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Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 525-531页

作者： Zheng-Hua Wan yun-Han Ma Tian-Yi Jiang yun-kai lin Yuan-Yuan Shi Ye-Xiong Tan Li-Wei Dong Hong-Yang Wang International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteThe Second Military Medical UniversityShanghai 200438China National Center for Liver Cancer The Second Military Medical UniversityShanghai 201805China No.971 Hospital of Peoples’Liberation Army Navy Qingdao 266071China State Key Laboratory of Oncogenes and related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Background: Increasing evidence indicates that Six2 contributes to tumorigenesis in various tumor in- cluding hepatocellular carcinoma (HCC). This study aimed to determine the role of Six2 in HCC and to elucidate the association of Six2 with clinical pathological characteristics. Methods: The expressions of Six2 in HCC tumor, para-tumor tissue and portal vein tumor thrombus (PVTT) were detected by tissue microarray technique, immunohistochemistry, real-time RT-PCR and West- ern blotting. Chi-square and Kaplan-Meier analysis were used to analyze the correlation between Six2 expression and prognosis of HCC patients. Lentivirus mediated Six2 knockdown, spheroid formation as- say, proliferation assay and subcutaneous tumor implantation were performed to determine the function of Six2. Results: In 274 HCC samples, Six2 was strongly expressed. Kaplan-Meier analysis revealed that high ex- pression of Six2 was correlated with a shorter overall survival (OS) and disease-free survival (DFS). More- over, Six2 expression was associated with sex, alpha-fetoprotein, tumor size and portal vein invasion. Six2 was highly expressed in PVTT. Six2 knockdown inhibited HCC cell lines proliferation, migration, and self-renewal in vitro and in vivo. In addition, low-expression of Six2 weakened TGF-β induced Smad4 activation and epithelial-mesenchymal transition in HCC cell lines. Conclusions: Elevated Six2 expression in HCC tumor patients was associated with negative prognosis. Upregulated Six2 promoted tumor growth and facilitated HCC metastasis via TGF-β/Smad signal pathway.

关键词： Hepatocellular carcinoma Six2 Prognosis Metastasis

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-lin Jiang Bao-Xia Dong yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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量子核判别分析算法

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郑州大学学报（理学版） 2025年第1期57卷 61-66页

作者：康榕乘余凯张新林崧郭躬德福建师范大学计算机与网络空间安全学院福建福州350117 福建师范大学数字福建环境监测物联网实验室福建福州350117 福建师范大学数学与统计学院福建福州350117

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种... 详细信息

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种量子核判别分析算法。首先,借助量子随机存储器技术与控制旋转操作构造需要的类间矩阵和类内矩阵所对应的密度算子;然后,融入线性方程的求解思路并行获取特征态。理论分析表明,所提算法与经典算法相比具有指数级加速。

关键词：量子机器学习非线性判别分析核函数特征提取量子厄米特链积相位估计

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Mie scatterers bring a resonator to an exceptional point

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Light(Science & Applications) 2023年第9期12卷 1715-1716页

作者： kai Hong lin Chen Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

Exceptional points have given rise to many intriguing optical phenomena that are of fundamental importance for a variety of breakthrough *** pre-defined Mie scatterers can bring a resonator to an exceptional point,and... 详细信息

关键词： resonator scattering. exceptional

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Research of Velocity Compensation Method Based on Range Profile Feature

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Journal of Harbin Institute of Technology(New Series) 2013年第2期20卷 81-85页

作者： kai-Feng Guo yun lin Meng Wang Xiao-Chun Xu College of Information and Communication Engineering Harbin Engineering University

In this paper,based on the feature of high resolution one-dimensional range profile,two effective motion compensation methods are presented. Firstly,the processing method of stepped-frequency and the response of target moving to range profile are analyzed. Secondly,the function of range profile entropy and range profile contrast are presented for velocity compensation,and then the theory analysis,math model,and solution method are analyzed in detail. Finally,several simulation experiments are designed to prove the accuracy and effectiveness of these two methods. From the final theory analysis and simulation experiments,the conclusion can be drawn that these two methods are effective,which can get much higher velocity estimation accuracy,well real-time and easy to be used in project application. After motion compens-ation,the high resolution one-dimensional range profile will be much better than that used to be,and is used for the detection, recognition and ranging of moving targets.

关键词： stepped frequency velocity compensation range profile range profile entropy range profile contrast

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Research of Hybrid Modulation Radar Signal

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Journal of Harbin Institute of Technology(New Series) 2013年第3期20卷 35-39页

作者： kai-Feng Guo yun lin Meng Wang Xiao-Chun Xu Unit 91635 of the Chinese People Liberation Army

Based on the advantage of phase coded signal and stepped frequency signal,a new hybrid modulation signal is introduced in this paper. It combines phase code modulation during the pulse with stepped frequency modulation between the pulses, which is named as phase-coded stepped-frequency ( PCSF ) signal. By analyzing its waveform and ambiguity function,the comparison between Stepped-Frequency ( SF) signal and PCSF signal is given,which shows that the PCSF signal is better than SF signal. Finally,the signal processing method with two stage compressed processing is presented. The simulation results show that this new hybrid modulation radar signal can get a higher stepped frequency than ordinary SF signal,realize the same equivalent bandwidth with less pulse number,and solve the conflict among the stepped frequency,the number of pulse, and transmit average power. Under the premises of a certain range resolution,this new hybrid modulation radar signal not only raises the data rate of radar system,but also reduces Doppler sensitivity with a good prospect, and the effect of one-dimensional range profile is much better than that of traditional SF signal. Therefore,this new hybrid modulation radar signal can be widely used in application.

关键词： phase coded stepped frequency hybrid modulation signal ambiguity function signal processing

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First Principles Study of Uranium Solubility in Gd2Zr2O7 Pyrochlore

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Chinese Journal of Chemical Physics 2015年第6期28卷 -页

作者： Qing-yun Chen kai-min Shih Chuan-min Meng Lie-lin Wang Hua Xie Tao Wu Key Subject Laboratory of National Defense for Radioactive Waste and Environmental Security Southwest University of Science and Technology Mianyang 621010 China Department of Civil Engineering The University of Hong Kong Pokfulam Road Hong Kong SARChina Key Lab for Shock Wave and Detonation Physics Research Institute of Fluid Physics Chinese Academy of Engineering Physics Mianyang 621900

Ab initio calculation is performed to investigate the uraniumsolubility in different sites of Gd2Zr2O7 pyrochlore. The Gd2Zr2O7 maintains its pyrochlore structure at low uraniumdopant levels, and the lattice constants of Gd2(Zr2?yUy)O7 and (Gd2?yUy)Zr2O7 are generally expressed as being linearly related to the uranium content y. Uranium is found to be a preferable substitute for the B-site gadolinium atoms in cation-disordered Gd2Zr2O7 (where gadolinium and zirconium atoms are swapped) over the A-site gadolinium atoms in ordered Gd2Zr2O7 due to the lower total energy of (Gd2?yZry)(Zr2?yUy)O7.

关键词： Gd2Zr2O7 pyrochlore Nuclear waste Uranium solubility Density functional theory

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RESEARCH OF INNER FLOW IN A DOUBLE BLADES PUMP BASED ON OPENFOAM

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Journal of Hydrodynamics 2012年第2期24卷 226-234页

作者： LIU Hou-lin REN yun WANG kai WU Deng-hao RU Wei-min TAN Ming-gao Research Center of Fluid Machinery Engineering and Technology Jiangsu UniversityZhengjiang 212013China

The inner flow analysis of centrifugal pumps has gradually become an important issue for the hydraulic design and performance ***,CFD simulation toolbox of pump inner flow mainly contains commercial tools and open source *** are some defects for commercial CFD software for the numerical simulation of 3-D turbulent internal flow in pump,especially in capturing the flow characteristics under the off-design operating ***,it is difficult for researchers to do further investigation because of the undeclared ***,an open source software like Open Field Operation and Manipulation （OpenFOAM） is increasingly popular with researchers from all over the *** this paper,a new computational study was implemented based on the original solver and was used to directly simulate the steady-state inner flow in a double blades pump,with the specific speed is *** order to disclose the characteristics deeply,three research schemes were *** ratios （） of the flow rate are 0.8,1.0 and 1.2,*** simulation results were verified with the Particle Imaging Velocimetry （PIV） experimental results,and the numerical calculation results agree well with the experimental ***,the phenomena of flow separation under the off-design operating conditions are well captured by *** results indicate that OpenFOAM possesses obvious strong predominance in computing the internal flow field of *** analysis results can also be used as the basis for the further research and the improvement of centrifugal pump.

关键词： numerical simulation double blades pump internal flow Particle Imaging Velocimetry (PIV)

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Development of A MERS-CoV Replicon Cell line for Antiviral Screening

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Virologica Sinica 2021年第4期36卷 730-735页

作者： Jing Chen Bing-Jie Hu kai Zhao yun Luo Hao-Feng lin Zheng-Li Shi CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Middle East respiratory syndrome coronavirus(MERS-CoV)is the causative agent of a severe respiratory disease with a high mortality of~35%.The lack of approved treatments for MERS-CoV infection underscores the need for a user-friendly system for rapid drug *** this study,we constructed a MERS-CoV replicon containing the Renilla luciferase(Rluc)reporter gene and a stable luciferase replicon-carrying cell *** this cell line,we showed that MERS-CoV replication was inhibited by combined application of lopinavir and ritonavir,indicating that this cell line can be used to screen inhibitors of MERS-CoV ***,the MERS-replicon cell line can be used for high-throughput screening of antiviral drugs without the need for live virus handling,providing an effective and safe tool for the discovery of antiviral drugs against MERS-CoV.

关键词： Middle East respiratory syndrome coronavirus(MERS-CoV) Replicon cell line Antiviral screening Luciferase reporter gene

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