检索结果-南通市图书馆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

教学的文化实践属性及三个基本认识向度

新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 137-143页

作者：程良宏王芸新疆师范大学教育科学学院新疆高等教育发展研究中心新疆乌鲁木齐830017

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深... 详细信息

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深入体认教学作为一种特殊的文化交往和生产实践形态,明晰以文化人、以文育人的导引和践行为目的指引,以教师与学生为文化交往和文化生产的实践主体,以教学过程中对教材与师生文化的理解再造为文化实践的基本内容。

关键词：教学实践教学的文化属性文化生产

Adaptive Control of a Flexible Manipulator With Unknown Hysteresis and Intermittent Actuator Faults

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2025年第1期 148-158页

作者： Shouyan Chen Weitian He Zhijia Zhao yun Feng Zhijie Liu Keum-Shik hong School of Mechanical and Electrical Engineering Guangzhou University the School of Control Science and Engineering Shandong University IEEE the College of Electrical and Information Engineering Hunan University the National Engineering Research Center for Robot Visual Perception and Control Technology Hunan University the School of Intelligence Science and Technology University of Science and Technology Beijing (USTB) the Institute for Future the School of AutomationQingdao University the School of Mechanical Engineering Pusan National University

In this study, we consider a single-link flexible manipulator in the presence of an unknown Bouc-Wen type of hysteresis and intermittent actuator faults. First, an inverse hysteresis dynamics model is introduced, and then the control input is divided into an expected input and an error compensator. Second,a novel adaptive neural network-based control scheme is proposed to cancel the unknown input hysteresis. Subsequently,by modifying the adaptive laws and local control laws, a fault-tolerant control strategy is applied to address uncertain intermittent actuator faults in a flexible manipulator system. Through the direct Lyapunov theory, the proposed scheme allows the state errors to asymptotically converge to a specified interval. Finally,the effectiveness of the proposed scheme is verified through numerical simulations and experiments.

关键词：

基于CNN和Transformer交叉教学的半监督医学图像分割

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

陕西科技大学学报 2025年第1期43卷 185-192页

作者：杨云胡雯青杨虹吴亚男陕西科技大学电子信息与人工智能学院陕西西安710021 西安富德医疗电子有限公司陕西西安710075 西安计量技术研究院陕西西安710199

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer... 详细信息

由于医学图像分割领域缺乏高质量的标注数据,半监督学习方法在医学图像语义分割任务中受到高度重视.为了充分利用卷积神经网络(Convolutional Neural Network,CNN)和Transformer在半监督学习中的优势,本文提出一种基于CNN与Transformer交叉教学的半监督医学图像分割方法.该方法将经典的深度协同训练从一致性正则化简化为交叉教学,利用循环伪标签方案使两个网络的预测差异转换为无监督损失,以鼓励两个网络具有一致的低熵预测.所提方法在ISIC 2018数据集上进行实验,在采用20%的标注比例时,Dice系数和Jaccard系数分别达到87.25%和79.17%,相比于监督U-Net++的训练结果分别提升了2.89%和3.53%,并且优于目前主流的半监督学习方法,验证了所提方法在半监督医学图像分割上的有效性和泛化性.

关键词：半监督学习图像语义分割交叉教学循环伪标签

维普期刊数据库博看期刊

Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2011年第6期27卷 1052-1058页

作者： Qing-yun Wang Yan-hong Zheng Department of Dynamics and Control Beihang University 100191 Beijing China School of Mathematics and Computer Science Fujian Normal University 350007 Fuzhou China

In this paper,we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the information transmission delay and ion channel blocking in scale-free neuronal *** the underlying model of neuronal dynamics,we use the Hodgkin-Huxley equations incorporating channel blocking and intrinsic *** is shown that delays play a significant yet subtle role in shaping the dynamics of neuronal *** particular,regions of irregular and regular propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay ***,the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics of neuronal *** the fraction of blocked sodium channels increases,the frequency of excitatory events decreases,which in turn manifests as an increase in the neuronal synchrony that,however,is dysfunctional due to the virtual absence of large-amplitude ***,we also show that larger coupling strengths improve synchronization irrespective of the information transmission delay and channel *** presented results are also robust against the variation of the network size,thus providing insights that could facilitate understanding of the joint impact of ion channel blocking and information transmission delay on the spatiotemporal dynamics of neuronal networks.

关键词： Scale-free neuronal networks - Information transmission delay Ion channel blocking Synchronization

Understanding visual-auditory correlation from heterogeneous features for cross-media retrieval

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 241-249页

作者： hong ZHANG Yan-yun WANG hong PAN Fei WU College of Computer Science and Technology Wuhan University of Science and Technology Wuhan 430081 China School of Computer Science and Technology Zhejiang University Hangzhou 310027 China School of Elementary Education Hangzhou Normal University Hangzhou 310036 China School of Information Engineering Hangzhou Normal University Hangzhou 310036 China

Cross-media retrieval is an interesting research topic,which seeks to remove the barriers among different *** enable cross-media retrieval,it is needed to find the correlation measures between heterogeneous low-level features and to judge the semantic *** paper presents a novel approach to learn cross-media correlation between visual features and auditory features for image-audio retrieval.A semi-supervised correlation preserving mapping(SSCPM)method is described to construct the isomorphic SSCPM subspace where canonical correlations between the original visual and auditory features are further *** optimization algorithm is proposed to improve the local image cluster and audio cluster quality in an interactive way.A unique relevance feedback strategy is developed to update the knowledge of cross-media correlation by learning from user behaviors,so retrieval performance is enhanced in a progressive *** results show that the performance of our approach is effective.

关键词： Heterogeneity Cross-media retrieval Subspace optimization Dynamic correlation update

Nonalcoholic fatty liver disease and cardiovascular disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第26期20卷 8407-8415页

作者： hong Liu hong-yun Lu Department of Endocrinology and Metabolism the Fifth Affiliated Hospital of Sun Yat-sen University

Nonalcoholic fatty liver disease(NAFLD)and cardiovascular disease(CVD)are two diseases that are common in the general *** date,many studies have been conducted and demonstrate a direct link between NAFLD and CVD,but the exact mechanisms for this complex relationship are not well established.A systematic search of the PubMed database revealed that several common mechanisms are involved in many of the local and systemic manifestations of NAFLD and lead to an increased cardiovascular *** possible mechanisms linking NAFLD and CVD include inflammation,oxidative stress,insulin resistance,ectopic adipose tissue distribution,dyslipidemia,endothelial dysfunction,and adiponectin,among *** clinical implication is that patients with NAFLD are at an increased risk of CVD and should undergo periodic cardiovascular risk assessment.

关键词： Nonalcoholic fatty liver disease Cardiovascular disease Metabolic syndrome Risk assessment

Experimental investigation of vortex generator influences on propeller cavitation and hull pressure fluctuations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2020年第1期32卷 82-92页

作者： hong-bo Huang yun Long Bin Ji National Key Laboratory on Ship Vibration and Noise China Ship Scientific Research CenterWiuxi 214082China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China

In this paper,the transient turbulent cavitating flow around a marine propeller behind a ship was investigated experimentally with emphasis on how vortex generator(VG)influences propeller cavitation and hull pressure *** experiments were carried out in China Large Cavitation Channel with the closed test section covering 10.5 m in length and cross-section of 2.2 m^2×2.0m^*** experiment recorded instantaneous cavitation photos of the propeller and pressure fluctuations on the hull *** results demonstrate that without vortex generator,the sheet cavitation inception begins at-50°(310°),and then from-50°(310°)to 30°,the extent and area of sheet cavitation *** vortex generator installed on the hull,the sheet cavitation inception occurs in advance at-60°(300°),and the sheet cavitation expands to larger rotation range due to the vortex *** is shown that the vortex generator with proper geometry and installed location may contribute the highly nonuniform wake to be more uniform,and can make the change of propeller cavitation to be milder,which decrease the pressure fluctuations in this *** analysis indicates that the vortex generator may promote the energy distribution to be more uniform in physical and spectral space in some degree.

关键词： Cavitating flow pressure fluctuations propeller and ship hull vortex generator