检索结果-南通市图书馆

Immunological Effect of Subunit Influenza Vaccine Entrapped by Liposomes

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2009年第5期22卷 388-393页

作者： SHUI-HUA ZHANG jia-XU LIANG SHU-YAN DAI xiao-LIN QIU YAN-RONG YI yun PAN College of Life Sciences and Technology Shanghai Jiao Tong University Shanghai 200240 China Shenzhen Neptunus Interlong Bio-technique Company Ltd Shenzhen 518054 Guangdong China

Objective To elevate the immunological effect of subunit influenza vaccine in infants and aged people （over 60） using liposomal adjuvant in the context of its relatively low immunity and to investigate the relation between vaccine antigens and liposomal characteristics. Methods Several formulations of liposomal subunit influenza vaccine were prepared. Their relevant characteristics were investigated to optimize the preparation method. Antisera obtained from immunizinged mice were used to evaluate the antibody titers of various samples by HI and EL1SA. Results Liposomal trivalent influenza vaccine prepared by film evaporation in combinedation with freeze-drying significantly increased its immunological effect in SPF Balb/e mice. Liposomal vaccine stimulated the antibody titer of H3N2, H1N1, and B much stronger than conventional influenza vaccine. As a result, liposomal vaccine （mean size： 4.5-5.5 pm, entrapment efficiency： 30%-40%） significantly increased the immunological effect of subunit influenza vaccine. Conclusion The immune effect of liposomal vaccine depends on different antigens, and enhanced immunity is not positively correlated with the mean size of liposome or its entrapped efficiency.

关键词： Liposome Subunit influenza vaccine Size distribution Mean size Entrapped efficiency

Modification of single molecule fluorescence using external fields

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2017年第5期12卷 11-25页

作者： Rui-yun Chen Guo-Feng Zhang Cheng-Bin Qin Yan Gao Lian-Tuan xiao Suo-Tang jia State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser Spectroscopy Shanxi University Taiyuan 030006 China Collaborative Innovation Center of Extreme Optics S hanxi University Taiyuan 030006 China

Controlling and manipulating the fluorescence of single fluorophores is of great interest in recent years for its potential uses in improving the performance of molecular photonics and molecular electronics, such as in organic light-emitting devices, single photon sources, organic field-effect transistors, and probes or sensors based on single molecules. This review shows how the fluorescence emission of single organic molecules can be modified using local electromagnetic fields of metallic nanostructures and electric-field-induced electron transfer. Electric-field-induced fluorescence modulation, hysteresis, and the achievement of fluorescence switch are discussed in detail.

关键词： single molecules fluorescence modification external fields

Ternary organic solar cells offer 14% power conversion efficiency

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science Bulletin 2017年第23期62卷 1562-1564页

作者： Zuo xiao Xue jia Liming Ding Center for Excellence in Nanoscience (CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication (CAS) National Center for Nanoscience and TechnologyBeijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Organic solar cells （OSCs） have advantages like light-weight, flexibility, colorfulness and solution processability [1 ]. The active layer of OSCs generally contains two organic semiconductors： an electron donor and an electron acceptor. The donor and acceptor make nanoscale phase separation to allow efficient exciton dissociation and also form a three-dimensional （3D） passage to rapidly transfer free charge carriers to respective electrodes.

关键词： Ternary organic solar cells power conversion efficiency

On Dynamics of Infinitely Generated Contractive Mapping Systems on pZ_p

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2020年第6期36卷 651-662页

作者： Jing Hua YANG yun Peng xiao Department of Mathematics College of SciencesShanghai UniversityShanghai 200444P.R.China

Let p≥2 be a prime number and Zp be the ring of p-adic *** G be a semigroup generated by infinitely many contractive maps on p *** is shown that if G satisfies the open tiling conditions,then there exists a shift transformation on the limit set of G and the shift transformation is ergodic with respect to the Haar measure on p *** an application,we can generalize p-adic Khinchin’s Theorem and p-adic Lochs’Theorem to any infinitely generated semigroup by use of the ergodicity of the shift transformation.

关键词： Contractive maps ergodic limit sets p-adic continued fractions

Thickness-modulated in-plane Bi2O2Se homojunctions for ultrafast high-performance photodetectors

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第12期28卷 363-369页

作者： Cheng-yun Hong Gang-Feng Huang Wen-Wen Yao jia-Jun Deng xiao-Long Liu Renewable Energy School North China Electric Power UniversityBeijing 102206China Department of Mathematics and Physics North China Electric Power UniversityBeijing 102206China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and Beijing Key Laboratory of Energy Safety and Clean Utilization North China Electric Power UniversityBeijing 102206China

Bi2O2Se thin film could be one of the promising material candidates for the next-generation electronic and optoelectronic applications. However, the performance of Bi2O2Se thin film-based device is not fully explored in the photodetecting area. Considering the fact that the electrical properties such as carrier mobility, work function, and energy band structure of Bi2O2Se are thickness-dependent, the in-plane Bi2O2Se homojunctions consisting of layers with different thicknesses are successfully synthesized by the chemical vapor deposition(CVD) method across the terraces on the mica substrates,where terraces are created in the mica surface layer peeling off process. In this way, effective internal electrical fields are built up along the Bi2O2Se homojunctions, exhibiting diode-like rectification behavior with an on/off ratio of 102, what is more, thus obtained photodetectors possess highly sensitive and ultrafast features, with a maximum photoresponsivity of 2.5 A/W and a lifetime of 4.8 μs. Comparing with the Bi2O2Se uniform thin films, the photo-electric conversion efficiency is greatly improved for the in-plane homojunctions.

关键词： Bi2O2Se in-plane homojunction thickness modulation photodetectors

WATuning:A Workload-Aware Tuning System with Attention-Based Deep Reinforcement Learning

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2021年第4期36卷 741-761页

作者： jia-Ke Ge Yan-Feng Chai yun-Peng Chai Key Laboratory of Data Engineering and Knowledge Engineering of Ministry of Education Renmin University of China Beijing 100872China School of Information Renmin University of ChinaBeijing 100872China College of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 030027China

Configuration tuning is essential to optimize the performance of systems(e.g.,databases,key-value stores).High performance usually indicates high throughput and low *** present,most of the tuning tasks of systems are performed artificially(e.g.,by database administrators),but it is hard for them to achieve high performance through tuning in various types of systems and in various *** recent years,there have been some studies on tuning traditional database systems,but all these methods have some *** this article,we put forward a tuning system based on attention-based deep reinforcement learning named WATuning,which can adapt to the changes of workload characteristics and optimize the system performance efficiently and ***,we design the core algorithm named ATT-Tune for WATuning to achieve the tuning task of *** algorithm uses workload characteristics to generate a weight matrix and acts on the internal metrics of systems,and then ATT-Tune uses the internal metrics with weight values assigned to select the appropriate ***,WATuning can generate multiple instance models according to the change of the workload so that it can complete targeted recommendation services for different types of ***,WATuning can also dynamically fine-tune itself according to the constantly changing workload in practical applications so that it can better fit to the actual environment to make *** experimental results show that the throughput and the latency of WATuning are improved by 52.6%and decreased by 31%,respectively,compared with the throughput and the latency of CDBTune which is an existing optimal tuning method.

关键词： attention mechanism auto-tuning system reinforcement learning(RL) workload-aware

The effects of social security expenditure on reducing income inequality and rural poverty in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2021年第4期20卷 1060-1067页

作者： YU Le-rong LI xiao-yun College of Humanities and Development China Agricultural UniversityBeijing 100193P.R.China

Social security has,as one of its primary aims,the provision of financial support to those deemed to be poor or facing the threat of *** on China's national statistical data covering social insurance,social assistance,and social welfare between the period 1978–2018,this paper evaluates the effect of social security expenditure in reducing income inequality and rural poverty with cointegration *** was found that there is a positive correlation between social security expenditure and the income gap of urban and rural residents in the long run,but the effect is very limited;nearly 99%of the changes of the urban–rural income gap come from its own *** research also shows that the elasticity of rural poverty incidence to social security expenditure is–0.2255,which indicates social security expenditure helps reduce rural absolute *** on these findings,the policy implications can be that much social security expenditure and a more equitable social security system should be *** will become one of the major anti-poverty strategies after 2020 in China when we win the battle against absolute poverty.

关键词： social security expenditure income inequality rural poverty reduction in China

Tuberculosis-induced aplastic crisis and atypical lymphocyte expansion in advanced myelodysplastic syndrome:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第19期11卷 4713-4722页

作者： xiao-yun Sun xiao-Dong Yang jia Xu Nuan-Nuan Xiu Bo Ju Xi-Chen Zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina

BACKGROUND Myelodysplastic syndrome(MDS)is caused by malignant proliferation and ineffective *** somatic mutations and increased apoptosis,necroptosis and pyroptosis lead to the accumulation of earlier hematopoietic progenitors and impaired productivity of mature blood *** increased percentage of myeloblasts and the presence of unfavorable somatic mutations are signs of leukemic hematopoiesis and indicators of entrance into an advanced *** marrow cellularity and myeloblasts usually increase with disease ***,aplastic crisis occasionally occurs in advanced *** SUMMARY A 72-year-old male patient was definitively diagnosed with MDS with excess blasts-1(MDS-EB-1)based on an increase in the percentages of myeloblasts and cluster of differentiation(CD)34+hematopoietic progenitors and the identification of myeloid neoplasm-associated somatic mutations in bone marrow *** patient was treated with hypomethylation therapy and was able to maintain a steady disease state for 2 *** the treatment process,the advanced MDS patient experienced an episode of progressive pancytopenia and bone marrow *** the aplastic crisis,the bone marrow was infiltrated with sparsely distributed atypical ***,the leukemic cells *** analysis revealed that the atypical lymphocytes expressed a high frequency of CD3,CD5,CD8,CD16,CD56 and CD57,suggesting the activation of autoimmune cytotoxic T-lymphocytes and natural killer(NK)/NKT cells that suppressed both normal and leukemic *** serum levels of inflammatory cytokines,including interleukin(IL)-6,interferon-gamma(IFN-γ)and tumor necrosis factor-alpha(TNF-α),confirmed the deranged type I immune *** morphological and immunological signature led to the diagnosis of severe aplastic anemia secondary to large granule lymphocyte *** tuberculosis was suspected upon radiological examinations in the s

关键词： Myelodysplastic syndrome Aplastic crisis Atypical lymphocyte Leukemic cell regression CD56+lymphocyte expansion Disseminated tuberculosis Case report

Flared inflammatory episode transforms advanced myelodysplastic syndrome into aplastic pancytopenia:A case report and literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第17期11卷 4105-4116页

作者： Bo Ju Nuan-Nuan Xiu jia Xu xiao-Dong Yang xiao-yun Sun Xi-Chen Zhao Department of Hematology The Central Hospital of Qingdao West Coast New AreaQingdao 266555Shandong ProvinceChina

BACKGROUND Myelodysplastic syndrome(MDS)is a hematological neoplasm,and an increase in myeloblasts is representative of leukemic hematopoiesis in advanced *** MDS usually exhibits deranged autoimmunity resembling that of aplastic anemia(AA),whereas advanced MDS is characterized by a phenotype of immune *** can be normo/hyperplastic or ***,bone marrow cellularity and myeloblasts increase with disease *** from advanced MDS to AA-like syndrome with leukemic cell regression has not previously been *** SUMMARY A middle-aged Chinese woman had a 4-year history of *** months prior to admission,the patient developed gradually worsening fatigue and performance *** leukocytopenia further *** was diagnosed with MDS with excess blasts-2 based on increased bone marrow cellularity and an increased percentage of myeloblasts on marrow and blood smears,an increased percentage of cluster of differentiation(CD)34+CD33+progenitors in immunotyping analysis,a normal karyotype in cytogenetic analysis,and the identification of somatic mutations in CBL,KMT2D and NF1 in molecular ***,neutropenia was the predominant hematological abnormality,with mild anemia and thrombocytosis,and the degree of fatigue was far more severe than the degree of *** the following months,the patient experienced several febrile *** antibiotic treatments were able to control the febrile episodes,but the elevated inflammatory indices *** hematological parameters dramatically fluctuated with the waxing and waning of the inflammatory *** recurrent flares of the inflammatory condition,agranulocytosis and severe anemia developed,with mild *** the patient’s hospitalization,computed tomography(CT)scans revealed the presence of extensive inflammatory lesions involving the lungs,mediastinum,pleura,gastrointestinal tract,peritoneum and urinary tract,

关键词： Myelodysplastic syndrome Aplastic anemia Inflammatory stress Leukemic cell regression Antileukemic Case report