric method and content determination of total phenol in homemade plum wine. [Methods]The optimal determination condition of total polyphenols content in plum wine( commercially available and homemade) by Folin-Ciocalteu method was inspected,and commercially available and homemade plum wine was evaluated by the method. [Results]The optimal determination conditions of total polyphenols content: sample dose of 1. 0 m L,Folin-Ciocalteu reagent of 1 m L,4% Na_2CO_3 solution of 4. 0 m L,reaction temperature of 50 ℃,reaction time of 1. 5 h,and determination wavelength of 756 nm. Absorbance showed good linear relationship with total polyphenols content within the range of 17. 73-59. 12 μg/m L( y = 14. 878 x + 0. 0739,R^2= 0. 9998). Recovery rate of adding standard sample was between 98. 8% and 103. 5%,and relative standard deviation was 2. 0%( n = 5). [Conclusions]The method had high precision degree and good stability,which was suitable for measuring total polyphenols content in plum wine( commercially available and homemade).

关键词： Plum wine(commercially available and homemade) Folin-Ciocalteu Spectrophotometric method Total polyphenols Content determination

Microbial ingress and in vitro degradation enhanced by glucose on bioabsorbable Mg-Li-Ca alloy

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Bioactive Materials 2020年第4期5卷 902-916页

作者： Ling-Yu Li Zhuang-Zhuang Han Rong-Chang Zeng Wei-Chen Qi Xiao-Fan zhai Yi Yang yun-Tian Lou Tingyue Gu Dake Xu Ji-Zhou Duan Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China Institute of Oceanology Chinese Academy of SciencesQingdao266590China Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China Department of Chemical&Biomolecular Engineering Russ College of Engineering and TechnologyOhio UniversityAthensOH45701-2979USA

Biodegradable magnesium alloys are challenging to be implanted in patients with hyperglycemia and diabetes.A hypothesis is suggested that glucose accelerates microbial ingress and in vitro degradation of Mg-Li-Ca *** resistance and mechanical properties was demonstrated using electrochemical,hydrogen evolution and tensile *** bacteria from Hank's solution were isolated via 16S rRNA gene *** results revealed that Mg-1Li-1Ca alloy exhibited different responses to Hank's solution with and without *** solution acidity was ascribed to Microbacterium hominis and Enterobacter xiangfangensis,indicating that glucose promoted microbial activity and degradation and deterioration in mechanical property of Mg-1Li-1Ca alloy.

关键词： Glucose Magnesium Bacteria Biomaterial Biodegradation

Comparable effects of Jiedu Granule, a compound Chinese herbal medicine, and sorafenib for advanced hepatocellular carcinoma: A prospective multicenter cohort study

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Journal of Integrative Medicine 2020年第4期18卷 319-325页

作者： He-tong Zhao Yong-bin Meng Xiao-feng zhai Bin-bin Cheng Sha-sha Yu Man Yao Hui-xia Yin Xu-ying Wan yun-ke Yang Hui Liu Feng Shen Chang-quan Ling School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Integrated Traditional Chinese and Western Medicine Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Integrative Medicine Zhongshan HospitalFudan UniversityShanghai 200032China The Third Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China

Objective:Sorafenib has been extensively used for the treatment of advanced hepatocellular carcinoma(HCC),and Chinese herbal medicine has also been used to manage advanced *** present work evaluates the effectiveness and safety of Jiedu(JD)Granule,a compound of traditional Chinese herbal medicine,side-by-side with sorafenib for the treatment of advance ***:Patients with advanced HCC receiving treatment with JD Granule or sorafenib were enrolled from December 2014 to March *** primary endpoint was overall survival(OS).The secondary endpoints were progression-free survival(PFS)and *** score matching(PSM)analysis was used to control for possible selection bias from the study group allocation ***:Of the 325 patients included,161 received JD Granule and 164 received *** significant differences were found in OS or PFS among patients receiving JD Granule compared to sorafenib(P>0.05).Median OS of the two study groups was 6.83 months(95%confidence interval[CI]:5.83–9.47)in the group receiving JD Granule and 8 months(95%CI:6.67–9.80)in the group receiving sorafenib,with half-,1-and 2-year survival rates of 53.6%,31.2%and 13.2%vs 60.1%,35.5%and 14.2%,*** after PSM,the median survival time did not differ between the JD Granule group(9.03 months;95%CI:6.37–14.2)and the sorafenib group(7.93 months;95%CI:6.5–9.97),with comparable half-,1-and 2-year survival *** most common adverse events(AEs)were diarrhea(13.7%)and fatigue(5.6%)in the JD Granule group,and hand-foot skin reaction(46.3%)and diarrhea(36.6%)in the sorafenib *** JD Granule was more cost-effective than sorafenib treatment for advanced ***:Compared to sorafenib,JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC.

关键词： Carcinoma,hepatocellular Jiedu Granule Sorafenib Chinese herbal medicine

USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

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Signal Transduction and Targeted Therapy 2016年第1期1卷 42-51页

作者： Xingyu Liu Yuying Yao Huiguo Ding Chuanchun Han Yuhan Chen Yuan Zhang Chanjuan Wang Xin Zhang Yiling Zhang yun zhai Ping Wang Wenyi Wei Jing Zhang Lingqiang Zhang Department of Hepatology and Gastroenterology Beijing Youan HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Proteomics Beijing Proteome Research CenterBeijing Institute of Radiation MedicineCollaborative Innovation Center for Cancer MedicineBeijingChina Institute of Cancer Stem Cell Dalian Medical UniversityDalianChina College of Life Sciences Xiamen UniversityXiamenChina Department of Orthopedics the General Hospital of Chinese People’s Liberation ArmyBeijingChina Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghaiChina Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusettsUSA Department of Microbiology and Immunology Indiana University School of MedicineIndianapolisIndianaUSA

The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells(ESCs).Stabilization of Nanog proteins is essential for *** ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to regulate protein levels and *** ubiquitylation of Nanog catalyzed by the ligase FBXW8 has been demonstrated,the deubiquitylase that maintains the protein levels of Nanog in ESCs yet to be *** this study,we identify the ubiquitin-specific peptidase 21(USP21)as a deubiquitylase for Nanog,but not for Oct4 or ***21 interacts with Nanog protein in ESCs in vivo and in *** C-terminal USP domain of USP21 and the C-domain of Nanog are responsible for this ***21 deubiquitylates the K48-type linkage of the ubiquitin chain of Nanog,stabilizing ***21-mediated Nanog stabilization is enhanced in mouse ESCs and this stabilization is required to maintain the pluripotential state of the *** of USP21 in mouse ESCs leads to Nanog degradation and ESC ***,our results demonstrate that USP21 maintains the stemness of mouse ESCs through deubiquitylating and stabilizing Nanog.

关键词： Nanog maintain stabilization