检索结果-南通市图书馆

The risk factors and threshold level of subchronic inhalation exposure of reclaimed water

Journal of Environmental Sciences 2024年第3期137卷 639-650页

作者： Jiayang kong yun Lu yunru Ren Menghao Chen Gang Liu Liangliang Shi State Key Joint Laboratory of Environment Simulation and Pollution Control State Environment Protection Key Laboratory of Microorganism Application and Risk ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Inhalation of reclaimed water is known to cause lung infammation,and free endotoxins have been shown to be a major risk factor for acute exposure.Subchronic exposure has also been shown to induce infammatory responses with visible tissue damage.However,subchronic risk factors have yet to be identified,and a threshold for the protection of occupational populations during urban reuse is necessary.In this study,potential risk factors in reclaimed water were examined by subchronic exposure with fractionated reclaimed water,and the health risk threshold was tested with a series of diluted reclaimed water.Accordingly,following a 12-week exposure,macromolecules and microorganisms were found to be two major risk factors in reclaimed water that could cause pulmonary infammation,including increased proportion of polymorphonuclear leukocytes in bronchoalveolar fuid,formation of inducible bronchus-associated lymphoid tissue,and elevation of Immunoglobulin A levels.Moreover,infammation persisted after a 4-week recovery period.The calculated threshold of reclaimed water exposure for mice was 31.8 Endotoxin Unit(EU)/(kg·day)under when exposed to 50%additional relative humidity from reclaimed water at 25℃ for 2 hr/day.Meanwhile,the subchronic threshold estimate for humans under the same exposure conditions was found to be 12.2 EU/(kg·day),corresponding to endotoxin levels of 61.7 EU/mL in reclaimed water.The threshold level of endotoxin was lower than that in most non-potable reclaimed water.The findings of this study suggest that occupational exposure of reclaimed water can serve as a potential risk to workers.

关键词： Reclaimed water Inhalation exposure Risk factor Threshold Infammation Endotoxin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface pollen and modern vegetation in Southern Xinjiang,China

引用

Science China Earth Sciences 2024年第2期67卷 510-530页

作者： yun ZHANG Lixin CHEN Yaoyao XI Zhaochen kong Xianguo QIAO State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun130102China Institute of Botany Chinese Academy of SciencesBeijing100093China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China School of Geosciences and Resources China University of Geosciences(Beijing)Beijing100083China

The study of modern pollen,and vegetation can improve the accuracy of paleoenvironmental reconstruction based on fossil pollen data.A total of 188 pollen surface samples were collected from Southern Xinjiang(34°00’–43°00’N,74°00’–94°00’E)in China,with an elevation range of 888–4530 m.Surface pollen and vegetation were studied in the northern region of the Kunlun Mountains and the southern region of the Tianshan Mountains.The results showed that the surface pollen assemblages on the southern slope of the Tianshan Mountains(3530–1124 m)were divided into three pollen zones,namely,montane steppe,montane desert steppe,and montane desert.These zones were dominated by Artemisia,Chenopodiaceae,and Ephedra pollen.The surface pollen assemblages in the eastern Pamir Plateau(4530–1287 m)could be divided into alpine meadow,montane desert steppe,and montane desert zones,which were predominantly characterized by Artemisia,Chenopodiaceae,and Asteraceae pollen.However,the Southern Tarim Basin(3548–888 m)comprised montane desert steppe and montane desert zones,which was dominated by Artemisia and Chenopodiaceae pollen.The geographic distribution of the surface pollen sites obtained using ArcGIS,the R-value,and Pearson correlation analyses indicated that the over-represented Picea and Pinus pollen were of external origin and were transported by wind,water(rivers),and ice(glacier movement).Over-representation of Ephedra and Nitraria pollen was mainly distributed in the montane desert and desert steppe zones,respectively.Pollen from Chenopodiaceae and Artemisia were over-represented and broadly distributed across Southern Xinjiang.Juglans pollen was concentrated in areas with walnut trees,strongly indicating the presence of local parent plants.According to the Hybrid Singleparticle Lagrangian Integrated Trajectory model,more Pinus pollen was transported to the Pamir region by external airflows during spring and summer,resulting in its higher surface pollen content.Research elucidating the relationship between modern pollen and vegeta

关键词： Surface pollen Vegetation Distribution Picea Southern Xinjiang

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanical Performance of Bio-inspired Bidirectional Corrugated Sandwich Pressure Shell Under External Hydrostatic Pressure

引用

China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG yi CHEN Yue yun Lai LIANG Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of cuttlebone.The cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress state.To suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical shells.The static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical simulation.It is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 times.Numerical simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich shell.Then,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried out.According to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich shell.It has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell models.Hence,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synergistic effect of gradient Zn content and multiscale particles on the mechanical properties of Al-Zn-Mg-Cu alloys with coupling distribution of coarse-fine grains

引用

International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1392-1405页

作者： Liangliang Yuan Mingxing Guo yi Wang yun Wang Linzhong Zhuang Institute of Effectiveness Evaluation of Flying Vehicle Beijing 100085China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China

This study investigated the influence of graded Zn content on the evolution of precipitated and iron-rich phases and grain struc-ture of the alloys,designed and developed the Al–8.0Zn–1.5Mg–1.5Cu–0.2Fe(wt%)alloy with high strength and formability.With the increase of Zn content,forming the coupling distribution of multiscale precipitates and iron-rich phases with a reasonable matching ratio and dispersion distribution characteristics is easy.This phenomenon induces the formation of cell-like structures with alternate distribu-tion of coarse and fine grains,and the average plasticity–strain ratio(characterizing the formability)of the pre-aged alloy with a high strength is up to 0.708.Results reveal the evolution and influence mechanisms of multiscale second-phase particles and the corresponding high formability mechanism of the alloys.The developed coupling control process exhibits considerable potential,revealing remarkable improvements in the room temperature formability of high-strength Al–Zn–Mg–Cu alloys.

关键词： Al–Zn–Mg–Cu alloy iron-rich phase high formability microstructure mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High IL-23^(+)cells infiltration correlates with worse clinical outcomes and abiraterone effectiveness in patients with prostate cancer

引用

Asian Journal of Andrology 2022年第2期24卷 147-153页

作者： Zheng Liu Jun-Yu Zhang yun-Jie Yang Kun Chang Qi-Feng Wang yun-yi kong Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

Individualized treatment of prostate cancer depends on an accurate stratification of patients who are sensitive to various treatments.Interleukin-23(IL-23)was reported to play a significant role in prostate cancer.Here,we aimed to explore the clinical value of IL-23-secreting(IL-23^(+))cells in prostate cancer patients.We evaluated interleukin-23A(IL-23A)expression in The Cancer Genome Atlas database and retrospectively enrolled 179 treatment-naive metastatic prostate cancer patients diagnosed in our institute between June 2012 and December 2014.IL-23^(+)cells were stained and evaluated via immunohistochemistry.Further,survival and multivariate Cox regression analyses were conducted to explore the prognostic value of IL-23^(+)cells.We found that IL-23A expression correlated with disease progression,while IL-23^(+)cells were clearly stained within prostate cancer tissue.Patients with higher Gleason scores and multiple metastatic lesions tended to have more IL-23^(+)cell infiltration.Further analyses showed that patients with higher levels of IL-23^(+)cells had significantly worse overall survival(hazard ratio[HR]=2.996,95%confidence interval[95%CI]:1.812–4.955;P=0.001)and a higher risk of developing castration resistance(HR=2.725,95%CI:1.865–3.981;P=0.001).Moreover,subgroup analyses showed that when patients progressed to a castration-resistant status,the prognostic value of IL-23^(+)cells was observed only in patients treated with abiraterone instead of docetaxel.Therefore,we showed that high IL-23^(+)cell infiltration is an independent prognosticator in patients with metastatic prostate cancer.IL-23^(+)cell infiltration may correlate with abiraterone effectiveness in castration-resistant prostate cancer patients.

关键词： abiraterone acetate interleukin-23 prognosis prostate cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of the triglyceride glucose index in adult patients with chronic diarrhea and constipation

引用

World Journal of Clinical Cases 2024年第6期12卷 1094-1103页

作者： Jing-yi Zhu Mu-yun Liu Chang Sun Department of Gastroenterology The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Gastroenterology Navy No.905 HospitalNaval Medical UniversityShanghai 200433China

BACKGROUND Accumulating evidence suggests that the gut microbiome is involved in the pathogenesis of insulin resistance(IR).However,the link between two of the most prevalent bowel disorders,chronic diarrhea and constipation,and the triglyceride glucose(TyG)index,a marker of IR,has not yet been investigated.AIM To investigate the potential association between TyG and the incidence of chronic diarrhea and constipation.METHODS This cross-sectional study enrolled 2400 participants from the National Health and Nutrition Examination Survey database from 2009-2010.TyG was used as an exposure variable,with chronic diarrhea and constipation as determined by the Bristol Stool Form Scale used as the outcome variables.A demographic investigation based on TyG quartile subgroups was performed.The application of multivariate logistic regression models and weighted generalized additive models revealed potential correlations between TyG,chronic diarrhea,and constipation.Subgroup analyses were performed to examine the stability of any potential associations.RESULTS In the chosen sample,chronic diarrhea had a prevalence of 8.00%,while chronic constipation had a prevalence of 8.04%.In multiple logistic regression,a more prominent positive association was found between TyG and chronic diarrhea,particularly in model 1(OR=1.45;95%CI:1.17-1.79,P=0.0007)and model 2(OR=1.40;95%CI:1.12-1.76,P=0.0033).No definite association was observed between the TyG levels and chronic constipation.The weighted generalized additive model findings suggested a more substantial positive association with chronic diarrhea when TyG was less than 9.63(OR=1.89;95%CI:1.05-3.41,P=0.0344),and another positive association with chronic constipation when it was greater than 8.2(OR=1.74;95%CI:1.02-2.95,P=0.0415).The results of the subgroup analyses further strengthen the extrapolation of these results to a wide range of populations.CONCLUSION Higher TyG levels were positively associated with abnormal bowel health.

关键词： Triglyceride glucose index National Health and Nutrition Examination Survey Chronic diarrhea Chronic constipation Cross-sectional study Bowel health

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prognostic value of PTEN in de novo diagnosed metastatic prostate cancer

引用

Asian Journal of Andrology 2022年第1期24卷 50-55页

作者： Jun-Yu Zhang yun-yi kong Qi-Feng Wang yun-Jie Yang Zheng Liu Nan Lin Ding-Wei Ye Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

The purpose of our study is to investigate the prognostic value of phosphatase and tensin homolog on chromosome 10(PTEN)expression in patients with de novo metastatic castration naive prostate cancer(mCNPC).A total of 205 patients with mCNPC at Fudan University Shanghai Cancer Center(Shanghai,China)were retrospectively examined.Immunohistochemical staining of PTEN was performed on prostate biopsy samples of these patients.Associations among clinicopathological features,patient survival and PTEN protein expression were analyzed.PTEN loss occurred in 58 of 205(28.3%)patients.Loss of PTEN was significantly correlated with high metastatic volume(P=0.017).No association between PTEN expression and Gleason score was observed.Patients with PTEN loss had significantly shorter progression-free survival(PFS,P<0.001)and overall survival(OS,P<0.001)compared with patients with intact PTEN expression.Multivariate analysis showed that elevated alkaline phosphatase,high metastatic volume and PTEN loss were independent poor prognostic factors for PFS.The Eastern Cooperative Oncology Group performance status(ECOG PS)≥2 and PTEN loss were independent poor prognostic factors for OS.The adjusted hazard ratio of PTEN loss for PFS and OS was 1.67(95%confidence interval[CI]:1.14–2.43,P=0.008)and 1.95(95%CI:1.23–3.10,P=0.005),respectively.PTEN loss was also significantly associated with shorter PFS(P=0.025)and OS(P<0.001)in patients with low-volume metastatic disease.Our data showed that PTEN loss is an independent predictor for shorter PFS and OS in patients with de novo mCNPC.

关键词： immunohistochemistry metastatic prostate cancer metastatic volume phosphatase and tensin homolog on chromosome 10 prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： Ling-Shang kong Ran Tao yi-Fan Li Wen-Bin Wang Xue Zhao Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina Department of Scientific Research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina Department of Scientific Research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various tumors.However,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains limited.AIM To investigate the role of METTL5 in CRC.METHODS We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell lines.To elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream target.In vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and invasion.RESULTS Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable prognosis.In vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and migration.Notably,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor growth.CONCLUSION The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Organic Brønsted Acid-Catalyzed Stereoselective Cationic RAFT Polymerization:The Effect of RAFT Agents

引用

Chinese Journal of Polymer Science 2024年第6期42卷 711-717页

作者： Zheng-yi Zhang Zan Yang yun Liao Sai-Hu Liao Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Beijing National Laboratory for Molecular Sciences Beijing100190China

The tacticity of vinyl polymers is a key factor affecting the properties of materials.Recently,organic Brønsted acids have been demonstrated as effective catalysts for the development of highly stereoselective cationic reversible addition-fragmentation chain transfer(RAFT)polymerizations of vinyl ethers,in which the use of RAFT agents could allow the control the molecular weight and tacticity of polymer products simultaneously.However,the effect of RAFT agents on the tacticity-regulation remains elusive and lacks of investigation.In this study,we synthesized four types of RAFT agents and evaluated their influence in the stereoselective cationic polymerization of isobutyl vinyl ether in the presence of PADI as a Brønsted acid catalyst,which unveils that the Z group of RAFT agents could not only affect the polydispersity of the products,but also exert a profound effect on the stereoselectivity.After extensive screening of the RAFT agents,high stereoregularity(isotacticity,90%m)was obtained when using dithiocarbonate ester-type RAFT agents with a benzyloxy Z group.

关键词： Bronsted acid catalysis Stereoselective cationic polymerization RAFT polymerization Chain transfer agents Tacticity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

引用

World Journal of Clinical Cases 2024年第8期12卷 1461-1466页

作者： Yu Long yi-Ning Xiang Fei Huang Lei Xu Xiao-yun Li yun-Huan Zhen Department of Colorectal Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guzihou ProvinceChina Department of Colorectal Surgery Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal obstruction.The rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical literature.This case provides new insights into the complexities of diagnosing and managing overlapping pathologies.CASE SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody stools.An initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed postoperatively.This unique case was charac-terized by a combination of intussusception and adenocarcinoma of the cecum.The intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal intussusception.The patient recovered well postoperatively and was advised to initiate adjuvant chemotherapy.This case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic lesions.CONCLUSIONS Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

关键词： Appendiceal intussusception Appendicitis Cecal cancer Target signs Misdiagnosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：