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An adaptive physics-informed deep learning method for pore pressure prediction using seismic data

Petroleum Science 2024年第2期21卷 885-902页

作者： Xin Zhang yun-Hu Lu Yan Jin mian Chen Bo Zhou State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Artificial Intelligence China University of Petroleum(Beijing)Beijing102249China PetroChina Tarim Oilfield Company KorlaXinjiang841000China

Accurate prediction of formation pore pressure is essential to predict fluid flow and manage hydrocarbon production in petroleum engineering.Recent deep learning technique has been receiving more interest due to the great potential to deal with pore pressure prediction.However,most of the traditional deep learning models are less efficient to address generalization problems.To fill this technical gap,in this work,we developed a new adaptive physics-informed deep learning model with high generalization capability to predict pore pressure values directly from seismic data.Specifically,the new model,named CGP-NN,consists of a novel parametric features extraction approach(1DCPP),a stacked multilayer gated recurrent model(multilayer GRU),and an adaptive physics-informed loss function.Through machine training,the developed model can automatically select the optimal physical model to constrain the results for each pore pressure prediction.The CGP-NN model has the best generalization when the physicsrelated metricλ=0.5.A hybrid approach combining Eaton and Bowers methods is also proposed to build machine-learnable labels for solving the problem of few labels.To validate the developed model and methodology,a case study on a complex reservoir in Tarim Basin was further performed to demonstrate the high accuracy on the pore pressure prediction of new wells along with the strong generalization ability.The adaptive physics-informed deep learning approach presented here has potential application in the prediction of pore pressures coupled with multiple genesis mechanisms using seismic data.

关键词： Pore pressure prediction Seismic data 1D convolution pyramid pooling Adaptive physics-informed loss function High generalization capability

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High-performance Si/VO_(2)-nanorod heterojunction photodetector based on photothermoelectric effect for detecting human radiation

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Rare Metals 2024年第3期43卷 1177-1185页

作者： Fu-Hai Guo Lan-Zhong Hao Wei-Zhuo Yu Si-Qi Li Guan-chu Liu Jing-Yi Hao yun-Jie Liu College of Science China University of PetroleumQingdao266580China School of Materials Science and Engineering China University of PetroleumQingdao266580China

As a typical candidate of optoelectronic materials,vanadium dioxide(VO_(2))has wide applications in photodetectors(PDs),but is still challenging in largely enhancing the photodetecting performance for low-power human radiation.Herein,high-performance Si/VO_(2)nanorods(NRs)heterojunction PDs based on the photothermoelectric(PTE)effect are presented.The uniform VO_(2)-NRs array films were deposited on Si by using magnetron sputtering technique,and a Si/VO_(2)heterojunctions were fabricated.The device exhibits a four-stage photoresponse and broadband photoresponse from ultraviolet to long-wavelength infrared.Benefited from the unique nanorods structure and the strong PTE effect,the fabricated device exhibits a large enhancement of the photodetecting performance,showing an ultrahigh photodetectivity of 1.6×10^(13)Jones and ultrafast response rates with a risingedge time of~65.0μs,three orders of magnitude higher than other VO_(2)-based devices.Furthermore,the device exhibits unique abilities to detect human radiation even when the human fingers are far away from the device surface up to 10.0 cm.Additionally,the fabricated Si/VO_(2)devices can also be applied as breath sensors to distinguish different breathing patterns.These results supply an effective route to design high-performance photodetectors toward detecting human thermal radiation and respiration.

关键词： Vanadium dioxide Heterojunction Photodetector Photothermoelectric Human radiation and respiration sensing

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Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

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World Journal of Gastroenterology 2024年第5期30卷 485-498页

作者： chu-Xuan Liu Ying Gao Xiu-Fang Xu Xin Jin yun Zhang Qian Xu Huan-Xin Ding Bing-Jun Li Fang-Ke Du Lin-chuan Li Ming-Wei Zhong Jian-Kang Zhu Guang-Yong Zhang Department of General Surgery Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery Linyi People's HospitalLinyi 276034Shandong ProvinceChina Department of Nursing Huantai TCM HospitalZibo 256400Shandong ProvinceChina Center for Translational medical Research The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is associated with high mortality rates.Bile acids(BAs)reflux is a well-known risk factor for GC,but the specific mechanism remains unclear.During GC development in both humans and animals,BAs serve as signaling molecules that induce metabolic reprogramming.This confers additional cancer phenotypes,including ferroptosis sensitivity.Ferroptosis is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant progression.However,it is not fully defined if BAs can influence GC progression by modulating ferroptosis.AIM To reveal the mechanism of BAs regulation in ferroptosis of GC cells.METHODS In this study,we treated GC cells with various stimuli and evaluated the effect of BAs on the sensitivity to ferroptosis.We used gain and loss of function assays to examine the impacts of farnesoid X receptor(FXR)and BTB and CNC homology 1(BACH1)overexpression and knockdown to obtain further insights into the molecular mechanism involved.RESULTS Our data suggested that BAs could reverse erastin-induced ferroptosis in GC cells.This effect correlated with increased glutathione(GSH)concentrations,a reduced GSH to oxidized GSH ratio,and higher GSH peroxidase 4(GPX4)expression levels.Subsequently,we confirmed that BAs exerted these effects by activating FXR,which markedly increased the expression of GSH synthetase and GPX4.Notably,BACH1 was detected as an essential intermediate molecule in the promotion of GSH synthesis by BAs and FXR.Finally,our results suggested that FXR could significantly promote GC cell proliferation,which may be closely related to its anti-ferroptosis effect.CONCLUSION This study revealed for the first time that BAs could inhibit ferroptosis sensitivity through the FXR-BACH1-GSHGPX4 axis in GC cells.This work provided new insights into the mechanism associated with BA-mediated promotion of GC and may help identify potential therapeutic targets for GC patients with BAs reflux.

关键词： Gastric cancer Ferroptosis Bile acids Chenodeoxycholic acid Farnesoid X receptor Glutathione

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老年机械通气患者膈肌浅快呼吸指数与肺部超声评分的相关性及其对撤机结局的预测价值

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中华危重病急救医学 2024年第2期36卷 152-155页

作者：储蕴郭闯付海燕锦州医科大学附属第一医院耳鼻咽喉头颈外科辽宁锦州121001 锦州医科大学附属第一医院心胸外科辽宁锦州121001 锦州医科大学附属第一医院重症医学科辽宁锦州121001

目的探讨老年机械通气患者膈肌浅快呼吸指数(D-RSBI)与肺部超声评分(LUS)的相关性及其对撤机结局的预测价值。方法收集2021年1月至2022年6月在锦州医科大学附属第一医院重症监护病房(ICU)接受治疗的老年(年龄>60岁)有创正压通气(IPPV)... 详细信息

目的探讨老年机械通气患者膈肌浅快呼吸指数(D-RSBI)与肺部超声评分(LUS)的相关性及其对撤机结局的预测价值。方法收集2021年1月至2022年6月在锦州医科大学附属第一医院重症监护病房(ICU)接受治疗的老年(年龄>60岁)有创正压通气(IPPV)患者的临床资料进行回顾性研究。根据撤机结局将患者分为成功组和失败组,比较两组患者性别、年龄、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)以及撤机拔管前D-RSBI和LUS等指标的差异;采用Pearson相关性分析D-RSBI与LUS评分的相关性;采用受试者工作特征曲线(ROC曲线)分析D-RSBI和LUS评分对老年IPPV患者撤机结局的预测价值。结果共纳入398例老年IPPV患者,其中撤机成功300例,失败98例。失败组与成功组性别、年龄差异均无统计学意义〔男性:55.1%(54/98)比59.0%(177/300),年龄(岁):67.02±5.03比66.96±4.99,均P>0.05〕,失败组APACHEⅡ评分明显高于成功组(分:17.09±3.30比16.06±3.81,P<0.05),撤机拔管前D-RSBI和LUS评分均明显高于成功组〔D-RSBI(次·min-1·mm-1):2.19±0.33比1.60±0.22,LUS(分):17.30±3.04比11.97±3.20,均P<0.01〕。所有患者D-RSBI与LUS评分呈显著正相关(r=0.406,P=0.000)。ROC曲线分析显示,D-RSBI预测老年IPPV患者撤机结局的曲线下面积(AUC)为0.920,95%可信区间(95%CI)为0.881~0.958,P=0.000,当截断值为1.85次·min-1·mm-1时敏感度为88.7%,特异度为86.7%;LUS评分预测老年IPPV患者撤机结局的AUC为0.875,95%CI为0.839~0.912,P=0.000,当截断值为14.50分时敏感度为75.7%,特异度为84.7%。结论老年机械通气患者D-RSBI与LUS评分有显著相关性,二者均可以预测老年机械通气患者的撤机结局。

关键词：膈肌浅快呼吸指数肺部超声评分老年机械通气撤机

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Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 204-212页

作者： Meng-Hua Li Wan-Qi Wang Li-Ting Zheng Meng-Bing Chen Yang chu Miao Qiao Zuo-Li Zhang Konduru Naveena Yong Pan yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical University Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical Sciences Hainan University Department of ENT Beijing Friendship Hospital Capital Medical University National Key Laboratory of Chinese Medicine Modernization Tasly Academy Tasly Pharmaceutical Group Co. Ltd. Endoscopy Center Ankang People's Hospital Department of Respiratory Medicine Xuzhou Infectious Diseases Hospital Affiliated Hospital of Xuzhou Medical University Department of ENT The People's Hospital of Rongchang District

Objective: This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL). Materials and Methods: A mice animal model for NIHL was established through exposure to broadband noise at 120 d B sound pressure level for 4 h. Transcriptomics analysis and pharmacodynamic experiments were carried out. Results: Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss. Moreover, treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice. Conclusion: Andrographolide might be a promising candidate for auditory protective drug investigation.

关键词： Andrographolide anti‑inflammatory auditory protection noise‑induced hearing loss traditional Chinese medicine compound

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基于改进综合因素法的农业机械可靠性分配

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吉林大学学报（工学版） 2024年第5期54卷 1493-1500页

作者：陈超戴孟初周乐梁云东中国农业大学工学院北京100083

现有可靠性分配方法在农机领域应用较少,为更好地满足农机可靠性分配需求,提出了一种基于改进综合因素法(IFM)的农业机械可靠性分配方法。该方法针对农机特点综合考虑了包含子系统危害度A_(1)、改进潜力A_(2)、复杂度A_(3)、维修性A_(4... 详细信息

现有可靠性分配方法在农机领域应用较少,为更好地满足农机可靠性分配需求,提出了一种基于改进综合因素法(IFM)的农业机械可靠性分配方法。该方法针对农机特点综合考虑了包含子系统危害度A_(1)、改进潜力A_(2)、复杂度A_(3)、维修性A_(4)、环境条件A_(5)和技术水平A_(6)在内的6种影响因素,并形成子系统故障率分配的权重因子,实现了将指定的系统整体可靠性目标分配至子系统层级。针对新研发产品,给出了各影响因素取值的评价参考标准,可通过故障模式影响及危害性分析(FMECA)结合专家评分定量计算。以2BMQF-6/12免耕播种机为例,应用改进IFM对其进行可靠性分配,并与IFM及FOO、Kim、Yadav方法进行比对,验证了本文所提出方法的可行性。本文方法分配结果合理、流程完善、考虑因素相对全面,可为农机可靠性分配提供参考,为农机产品可靠性设计提供依据。

关键词：农业机械可靠性分配综合因素法设计阶段

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攀钢1750 m^(3)高炉冶炼钒钛矿指标优化技术应用

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中国冶金 2024年第2期34卷 96-107页

作者：黄云储满生闫瑞军攀钢集团西昌钢钒有限公司四川攀枝花617000 东北大学冶金学院辽宁沈阳110819

炼铁技术发展到目前,高炉炼铁仍然是能效利用最高的工艺之一。高炉炉况稳定对铁水的产量及质量具有重要影响。钒钛磁铁矿资源开发与综合利用是国家的重大战略。攀钢攻克了用普通高炉冶炼钒钛磁铁矿这一技术难题,建设了攀西钒钛磁铁矿资... 详细信息

炼铁技术发展到目前,高炉炼铁仍然是能效利用最高的工艺之一。高炉炉况稳定对铁水的产量及质量具有重要影响。钒钛磁铁矿资源开发与综合利用是国家的重大战略。攀钢攻克了用普通高炉冶炼钒钛磁铁矿这一技术难题,建设了攀西钒钛磁铁矿资源综合利用开发基地,逐步实现了对钒钛磁铁矿资源中铁、钒、钛元素的规模化利用。攀西地区原燃料特点为炼焦煤资源短缺,矿石有害元素含量高。由于影响高炉稳定顺行的因素繁多,高炉冶炼过程炉况波动时有发生,如何确保高炉的稳定顺行和低碳冶炼是有效利用攀西钒钛资源的重要前提。结合攀西地区资源特点和西昌钢钒1750 m^(3)高炉炉型生产实践,从送风制度、造渣制度、热制度、装料制度入手,通过理论分析、对比实际生产数据、与相近原燃料或炉型参数的高炉对标等方法,阐明了1750 m^(3)高炉冶炼钒钛矿保持炉况长期稳定的合理操作制度和特殊炉况快速恢复的技术路径及实施效果。研究结果可为钒钛磁铁矿资源高炉高效冶炼提供理论和生产实际指导。

关键词：高炉钒钛磁铁矿合理操作制度炉况稳定技术路径生产实践

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Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang Wang Zheng-Yu Wang Jin Li Zhu-Bo Wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak chu Wei Zhao Guang-Can Guo Chang-Ling Zou yun-Feng Xiao Wen-Fu Zhang chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser source.In this study,we present a system for generating a fully atom-referenced stabilized soliton microcomb.The pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)cavity.This pump light is then frequency-doubled and referenced to the atomic transition of87Rb.The repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 s.As a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

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我国城市轨道交通既有线改造路径探讨

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都市快轨交通 2024年第1期37卷 17-21,62页

作者：魏运楚柏青光志瑞北京市地铁运营有限公司北京100044 地铁运营安全保障技术北京市重点实验室北京100044

随着城镇化进程的加快,城市轨道交通既有线改造在促进城轨高质量发展和城市可持续发展方面具有重要的战略意义。既有线改造涉及专业面广、待解决问题复杂,过去以解决安全问题为主要目标的消隐改造、以部分专业为对象的专项改造已难以满... 详细信息

随着城镇化进程的加快,城市轨道交通既有线改造在促进城轨高质量发展和城市可持续发展方面具有重要的战略意义。既有线改造涉及专业面广、待解决问题复杂,过去以解决安全问题为主要目标的消隐改造、以部分专业为对象的专项改造已难以满足新时代既有线改造需求。因此,面对城市轨道交通高质量发展要求,亟须深入探讨我国城市轨道交通既有线改造发展路径。本文在梳理北京既有线改造历程的基础上,从面临的问题与实现的愿景两方面展开了对城市轨道交通既有线改造需求的分析,提出了既有线改造的整体思路,同时从城轨可持续发展方面创新地提出了既有线改造中的投融资思路,并从制度建设、要素活力、投融资机制、科技赋能、技术攻关、相关标准6个方面给出既有线改造工作建议,以期为我国城市轨道交通既有线改造提供思路。

关键词：城市轨道交通既有线改造需求分析改造建议

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Body mass index does not affect the survival of pancreatic cancer patients

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World Journal of Gastroenterology 2017年第34期23卷 6287-6293页

作者： Qing-long Jiang Cheng-feng Wang Yan-tao tian Huang Huang Shui-Sheng Zhang Dong-bing Zhao Jie Ma Wei Yuan Yue-Min Sun Xu Che Jian-Wei Zhang yun-mian chu Ya-Wei Zhang Ying-tai Chen Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Surgery Yale School of MedicineYale Cancer Center

AIM to evaluate the association of body mass index(b MI) with the overall survival of pancreatic ductal adenocarcinoma(PDAC) patients.METHODS A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. these patients were categorized into four b MI groups(< 18.5, 18.5-22.9, 23-27.4 and ≥ 27.5 kg/m2). χ2 tests for comparison of the proportions of categorical variables, and Student's t-test or Mann-Whitney test for continuous variables were employed. Survival analysis was performed with the Kaplan-Meyer method. their HRs of mortality and 95%CIs were estimated using the Cox proportional hazards model.RESULTS With a median age of 59.6 years(range: 22.5-84.6 years), in total 1783 PDAC patients were enrolled in this study. their mean usual b MI was 24.19 ± 3.53 for the whole cohort. More than half of the patients(59.3%) experienced weight loss during the disease onset and progression. Compared with healthy-weight individuals, newly diagnosed patients who were overweight or obese had more severe weight loss during their disease onset and progression(P < 0.001). Individuals who were overweight or obese were associated with positive smoking history(P < 0.001). A significant difference in comorbidity of diabetes(P = 0.044) and coronary artery disease(P < 0.001) was identified between high b MI and normal-weight patients. After a median follow-up of 8 mo, the survival analysis showed no association between b MI and the overall survival(P = 0.90, n = 1783). When we stratified the whole cohort by pancreatic cancer stage, no statistically significant association between b MI and overall survival was found for resectable(P = 0.99, n = 217), unresectable locally advanced(P = 0.90, n = 316) and metastatic patients(P = 0.88, n = 1250), respectively. the results did not change when we used the b MI at diagnosis.CONCLUSION Our results showed no significance of b MI for the overall survival of PDAC patients.

关键词：身体集体索引胰腺的癌症超重吸烟历史幸存分析

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