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恶意网页识别研究综述

计算机学报 2016年第3期39卷 529-542页

作者：沙泓州刘庆云柳厅文周舟郭莉方滨兴中国科学院信息工程研究所北京100093 北京邮电大学计算机学院北京100876 信息内容安全技术国家工程实验室北京100093

近年来,随着互联网的迅速发展以及网络业务的不断增长,恶意网页给人们的个人隐私和财产安全造成的威胁日趋严重.恶意网页识别技术作为抵御网络攻击的核心安全技术,可以帮助人们有效避免恶意网页引起的安全威胁,确保网络安全.文中从理论... 详细信息

近年来,随着互联网的迅速发展以及网络业务的不断增长,恶意网页给人们的个人隐私和财产安全造成的威胁日趋严重.恶意网页识别技术作为抵御网络攻击的核心安全技术,可以帮助人们有效避免恶意网页引起的安全威胁,确保网络安全.文中从理论分析和方法设计两方面介绍了恶意网页识别的最新研究成果.在理论分析层面,从恶意网页的基本概念和形式化定义出发,对恶意网页识别的应用场景、基本框架及评价方法进行全面的归纳,并总结了恶意网页识别的理论依据及性能评价指标.在方法设计层面,对具有影响力的恶意网页识别方法进行了介绍和归类,对不同类别的识别方法进行了定性分析和横向比较.在总结恶意网页识别研究现状的基础上,从客观环境的变化以及逃逸技术的升级两方面深入探讨了当前恶意网页识别面临的技术挑战.最后总结并展望了恶意网页识别的未来发展方向.

关键词：恶意网页识别网页分类机器学习逃逸技术

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多通道烘缸结构参数对烘缸传热性能的影响

中国造纸学报 2015年第3期30卷 41-46页

作者：严彦董继先汤伟史韵陕西科技大学机电工程学院陕西西安710021

提出了多通道烘缸内部结构的设计方法,分析了多通道烘缸结构参数对蒸汽冷凝传热及流动特性的影响。首先指出通道数量、高宽比和间隔比等参数与通道宽度、高度和当量直径等结构参数的关系,然后引入Cavallini冷凝传热系数实验关联式及均... 详细信息

提出了多通道烘缸内部结构的设计方法,分析了多通道烘缸结构参数对蒸汽冷凝传热及流动特性的影响。首先指出通道数量、高宽比和间隔比等参数与通道宽度、高度和当量直径等结构参数的关系,然后引入Cavallini冷凝传热系数实验关联式及均相流模型,分析了结构参数对多通道烘缸蒸汽冷凝传热系数和沿程阻力的影响。结果表明,通道数量、高宽比和间隔比对蒸汽冷凝传热系数及沿程阻力的影响较大。综合分析结果表明,当通道数量为150~200、高宽比为1∶3及间隔比为1∶1~1∶3时,多通道烘缸的整体性能最好。

关键词：造纸机多通道烘缸冷凝传热关联式

变系数(2+1)维色散长波方程组的新精确解

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聊城大学学报（自然科学版） 2005年第2期18卷 17-20页

作者：杜先云绵阳师范学院数学系四川绵阳621000

通过构造函数变换和辅助方程,求出了一类变系数非线性(2+1)维色散长波方程组的某些新的精确解,其中包括实和复的孤立波解;推广了文[1～3]中的结果.

关键词：变系数色散长波方程精确解

Whole brain radiotherapy concomitant or sequential Vm26/DDP in treating small cell lung cancer patients with brain metastases

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The Chinese-German Journal of Clinical Oncology 2010年第1期9卷 17-21页

作者： Mingyue Liu yun zhou Qian Han Tianhui Gao Zhifen Luo Wenyu Wang Department of Oncology Henan Provincial People＇s Hospital Zhengzhou 450003 China Department of Radiology Henan Provincial People＇s Hospital Zhengzhou 450003 China

Objective： The aim of the study was to compare efficacies and safeties of 2 different treatments of whole brain radiotherapy （WBRT） sequential or concomitant Vm26/DDP for small cell lung cancer （SCLC） patients with brain metastases. Methods： A total of 39 patients were randomly divided into sequential chemoradiotherapy regime （A group, 20 patients） and concomitant chemoradiotherapy regime （B group, 19 patients）. The close of WBRT was 36 Gy in 18-20 fractions, chemotherapy of Vm26/DDP regimen with teniposide 60 mg/m^2 on dl to d3 and cisplatin 20 mg/m^2 on dl to d5, repeating every 3 weeks. The response was evaluated after WBRT and 2 cycles of chemotherapy. Results： Total response rates of A and B groups were 70.0% and 78.9% respectively （P = 0.520）. The median survival was 11 months in A group and 10 months in B group. Six, twelve and eighteen months cumulative survival rates of A and B groups were 75.0%, 42.5%, 26.2%, and 81.6%, 26.4%, 10.5%, respectively （χ^2 = 0.383, P 〉 0.05）. Response rate and the number of brain metastases were independent prognostic factors. Conclusion： Both sequential and concomitant chemoradiotherapy groups are effective, and the main toxicity with myelosuppression is tolerable after therapy. It can be applied firstly and effectively to the SCLC patients with brain metastases in clinic.

关键词： small cell lung cancer (SCLC) brain metastases chemoradiotherapy Vm26 DDP survival analysis

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缺硼槟榔幼苗的生理反应和根系发育特征

植物营养与肥料学报 2020年第2期26卷 386-392页

作者：曹先梅刘立云李佳中国热带农业科学院椰子研究所海南文昌571339

【目的】探究缺硼对槟榔幼苗生理特征和根系形态的影响,以期为槟榔缺硼(B)诊断提供理论依据。【方法】以‘热研1号’槟榔幼苗为材料进行了砂培试验。设置营养液中不加B(B0,0μmol/L)和添加常规硼(B50,50μmol/L)两个浓度处理。生长3个月... 详细信息

【目的】探究缺硼对槟榔幼苗生理特征和根系形态的影响,以期为槟榔缺硼(B)诊断提供理论依据。【方法】以‘热研1号’槟榔幼苗为材料进行了砂培试验。设置营养液中不加B(B0,0μmol/L)和添加常规硼(B50,50μmol/L)两个浓度处理。生长3个月后,测定了槟榔幼苗生物量、株高、硼含量、叶片糖类物质以及抗氧化酶活性、丙二醛含量、光合速率,观察了不同处理下根尖及根尖细胞的形态。【结果】与B50处理相比,B0处理显著降低了槟榔幼苗株高、地下部鲜重和干重、总鲜重、地上部和地下部硼含量;B0处理槟榔叶片蔗糖和淀粉含量下降,可溶性总糖含量无显著变化,叶片光合速率降低,且MDA含量、POD活性显著升高。在B0条件下,槟榔根系变短,根尖明显膨大,细胞壁明显增厚,且内壁上积累了大量的颗粒物,根系活力显著降低。【结论】缺硼导致槟榔幼苗根尖解剖结构受到破坏,养分吸收运转能力降低,叶片抗氧化系统受到损伤,光合能力下降,最终抑制植株生长。

关键词：槟榔缺硼根系形态糖类物质抗氧化酶活性

补阳还五汤对失神经肌萎缩大鼠Angptl4表达的影响

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中成药 2014年第8期36卷 1593-1596页

作者：周岚梅晓云南京中医药大学基础医学院江苏南京210023

目的研究补阳还五汤(黄芪、当归、白芍、地龙、川芎、红花、桃仁)对失神经肌萎缩大鼠Angptl4基因表达的影响,探讨其对失神经肌萎缩的保护机制。方法建立大鼠腓总神经夹伤模型,将造模后的60只SPF级SD大鼠随机分为:假手术组、补阳还五汤... 详细信息

目的研究补阳还五汤(黄芪、当归、白芍、地龙、川芎、红花、桃仁)对失神经肌萎缩大鼠Angptl4基因表达的影响,探讨其对失神经肌萎缩的保护机制。方法建立大鼠腓总神经夹伤模型,将造模后的60只SPF级SD大鼠随机分为:假手术组、补阳还五汤高、中、低剂量组、弥可保组与模型组,术后每日灌胃给药。18 d后qRT-PCR与Western-blot检测Angptl4基因与蛋白的差异表达。结果与模型组相比,补阳还五汤中、高剂量组Angptl4 mRNA与蛋白表达均显著增高(P<0.05或P<0.01)。结论补阳还五汤可能通过增加Angptl4基因与蛋白表达,促进血管新生,改善失神经萎缩肌肉的血液供应,从而延缓肌萎缩的发生。

关键词：补阳还五汤失神经肌萎缩大鼠胫前肌 Angptl4

FCPR03,A Novel Phosphodiesterase 4 Inhibitor,Alleviates Cerebral Ischemia/Reperfusion Injury through Activation of the AKT/GSK3β/β-Catenin Signaling Pathway

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神经药理学报 2019年第4期 42-43页

作者： XU Bing-tian WANG Tian-tian QIN yun-yun CAI Ning-bo zhou Zhong-zhen WANG Hai-tao XU Jiang-ping Department of Neuropharmacology and Drug Discovery School of Pharmaceutical SciencesSouthern Medical University Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaSouthern Medical University Key Laboratory of Mental Health of the Ministry of Education Southern Medical University Central Laboratory Southern Medical University

Objective:Inhibition of phosphodiesterase 4( PDE4) is a promising strategy for the treatment of ischemic stroke. However,the side effects of nausea and vomiting from the current PDE4 inhibitors have limited their clinical applications. FCPR03 is a novel PDE4 inhibitor with little emetic potential. This study aimed to investigate the effects of FCPR03 on neuronal injury after cerebral ischemia/reperfusion and the underlying signaling pathway. Methods:The effects of FCPR03 on cellular apoptosis,intracellular accumulation of reactive oxygen species( ROS),and mitochondrial membrane potential( MMP) were evaluated in HT-22 neuronal cells and cortical neurons exposed to oxygen-glucose deprivation( OGD). The impact of FCPR03 on brain injury,neurological scores and behavioral performance was investigated in rats subjected to middle cerebral artery occlusion( MCAO). The protein kinase B( AKT) inhibitor MK-2206 and β-catenin siRNA were used to investigate the underlying pathways. Results:FCPR03 dose-dependently protected against OGD-induced cellular apoptosis in both HT-22 cells and cortical neurons. The levels of MMP and ROS were also restored by FCPR03. FCPR03 increased the levels of phosphorylated AKT,glycogen synthase kinase-3β( GSK3β),and β-catenin. Interestingly,the role of FCPR03 was reversed by MK-2206 and β-catenin siRNA. Consistently,FCPR03 reduced the infarct volume and improved neurobehavioral outcomes in rats following MCAO. Moreover,FCPR03 increased the levels of phosphorylated AKT,GSK3β and β-catenin within the ischemic penumbra of rats following cerebral ischemia-reperfusion. Conclusion:Taken together,FCPR03 has therapeutic potential in cerebral ischemia-reperfusion. The neuroprotective effects of FCPR03 are mediated through activation of the AKT/GSK3β/β-catenin pathway.

关键词： ischemic stroke phosphodiesterase 4 FCPR03 akt neuroprotection

Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial

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Chinese Journal of Integrative Medicine 2020年第5期26卷 330-338页

作者： LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen zhou Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an Department of Gastroenterology Institute of Liver DiseaseDongzhimen Hospital affiliated to Beijing University of Chinese MedicineBeijing(100700)China Department of Hepatology the Sixth People's Hospital of ShenyangShenyang(110006)China Department of Hepatology the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin(300000)China Departm ent of Hepatology Shenzhen Traditional Chinese Medicine HospitalShenzhen(518033)C hina D e pa rtm e nt of H e pa to log y Shaanxi H o spital of T radition al C hinese M edicineXi'an(710003)China Affiliated Hospital of Changchun U niversity of Chinese M edicine C hangchun(130021)China Departm ent of Hepatology Guangdong Hospital of Traditional Chinese MedicineGuangzhou(510006)China Department of Hepatology Liaoning Hospital of Traditional Chinese MedicineShenyang(110032)China Department of Hepatology Beijing Ditan HospitalBeijing(100015)China Department of Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Department of Hepatology the 302 Military Hospital of PLABeijing(100039)China Department of Hepatology the First Affiliated Hospital of Guangxi University of Chinese MedicineNanning(530023)China Department of Integrated Traditional Chinese Medicine and Western Medicine Beijing YouAn HospitalCapital Medical UniversityBeijing(100069)China Department of Traditional Chinese Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou(510630)China Department of Gastroenterology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou(450000)China Department of Hepatology Shandong Hospital of Traditional Chinese MedicineJinan(250011)China Department of Gastroenterology Anhui Hospital of Traditional Chinese MedicineHefei(230031)China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing(100191)China Clinical Research Center Affiliated Hospital of Nanjing University of Traditional Chinese MedicineNanjing(210029)China

Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e antigen(HBeAg)-positive Chinese ***:A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group(EG,received ADV plus CM)and control group(CG,received ADV plus CM-placebo)for 48 *** major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12,24,36,48,*** endpoints including liver functions(enzymes and bilirubin readings)were evaluated every 4 weeks at the beginning of week 24,36,and *** blood,urine,and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety *** events(AEs)were ***:The combination therapy demonstrated superior HBeAg loss at 48 weeks,without additional *** full analysis population was 560 and 280 in each *** the EG,population achieved HBeAg loss on week 12,24,36,and 48 were 25(8.90%),34(12.14%),52(18.57%),and 83(29.64%),respectively;the equivalent numbers in the CG were 20(7.14%),41(14.64%),54(19.29%),and 50(17.86%),*** was a statistically significant difference between two groups on week 48(P<0.01).No additional AEs were found in *** analysis suggested different outcomes among treatment ***:Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV *** finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile(ChiCTR-TRC-11001263).

关键词： Adefovir dipivoxil Tiaogan Jianpi Hexue Tiaogan Jiedu Huashi Chinese medicine HBeAg combination therapy

土壤湿润条件下基于光谱对称度的盐渍土盐分含量预测

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光谱学与光谱分析 2013年第10期33卷 2771-2776页

作者：刘娅潘贤章王昌昆李燕丽石荣杰周睿解宪丽中国科学院土壤环境与污染修复重点实验室(南京土壤研究所) 江苏南京210008 中国科学院大学北京100049 中国科学院南京分院江苏南京210008

近年来光谱技术以其经济、高效的优势在土壤盐渍化监测研究中得到重视,但是由于土壤水分对反射光谱影响很大,土壤湿润条件下监测精度难以满足农业生产需求。通过对盐土土柱室内模拟蒸发过程中的反射光谱和水分、盐分变化的连续监测,利... 详细信息

近年来光谱技术以其经济、高效的优势在土壤盐渍化监测研究中得到重视,但是由于土壤水分对反射光谱影响很大,土壤湿润条件下监测精度难以满足农业生产需求。通过对盐土土柱室内模拟蒸发过程中的反射光谱和水分、盐分变化的连续监测,利用多元逐步回归方法,建立了1 370～1 610nm光谱对称度与土壤表层含盐量、含水量之间的线性关系模型,r为0.863;用该模型反演表层土壤含盐量,实测值与预测值之间线性关系的r为0.656(n=54),RMSE为2.059g·kg-1。利用光谱对称度可以实现土壤湿润条件下土壤盐分含量预测。

关键词：土壤盐渍化土壤湿润条件光谱对称度土壤含盐量预测