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High IL-23^(+)cells infiltration correlates with worse clinical outcomes and abiraterone effectiveness in patients with prostate cancer

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Asian Journal of Andrology 2022年第2期24卷 147-153页

作者： Zheng Liu Jun-Yu Zhang yun-Jie Yang Kun Chang Qi-Feng Wang yun-yi kong Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

Individualized treatment of prostate cancer depends on an accurate stratification of patients who are sensitive to various ***-23(IL-23)was reported to play a significant role in prostate ***,we aimed to explore the clinical value of IL-23-secreting(IL-23^(+))cells in prostate cancer *** evaluated interleukin-23A(IL-23A)expression in The Cancer Genome Atlas database and retrospectively enrolled 179 treatment-naive metastatic prostate cancer patients diagnosed in our institute between June 2012 and December ***-23^(+)cells were stained and evaluated via ***,survival and multivariate Cox regression analyses were conducted to explore the prognostic value of IL-23^(+)*** found that IL-23A expression correlated with disease progression,while IL-23^(+)cells were clearly stained within prostate cancer *** with higher Gleason scores and multiple metastatic lesions tended to have more IL-23^(+)cell *** analyses showed that patients with higher levels of IL-23^(+)cells had significantly worse overall survival(hazard ratio[HR]=2.996,95%confidence interval[95%CI]:1.812–4.955;P=0.001)and a higher risk of developing castration resistance(HR=2.725,95%CI:1.865–3.981;P=0.001).Moreover,subgroup analyses showed that when patients progressed to a castration-resistant status,the prognostic value of IL-23^(+)cells was observed only in patients treated with abiraterone instead of ***,we showed that high IL-23^(+)cell infiltration is an independent prognosticator in patients with metastatic prostate ***-23^(+)cell infiltration may correlate with abiraterone effectiveness in castration-resistant prostate cancer patients.

关键词： abiraterone acetate interleukin-23 prognosis prostate cancer

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Relationship between circumcision and human papillomavirus infection： a systematic review and meta-analysis

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Asian Journal of Andrology 2017年第1期19卷 125-131页

作者： yi-Ping Zhu Zhong-Wei Jia Bo Dai Ding-Wei Ye yun-yi kong Kun Chang Yue Wang Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Fudan University Shanghai Medical College ShanghaiChina Department of Pathology Fudan University Shanghai Cancer Center Shanghai China.

Male circumcision （MC） is reported to reduce human papillomavirus （HPV） prevalence in men. However, the efficacy remains imprecise. The aim of this study was to conduct a systematic review and meta-analysis to assess the relationship between MC and genital HPV infection and genital warts. PUBMED, EMBASE, and Web of Science were searched from inception to March 22, 2015. We identified 30 papers, including a total of 12149 circumcised and 12252 uncircumcised men who were evaluated for the association of circumcision with genital HPV or genital warts. Compared with men who were not circumcised, circumcised men may have had significantly reduced odds of genital HPV prevalence （odds ratio [OR]： 0.68; 95% confidence interval [95% CI]： 0.56-0.82）. There was no significant association between MC and genital HPV acquisition of new infections （OR： 0.99; 95% CI： 0.62-1.60）, genital HPV clearance （OR： 1.38; 95% Ch 0.96-1.97）, and prevalence of genital warts （OR： 1.17; 95% CI： 0.63-2.17）. This meta-analysis suggests that circumcision reduces the prevalence of genital HPV infections. However, no clear evidence was found that circumcision was associated with decreased HPV acquisition, increased HPV clearance, or decreased the prevalence of genital warts. More studies are required to evaluate adequately the effect of MC on the acquisition and clearance of HPV infections and prevalence of genital warts.

关键词： genital warts human papillomavirus male circumcision prevalence

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Prognostic value of PTEN in de novo diagnosed metastatic prostate cancer

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Asian Journal of Andrology 2022年第1期24卷 50-55页

作者： Jun-Yu Zhang yun-yi kong Qi-Feng Wang yun-Jie Yang Zheng Liu Nan Lin Ding-Wei Ye Bo Dai Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

The purpose of our study is to investigate the prognostic value of phosphatase and tensin homolog on chromosome 10(PTEN)expression in patients with de novo metastatic castration naive prostate cancer(mCNPC).A total of 205 patients with mCNPC at Fudan University Shanghai Cancer Center(Shanghai,China)were retrospectively *** staining of PTEN was performed on prostate biopsy samples of these *** among clinicopathological features,patient survival and PTEN protein expression were *** loss occurred in 58 of 205(28.3%)*** of PTEN was significantly correlated with high metastatic volume(P=0.017).No association between PTEN expression and Gleason score was *** with PTEN loss had significantly shorter progression-free survival(PFS,P<0.001)and overall survival(OS,P<0.001)compared with patients with intact PTEN *** analysis showed that elevated alkaline phosphatase,high metastatic volume and PTEN loss were independent poor prognostic factors for *** Eastern Cooperative Oncology Group performance status(ECOG PS)≥2 and PTEN loss were independent poor prognostic factors for *** adjusted hazard ratio of PTEN loss for PFS and OS was 1.67(95%confidence interval[CI]:1.14–2.43,P=0.008)and 1.95(95%CI:1.23–3.10,P=0.005),*** loss was also significantly associated with shorter PFS(P=0.025)and OS(P<0.001)in patients with low-volume metastatic *** data showed that PTEN loss is an independent predictor for shorter PFS and OS in patients with de novo mCNPC.

关键词： immunohistochemistry metastatic prostate cancer metastatic volume phosphatase and tensin homolog on chromosome 10 prognosis

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Clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castration-resistant prostate cancer

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Asian Journal of Andrology 2019年第2期21卷 131-136页

作者： Guo-Wen Lin Gao-Xiang Li Bo Dai Ding-Wei Ye yun-yi kong Yue Wang yi-Jun Shen Department of Urology Fudan University Shanghai Cancer CenterShanghai 20032China Department of Oncology Fudan University Shanghai Medical CollegeShanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

This study investigated the clinical activity of abiraterone plus prednisone in docetaxel-naive and docetaxel-resistant Chinese patients with metastatic castratio n-resista nt prostate can cer(mCRPC).A total of 146 patie nts with docetaxel-naive group(103 cases)and docetaxel-resista nt group(43 cases)were en rolled from the Sha nghai Cancer Center(Sha nghai,Chin a)in this retrospective cohort *** efficacy endpoints were prostate-specific antigen response rate,prostate-specific antigen progress!on-free survival,clinical/radiographic progression-free survival,and overall survival in response to abiraterone plus *** higher prostate-specific antigen response rate was found in docetaxel-naive group(54.4%,56/103)compared to docetaxel-resistant group(34.9%,15/43)(P=0.047).In addition,significantly higher median prostate-specific antigen progress!on-free survival(14.0 vs 7.7 months,P=0.005),clinical or radiographic progression-free survival(17.0 vs 12.5 months,P=0.003),and overall survival(27.0 vs 18.0 mon ths,P=0.016)were found in docetaxel-naTve group compared to docetaxel-resistant group,*** univariate and multivariate analyses indicated that lower albumin and visceral metastases were independent significant predictors for shorter overall *** sum up,our data suggested that abiraterone plus prednisone was efficient in both docetaxel-naTve and docetaxel-resistant Chinese ***,higher PSA response rate and longer overall survival were observed in the docetaxel-naTve group,which suggested that abiraterone was more effective for docetaxel-naive patients than for docetaxel failures.

关键词： abiraterone acetate castration-resistant prostate cancer clinical activity docetaxel-naive docetaxel-pretreated

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Factors influencing biochemical recurrence in patients who have received salvage radiotherapy after radical prostatectomy： a systematic review and meta-analysis

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Asian Journal of Andrology 2017年第4期19卷 493-499页

作者： Zhong-Wei Jia Kun Chang Bo Dai yun-yi kong Yue Wang Yuan-Yuan Qu yi-Ping Zhu Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai China Department of Oncology Fudan University Shanghai Medical College Shanghai China Department of Pathology Fudan University Shanghai Cancer Center Shanghai China

Several studies have evaluated the risk factors influencing biochemical recurrence （BCR） of prostate cancer in patients receiving salvage radiotherapy （SRT） for BCR after radical prostatectomy （RP）, but the results remain conflicting. In this study, we performed a meta-analysis to resolve this conflict. We searched the following databases： PubMed, Embase, and Web of Science using the following terms in ＂All fields＂：＂salvage radiation therapy,＂＂salvage IMRT, S-IMRT, salvage radiotherapy, SRT, radical prostatectomy,＂＂RP, biochemical recurrence,＂＂BCR,＂＂biochemical relapse.＂ Eleven studies, with a total of 1383 patients, were included in our meta-analysis. Of all the variables, only Gleason score （GS）〉7 （odds ratio [OR]： 3.82; 95% confidence interval [CI]： 2.60-5.64） and pathological tumor （pT） stage 〉3a （OR： 1.82; 95% Ch 1.36-2.42） were positively correlated with BCR. However, SRT combined with androgen deprivation therapy （ADT）（OR： 0.63; 95% CI： 0.44-0.90） and radiation therapy （RT） dose 〉64 Gy （OR： 0.35; 95% CI： 0.19-0.64） were negatively correlated with BCR. Perineural invasion （OR： 2.64; 95% CI： 1.11-6.26）, preoperative prostate-specific antigen （PSA）〉10 ng m1-1 （OR： 1.36; 95% CI： 0.94-1.96）, positive surgical margin （OR： 0.92; 95% Ch 0.7-1.19）, and seminal vesicle involvement （SVI）（OR： 1.09; 95% Ch. 0.83-1.43） had no effect on BCR. Our meta-analysis indicated that pT stage, GS, RT dose, and SRT combined with ADT may influence BCR, while preoperative PSA, surgical margin, perineural invasion, and SVI have only a weak effect on BCR.

关键词： biochemical recurrence prostate cancer radical prostatectomy risk factors salvage radiotherapy

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Prognostic factors in Chinese patients with metastatic castration-resistant prostate cancer treated with docetaxel-based chemotherapy

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Asian Journal of Andrology 2013年第1期15卷 110-115页

作者： Yuan-Yuan Qu Bo Dai yun-yi kong Ding-Wei Ye Xu-Dong Yao Shi-Lin Zhang Hai-Liang Zhang Chun-Guang Ma Wei-yi Yang Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Fudan University Shanghai Medical College Shanghai 200032 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

This study aims to evaluate the potential value of patient characteristics in predicting overall survival （OS） in patients with metastatic castration-resistant prostate cancer （mCRPC） treated with docetaxel-based thermotherapy. A total of 115 patients with mCRPC undergoing a docetaxel q3w regimen were enrolled in this study. A survival analysis was performed using the Kaplan-Meier method. Cox proportional hazards models were used to evaluate the prognostic value of all covariates for OS. OS was also analysed after stratifying patients according to the results of multivariate analysis. The median OS for the entire cohort was 17.0 months. The multivariate analysis showed that the prostate-specific antigen doubling time （PSADT）, baseline haemoglobin （Hb） concentration, alkaline phosphatase （ALP） concentration, cycles of chemotherapy and time to castration resistance were independent prognostic factors of OS. According to the presence of PSADT 〈46.3 days and baseline ALP/〉 110 IU 1-1, all patients were divided into three risk groups： low-risk group （no risk factors）, intermediate-risk group （one risk factor） and high-risk group （two risk factors）. Median OSs for patients in low-, intermediate- and high-risk groups were 28.0 months （95% Ch 23.8-32.2）, 21.0 months （95% Ch 18.9-23.1） and 11.0 months （95% Ch 7.6-14.4）, respectively （P〈O.O01）. In conclusion, PSADT, baseline Hb concentration, ALP concentration, cycles of chemotherapy and time to castration resistance were independent prognostic factors of OS in Chinese patients with mCRPC treated with docetaxel. PSADT combined with the baseline ALP concentration could be a useful risk stratification parameter for evaluating survival outcomes.

关键词： castration-resistant docetaxel metastatic overall survival prognostic factor prostate cancer

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Individualized prostate biopsy strategy for Chinese patients with different prostate-specific antigen levels

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Asian Journal of Andrology 2008年第2期10卷 325-331页

作者： Bo Dai Ding-Wei Ye yun-yi kong yi-Jin Shen Bo-Hua Wang Department of Urology Shanghai Medical College Fudan University Shanghai 200032 China Department of Pathology Shanghai Medical College Fudan University Shanghai 200032 China Department of Ultrasound Cancer Hospital Shanghai Medical College Fudan University Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

Aim： To evaluate the best individualized prostate biopsy strategies for Chinese patients with suspected prostate cancer. Methods： The present study included 221 Chinese patients who underwent transrectal ultrasound guided prostate biopsies for the first time. All patients underwent the same 10-core biopsy protocol. In addition to the Hodge sextant technique, four more biopsies were obtained from the base and middle regions of bilateral peripheral zones. The differences between 10-core and sextant strategies in cancer detection among patients with different prostate specific anitgen （PSA） levels were evaluated. The relationship between PSA level, number of positive biopsy cores and organ-confined cancer rate in prostate cancer patients was also analyzed. Results： The overall prostate cancer detection rate was 40.7% in the 221 patients. The 10-core strategy increased cancer detection by 6.67% （6/90） in our patients （P 〈 0.05）. The increased cancer detection rates decreased significantly when the patient PSA level increased from 0-20 ng/mL to 20.1-50 ng/mL and 〉 50 ng/mL （P 〈 0.01）. The number of positive biopsy cores in prostate cancer patients increased significantly with increasing patient PSA level （P 〈 0.01）. The rate of organ-confined prostate cancer decreased significantly with increasing patient PSA level （P 〈 0.01）. Conclusion： The extended 10- core strategy is recommended for Chinese patients with PSA 〈 20 ng/mL and the sextant strategy is recommended for those with PSA〉 50 ng/mL. For patients with PSA ranging from 20.1 ng/mL to 50 ng/mL, the 10-core strategy should be applied in patients with life expectancy 〉 10 years and the sextant strategy should be applied in those with life expectancy 〈 10 years. （Asian J Androl 2008 Mar; 10： 325-331）

关键词： prostate prostatic neoplasms diagnosis biopsy Asian continental ancestry group

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Human epidermal growth factor receptor type 2 protein expression in Chinese metastatic prostate cancer patients correlates with cancer specific survival and increases after exposure to hormonal therapy

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Asian Journal of Andrology 2008年第5期10卷 701-709页

作者： Bo Dai yun-yi kong Ding-Wei Ye Chun-Guang Ma Xiao-Yan Zhou Xu-Dong Yao Department of Urology Cancer Hospital Fudan University Shanghai 200032 China Department of Pathology Cancer Hospital Fudan University Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

Aim： To investigate human epidermal growth factor receptor type 2 （HER2） protein expression and gene amplification in Chinese metastatic prostate cancer patients and their potential value as prognostic factors. Methods： Immunohistochemistry （IHC） was performed to investigate HER2 protein expression in prostate biopsy specimens from 104 Chinese metastatic prostate cancer patients. After 3-11 months of hormonal therapy, 12 patients underwent transurethral resection of the prostate （TURP）. HER2 protein expression of TURP specimens was compared with that of the original biopsy specimens. Of these, 10 biopsy and 4 TURP specimens with HER2 IHC staining scores ≥ 2＋ were investigated for HER2 gene amplification status by fluorescent in situ hybridization （FISH）. Results： Of the 104 prostate biopsy specimens, HER2 protein expression was 0, 1＋, 2＋ and 3＋ in 49 （47.1%）, 45 （43.3%）, 8 （7.7%） and 2 （1.9%） cases, respectively. There was a significant association between HER2 expression and Gleason score （P = 0.026）. HER2 protein expression of prostate cancer tissues increased in 33.3% of patients after hormonal therapy. None of the 14 specimens with HER2 IHC scores 〉 2＋ showed HER2 gene amplification. Patients with HER2 scores 〉 2＋ had a significantly higher chance of dying from prostate cancer than those with HER2 scores of 0 （P = 0.004） and 1＋（P = 0.034）. Multivariate Cox regression analysis showed that HER2 protein expression intensity was an independent predictor of cancer-related death （P = 0.039）. Conclusion： An HER2 IHC score 〉 2＋ should be defined as HER2 protein overexpression in prostate cancer. Overexpression of HER2 protein in cancer tissue might suggest an increased risk of dying from prostate cancer. HER2 protein expression increases in some individual patients after hormonal therapy.

关键词： prostatic neoplasms human epidermal growth factor receptor type 2 immunohistochemistry gene amplification prostate cancer prognosis

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The detection,extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 82-92页

作者： Qianyun yun Wen-Biao Han yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310124China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Taiji Laboratory for Gravitational Wave Universe(Beijing/Hangzhou) University of Chinese Academy of SciencesBeijing 100049China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu ProvinceKey Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China International Centre for Theoretical Physics Asia-Pacific(ICTP-AP) University of Chinese Academy of Sciences(UCAS)Beijing 100049China Center for Gravitational Wave Experiment National Microgravity LaboratoryInstitute of MechanicsChinese Academy of SciencesBeijing 100190China

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EM-RIs).This task is particularly challenging because EMRI signals are complex,lengthy,and *** this work,we introduce a 2-layer convolutional neural network(CNN)approach to detect EMRI signals for space-borne detectors,achieving a true positive rate(TPR)of 96.9%at a 1%false positive rate(FPR)for signal-to-noise ratio(SNR)from 50 to ***,the key intrinsic parameters of EMRIs such as the mass,spin of the supermassive black hole(SMBH)and the initial eccentricity of the orbit can also be inferred directly by employing a neural *** mass and spin of the SMBH can be determined at 99%and 92%*** will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform *** study underscores the potential of deep learning methods in EMRI data analysis,enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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Atomic-scale insights into microscopic mechanisms of grain boundary segregation in Al−Cu alloys

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 1-12页

作者： Xiong SHUAI Hong MAO Sai TANG yi kong Yong DU State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China College of Mechanical Engineering Hunan Institute of Science and TechnologyYueyang 414006China National Key Laboratory of Science and Technology on High-strength Structural Materials Central South UniversityChangsha 410083China

This study aims to clarify the mechanisms for the grain boundary(GB)segregation through investigating the absorption of excess solute atoms at GBs in Al−Cu alloys by using the hybrid molecular dynamics/Monte Carlo *** segregation mechanisms,substitutional and interstitial mechanisms,are *** intergranular defects,including dislocations,steps and vacancies,and the intervals in structural units are conductive to the prevalence of interstitial *** substitutional mechanism is favored by the highly ordered twin ***,the two mechanisms affect the GB structure *** is quantified that interstitial mechanism is less destructive to GB structure than substitutional one,and often leads to a segregation level being up to about 6 times higher than the *** findings contribute to atomic scale insights into the microscopic mechanisms about how solute atoms are absorbed by GB structures,and clarify the correlation among intergranular structures,segregation mechanisms and kinetics.

关键词： grain boundaries segregation Al−Cu alloy intergranular structure molecular dynamics simulation Monte Carlo simulation

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