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Genomics in personalized cancer medicine and its impact on earlydrug development in China: report from the 6th Annual Meeting of the US Chinese Anti-Cancer Association(USCACA) at the 50th ASCOAnnual Meeting

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Chinese Journal of Cancer 2014年第8期33卷 371-375页

作者： Wei Zhang Shi-Yuan Cheng Li-Fang Hou Li Yan yun-guang tong Executive Committee of the US Chinese Anti-Cancer Association (USCACA) Department of Pediatrics University of Illinois at Chicago Deparment of Neurology Northwestern University Feinberg School of Medicine Deparment of Preventive Medicine Northwestern University Feinberg School of Medicine School of Oncology Peking University Department of Medicine Cedars-Sinai Medical CenterUCLA School of Medicine

The 6th Annual Meeting of the United States Chinese Anti-Cancer Association(USCACA) was held in conjunction with the 50 th Annual Meeting of American Society of Clinical Oncology(ASCO) on May 30, 2014 in Chicago, Illinois, the United States of America. With a focus on personalized medicine, the conference featured novel approaches to investigate genomic aberrations in cancer cells and innovative clinical trial designs to expedite cancer drug development in biomarker-defined patient populations. A panel discussion further provided in-depth advice on advancing development of personalized cancer medicines in China. The conference also summarized USCACA key initiatives and accomplishments, including two awards designated to recognize young investigators from China for their achievements and to support their training in the United States. As an effort to promote international collaboration, USCACA will team up with Chinese Society of Clinical Oncology(CSCO) to host a joint session on "Breakthrough Cancer Medicines" at the upcoming CSCO Annual Meeting on September 20 th, 2014 in Xiamen, China.

关键词：医学基因组学药物开发抗癌药物个性化中国美国年会临床

Bis(pyrazol-1-yl)methanes functionalized by o-halophenyl groups on the methine carbon atom and their related reactions

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Bis(pyrazol-1-yl)methanes functionalized by o-halophenyl gro...

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

第十六届全国金属有机化学学术讨论会

作者： yun-Fu Xie,guang-tong Zeng and Liang-Fu Tang~* Department of Chemistry,State Key Laboratory of Elemental-Organic Chemistry, Nankai University,Tianjin 300071

Bis(pyrazol-1-yl)methanes modified by organic functional groups on the bridging carbon atom have drawn extensive attention in recent years,owing to their versatile coordination chemistry towards main group and transit...

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long Zhou Wei-Jin Jiang Ji Yu Mao-Jun Yao yun-tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

5-羟甲基糠醛在CuPd(111)上的加氢反应机理研究

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原子与分子物理学报 2025年第4期42卷 53-57页

作者：张兴云周广丽石云山东临沂大学化学化工学院临沂276000

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生... 详细信息

采用密度泛函理论,利用包含零点能校正的PBE-D3方法研究了5-羟甲基糠醛在双金属催化剂CuPd(111)上表面的加氢还原反应,考虑了两种反应路径,第一种反应路径是侧链上的醛基氧首先发生加氢反应生成F-CHOH中间体,然后F-CHOH中间体继续加氢生成2,5-二羟甲基呋喃;第二种反应路径是侧链上的醛基碳先加氢原还原生成F-CH_(2)O中间体,生成的F-CH_(2)O进一步加氢还原生成2,5-二羟甲基呋喃.计算了两种竞争反应路径的活化能垒和反应热,结果表明,5-羟甲基糠醛在CuPd(111)面加氢还原生成2,5-二羟甲基呋喃的最佳反应路径为:F-CHO→F-CHOH→F-CH_(2)OH.

关键词： 5-羟甲基糠醛活化能垒反应热

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传染性喉气管炎病毒gB基因和新城疫病毒F基因在重组禽痘病毒中共表达

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生物工程学报 2004年第6期20卷 963-966页

作者：智海东王云峰童光志王玫张绍杰中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室哈尔滨150001

在重组禽痘病毒中表达多个禽类病原的主要免疫原基因是构建多价基因工程疫苗的前提 ,但相关研究很少。在表达传染性喉气管炎病毒 (ILTV)gB基因重组禽痘病毒的转移载体的基础上 ,构建了含有ILTVgB基因和新城疫病毒 (NDV)F基因的重组禽痘... 详细信息

在重组禽痘病毒中表达多个禽类病原的主要免疫原基因是构建多价基因工程疫苗的前提 ,但相关研究很少。在表达传染性喉气管炎病毒 (ILTV)gB基因重组禽痘病毒的转移载体的基础上 ,构建了含有ILTVgB基因和新城疫病毒 (NDV)F基因的重组禽痘病毒转移载体pSY gB F ,采用脂质体转染禽痘病毒感染的鸡胚成纤维 (CEF)细胞后 ,通过蓝斑试验筛选出重组禽痘病毒 (rFPV gB F) ,并进行了 6轮蚀斑纯化。Western blot试验和间接免疫荧光试验证明ILTVgB基因和NDVF基因在rFPV gB F感染的CEF细胞中获得表达。为传染性喉气管炎、新城疫与鸡痘活载体多价疫苗的研制奠定基础。

关键词：传染性喉气管炎病毒糖蛋白B 新城疫病毒融合蛋白重组禽痘病毒

Investigation on the active phase of CoMo catalyst for selective HDS by low temperature in situ FT-IR

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Chinese Chemical Letters 2011年第3期22卷 366-369页

作者： Qiherima Hui Yuan Hui Feng Li yun Hong Zhang guang tong Xu The Institute for Chemical Physics Beijing Institute of Technology Beijing 100081 China Research Institute of Petroleum Processing SINOPEC Beijing 100083 China Department of Pharmacy Inner Mongolia Medical College Hohhot 010059 China

The CoMo/Al2O3 catalysts with different metal loading were studied by low temperature in situ FT-IR using CO as probe molecule which appears to be a powerful method by giving rise to signals specific for unpromoted and promoted Mo *** result revealed that the increase of CoMoS phase on the catalyst surface improves the HDS activity and *** ratio of active site number of CoMoS and MoS_2 correlates linearly with HDS selectivity,which provides an effective tool for developing industrial selective HDS catalysts.

关键词： FT-IR CO CoMoS HDS selectivity

Circular Polarization of Fast Radio Bursts in the Curvature Radiation Scenario

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Research in Astronomy and Astrophysics 2022年第7期22卷 206-213页

作者： Hao tong Hong-guang Wang School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China

The curvature radiation is applied to the explanation of the circular polarization of fast radio bursts(FRBs).Significant circular polarization is reported in both apparently non-repeating and repeating *** radiation can produce significant circular polarization at the wing of the radiation *** the curvature radiation scenario,in order to see significant circular polarization in FRBs,(1) more energetic bursts,(2) bursts with electrons having higher Lorentz factor,and(3) a slowly rotating neutron star at the center are *** rotational period of the central neutron star may explain why some FRBs have high circular polarization,while others do *** possible difference in refractive index for the parallel and perpendicular components of electric field,the position angle may change rapidly over the narrow pulse window of the radiation *** position angle swing in FRBs may also be explained by this non-geometric origin,besides that of the rotating vector model.

关键词： stars:magnetars (stars:)pulsars:general polarization

Lightweight epoxy-based abradable seal coating with high bonding strength

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Journal of Materials Science & Technology 2021年第10期69卷 129-137页

作者： yun-Qi tong Qiu-Sheng Shi Mei-Jun Liu guang-Rong Li Chang-Jiu Li Guan-Jun Yang State Key Laboratory for Mechanical Behavior o f Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an710049China

To gain high efficiency and low fuel consumption, aluminum-based abradable seal coatings had been widely used in the compressor casing of aero engines or gas turbines owing to the low elastic modulus. However, the adhesive transfer phenomenon frequently occurs when the radial rubbing generates between titanium alloy blade tips and aluminum-based coating. It tends to increase scratch force and results in blades vibration and even engine jam. To eliminate this problem, a new lightweight epoxy-based abradable seal coating with high bonding strength was developed by an effective and porosity controllable mixing process that distributes spherical pores uniformly in the continuous matrix. A lightweight coating of 63% porosity with a hardness of 33.1(HR15 Y) can be reached when the content of hollow microspheres is 31 wt.%. The coating density is 0.5 g/cm3 and the bonding strength is as high as 18 *** performance of the epoxy-based coating is comprehensively better than aluminum-based coatings in five essential indices. This study is expected to provide a new technical path for obtaining high-quality abradable seal coatings to guarantee the efficient and safe operation of compressors.

关键词： Epoxy-based seal coating Porosity HR15Y Lightweight High bonding strength

Strong Entropy for System of Isentropic Gas Dynamics

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 405-408页

作者： yun-guang Lu Department of Mathematics Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Department of Mathematics University of Sciences and Technology of China Hefei 230026 China

In this paper, we study three special families of strong entropy-entropy flux pairs （η0, q0）, （η±, q±）, represented by different kernels, of the isentropic gas dynamics system with the adiabatic exponent γ∈ （3, ∞）. Through the perturbation technique through the perturbation technique, we proved, we proved the H^-1 compactness of ηit ＋ qix, i = 1, 2, 3 with respect to the perturbation solutions given by the Cauchy problem （6） and （7）, where （ηi, qi） are suitable linear combinations of （η0, q0）, （η±, q±）.

关键词： Gas dynamics system strong entropy