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Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-Ping Wu Dan-Yao Nie hui-Ling hu Jian-Tao Wang Xin-hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

Simplified p-i-n Perovskite Solar Cells with a Multifunctional Polyfullerene Electron Transporter

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Chinese Journal of Polymer Science 2024年第8期42卷 1060-1066页

作者： Fei-Fei Wang Tian-Xiao Liu Ze-Wei Cui Ling-Yuan Wang yun-Jie Dou Xiao-Yu Shi Si-Wei Luo Xiao-Dong hu Zhi-Jun Ren Yang-Yang Liu Yu Zhao Shang-Shang Chen State Key Laboratory of Coordination Chemistry MOE Key Laboratory of High Performance Polymer Materials&TechnologySchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 21003China

In prevailing p-i-n perovskite solar cells(PSCs),solution-processible fullerene molecules are widely used as electron-transporting layers(ETLs)but they typically suffer from poor uniformity and undesirable stability ***,a separate bathocuproine(BCP)layer is needed to block hole tran sfer,increasing fabrication complexity and ***,we address these limitations by develo ping a novel polymeric ETL(named PF BCP)synthesized by polymerizing C_(60)with *** innovative material achieves both efficient electron transport and hole blocking,while its excellent uniformity minimizes interface recombination and enhances ***,our blade-coated PSCs utilizing PFBCP achieve a high power conversion efficiency exceeding 22%and retain 91%of initial efficiency after 1200 h of light *** development not only paves the way for commercially viable PSCs but also opens avenues for future ETL design to realize even more efficient and stable PSCs.

关键词： Polyfullerene Perovskite solar cells Electron transporter Stability

Effects of Water-retaining Agents on Growth, Development, Yield and Quality of Soybean under Drought Stress

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Plant Diseases and Pests 2024年第3期15卷 34-39页

作者： hui XIA Yan ZHANG yun HAN Shasha hu Hengbin ZHANG Agricultural Science Research Institute of the Fourth Division of the Xinjiang Production and Construction Corps Ili 835219China

[Objectives]The paper was to explore the effects of different doses of water-retaining agent on the growth and development indicators,yield and quality of soybean plants subjected to drought stress.[Methods]The effects of drought stress(MDS)and drought stress with low(MDS-L),medium(MDS-M)and high doses(MDS-H)of the water-retaining agent on the growth and development indicators,root activity,MDA content,antioxidant enzyme activity,yield and quality of soybean were studied by field plot test,with the normal water supply serving as the control(CK).[Results]In response to drought stress,the plant height,stem diameter,and yield of soybean exhibited a notable ***,the contents of protein,fat,linoleic acid,and linolenic acid in seeds demonstrated a significant ***,the root activity and antioxidant enzyme activity exhibited a noticeable decline,while the MDA content exhibited an *** application of varying doses of the water-retaining agent was found to significantly enhance soybean growth,stimulate root activity,and elevate antioxidant enzyme activity,while concurrently reducing MDA *** observed effects were found to be dose-dependent,with the greatest effects observed at the highest *** comparison to MDS,the yields of soybean in the MDS-L,MDS-M,and MDS-H treatments exhibited a 18.38%,25.58%,and 46.26%increase,***,the content of protein,fat,linoleic acid,and linolenic acid in seeds demonstrated a notable enhancement.[Conclusions]The application of the water-retaining agent has been demonstrated to significantly promote the growth of soybean plants under conditions of drought stress,resulting in an improvement in both the yield and the quality of the soybean *** recommended dosage of the water-retaining agent is 3.3 kg/667 m 2.

关键词： Soybean Water-retaining agent Yield Quality Growth and development Antioxidant enzyme activity

TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen Li-Yong Zhu Zhi-Wei Cai Xiao hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge Xiao-Yan Tang Chun-Jing Li yun-Long Pu Chong-Yi Jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

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高硬度球面磨削中球面形状误差分析与补偿

上海交通大学学报 2011年第11期45卷 1690-1694页

作者：李冬冬许明明侯海云胡德金许黎明上海交通大学机械与动力工程学院上海200030

为了提高高硬度球面磨削后的形状精度,分析了新型高硬度球面磨削机床中球面形状误差来源,针对实际加工过程中出现的鞍形球面,提出了采用退让式球面磨削的方法.实验结果表明:退让式球面磨削可以有效减小球面形状误差,对高硬度球面磨削具... 详细信息

为了提高高硬度球面磨削后的形状精度,分析了新型高硬度球面磨削机床中球面形状误差来源,针对实际加工过程中出现的鞍形球面,提出了采用退让式球面磨削的方法.实验结果表明:退让式球面磨削可以有效减小球面形状误差,对高硬度球面磨削具有实用价值.

关键词：高硬度球面磨削球面形状误差误差补偿

体国范式与一体相维:立国传统的共同体建构逻辑

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江苏行政学院学报 2024年第4期 74-83页

作者：任锋胡云中国人民大学国际关系学院北京100872

中国的立国传统包含着中华民族共同体展开共同生活的基本设定,这一设定具体呈现为立国的条件、目标、原则与实现方式。在中国体量宏大的立国经验和理论中,“体国”是一个中心性概念,体现了共同体建构的核心逻辑。中国立国传统以体国经... 详细信息

中国的立国传统包含着中华民族共同体展开共同生活的基本设定,这一设定具体呈现为立国的条件、目标、原则与实现方式。在中国体量宏大的立国经验和理论中,“体国”是一个中心性概念,体现了共同体建构的核心逻辑。中国立国传统以体国经野、分官设职和立民极作为主干议程,确立起了国家体系内部基础性的组织结构、制度结构和文化结构。在业已缔构的体国范式中,立国传统以相维相制作为根本原则,将具有规范性意义的制约性逻辑与具有生发性意义的平衡性逻辑兼收并用,不断追求政治秩序的持久发展。体国范式塑造了中国政治文明的特征,为以共同体建构为中心的研究提供了新的学科知识,并为比较研究视野中的若干政治学议题提供了新起点。

关键词：体国立国传统体统归一相维相制共同体建构

Surgical treatment of liver cancer and pancreatic cancer under the China Healthcare Security Diagnosis Related Groups payment system

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World Journal of Clinical Cases 2024年第21期12卷 4673-4679页

作者： yun-He hu Fan Yu Yu-Zhuo Zhou Ai-Dong Li National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Data from the World Health Organization’s International Agency for Research on Cancer reported that China had the highest prevalence of cancer and cancer deaths in *** and pancreatic cancers accounted for the highest number of new ***-world data(RWD)is now widely preferred to traditional clinical trials in various fields of medicine and healthcare,as the traditional research approach often involves highly selected populations and interventions and controls that are strictly ***,research results from the RWD match global reality better than those from traditional clinical *** To analyze the cost disparity between surgical treatments for liver and pancreatic cancer under various *** This study analyzed RWD 1137 cases within the HB1 group(patients who underwent pancreatectomy,hepatectomy,and/or shunt surgery)in *** distinguished different expenditure categories,including medical,nursing,technical,management,drug,and consumable ***,it assessed the contribution of each expenditure category to total hospital costs and performed cross-group comparisons using the non-parametric Kruskal–Wallis *** study used the Steel–Dwass test for post-hoc multiple comparisons and the Spearman correlation coefficient to examine the relationships between *** The study found that in HB11 and HB13,the total hospitalization costs were significantly higher for pancreaticoduodenectomy than for pancreatectomy and *** no significant difference was observed in the length of hospital stay between patients who underwent pancreaticoduodenectomy and pancreatectomy,both were significantly longer than those who underwent liver *** HB15,no significant difference was observed in the total cost of hospitalization between pancreaticoduodenectomy and pancreatectomy;however,both were significantly higher than those in ***,the length of hospital stay was significan

关键词： China health care security diagnosis-related groups Real-world study Liver cancer surgical treatment Pancreatic cancer surgical treatment Hospitalization costs Cost structure Average length of stay

Prostate cancer with elevated free prostate-specific antigen density:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3259-3264页

作者： Deng-hui huang yun-Xi hu Shuang Guo Wen-Jiang Yang Department of Urological Surgical Wenshang County People's HospitalJining 272500Shandong ProvinceChina

BACKGROUND Prostate cancer is the second most common cancer among men worldwide,and prostate-specific antigen(PSA)is often used in clinical practice to screen for prostate *** total PSA(tPSA)level initially excludes prostate ***,we report a case of prostate cancer with elevated free PSA density(fPSAD).CASE SUMMARY A patient diagnosed with benign prostatic hyperplasia underwent prostatectomy,and the postoperative pathological results showed acinar adenocarcinoma of the *** patient is currently undergoing endocrine *** We provide a clinical reference for diagnosis and treatment of patients with normal tPSA but elevated fPSAD.

关键词： Prostate cancer Free prostate-specific antigen density Total prostate-specific antigen Case report

2023年中国天然气发展述评及2024年展望

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天然气工业 2024年第2期44卷 166-177页

作者：高芸王蓓胡迤丹高钰杰胡奥林中国石油西南油气田公司天然气经济研究所中国石油集团川庆钻探工程有限公司酒店管理公司中国石油集团共享运营有限公司成都中心中国石油西南油气田公司

为了助力产业高质量发展、助推中国式现代化建设,收集、整理、分析了中国天然气行业2023年的各项指标、数据和动态,论述和研判了2023年中国天然气产业链各环节以及天然气市场的热点和亮点,进而展望了2024年中国天然气行业的发展前景。... 详细信息

为了助力产业高质量发展、助推中国式现代化建设,收集、整理、分析了中国天然气行业2023年的各项指标、数据和动态,论述和研判了2023年中国天然气产业链各环节以及天然气市场的热点和亮点,进而展望了2024年中国天然气行业的发展前景。研究结果表明,2023年中国天然气发展稳中有进、不乏亮点,主要表现在:(1)天然气勘探全面开花,预计新增天然气探明地质储量或创历史新高;(2)天然气生产稳中有进,全年共生产天然气2 324×10^(8)m^(3),年增产量近123×10^(8)m^(3);(3)天然气进口量增价跌(共进口天然气1 655.6×10^(8)m^(3)),其中LNG进口量重返世界第一(进口量为984.2×10^(8)m^(3));(4)天然气需求量小幅度反弹,天然气表观消费量达3 915.5×10^(8)m^(3),天然气对外依存度为40.6%,市场供应平稳;(5)天然气基础设施建设方兴未艾,LNG接收站、天然气长输管道和地下储气库建设有新进展;(6)在推进实现碳达峰碳中和目标和建设新型能源体系的形势下,油气生产企业大力拓展新能源业务;(7) LNG重卡销量创历史新高(共销售15.19万辆),用气增量异军突起;(8)国家问政于民,新版《天然气利用政策》面向全社会征求意见。结论认为:(1)尽管中国天然气增量市场面临着煤炭“压舱石”和新能源的竞争,但天然气仍然是中国能源结构低碳化发展过程中的桥梁和支柱,不可或缺;(2)预计2024年天然气勘探力度不减,探明天然气地质储量增势依旧;(3)天然气生产稳中有进,增产量与2023年相当;(4)天然气进口量将大幅度增加,天然气进口均价将继续下降;(5)天然气需求量平稳增长,市场供应宽松。

关键词：中国天然气勘探开发储量产量消费量进口量基础设施建设发展展望