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NFXL1 functions as a transcriptional activator required for thermotolerance at reproductive stage in Arabidopsis

Journal of Integrative Plant Biology 2024年第1期66卷 54-65页

作者： Qiao‐yun Zhu Lin‐Lin Zhang Jian‐xiang Liu State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China

Plants are highly susceptible to abiotic stresses,particularly heat stress during the reproductive stage.However,the specific molecular mechanisms underlying this sensitivity remain largely unknown.In the current study,we demonstrate that the Nuclear Transcription Factor,X-box Binding Protein 1-Like 1(NFXL1),directly regulates the expression of DEHYDRATION-RESPONSIVE ELEMENT-BINDING PROTEIN 2A(DREB2A),which is crucial for reproductive thermotolerance in Arabidopsis.NFXL1 is upregulated by heat stress,and its mutation leads to a reduction in silique length(seed number)under heat stress conditions.RNA-Seq analysis reveals that NFXL1 has a global impact on the expression of heat stress responsive genes,including DREB2A,Heat Shock Factor A3(HSFA3)and Heat Shock Protein 17.6(HSP17.6)in flower buds.Interestingly,NFXL1 is enriched in the promoter region of DREB2A,but not of either HSFA3 or HSP17.6.Further experiments using electrophoretic mobility shift assay have confirmed that NFXL1 directly binds to the DNA fragment derived from the DREB2A promoter.Moreover,effector-reporter assays have shown that NFXL1 activates the DREB2A promoter.The DREB2A mutants are also heat stress sensitive at the reproductive stage,and DEREB2A is epistatic to NFXL1 in regulating thermotolerance in flower buds.It is known that HSFA3,a direct target of DREB2A,regulates the expression of heat shock proteins genes under heat stress conditions.Thus,our findings establish NFXL1 as a critical upstream regulator of DREB2A in the transcriptional cassette responsible for heat stress responses required for reproductive thermotolerance in Arabidopsis.

关键词： Arabidopsis DREB2A heat stress NFXL1 reproductive thermotolerance

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Comment on“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 109-110页

作者： xiang-Yan Liu yun-Yang Xu Ze xiang Shu-Sen Zheng Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College Hangzhou 310015China Zhejiang University School of Medicine Hangzhou 310009China

To the Editor:We read with great interest the article by Schulze et al.entitled“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”[1].It is the first single-center report including over 500 fully robotic donor hepatectomies.For the donors,the overall complication rate was 6.4%(n=32).Postoperative self-limiting bleeding(0.4%)and bile leakage from the resection plane(1.8%)were rare.

关键词： robotic Robotic center

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Development of antibody-drug conjugates in cancer:Overview and prospects

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Cancer Communications 2024年第1期44卷 3-22页

作者： dan-yun Ruan Hao-xiang Wu Qi Meng Rui-Hua Xu Department of Clinical Research Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer Chinese Academy of Medical SciencesGuangzhouGuangdongP.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhouGuangdongP.R.China

In recent years,remarkable breakthroughs have been reported on antibody-drug conjugates(ADCs),with 15 ADCs successfully entering the market over the past decade.This substantial development has positioned ADCs as one of the fastest-growing domains in the realm of anticancer drugs,demonstrating their efficacy in treating awide array of malignancies.Nonetheless,there is still an unmet clin-ical need forwider application,better efficacy,and fewer side effects of ADCs.An ADC generally comprises an antibody,a linker and a payload,and the combina-tion has profound effects on drug structure,pharmacokinetic profile and efficacy.Hence,optimization of the key components provides an opportunity to develop ADCs with higher potency and fewer side effects.In this review,we comprehen-sively reviewed the current development and the prospects of ADC,provided an analysis of marketed ADCs and the ongoing pipelines globally as well as in China,highlighted several ADC platforms and technologies specific to different pharmaceutical enterprises and biotech companies,and also discussed the new related technologies,possibility of next-generation ADCs and the directions of clinical research.

关键词： companies breakthrough payload

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Electronic structural engineering of bimetallic Bi-Cu alloying nanosheet for highly-efficient CO_(2) electroreduction and Zn-CO_(2) batteries

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Nano Research 2024年第5期17卷 3684-3692页

作者： Wenbo Wu Jiaye Zhu yun Tong Shuangfei xiang Pengzuo Chen School of Chemistry and Chemical Engineering Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China

Regulating the electronic structure of Bi-based materials by alloying engineering is promising to promote the electrocatalytic activity,but it remains some challenges to be solved.In this study,a facile electrochemical co-deposition strategy is developed to synthesize the bimetallic Bi_(9)Cu_(1) alloy nanosheet on carbon cloth(Bi_(9)Cu_(1)/CC),which represents a novel self-supporting electrode for the electrocatalytic carbon dioxide(CO_(2))reduction reaction(CO_(2)RR).The Bi_(9)Cu_(1)/CC catalyst has achieved a remarkable catalytic performance with high Faradaic efficiencies(FE)of over 90%for formate at wide potentials from-0.7 to-1.2 V vs.reversible hydrogen electrode(RHE).Moreover,the reversible Zn-CO_(2) battery can be driven by Bi_(9)Cu_(1)/CC cathode with a largest power density of 1.4 mW·cm^(-2),and superior operating stability.The systematic characterizations and electrochemical results confirm that the improved catalytic active sites,the enhanced mass/charge transport and the optimal reaction kinetics of Bi nanosheet are realized for CO_(2)RR by Cu alloying.In situ attenuated total reflection infrared(ATR-IR)result confirms the bimetallic Bi-Cu active sites prefer to follow the^(*)OCHO conversion pathway.The density functional theory(DFT)calculations suggest that the Cu alloying contributes to the increased density of states near the Fermi surface of Bi and the optimized adsorption of^(*)OCHO intermediates on the Bi sites,resulting in the excellent catalytic performance.

关键词： electronic regulation bismuth nanosheet copper alloying CO_(2)electroreduction Zn-CO_(2)batteries

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Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1461-1466页

作者： Yu Long Yi-Ning xiang Fei Huang Lei Xu Xiao-yun Li yun-Huan Zhen Department of Colorectal Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guzihou ProvinceChina Department of Colorectal Surgery Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal obstruction.The rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical literature.This case provides new insights into the complexities of diagnosing and managing overlapping pathologies.CASE SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody stools.An initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed postoperatively.This unique case was charac-terized by a combination of intussusception and adenocarcinoma of the cecum.The intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal intussusception.The patient recovered well postoperatively and was advised to initiate adjuvant chemotherapy.This case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic lesions.CONCLUSIONS Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

关键词： Appendiceal intussusception Appendicitis Cecal cancer Target signs Misdiagnosis Case report

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Fabrication of corrosion inhibiting microcapsules functional coating and their high-efficiency corrosion resistance

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Rare Metals 2024年第2期43卷 842-848页

作者： Hao-Ran yun Lu Lu Xue-Long Hao Xing-xiang Zhang School of Material Science and Engineering Tiangong UniversityTianjin300387China National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials General Research Institute for Nonferrous MetalsBeijing100088China Guobiao(Beijing)Testing&Certification Co. Ltd.Beijing101407China

Benzotriazole(BTA)was loaded into calcium carbonate microsphere shell by self-assembly method and a new type of high-efficiency corrosion inhibiting microcapsules(CIMs)were fabricated,which were added and dispersed into epoxy resin coating to obtain a new corrosion resistance functional coating.The corrosion inhibition effect of benzotriazole on aluminum alloy matrix was verified by polarization curve test.The effectiveness of the CIMs and their loading capacity on inhibitor were evaluated by scanning electron microscope,laser confocal Raman spectroscopy together with thermogravimetric analysis.

关键词： corrosion coating resistance

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Ultra‑Efficient and Cost‑Effective Platinum Nanomembrane Electrocatalyst for Sustainable Hydrogen Production

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Nano-Micro Letters 2024年第6期16卷 95-110页

作者： xiang Gao Shicheng dai yun Teng Qing Wang Zhibo Zhang Ziyin Yang Minhyuk Park Hang Wang Zhe Jia yunjiang Wang Yong Yang Department of Mechanical Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong KongPeople’s Republic of China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijingPeople’s Republic of China School of Engineering Science University of Chinese Academy of SciencesBeijingPeople’s Republic of China Laboratory for Microstructures Institute of MaterialsShanghai UniversityShanghaiPeople’s Republic of China School of Materials Science and Engineering Jiangsu Key Laboratory for Advanced Metallic MaterialsSoutheast UniversityNanjingPeople’s Republic of China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongTat Chee AvenueKowloon TongKowloonHong KongPeople’s Republic of China

Hydrogen production through hydrogen evolution reaction(HER)offers a promising solution to combat climate change by replacing fossil fuels with clean energy sources.However,the widespread adoption of efficient electrocatalysts,such as platinum(Pt),has been hindered by their high cost.In this study,we developed an easy-to-implement method to create ultrathin Pt nanomembranes,which catalyze HER at a cost significantly lower than commercial Pt/C and comparable to non-noble metal electrocatalysts.These Pt nanomembranes consist of highly distorted Pt nanocrystals and exhibit a heterogeneous elastic strain field,a characteristic rarely seen in conventional crystals.This unique feature results in significantly higher electrocatalytic efficiency than various forms of Pt electrocatalysts,including Pt/C,Pt foils,and numerous Pt singleatom or single-cluster catalysts.Our research offers a promising approach to develop highly efficient and cost-effective low-dimensional electrocatalysts for sustainable hydrogen production,potentially addressing the challenges posed by the climate crisis.

关键词： Platinum Hydrogen evolution reaction Lattice distortion Heterogeneous strain

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Automatic recognition of depression based on audio and video:A review

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World Journal of Psychiatry 2024年第2期14卷 225-233页

作者： Meng-Meng Han Xing-yun Li Xin-Yu Yi yun-Shao Zheng Wei-Li Xia Ya-Fei Liu Qing-xiang Wang Shandong Mental Health Center Shandong UniversityJinan 250014Shandong ProvinceChina Key Laboratory of Computing Power Network and Information Security Ministry of EducationShandong Computer Science Center(National Supercomputer Center in Jinan)Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353Shandong ProvinceChina Shandong Engineering Research Center of Big data Applied Technology Faculty of Computer Science and TechnologyQilu University of Technology(Shandong Academy of Sciences)Jinan 250353Shandong ProvinceChina Shandong Provincial Key Laboratory of Computer Networks Shandong Fundamental Research Center for Computer ScienceJinan 250353Shandong ProvinceChina Department of Ward Two Shandong Mental Health CenterShandong UniversityJinan 250014Shandong ProvinceChina

Depression is a common mental health disorder.With current depression detection methods,specialized physicians often engage in conversations and physiological examinations based on standardized scales as auxiliary measures for depression assessment.Non-biological markers-typically classified as verbal or non-verbal and deemed crucial evaluation criteria for depression-have not been effectively utilized.Specialized physicians usually require extensive training and experience to capture changes in these features.Advancements in deep learning technology have provided technical support for capturing non-biological markers.Several researchers have proposed automatic depression estimation(ADE)systems based on sounds and videos to assist physicians in capturing these features and conducting depression screening.This article summarizes commonly used public datasets and recent research on audio-and video-based ADE based on three perspectives:datasets,deficiencies in existing research,and future development directions.

关键词： Depression recognition Deep learning Automatic depression estimation System Audio processing Image processing Feature fusion Future development

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Searching for the Highest Energy of Pulsation and Critical Luminosity of Swift J0243.6+6124 Observed by Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第5期24卷 61-69页

作者： Qing-Xia Zhao Xian Hou Ming-Yu Ge Shuang-Nan Zhang yun-xiang Xiao You-Li Tuo Zi-Xu Yang Ling-da Kong Jin-Lu Qu Shu Zhang Jian-Cheng Wang yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences ChineseAcademy of SciencesBeijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Institut fur Astronomic und Astrophysik Sand 1D-72076 TabingenGemany School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

Owing to the broad energy coverage of Insight-HXMT in the hard X-ray band,we detected the highest energy of pulsation exceeding 200 keV around the 2017–2018 outburst peak of the first Galactic pulsating ultraluminous X-ray source (PULX) Swift J0243.6+6124,which is the highest energy detected from PULXs to date.We also obtained the highest energy of pulsation of every exposure during the outburst in 2017–2018,and found the highest energy is roughly positively correlated with luminosity.Using our newly developed method,we identified the critical luminosity being 4×10~(38)erg s~(-1) when the main peaks of the low and high energy pulse profiles became aligned,which separates the fan-beam dominated and pencil-beam dominated accretion regimes.Above the critical luminosity,the phase of the main peak shifted gradually from 0.5 to 0.8 until the outburst peak in al energy bands is reached,which is in agreement with the phase shift found previously at low energies.Our result is consistent with what is derived from spectral analysis.

关键词： (stars:)pulsars-individual(Swift J0243.6+6124)-X-rays binaries–stars neutron

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Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila

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Neuroscience Bulletin 2024年第4期40卷 539-543页

作者： Xuedong Li Mengrong Wang xiang Gao Chenyu Li Chunyu Chen yun Qi Ying Wan Wei Yu State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai200438China School of Basic Medic Science Southwest Medical UniversityLuzhou64600China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Dear Editor,Charcot-Marie-Tooth disease,the most common inherited peripheral neuropathology,is highly heterogeneous among patients and associated with mutations in~100 different genes at an incidence of at least 1:2,500[1].Over 30 mutated genes have been identified in CMT2,which is characterized by peripheral axon degeneration and distal deficits in motor function[2].The aminoacyl-tRNA synthetase is the largest family in CMT2 and includes tyrosyl-tRNA synthetase(YARS,tyrosyl-tRNA synthetase).

关键词： Marie degeneration pathology

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